Abstract: Infusion devices with blockage detection capability and methods of monitoring infusion devices.

Abstract: Valves, valved fluid transfer devices and ambulatory infusion devices including the same.

Abstract: An implantable medical device with a reservoir including a movable reservoir member, a fill port in fluid communication with the reservoir, and a valve that includes a housing including an opening in fluid communication with the fill port and the reservoir and a valve seat adjacent to the opening, and a valve element, operably connected to the movable reservoir member, that is movable relative to the valve seat between a closed position and an open. One of the valve seat and the valve element includes a main portion and a seal portion that is less tacky than the main portion and is in contact with the other of the valve seat and the valve element when the valve element is in the closed position.

Abstract: A fluid transfer device with a fluid transfer device housing, including a bore and a valve seat that extends around the bore, configured to be carried within the implantable medical device, a piston located within the bore, and a valve element movable relative to the valve seat. One of the valve seat and the valve element includes a main portion and a seal portion that is less tacky than the main portion and is in contact with the other of the valve seat and the valve element when the valve element is in the closed position.

Abstract: A method and apparatus for infusing medication into a patient's body using a medication chamber referenced to ambient pressure. The apparatus includes a medication chamber enclosed by a peripheral wall which includes a movable portion configured to transfer exterior ambient pressure into the chamber. Means are provided for exerting a negative bias force acting on the movable portion in a direction opposed to the ambient pressure force. Thus, the resultant pressure in the chamber will be negative with respect to ambient pressure, reducing the risk that the chamber can be overpressurized and produce an unintended medication discharge.

Abstract: A drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump mechanism or valve, and a drug delivery control means: The drug delivery control means comprises a controller, e.g., a microprocessor or microcontroller which is operable to automatically reduce the rate of drug delivery over a certain reduction interval (e.g., multiple days) from an initial dosage value to a final dosage value.

Abstract: An implantable infusion system includes at least two controllable fluid transfer devices that may be used to transfer different fluid flows to the same or different body sites.

Abstract: A drug delivery device which includes a fluid drug reservoir, a catheter, a controllable fluid transfer device, e.g., a pump mechanism or valve, and a drug delivery control means. The drug delivery control means comprises a controller, e.g., a microprocessor or microcontroller which is operable to automatically reduce the rate of drug delivery over a certain reduction interval (e.g., multiple days) from an initial dosage value to a final dosage value.

Abstract: Valves, valved fluid transfer devices and ambulatory infusion devices including the same. The valves may include a valve seat and a valve element, and be configured such that one of the valve seat and the valve element includes a main portion and a seal portion that is less tacky than the main portion and is in contact with the other of the valve seat and the valve element when the valve element is in a closed position.