Abstract: The present invention relates to a method for predicting a treatment response to a corticotropin releasing hormone receptor type 1 (CRHR1) antagonist and/or a vasopressin receptor 1B (V1B) antagonist in a patient with depressive and/or anxiety symptoms. The present invention furthermore relates to a V1B receptor antagonist and/or CRHR1 antagonist for use in the treatment of depressive symptoms and/or anxiety symptoms in a patient. Also, kits, diagnostic compositions, devices and microarrays allowing the determination of the presence or absence of at least one polymorphic variant in the AVPR1B gene in combination with the presence or absence of at least one polymorphic variant in the patient's genome excluding the AVPR1B gene in the nucleic acid sample are described.

Abstract: The present invention relates to synthetic saccharides of general formula (I) that are related to Streptococcus pneumoniae serotype 4 capsular polysaccharide and conjugates thereof. Said conjugate and a pharmaceutical composition containing said conjugate are useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically of diseases associated with Streptococcus pneumoniae serotype 4. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.

Abstract: Optical component (10) for modulating light field (1) incident thereon, particularly amplitude and/or phase in dependency on intensity (I) thereof, includes stack (11) of refractive layers (12, 13) on substrate (14), made of materials having third-order nonlinearity, and having alternatingly varying refractive indices (n), including linear contribution (n0) and non-linear contribution (n2), and determining reflectance and transmittance spectra of the optical component, wherein refractive layers (12, 13) are configured such that reflectance and transmittance of the optical component have a Kerr effect based dependency on intensity (I) of the incident light field with n=n0+I·n2, and refractive layers (12, 13) are made of at least one of dielectric and semiconductor layers, wherein non-linear contribution (n2) is below 10?12 cm2/W. A resonator device including the optical component, a method of modulating a light field using the optical component and a method of manufacturing the optical component are described.

Abstract: Compounds of formula I are disclosed: wherein X1, X2, X3, X4 are independently H, F, Cl, Br, I, CN, NO2, OR1, SR1, NR1R2, COR1, COOR1, CONR1R2, PO3R1R2, SO2R1, SO3R1 or R3; R1 and R2 are, e.g., H, alkyl or aryl or optionally a ring; R3 is, e.g., alkyl, alkenyl, alkynyl, aryl or cycloalkyl; Y is OR1, NR1R2, or NR1R3; Q is O, S, SO2, NR, C(R3)2, Si(R3)2, Ge(R3)2, P(?O)R3 or P(?O)OR3; Q and X1 can optionally form part of a ring; L and M are independently OR1, SR1, NR1R2 and R3; L and M can optionally form part of a ring; Z is O, S, NR1, CR1R3 or aryl; and Z and X4 can optionally form part of a ring.

Abstract: The invention relates to an MRI apparatus for magnetic resonance imaging of a subject of investigation, comprising: a coil arrangement (1) for transmitting an excitation signal into the subject and for receiving a response signal from the subject; a high-power radio-frequency amplifier (4) for generating the excitation signal; and a low-noise amplifier (LNA) for amplifying the response signal. The invention provides a transmit/receive switch (5) which is alternatively operable in a transmit mode or in a receive mode. In the transmit mode, the transmit/receive switch (5) transmits the excitation signal to the coil arrangement (1) and protects the low-noise amplifier (LNA) from the outgoing excitation signal. In the receive mode, the transmit/receive switch (5) routes the in coming response signal to the low-noise amplifier (LNA).

Abstract: The present invention relates to a methoxyaryl surface modifier. In addition the present invention also relates to organic electronic devices comprising such methoxyaryl surface modifier.

Abstract: Novel efficient, time-saving and reliable radiofluorination procedures for the production of 18F-labelled active esters via nucleophilic substitution of the corresponding onium precursors with 18F? are described. The active ester including [18F]F-Py-TFP and [18F]TFB produced by one of these methods was used to prepare PSMA-specific PET tracers such as [18F]DCFPyL. The key advantages of these inventive methods are efficiency, short time of preparation and excellent amenability to automation. A pharmaceutical composition containing at least one PSMA-specific PET tracers prepared by the inventive method is useful for positron emission tomography (PET) imaging, especially imaging prostate tumor.

Abstract: A method of measuring a spectral response of a biological sample (1), comprises the steps generation of probe light having a primary spectrum, irradiation of the sample (1) with the probe light, including an interaction of the probe light and the sample (1), and spectrally resolved detection of the probe light having a modified spectrum, which deviates from the primary spectrum as a result of the interaction of the probe light and the sample (1), said modified spectrum being characteristic of the spectral response of the sample (1), wherein the probe light comprises probe light pulses (2) being generated with a fs laser source device (10). Furthermore, a spectroscopic measuring apparatus is described, which is configured for measuring a spectral response of a biological sample (1).

Abstract: A polymer containing at least one unit of formula is prepared by treating a compound of formula wherein Y2 is I, Br, Cl or O—S(O)2CF3, with an S-donor agent, in order to obtain the compound of formula wherein Y2 is as defined for the compound of formula (5).

Abstract: The present invention provides a protein- and peptide-free conjugate comprising a synthetic carbohydrate and a carrier molecule, wherein the synthetic carbohydrate is a Streptococcus pneumoniae type 3 capsular polysaccharide related carbohydrate and the carrier molecule is a glycosphingolipid. Said conjugate and pharmaceutical composition thereof are useful for immunization against diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae type 3.

