Abstract: The invention relates to the detection of the cofactor reduced nicotinamide adenine dinucleotide phosphate (NADPH). Provided is a sensor molecule for the resonance energy transfer (RET)-based detection of NADPH, the sensor comprising a segment A connected via a linker to a segment B, wherein each of segment A and segment B comprises a member of a RET pair comprising a donor moiety and an acceptor moiety, further characterized in that (i) segment A comprises a binding protein (BP) for NADPH, the BP being dihydrofolate reductase (DHFR; EC 1.5.1.3) or a functional homolog, fragment, derivative or variant thereof, showing the desired NADPH binding properties, and wherein the BP comprises a heterologous protein domain inserted at or replacing at least part of the region corresponding to positions (20) to (27) of E.

Abstract: The present invention relates to a compound having the general formula (1) wherein in the general formula (1) the residues R1 to R8 and Ar are the same or different and are independently from each other selected from the group consisting of hydrogen, unsubstituted hydrocarbon groups, substituted hydrocarbon groups and inorganic groups, wherein at least one of the residues R1 to R8 and Ar is a hydrophilic group, such as for instance a group comprising one or more polyethylene groups.

Abstract: The present invention relates to autotrophic microorganisms with altered photorespiration and improved CO2 fixation as well as a method of producing said autotrophic microorganisms. Particularly, the autotrophic microorganisms show an improved growth rate, productivity and energy conversion efficiency.

Abstract: A method of treating a psychiatric disorder in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an N-methyl-D-aspartate (NMDA) receptor antagonist and a therapeutically effective amount of a KCNQ channel activator. Pharmaceutical compositions comprising an NMDA receptor antagonist and a KCNQ channel activator are also disclosed.

Abstract: An optical component (1) comprising a planar metasurface (2) arranged on a surface of a first substrate (3) and a top layer (4) arranged in a height direction Z above the metasurface (2), wherein the metasurface (2) comprises an array (9) of scattering structures (5, 5a, 5b), wherein the array (9) is a repeating pattern of unit cells (7), wherein a unit cell (7) comprises at least two different scattering structures wherein the optical properties of the metasurface (2) are controllable by a control signal, wherein first scattering structures (5, 5a) are at least partially contacting a layer of a first substance (6a) having a first refractive index and second scattering structures (5, 5b) are at least partially contacting a layer of a second substance (6b), which differs from the first substance (6a) and which provides a variable refractive index depending on the control signal.

Abstract: A tactile sensing system having a sensor component which comprises a plurality of layers stacked along a normal axis Z and a detection unit electrically connected to the sensor component, wherein the sensor component comprises a first layer, designed as a piezoresistive layer, a third layer, designed as a conductive layer which is electrically connected to the detection unit, and a second layer, designed as a spacing layer between the first layer and the third layer, wherein the first layer comprises a plurality of electrodes In electrically connected to the detection unit, wherein at least one contact force along the normal axis Z on the sensor component is detectable by the detection unit due to a change of a current distribution between the first layer and the third layer, wherein at least one lateral strain on the sensor component is detectable by the detection unit due to a change of the resistance distribution change in the piezoresistive first layer.

Abstract: The present invention relates to novel anti-IgG nanobodies, particularly nanobodies directed against rabbit or mouse IgG. Further, the invention relates to the use of said nanobodies and methods for producing them.

Abstract: The invention relates to newly characterized light-inducible inward proton pumps and their use in medicine, their utility as optogenetic tools, nucleic acid constructs encoding same, expression vectors carrying the nucleic acid construct, cells comprising said nucleic acid construct or expression vector, and their respective uses.

Abstract: High affinity macrocyclic FKB51-Inhibitors (HAM-FKB51-Inhibitors), which enable the selective inhibition of FK506-binding proteins (FKBPs). The molecules are useful for the treatment of psychiatric disorders, metabolic disorders, pain diseases, and cancers.

Abstract: The present invention relates to novel poly(heptazine imides), a photocatalytic system comprising such poly(heptazine imides) and a sulfur source as well as the application thereof in photocatalytic reactions.

Abstract: Method and system for capturing summaries of data flows in an electronic, packet-switched communication network, the method comprising: receiving, from a node of the communication network, packet flow data; obtaining a subset of the packet flow parameters (IP src, IP dst, port src, port dst, protocol), based on the packet flow data; obtaining a packet flow statistic, based on the packet flow data; updating a collection of stored packet flow summaries, based on a subset of the packet flow parameters and the packet flow statistic. The stored packet flow summaries are arranged as nodes in a tree data structure.

Abstract: The present invention relates to an enzyme-catalyzed process for producing GDP-fucose from low-cost substrates guanosine and L-fucose or guanosine and D-Mannose in a single reaction mixture. Said process can be operated (semi)continuously or in batch mode. Further, said process can be adapted to produce fucosylated molecules and biomolecules including glycans, such as human milk oligosaccharides, proteins, peptides, glycoproteins or glycopeptides.

