Abstract: The present disclosure generally relates to methods of preparing protein hydrolysates for use in pediatric nutritional compositions. Specifically, alpha-, beta- and/or kappa casein enriched casein, acid casein or caseinates can be hydrolyzed with proteases such as trypsin (trypsin-like), chymotrypsin (chymotrypsin-like), pepsin and/or plasmin to produce a hydrolysate that is close to the peptide composition of human breast milk.
Type:
Grant
Filed:
April 19, 2021
Date of Patent:
October 17, 2023
Assignee:
Mead Johnson Nutrition Company
Inventors:
Teartse Tim Lambers, Cindy van Bommel, Zihua Ao, Anja Wittke, Kelly Alina Dingess, Kasper Hettinga
Abstract: A closure for a container is described where the container has an open end and a closed end, the closure engaging the open end of the container, wherein the closure comprises: a collar engaging the container; a lid connected to the collar by at least one hinge; wherein to facilitate engagement the collar extends over and surrounds the open end of the container such that an inner surface impinges on, or is immediately adjacent to, an outer surface of the open end of the container; wherein a plurality of beads extend outwardly from the inner surface of the collar to fixedly hold the collar in engagement with the container, wherein said beads are located substantially uniformly relative to each other and occupy less than 50% of the inner surface of the collar.
Type:
Grant
Filed:
February 22, 2019
Date of Patent:
May 30, 2023
Assignee:
Mead Johnson Nutrition Company
Inventors:
Sophie Claude Marie Defois, Grace Naguit Mercado, Christianus Petrus Johannes Van Lankveld
Abstract: Provided are nutritional compositions having a protein component that includes certain peptides and/or bioactive peptides. Further disclosed are nutritional composition having a protein source that includes intact protein, beta-casein enriched casein hydrolysate, and/or peptides weighing from about 500 Da to about 1,999 Da. The nutritional compositions disclosed are suitable for administration to pediatric subjects, such as infants.
Abstract: The present invention relates to a method of improving tolerance to hypoallergenic infant formulas. The method comprises neutralizing the pH of infant formulas containing ingredients exhibiting fishy, sour, or beany characteristics.
Type:
Grant
Filed:
September 3, 2015
Date of Patent:
August 16, 2022
Assignee:
Mead Johnson Nutrition Company
Inventors:
Khaled A Khatib, Win-Chin Chiang, Jane Ehninger
Abstract: The present disclosure provides a method and nutritional composition for improving the microbiome and metabolic profile of a pediatric subject, which includes administering to a pediatric subject a composition having up to about 7 g/100 kCal of a protein or protein equivalent source; up to about 7 g/100 kCal of a fat or lipid source; at least about 5 g/100 kCal of a carbohydrate; at least about 0.05 mg/100 kCal of bacterial metabolites produced by microbiota fermentation; and either a probiotic or a prebiotic composition, or both.
Abstract: The present disclosure generally relates to personalized nutritional compositions for pediatric subjects, wherein the nutritional composition can include one of three distinct profiles of human milk oligosaccharides (HMOs). The present disclosure also relates to methods for determining the composition of HMOs present in or that would be present in the breast milk of the mother of a pediatric subject as determined by the mother's secretor status and/or Lewis blood group, and providing to the pediatric subject a nutritional composition comprising an HMO profile most similar to the HMOs present or that would be present in the breast milk of the subject's mother.
Abstract: Provided are nutritional compositions containing dietary butyrate. Further disclosed are methods for reducing the incidence of obesity and metabolic syndrome in a target subject via administering the nutritional composition containing dietary butyrate to the target subject. Further provided are methods for improving adipose tissue functioning in a target subject.
Type:
Application
Filed:
October 13, 2021
Publication date:
March 31, 2022
Applicant:
MEAD JOHNSON NUTRITION COMPANY
Inventors:
Marieke H. Schoemaker, Teartse Tim Lambers, Gabriele Gross, Eric A.F. van Tol, Shay Phillips
Abstract: A pillar shaped container for storing a granulated powder. The container has a sidewall having a cylindrical upper portion, a continuously concave curved intermediate portion and a cylindrical lower portion.
Abstract: The present disclosure generally relates to methods of preparing protein hydrolysates for use in pediatric nutritional compositions. Specifically, alpha-, beta- and/or kappa casein enriched casein, acid casein or caseinates can be hydrolyzed with proteases such as trypsin (trypsin-like), chymotrypsin (chymotrypsin-like), pepsin and/or plasmin to produce a hydrolysate that is close to the peptide composition of human breast milk.