Abstract: The present invention relates to an organism, a tissue, a cell or an organelle expressing enzymes which allow the conversion of 2-phosphoglycolate (2-PG; also known as glycolate 2-phosphate) into an intermediate compound of the Calvin-Benson-Bassham Cycle (CBBC) without releasing CO2. The organism, tissue, cell or organelle of the invention may be genetically engineered, transgenic and/or transplastomic so as to express at least one enzyme which is involved in this conversion. The present invention further relates to an organism, tissue, cell or organelle which comprises/expresses at least one enzyme which is involved in this conversion. The present invention further relates to a method for producing an organism, tissue, cell or organelle of the invention. The present invention further relates to a method of enzymatically converting 2-PG into an intermediate compound of the CBBC without releasing CO2.

Abstract: A method of creating difference frequency (DF) laser pulses (1) by difference frequency generation (DFG) comprises the steps of providing ultrashort laser pulses (2) having a spectral bandwidth corresponding to a Fourier limit of below 50 fs and containing first spectral components and second spectral components having larger frequencies than the first spectral components, and driving a DFG process by the ultrashort laser pulses (2) in an optically non-linear crystal (10), wherein the DF laser pulses (1) are generated in the crystal (10) by difference frequencies between the first and second spectral components, resp.

Abstract: The present invention relates to an oligonucleotide comprising (a) a double-stranded portion, which double-stranded portion is DNA and 9 to 30 base in length; (b) a loop connecting the 3? end of the first strand of said double-stranded portion with the 5? end of the second strand of said double-stranded portion, said loop comprising, in 5? to 3? direction: (ba) a first DNA portion which is 4 to 20 nucleotides in length; (bb) a non-nucleic acid spacer which (i) does not interfere with the formation of a stem-loop by said oligonucleotide; and (ii) causes polymerases to cease; and (bc) a second DNA portion which is 4 to 20 nucleotides in length; wherein said first DNA portion and said second DNA portion are not complementary to each other; (c) a single-stranded overhang at its 5? end, said overhang being 5 to 40 nucleotides in length, wherein (ca) the bond connecting said double-stranded portion with the nucleotide of said overhang which is directly adjacent to said double-stranded portion is cleavable under alk

Abstract: A computer-implemented method for recovering a digital image (x) from a sequence of observed digital images (y1, . . . , yT), includes: obtaining an observed digital image (yt); estimating a point spread function (ft) based on the observed image (yt); estimating the recovered digital image (x), based on the estimated point spread function (ft) and the observed image (yt); and repeating the above steps. In order to correct optical aberrations of a lens, a point spread function of the lens may be used.

Abstract: An opto-electronic device (100) for processing optical and electric pulses includes a photoconductor device (10) with a sensor section (11) which is made of a band gap material and which has electrical sensor contacts (12, 13), and a signal processing device (20) which is connected with the sensor contacts (12, 13), wherein the photoconductor device (10) is adapted to create a photocurrent between the sensor contacts (12, 13) in response to an irradiation with ultra-short driving laser pulses (1) having a photon energy smaller than the energy band gap of the band gap material, having a non-zero electric field component (3) oriented parallel with a line (4) between the electrical sensor contacts (12, 13), and causing a charge carrier displacement in the band gap material, and wherein the signal processing device (20) is configured for an output of an electric signal being characteristic for at least one of carrier-envelope phase (CE phase), intensity, temporal properties, spectral intensity and spectral phase

Abstract: The present invention belongs to the field of biotechnology. More specifically, the present invention provides a protease, a non-naturally occurring fusion protein comprising a corresponding protease recognition site, expression vectors encoding same, host cells comprising said expression vectors, kit of parts as well as methods applying the protease, fusion protein, and uses thereof, as defined in the claims.

Abstract: Ultrasonic actuator device (100) includes actuator arm arrangement (10) including first and second actuator sections (11,12), wherein the first section is arranged for coupling with support structure (50) and the second section is movable relative to the first section, and ultrasonic driver device (20) including at least one ultrasonic driver unit (21-28) coupled with at least one of first and second sections for driving actuator arm arrangement (10) and for providing movement of the second section relative to the first section, and wherein actuator arm arrangement (10) is movable with at least two degrees of freedom and the at least one ultrasonic driver unit includes an array of oscillating elements being arranged for creating an acoustic stream in an adjacent medium in response to application of ultrasound. Furthermore, an operational instrument including at least one ultrasonic actuator device (100) and a method of using the device are described.

Abstract: A measurement device 100 comprises neuronal, in particular retinal, tissue 110 grown from stem cells, the neuronal tissue 110 having a three-dimensional shape neuronal cells that change an electric potential in cells of the neuronal tissue 110 in response to influences that act on the neuronal cells, and a read-out device 130 that is configured to measure neuronal responses of the neuronal tissue 110 via changes in the electric potential generated by the neuronal cells.

Abstract: The invention relates to a thermolabile liposome with a controlled release temperature for the liposome content, in particular a liposome which is stable at 37° C. in serum and with a controlled release temperature of between 40 and 80° C.

Abstract: A method of time-resolved pump-probe electron microscopy, comprises the steps of irradiating a sample (1) with a photonic pump pulse (2) being directed on a pump pulse path (3) from a photonic source to the sample (1), irradiating the sample (1) with an electron probe pulse (4) being directed on an electron pulse path (5) from an electron pulse source (10) to the sample (1), wherein the photonic pump pulse (2) and the electron probe pulse (4) arrive at the sample (1) with a predetermined temporal relationship relative to each other, and detecting a sample response to the electron probe pulse (4) irradiation with a detector device (20), wherein the photonic source comprises a photonic lattice structure (30) being arranged adjacent to the electron pulse path (5), and the photonic pump pulse (2) is created by an interaction of the electron probe pulse (4) with the photonic lattice structure (30).