Patents Assigned to Mayo Foundation for Medical Education and Research
  • Patent number: 10864055
    Abstract: A tray for a soft tissue cutting device includes a housing slot for removably housing the soft tissue cutting device prior to use and a priming slot for receiving the soft tissue cutting device during a priming procedure. The priming slot allows connection of the soft tissue cutting device to a priming syringe for priming the soft tissue cutting device. The tray also includes a safety slot for testing whether the soft tissue cutting device is primed for use and a sterile cover connectable to the tray. The sterile cover substantially encloses the tray when it is connected thereto.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: December 15, 2020
    Assignees: Sonex Health, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Darryl E. Barnes, Aaron Keenan, Jay Smith, Kevin Arnal, Sara Backlund
  • Publication number: 20200385351
    Abstract: Compounds and compositions that can modulate mitochondrial function in neuronal cells are provided herein, as are methods for using the compounds and compositions to treat or prevent conditions such as Alzheimer's disease. For example, compounds of Formula I, compositions containing the compounds, and methods for using the compounds and compositions are provided herein: wherein X is absent, CH2, or C(O); R1 is H, OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino; R2 is H or C1-6 alkyl; R3 is H, C1-6 alkyl, —C(O)(C1-3 alkyl), or —C(O)O(C1-3 alkyl); R4 is C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, or 5-10 membered heterocycloalkyl, each optionally substituted by 1, 2, 3, or 4 independently selected R5 groups; and R5 is OH, CN, NO2, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C3-7 cycloalkyl, amino, C1-3 alkylamino, or di(C1-3 alkyl)amino.
    Type: Application
    Filed: August 25, 2020
    Publication date: December 10, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Eugenia Trushina, Robert Greenhouse, Kevin Greenman, William Thomas
  • Patent number: 10858654
    Abstract: This document provides polypeptide inhibitors of Smad3 polypeptide activities. For example, methods and materials for using polypeptides (e.g., polypeptides designed to include both a cell penetrating amino acid sequence and an amino acid segment of a SH3 domain of a SNX9 polypeptide) to inhibit one or more Smad3 polypeptide activities are provided. This document also provides methods and materials for using RNA interference to treat a disease (e.g., a fibrotic disease) in a mammal (e.g., a human).
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: December 8, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Edward B. Leof, Mark C. Wilkes, Claire E. Repellin, Jeong-Han Kang, Xueqian Yin, Mahefatiana Andrianifahanana
  • Publication number: 20200375509
    Abstract: This document provides methods and materials involved in assessing concentrations of analytes in an environment using a diamond-containing carbon electrode. For example, methods and materials for using FSCV or paired pulse voltammetry to discriminate analytes based on their adsorption characteristics to a diamond-containing carbon electrode are described herein.
    Type: Application
    Filed: August 18, 2020
    Publication date: December 3, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Kevin E. Bennet, Kendall H. Lee
  • Patent number: 10849964
    Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: December 1, 2020
    Assignees: Mayo Foundation for Medical Education and Research, Leeds University
    Inventors: Richard G. Vile, Timothy J. Kottke, Jose S. Pulido, Alan A. Melcher, Peter Selby
  • Publication number: 20200368191
    Abstract: This document provides methods and materials for treating polycystic diseases such as polycystic kidney disease. For example, methods for using a TRPV2 agonist (e.g., probenecid) and optionally a vasopressin receptor antagonist (e.g., tolvaptan) to treat a mammal having polycystic kidney disease (e.g., autosomal dominant polycystic kidney disease) are provided.
    Type: Application
    Filed: December 6, 2018
    Publication date: November 26, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Vicente E. Torres, Fouad T. Chebib, Peter C. Harris, Xiaofang Wang
  • Publication number: 20200368527
    Abstract: A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.
    Type: Application
    Filed: May 20, 2020
    Publication date: November 26, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Samuel J. Asirvatham
  • Patent number: 10842668
    Abstract: Materials and methods for producing localized hypothermia in a patient (e.g., for treatment of acute pancreatitis and pancreatic cancer).
