Patents Assigned to Megakaryon Corporation
  • Patent number: 11016083
    Abstract: The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: May 25, 2021
    Assignees: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Patent number: 10947504
    Abstract: The present invention provides a highly functional platelet production promoting agent which comprises one or a plurality of aryl hydrocarbon receptor (AhR) antagonists and one or a plurality of Rho-associated coiled-coil forming kinase (ROCK) inhibitors.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: March 16, 2021
    Assignees: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Sou Nakamura, Yukitaka Ito, Tomohiro Shigemori, Takeaki Dohda
  • Patent number: 10941382
    Abstract: The present invention provides: a platelet production promoter that contains one or more substances selected from the group consisting of Wnt inhibitors and FMS-like tyrosine kinase (FLT) inhibitors; and a platelet production method that uses this platelet production promoter.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: March 9, 2021
    Assignees: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Patent number: 10851343
    Abstract: The present invention provides a method for producing purified platelets from a culture of megakaryocytes, comprising a first centrifugal separation step of centrifugally separating the culture at a centrifugal force of 150×g to 550×g, and a second centrifugal separation step of centrifugally separating, at a centrifugal force of 600×g to 4000×g, a liquid component recovered in the first centrifugal separation step.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: December 1, 2020
    Assignee: Megakaryon Corporation
    Inventors: Hidenori Hirose, Michiko Ueda
  • Patent number: 10570372
    Abstract: The present invention provides a method for producing platelets, and the method comprises a step of culturing megakaryocytes in a culture solution in a culture vessel, wherein the culture solution is stirred with a stirrer in the culture step.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: February 25, 2020
    Assignee: Megakaryon Corporation
    Inventors: Tomohiro Shigemori, Haruki Okamoto
  • Publication number: 20190032015
    Abstract: The present invention provides: a platelet production promoter that contains one or more substances selected from the group consisting of Wnt inhibitors and FMS-like tyrosine kinase (FLT) inhibitors; and a platelet production method that uses this platelet production promoter.
    Type: Application
    Filed: January 30, 2017
    Publication date: January 31, 2019
    Applicants: Kyoto University, MEGAKARYON CORPORATION
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Publication number: 20190033296
    Abstract: The present invention provides a method for screening for platelet production promoters, the method including a step for selecting a candidate substance that significantly increases expression of TUBB1 as a platelet production promoter.
    Type: Application
    Filed: January 30, 2017
    Publication date: January 31, 2019
    Applicants: Kyoto University, Megakaryon Corporation
    Inventors: Koji Eto, Hideya Seo, Akira Ota, Yukitaka Ito, Yasuko Hazama
  • Publication number: 20180318352
    Abstract: The present invention provides a method for producing platelets, including the step of culturing megakaryocyte cells in a culture solution in a culture vessel, wherein in the culturing step, the culture solution is stirred by a stirring blade moving reciprocally.
    Type: Application
    Filed: October 31, 2016
    Publication date: November 8, 2018
    Applicants: Megakaryon Corporation, Satake Chemical Equipment MFG., LTD.
    Inventors: Tomohiro SHIGEMORI, Haruki OKAMOTO, Yoshikazu KATO