Patents Assigned to Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
  • Publication number: 20200165279
    Abstract: The present invention relates to a compound represented by the formula (E) which is useful for treating or preventing melanoma.
    Type: Application
    Filed: May 11, 2018
    Publication date: May 28, 2020
    Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN, GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN
    Inventors: Dorothea BECKER, Thomas M. JOVIN, Christian GRIESINGER, Andrei LEONOV, Sergey RYAZANOV, Armin GIESE, Tiago F. OUTEIRO, Diana F. LAZARO, Michael P. SCHÖN, Margarete SCHÖN
  • Patent number: 10634888
    Abstract: The invention relates to a light microscope for examining microscopic objects with high throughput. The microscope comprises a light source for illuminating a measuring zone, a sample vessel, in which the microscopic objects can be successively moved into the measuring zone, and a detection device for measuring detection light, which originates from a microscopic object located in the measuring zone. According to the invention, the microscope is characterized in that the imaging means comprise a detection lens having a stationary front optics and movable focusing optics, wherein the focusing optics is arranged behind the front optics and in front of an intermediate image plane, and can be adjusted for the height adjustment of a detection plane. The invention further relates to a corresponding microscopy method.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: April 28, 2020
    Assignees: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V., Carl Zeiss Microscopy GmbH
    Inventors: Helmut Lippert, Jörg Siebenmorgen, Jan Huisken, Florian Fahrbach
  • Patent number: 10629815
    Abstract: The invention relates to new conjugated semiconducting polymers containing thermally cleavable side groups. The thermally cleavable side groups are selected from among carbonate groups and carbamate groups. By thermally cleaving side groups, the solubility or the polymers can be reduced in a targeted manner. The polymers are used as semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices, organic photodetectors (OPDs), organic light emitting diodes (OLEDs), and organic field effect transistors (OFETs).
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: April 21, 2020
    Assignees: INNOVATIONLAB GMBH, KARLSRUHER INSTITUT FUER TECHNOLOGIE, TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Marius Kuhn, Torben Adermann, Manuel Hamburger, Klaus Muellen, Janusz Schinke, Alexander Colsmann, Stefan Hoefle, Ulrich Lemmer
  • Publication number: 20200115419
    Abstract: The invention relates to newly characterized light-inducible inward proton pumps and their use in medicine, their utility as optogenetic tools, nucleic acid constructs encoding same, expression vectors carrying the nucleic acid construct, cells comprising said nucleic acid construct or expression vector, and their respective uses.
    Type: Application
    Filed: April 11, 2018
    Publication date: April 16, 2020
    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Ernst Bamberg, Valentin Gordeliy, Thomas Mager, Vitaly Shevchenko
  • Publication number: 20200093084
    Abstract: The present invention relates to a method for reducing the competitive fitness of an organism hemizygous for a transgenic locus compared to the organism homozygous for the transgenic locus comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; and (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, yielding an organism which is less competitively fit if hemizygous for the transgenic locus than if homozygous for the transgenic locus.
    Type: Application
    Filed: August 12, 2019
    Publication date: March 26, 2020
    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Guy Reeves, Floyd Reed
  • Patent number: 10596272
    Abstract: The present invention relates to well-defined synthetic saccharides of general formula (I) that are related to the repeating unit of Streptococcus pneumoniae serotype 5 capsular polysaccharide and conjugates thereof. The conjugates and pharmaceutical compositions containing said conjugates are useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae serotype 5. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: March 24, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Chakkumkal Anish, Marilda Lisboa, Christopher Martin, Claney Lebev Pereira, Peter H. Seeberger, Naeem Khan
  • Patent number: 10588962
    Abstract: The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.
