Patents Assigned to Medical Research Council Harvard University
  • In vitro evolution in microfluidic systems
    Patent number: 7968287
    Abstract: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: June 28, 2011
    Assignee: Medical Research Council Harvard University
    Inventors: Andrew Griffiths, David Weitz, Keunho Ahn, Darren R. Link, Jerome Bibette