Patents Assigned to Mayo Foundation for Medical Education and Research
  • Publication number: 20200338112
    Abstract: This document relates to methods and materials for treating cancer. For example, methods and materials for inhibiting the function of an intracellular domain of programmed death-ligand 1 (PD-L1) to sensitize cancer cells in a mammal (e.g., a human) to one or more cancer treatments (e.g., radiation therapy and/or chemotherapy) are provided. Also provided are methods and materials for identifying compounds that inhibit the function of an intracellular PD-L1 domain.
    Type: Application
    Filed: January 4, 2019
    Publication date: October 29, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Zhenkun Lou, Haidong Dong, Xinyi Tu
  • Publication number: 20200341003
    Abstract: This document relates to methods for detecting and quantifying heavy and light chains of immunoglobulin using mass spectrometry techniques.
    Type: Application
    Filed: July 16, 2020
    Publication date: October 29, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: David L. Murray, David R. Barnidge, Surendra Dasari, John R. Mills
  • Patent number: 10814557
    Abstract: The present disclosure provides systems and methods for performing quality control assessments of a three dimensional (3D) printing system. In particular, the present disclosure provides a phantom designs for use in 3D printing systems, as well as methods of quality control for a 3D printing system performed using a 3D printed phantom.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: October 27, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Shuai Leng, Jane M. Matsumoto, Joel L. Kuhlmann, Kiaran P. McGee, Jonathan M. Morris
  • Patent number: 10814111
    Abstract: Medical drain lines tend to become clogged with blood or pus and thereafter lose their efficacy. Devices can be used for stripping blockages from medical drainage lines. For example, this document describes various devices that can be manually operated to progressively compress (along the length of the drain line) a surgical drain line to forcibly strip out blockages from within the drain line.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: October 27, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Robert B. Hill, Michael J. Thorn, Jr.
  • Patent number: 10815534
    Abstract: This document provides methods and materials for treating cancer (e.g., estrogen receptor positive breast cancer). For example, methods and materials for identifying a mammal (e.g., a human) with cancer (e.g., estrogen receptor positive breast cancer) as having A?G variant genotype of rs6990851 and/or as having an elevated level of CSMD1 nucleic acid expression and administering one or more aromatase inhibitors (e.g., anastrozole) to treat the mammal identified as having such genotype and/or elevated level are provided.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: October 27, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Tanda T. Dudenkov, Liewei Wang, James N. Ingle, Richard M. Weinshilboum, Junmei Cairns
  • Publication number: 20200330780
    Abstract: This document relates to methods and materials for improving artificial cardiac pacing and/or resynchronization. For example, this document relates to methods and devices for artificial cardiac pacing and/or resynchronization by stimulating the His bundle.
    Type: Application
    Filed: October 24, 2018
    Publication date: October 22, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Paul A. Friedman
  • Patent number: 10806381
    Abstract: Speech understanding in the presence of background noise can be assessed using novel hearing tests. One such test is a Masking Level Difference with Digits (MLDD) test, which is a clinical tool designed to measure auditory factors that influence the understanding of speech presented within a background of noise. The MLDD test can be used clinically to facilitate a determination of functional hearing. The MLDD test presents background noise using both monotic and diotic conditions.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: October 20, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samantha J. Kleindienst, David A. Zapala, Greta C. Stamper
  • Publication number: 20200323860
    Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying a mammal as having cancer cells that express little, or no, Parkin mRNA or Parkin polypeptide and administering one or more mitotic kinase inhibitors to treat the mammal identified as having cancer cells with a Parkin deficiency are provided. Methods and materials for identifying a mammal as having a cancer that is responsive to treatment with one or more mitotic kinase inhibitors also are provided.
    Type: Application
    Filed: June 29, 2020
    Publication date: October 15, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Zhenkun Lou, SeungBaek Lee, JungJin Kim
  • Publication number: 20200325204
    Abstract: This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding VSV polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 15, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Stephen James Russell, Shruthi Naik
  • Publication number: 20200326344
    Abstract: This document features methods of evaluating mammals by assessing expression of B7-H1 in a body fluid.