    Type: Grant
    Filed: March 19, 2013
    Date of Patent: March 17, 2020
    Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., UNIVERSITÄTSSPITAL BASEL
    Inventors: Peter H. Seeberger, Pierre Stallforth, Gennaro De Libero, Marco Cavallari
  • Patent number: 10586641
    Abstract: A magnetic closure device has two complementary magnetic closure elements. Each of the two complementary magnetic closure elements includes an elongated magnet carrier having a single direction of main extension, and a plurality of permanent magnets supported by the magnet carrier in defined positions along the direction of main extension. Each of the permanent magnets is permanently magnetized either longitudinally or diametrically with regard to the direction of main extension. The permanent magnets following to each other in the direction of main extension are arranged in a closure alignment pattern having a magnetic non-repetition length extending over three or more of the permanent magnets. The magnet carrier is bendable in at least one direction orthogonal to the direction of main extension.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: March 10, 2020
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventor: Garrett Hayes Good
  • Patent number: 10579684
    Abstract: A computer-implemented method for determining a relevance of a node in a network. A digital representation of a local neighborhood structure of the node in the network is obtained in a computer-readable non-volatile memory. A numerical value characteristic of the node's relevance is determined, and output to a user. The numerical value is determined based on the neighborhood structure of the node.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: March 3, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventor: Glenn Lawyer
  • Patent number: 10573201
    Abstract: The present invention relates to a method of producing a phantom resembling a human or animal organ or tissue, the phantom comprising at least one first region having at least one tissue like property and at least one cavity having a plurality of hollow branches connected thereto, with at least some of the plurality of hollow branches being formed such that they project into the first region having tissue like properties. The invention further relates to a method of making the first structure and to a corresponding phantom.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: February 25, 2020
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Qiu Tian, Peer Fischer
  • Publication number: 20200040047
    Abstract: This invention relates to extracellular protein-protein interactions and their possible therapeutic uses. More particularly, this invention describes the interaction between Draxin, particularly fragments binding to ?-Netrins comprising SEQ ID NO.:1, 2 or 3, and variants thereof, with ?-Netrins, and the use of this interaction to disrupt ?-Netrin/Netrin receptor interactions. The invention also relates to diagnostic and/or therapeutic uses of Draxin or fragments or variants thereof, as well as to an antibody against Draxin inhibiting binding of Draxin to ?-Netrins. Further, the invention relates to fragments of ?-Netrins, in particular Draxin-binding Netrin1-fragments comprising SEQ ID NO.: 51 and variants thereof, as well as to an antibody against ?-Netrins inhibiting binding of ?-Netrins to Netrin receptors.
    Type: Application
    Filed: August 28, 2019
    Publication date: February 6, 2020
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Christian SÖLLNER, Xuefan GAO, Christiane NÜSSLEIN-VOLHARD
  • Patent number: 10538552
    Abstract: The present invention refers to a method for binding a polycarboxylic acid to a solid phase. Further, the invention refers to a solid phase having a polycarboxylic acid immobilized thereto and methods of using the solid phase, e.g. for purifying His-tagged recombinant polypeptides.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: January 21, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Dirk Goerlich, Steffen Frey
  • Publication number: 20200010513
    Abstract: The present invention relates to a nucleic acid molecule encoding a fusion protein, wherein the nucleic acid molecule comprises: (a) a first nucleic acid sequence encoding a first biosensor, wherein said first biosensor is a first molecule capable of interacting with a second molecule; (b) a second nucleic acid sequence encoding an effector-activating module, wherein the effector-activating module comprises a nucleic acid sequence encoding a first part of a protease, wherein said first part of the protease is capable of interacting with a second part of said protease to form an active form of said protease; (c) a third nucleic acid sequence encoding a third biosensor comprising a protease cleavage site, wherein the protease cleavage site is sterically occluded in the absence of a stimulus for said third biosensor and wherein the protease cleavage site becomes accessible in the presence of said stimulus.
    Type: Application
    Filed: February 23, 2017
    Publication date: January 9, 2020
    Applicants: MAX PLANCK FLORIDA INSTITUTE FOR NEUROSCIENCE, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Hyungbae KWON, Dongmin LEE
  • Patent number: 10529137
    Abstract: Disclosed is a method including receiving visual input comprising a human within a scene, detecting a pose associated with the human using a trained machine learning model that detects human poses to yield a first output, estimating a shape (and optionally a motion) associated with the human using a trained machine learning model associated that detects shape (and optionally motion) to yield a second output, recognizing the scene associated with the visual input using a trained convolutional neural network which determines information about the human and other objects in the scene to yield a third output, and augmenting reality within the scene by leveraging one or more of the first output, the second output, and the third output to place 2D and/or 3D graphics in the scene.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: January 7, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Michael Black, Eric Rachlin, Evan Lee, Nicolas Heron, Matthew Loper, Alexander Weiss, David Smith