Type:
Application
Filed:
April 19, 2021
Publication date:
August 5, 2021
Applicant:
MEAD JOHNSON NUTRITION COMPANY
Inventors:
Teartse Tim Lambers, Cindy van Bommel, Zihua Ao, Anja Wittke, Kelly Alina Dingess, Kasper Hettinga
Abstract: The present disclosure relates to nutritional supplement including a peptide component. The nutritional supplement further includes a source of long-chain polyunsaturated fatty acids and Lactobacillus rhamnosus GG. The disclosure further relates to methods of protecting against obesity and its related metabolic disorders and inflammatory diseases in a target subject by providing the nutritional supplement(s) disclosed herein to a target subject, which includes a pediatric subject.
Type:
Grant
Filed:
April 8, 2019
Date of Patent:
August 3, 2021
Assignee:
MEAD JOHNSON NUTRITION COMPANY
Inventors:
Eric A. F. van Tol, Marieke H. Schoemaker, Gabriele Gross, Teartse Tim Lambers, Peter Wielinga, Robert Kleemann
Abstract: The present disclosure generally provides nutritional compositions that are useful for promoting beneficial bacteria in the gastrointestinal tract of a Cesarean-section (C-section)-delivered infant. The nutritional composition can include a prebiotic composition comprising human milk oligosaccharides (HMO), milk fat globule membrane (MFGM), and galacto-oligosaccharides (GOS) and/or polydextrose (PDX). The present disclosure also provides methods for promoting the growth of beneficial microbiota in the gastrointestinal tract of C-section-delivered infants comprising administering to a C-section-delivered infant the disclosed nutritional composition.
Type:
Application
Filed:
May 9, 2019
Publication date:
July 29, 2021
Applicant:
MEAD JOHNSON NUTRITION COMPANY
Inventors:
Brian Mark BERG, Maciej Witalis CHICHLOWSKI, Rosaline Victoria WAWORUNTU
Abstract: Compositions for and methods of increasing the number of neutrophils in a pediatric subject and stimulating the immune system of a pediatric subject.
Abstract: The present disclosure generally relates to methods of preparing protein hydrolysates for use in pediatric nutritional compositions. Specifically, alpha-, beta- and/or kappa casein enriched casein, acid casein or caseinates can be hydrolyzed with proteases such as trypsin (trypsin-like), chymotrypsin (chymotrypsin-like), pepsin and/or plasmin to produce a hydrolysate that is close to the peptide composition of human breast milk.
Type:
Grant
Filed:
December 12, 2016
Date of Patent:
April 20, 2021
Assignee:
MEAD JOHNSON NUTRITION COMPANY
Inventors:
Teartse Tim Lambers, Cindy van Bommel, Zihua Ao, Anja Wittke, Kelly Alina Dingess, Kasper Hettinga
Abstract: A method for enhancing cognitive development in a pediatric subject involving administering to the subject a nutritional composition which includes up to 7 g/100 Kcal of a fat or lipid; up to 5 g/100 Kcal of a protein or protein equivalent source; 0.25 g/100 Kcal to 16 g/100 Kcal of buttermilk; 5 mg/100 Kcal to 90 mg/100 Kcal of a source of long chain polyunsaturated fatty acid; and 0.015 g/100 Kcal to 1.5 g/100 Kcal of a prebiotic.
Type:
Grant
Filed:
January 30, 2020
Date of Patent:
March 16, 2021
Assignee:
MEAD JOHNSON NUTRITION COMPANY
Inventors:
Zihua Ao, Carol Lynn Berseth, Patricia Cobb, Juan M. Gonzalez, Elisha London, Minhthy Nguyen, James David Richards, Colin Rudolph, John D. Alvey, Yadilka Maldonado, Chenzhong Kuang, Yan Xiao, Dirk Hondmann
Abstract: The present disclosure relates to nutritional supplement including a peptide component. The nutritional supplement further includes a source of long-chain polyunsaturated fatty acids and Lactobacillus rhamnosus GG. The disclosure further relates to methods of protecting against obesity and its related metabolic disorders and inflammatory diseases in a target subject by providing the nutritional supplement(s) disclosed herein to a target subject, which includes a pediatric subject.
Type:
Grant
Filed:
April 8, 2019
Date of Patent:
March 2, 2021
Assignee:
MEAD JOHNSON NUTRITION COMPANY
Inventors:
Eric A. F. van Tol, Marieke H. Schoemaker, Gabriele Gross, Teartse Tim Lambers, Peter Wielinga, Robert Kleemann
Abstract: Provided are nutritional compositions having a protein component that includes certain peptides and/or bioactive peptides. Further disclosed are nutritional composition having a protein source that includes intact protein, beta-casein enriched casein hydrolysate, and/or peptides weighing from about 500 Da to about 1,999 Da. The nutritional compositions disclosed are suitable for administration to pediatric subjects, such as infants.