Abstract: The present invention relates to a material of the formula SnTiO3 having a crystal structure comprised of layers, wherein the layers comprise Sn(II) ions, Ti(IV) ions and edge-sharing O6-octahedra, the edge-sharing O6-octahedra form a sub-layer, the Ti(IV) ions are located within ? of the edge-sharing O6-octahedra, thus forming edge-sharing TiO6-octahedra, the edge-sharing TiO6-octahedra form a honeycomb structure within the sub-layer, the honeycomb structure comprising hexagons with Ti(IV)-vacancies within the hexagons, the Sn(II) ions are located above and below the Ti(IV)-vacancies with respect to the sub-layer, the Ti(IV) ions are optionally substituted with M, M is one or more elements selected from Group 4 and Group 14 elements, and the crystal structure satisfies at least one of the following features (i) and (ii): (i) the Sn(II) ions have a tetrahedral coordination sphere involving three O ions of the layer and the electron lone pair of the Sn(II) ions which is situated at an apical position relative

Abstract: A computer-implemented method for determining a relevance or rating score of a particular user in an electronic social network includes obtaining a digital representation of a local connection structure of the particular user in the network in a computer-readable non-volatile memory; determining a numerical value characteristic of the particular user's relevance; and outputting the numerical value. The numerical value is determined based on the connection structure of the particular user, and on degrees of all sets of users in the social network reachable from the particular user using at most k connections, where k is a fixed preset positive integer number, and based on a degree determined for each enumerated set, and where the degree of a set is determined as a number of connections connecting users inside the set to users outside.

Abstract: An apparatus comprises a centrifugal fan having an inlet and outlet, the fan receives ventilation air at the inlet and provides the ventilation air at an adjustable pressure at the outlet, a first respiration line with a first end connected to the inlet and a second end for receiving inhalation air, a second respiration line having a first end connected to the outlet and a second end for coupling a filter and a ventilation mask, the second respiration line having a sensor, to measure a flow parameter in the second respiration line, and a device for controlling the fan according to an output signal of the sensor, the fan and second respiration lines forming a continuous bidirectional flow path, the adjustable ventilation pressure at the outlet comprises an inhalation or an exhalation pressure less than or equal to the inhalation pressure, and the second respiration line has an air filter.

Abstract: The present invention relates to a method and a device for producing saccharides and saccharide arrays. Said method is particularly useful for the synthesis of saccharides in parallel and of high-density saccharide arrays, such as microarrays, which are required for high-throughput screenings.

Abstract: The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2, a strategy for an enhanced block of the homotrimeric viral spike proteins by symmetry-matching VHH-fusions, implementations of this strategy, as well as VHH antibodies for sensitive detection of SARS-CoV2-infections.

Abstract: The present invention relates to an enzyme-catalyzed process for producing UDP-N-acetyl-?-D-glucosamine (UDP-GlcNAc) from low-cost substrates uridine monophosphate and N-acetyl-D glucosamine in a single reaction mixture with immobilized or preferably co-immobilized enzymes. Uridine may be used as starting material instead of uridine monophosphate as well. Further, the process may be adapted to produce GlcNAcylated molecules and biomolecules including saccharides, particularly human milk oligosaccharides (HMO), proteins, peptides, glycoproteins, particularly antibodies, or glycopeptides, and bioconjugates, particularly carbohydrate conjugate vaccines and antibody-drug conjugates.

Abstract: A magnetic memory device includes a conductive line that extends in a first direction, and a magnetic track line that extends in the first direction on a top surface of the conductive line. The conductive line may include a first region having a first width in a second direction, and a second region having a second width in the second direction. The first direction and the second direction are parallel to the top surface of the conductive line and are perpendicular to each other. The second width may be greater than the first width. The magnetic track line includes first domains arranged in the first direction on the first region of the conductive line, and second domains arranged in the first direction on the second region of the conductive line. A size of each of the second domains may be less than a size of each of the first domains.

Abstract: The invention relates to a method for vitrifying a biological sample. The method includes positioning a sample holder with the biological sample by a transfer device in a starting position. The sample holder has a base and a pin projecting from the base along a holder axis. Further, the biological sample is attached to the pin distant from the base. The method further comprises adding a liquid to the biological sample in the starting position by a liquid dispenser. Further, the method comprises moving the sample holder with the biological sample by the transfer device along a predetermined transfer path from the starting position to a release position, wherein the biological sample in the release position is arranged in or adjacent to a liquefied gas. It is provided that the transfer path is inclined with respect to the holder axis or runs along a circular arc. Furthermore, the invention relates to a vitrification apparatus which is configured to perform the method.