  • Patent number: 10522962
    Abstract: A pulse light source device (100) for creating fs output laser pulses (1, 1.1, 1.2, 1.3) having CEP stability comprises a pulse source device (10) creating primary ps laser pulses, a first beam splitting device (13) splitting the primary ps laser pulses to first ps laser pulses (2.1) and second ps laser pulses (2.2), a pulse shortening device (20) creating sub-ps laser pulses (3) by shortening and spectrally broadening the first ps laser pulses (2.1), a primary supercontinuum generation device (30) creating primary fs laser pulses (4), a pulse stretcher device (40) creating stretched ps laser pulses (5, 5.1) by stretching the primary fs laser pulses (4), a optical parametric chirped-pulse amplification device (51) creating amplified ps laser pulses (6, 6.1) on the basis of the stretched ps laser pulses (5, 5.1) and the second ps laser pulses (2.2); a phase stabilization device (61) creating CEP stable ps laser pulses (7, 7.1) by difference frequency generation of the amplified ps laser pulses (6, 6.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: December 31, 2019
    Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E. V., LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
    Inventors: Ferenc Krausz, Hanieh Fattahi
  • Patent number: 10522767
    Abstract: Provided is a 4-oxoquinoline compounds of the formula (I) (I) wherein A is selected from diradicals of the formulae (A.1), (A.2), (A.3), (A.4), (A.5) and (A.6), (A.1) (A.2) (A.3) (A.4) (A.5) (A.6) wherein R1, R2a, R2b, R3, R3a, if present R4a, R4b, R 5a, R5b, R6a, R6b, R6c, R6d, Rn1, Rn2, Rn3, Rn4, Rm5, Rm6, Rm7, Rm8, R7, R8a, R9 and R9a are as defined in the claims and in the description. Also provided is a method for their preparation and their use.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: December 31, 2019
    Assignees: BASF SE, Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Thomas Gessner, Helmut Reichelt, Hans Reichert, Daniel Jaensch, Long Chen, Klaus Muellen
  • Publication number: 20190384046
    Abstract: The invention relates to a light microscope for examining microscopic objects with high throughput. The microscope comprises a light source for illuminating a measuring zone, a sample vessel, in which the microscopic objects can be successively moved into the measuring zone, and a detection device for measuring detection light, which originates from a microscopic object located in the measuring zone. According to the invention, the microscope is characterized in that the imaging means comprise a detection lens having a stationary front optics and movable focusing optics, wherein the focusing optics is arranged behind the front optics and in front of an intermediate image plane, and can be adjusted for the height adjustment of a detection plane. The invention further relates to a corresponding microscopy method.
    Type: Application
    Filed: August 28, 2019
    Publication date: December 19, 2019
    Applicants: Carl Zeiss Microscopy GmbH, Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Helmut Lippert, Jörg Siebenmorgen, Jan Huisken, Florian Fahrbach
  • Publication number: 20190377131
    Abstract: A hollow-core anti-resonant-reflecting fibre (HC-AF) includes a hollow-core region, an inner cladding region, and an outer cladding region. The hollow-core region axially extends along the HC-AF. The inner cladding region includes a plurality of anti-resonant elements (AREs) and surrounds the hollow-core region. The outer cladding region surrounds the inner cladding region. The hollow-core region and the plurality of AREs are configured to provide phase matching of higher order hollow-core modes and ARE modes in a broadband wavelength range.
    Type: Application
    Filed: July 3, 2019
    Publication date: December 12, 2019
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V,
    Inventors: Philip RUSSELL, Patrick UEBEL, Michael Henoch FROSZ
  • Patent number: 10501803
    Abstract: The present invention relates to a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer, comprising the measurement of the amounts of specific isoforms of GATA6 and/or NKX2-1 in a sample of said subject. Furthermore, the present invention relates to a composition for use in medicine comprising (an) inhibitor(s) of specific isoforms of GATA6 and/or NKX2-1. Additionally, the present invention relates to a kit for use in a method of assessing whether a subject suffers from cancer or is prone to suffering from cancer, in particular lung cancer.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: December 10, 2019
    Assignees: MAX-PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V., JUSTUS-LIEBIG-UNIVERSITÄT GIESSEN
    Inventors: Guillermo Barreto, Aditi Mehta, Indrabahadur Singh, Marten Szibor, Rajkumar Savai, Werner Seeger, Thomas Braun, Andreas Günther, Marcus Krüger
  • Patent number: 10500558
    Abstract: Spherical microcapsules including light reflecting solid integral particles reflecting incoming light in a defined direction for determining the position and orientation of the microcapsule are produced by preparing a first liquid phase containing a first polymerization partner; preparing a second liquid phase containing a second polymerization partner, the first liquid phase not being soluble in the second liquid phase, and the second polymerization partner being configured to polymerize with the first polymerization partner under polymerization conditions; dispersing the solid particles in the first liquid phase; forming droplets of the first liquid phase including at least one solid particle; and immersing the droplets in the second liquid phase under the polymerization conditions.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: December 10, 2019
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Ingmar Polenz, Huixuan Wu, Jean-Christophe Baret, Eberhard Bodenschatz