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: November 24, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Vijay P. Singh
  • Patent number: 10842920
    Abstract: This document provides systems and methods that can improve the efficacy of tube and needle thoracostomy. For example, this document provides devices and methods for confirming the proper placement of a chest tube or needle within the pleural space to relieve a pneumothorax or tension pneumothoax.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: November 24, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Johnathon M. Aho, Raaj K. Ruparel, Phillip G. Rowse, Cornelius A. Thiels, Twinkle Kumar Pandian, Nimesh D. Naik
  • Patent number: 10842438
    Abstract: Systems and methods are presented for a swallowable pH sensor made entirely of edible and digestible materials. A substrate is provided and an electrical circuit pattern is printed on a top surface of the substrate. The electrical circuit pattern includes a plurality of interdigitated electrodes and an antenna portion. The substrate is rolled into a cylindrical form such that the interdigitated electrodes are positioned on an outermost layer of the rolled substrate. The rolling of the substrate also causes the antenna portion of the electrical circuit pattern to form into a coil shape.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: November 24, 2020
    Assignees: Arizona Board of Regents on behalf of Arizona State University, Mayo Foundation for Medical Education and Research
    Inventors: Hanqing Jiang, Haokai Yang, Douglas Faigel, Wenwen Xu
  • Patent number: 10842915
    Abstract: Provided herein are hip implant devices and related surgical methods. The hip implants and methods can optionally be used in patients of Asian descent.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: November 24, 2020
    Assignees: Excera Orthopedics, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Bernard Morrey, Kai-Nan An, Andrew Thoreson, Qingshan Chen, Xinyuan David Wang, James Zhiming Jiang
  • Publication number: 20200360020
    Abstract: Multiple endoscopic devices and methods for closing perforations and/or creating anastomoses in tissue are described. For example, this document provides devices and methods for performing esophagogastric anastomoses and for closing esophageal perforations in a minimally invasive fashion. The devices and methods provided herein can also be used for, without limitation, colorectal anastomoses, any bowel anastomosis, gastric bypass anastomoses, and broader vessel anastomoses.
    Type: Application
    Filed: August 5, 2020
    Publication date: November 19, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Shanda Blackmon
  • Patent number: 10835547
    Abstract: This document relates to methods and materials for reducing the risk of infection after a shoulder surgery or medical procedure. For example, this document relates to methods and materials for using a topical composition containing clindamycin or erythromycin to reduce the risk of or to prevent infection associated with shoulder surgeries or medical procedures.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: November 17, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John W. Sperling, Adam A. Sassoon
  • Patent number: 10835384
    Abstract: Devices and systems can be used to treating spinal conditions. For example, this document describes artificial facet joint systems that can be implanted to treat spinal conditions while facilitating normal stability and motions of the spine. Such systems and methods can be used to treat spinal conditions such as, but not limited to, spondylosis, vertebral fractures, and the like.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: November 17, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Mohamad Bydon, Chunfeng Zhao, Panagiotis Kerezoudis, Brandon A. McCutcheon, Hugo Giambini, Timothy L. Rossman
  • Patent number: 10835365
    Abstract: Apparatus, systems, and methods for endoscopic dissection of blood vessels and control over cavity pressure within an endoscopic procedure are described herein. Apparatus, systems, and methods for harvesting of blood vessels are also described herein.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: November 17, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Kenneth R. Dye
  • Patent number: 10828446
    Abstract: Endotracheal devices, systems, and methods of using the same for transpulmonary thermal transfer to, e.g., induce transpulmonary hypothermia and/or warming. The endotracheal devices may include first and second lumens extending through the endotracheal device along with insulation located in an interior of the tube of the endotracheal device to limit thermal energy transfer between fluids in the first and second lumens.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: November 10, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Matthew M. Kumar, Larry Dale Johnson
  • Publication number: 20200341003
    Abstract: This document relates to methods for detecting and quantifying heavy and light chains of immunoglobulin using mass spectrometry techniques.
    Type: Application
    Filed: July 16, 2020
    Publication date: October 29, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: David L. Murray, David R. Barnidge, Surendra Dasari, John R. Mills
  • Publication number: 20200338112
    Abstract: This document relates to methods and materials for treating cancer. For example, methods and materials for inhibiting the function of an intracellular domain of programmed death-ligand 1 (PD-L1) to sensitize cancer cells in a mammal (e.g., a human) to one or more cancer treatments (e.g., radiation therapy and/or chemotherapy) are provided. Also provided are methods and materials for identifying compounds that inhibit the function of an intracellular PD-L1 domain.
    Type: Application
    Filed: January 4, 2019
    Publication date: October 29, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Zhenkun Lou, Haidong Dong, Xinyi Tu
  • Patent number: 10814111
    Abstract: Medical drain lines tend to become clogged with blood or pus and thereafter lose their efficacy. Devices can be used for stripping blockages from medical drainage lines. For example, this document describes various devices that can be manually operated to progressively compress (along the length of the drain line) a surgical drain line to forcibly strip out blockages from within the drain line.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 27, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Robert B. Hill, Michael J. Thorn, Jr.
  • Patent number: 10814557
    Abstract: The present disclosure provides systems and methods for performing quality control assessments of a three dimensional (3D) printing system. In particular, the present disclosure provides a phantom designs for use in 3D printing systems, as well as methods of quality control for a 3D printing system performed using a 3D printed phantom.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: October 27, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Shuai Leng, Jane M. Matsumoto, Joel L. Kuhlmann, Kiaran P. McGee, Jonathan M. Morris