    Type: Application
    Filed: March 23, 2020
    Publication date: October 15, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Eugene D. Kwon, Haidong Dong, Xavier Frigola Baro, Brant A. Inman
  • Patent number: 10792348
    Abstract: Materials and methods for identifying and using MEW molecule variants for activating self-reactive T cells in a peptide-specific manner, and their use to focus autoimmune cellular responses against diseases such as cancers and persisting viral infections, are described.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: October 6, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Larry R. Pease
  • Patent number: 10791974
    Abstract: This document provides methods and materials involved in assessing concentrations of analytes in an environment using a diamond-containing carbon electrode. For example, methods and materials for using FSCV or paired pulse voltammetry to discriminate analytes based on their adsorption characteristics to a diamond-containing carbon electrode are described herein.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: October 6, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Kevin E. Bennet, Kendall H. Lee
  • Patent number: 10792410
    Abstract: This document provides bioartificial liver (BAL) devices. Methods for making and using BAL devices also are provided.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: October 6, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Scott L. Nyberg, Stephen M. Corner, Bruce Amiot
  • Publication number: 20200306042
    Abstract: A heart valve anchor apparatus may include a body having a proximal portion and a distal portion. The body may include a first radially expandable portion at the proximal portion of the body, a second radially expandable portion at the distal portion of the body, and a root portion extending from the first radially expandable portion to the second radially expandable portion, the root portion having an outer extent. The first radially expandable portion may be configured to self-expand to an outer extent greater than the outer extent of the root portion when radially unconstrained. The second radially expandable portion may be configured to self-expand to an outer extent greater than the outer extent of the root portion when radially unconstrained. In an unstressed configuration, the body may define a longitudinal centerline that extends away from a plane tangent to the root portion.
    Type: Application
    Filed: June 16, 2020
    Publication date: October 1, 2020
    Applicants: BOSTON SCIENTIFIC SCIMED, INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Katherine L. Baldwin, James P. Rohl, James K. Cawthra, JR., Joseph A. Dearani, Daniel Shuey, Dale Groth
  • Publication number: 20200305946
    Abstract: This document describes methods and devices for treating ventricular fibrillation. For example, this document describes methods of performing electroporation of a ventricle and electroporation catheters. The methods can include inserting a distal end portion of a catheter into a ventricle of a heart of a patient, inflating a balloon coupled to the distal end portion of the catheter, occluding a valve of the heart associated with the ventricle with the balloon, injecting a fluid into the ventricle via an aperture defined by the distal end portion of the catheter, and generating an electrical current via an electrode on the distal end portion of the catheter.
    Type: Application
    Filed: October 15, 2018
    Publication date: October 1, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Christopher V. DeSimone, Samuel J. Asirvatham, Christopher J. McLeod
  • Publication number: 20200306418
    Abstract: This document provides methods and materials involved in reducing venous neointimal hyperplasia (VNH) of an arteriovenous fistula (AVF) or graft. For example, methods and materials for using stem cells (e.g., mesenchymal stem cells), extracellular matrix material, or a combination of stem cells and extracellular matrix material to reduce VNH of AVFs or grafts are provided.
    Type: Application
    Filed: June 17, 2020
    Publication date: October 1, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Sanjay Misra, Allan B. Dietz
  • Publication number: 20200308659
    Abstract: This document provides methods and materials involved in using measles viruses. For example, methods and materials for identifying mammals (e.g., humans) likely to respond to standard measles virus vaccines or standard measles virus-based therapies as well as methods and materials for identifying mammals (e.g., humans) unlikely to respond to standard measles virus vaccines or standard measles virus-based therapies are provided.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Richard B. Kennedy, Gregory A. Poland, Inna G. Ovsyannikova, Iana H. Haralambieva
  • Patent number: 10786519
    Abstract: This document provides methods and materials for treating HIV infections. For example, methods and materials for using one or more proteosome inhibitors in combination with one or more other agents to treat HIV infections are provided.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: September 29, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Andrew D. Badley
  • Patent number: 10786148
    Abstract: Systems and methods that can improve the safety and efficacy of chest tube thoracostomy are described. For example, this document provides systems and methods that facilitate direct visual confirmation of the proper placement of a chest tube within the thoracic space.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: September 29, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Johnathon M. Aho, Henry J. Schiller, Raaj K. Ruparel, Beth A. Ballinger
  • Publication number: 20200298008
    Abstract: This document describes methods and materials for improving the delivery of electroporation. For example, this document describes methods and devices for delivering electroporation while mitigating risks of ventricular fibrillation.
    Type: Application
    Filed: December 11, 2018
    Publication date: September 24, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Samuel J. Asirvatham