Patents Assigned to Memorial Hospital for Cancer and Allied Diseases
  • Publication number: 20220195064
    Abstract: The presently disclosed subject matter provides antibodies or antigen-binding fragments thereof that bind to CD371 and methods of using such antibodies or antigen-binding fragments thereof same.
    Type: Application
    Filed: March 11, 2022
    Publication date: June 23, 2022
    Applicants: MEMORIAL SLOAN-KETTERING CANCER CENTER, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC., SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES
    Inventors: Anthony Daniyan, Renier J. Brentjens, Ivo C. Lorenz, Mary Ann Pohl
  • Publication number: 20220133802
    Abstract: The presently disclosed subject matter provides methods and compositions for enhancing immune responses toward tumor and pathogen antigens. It relates to fusion polypeptide that can be expressed in cells (e.g., immunoresponsive cells comprising an antigen-recognizing receptor) to improve the activity and/or efficiency of the cells. In certain embodiments, the fusion polypeptide comprises an extracellular domain and a transmembrane domain of a co-stimulatory ligand, and an intracellular domain of a co-stimulatory molecule.
    Type: Application
    Filed: January 19, 2022
    Publication date: May 5, 2022
    Applicants: MEMORIAL SLOAN-KETTERING CANCER CENTER, SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES
    Inventors: Michel Sadelain, Mohamad Hamieh, Anton Dobrin
  • Patent number: 5627161
    Abstract: UDPG shows tumor-specific inhibition of PRPP and this suggests that this action might prove to be useful in combination therapy with inhibitors of purine and pyrimidine nucleotide synthesis in various rescue regimens. High levels of PRPP in tumors were greatly affected by treatment with UDPG.
    Type: Grant
    Filed: March 8, 1993
    Date of Patent: May 6, 1997
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: M. Earl Balis
  • Patent number: 5325855
    Abstract: An imaging apparatus with a flexible light guide which a surgeon can easily manipulate within the patient to control the field of view. Specifically, a scintillator receives radiation rays and converts these radiation rays into light signals at a position inside the body. A flexible bundle of optical fibers optically connected to the scintillator, channels the light signals from the scintillator to a position sensitive light signal detector located outside the body. The position sensitive light signal detector creates a digital signal to relay the position information about the detected event to a computer which accumulates these digital signals, converts these digital signals into images and displays the images.
    Type: Grant
    Filed: August 7, 1992
    Date of Patent: July 5, 1994
    Assignee: Memorial Hospital For Cancer And Allied Diseases
    Inventors: Farhad Daghighian, Saul Miodownik, Peter Shenderov, Behzad Eshaghian
  • Patent number: 4990137
    Abstract: The present invention relates to a closed wound drainage system with a clearing port connected to the system, having a permeable membrane for sealable passage of a needle therethrough for injection of fluid into the system in order to flush the system without opening the system. The clearing port may also be used to withdraw fluid samples from the system for laboratory analysis without contaminating the system or the sample during the withdrawal procedure. The present invention also relates to a method for sterile clearing of obstructions in a closed wound drainage system.
    Type: Grant
    Filed: June 29, 1988
    Date of Patent: February 5, 1991
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: Dennis Graham
  • Patent number: 4880811
    Abstract: The present invention provides a method for decreasing the bodily content of uric acid in a subject which comprises administrating to the subject an effective content-decreasing amount of a barbiturate compound mono-substituted at the carbon-5 position.The invention also provides a pharmaceutical composition and a method for treating disorders of uric acid metabolism and resulting ailments in a subject.
    Type: Grant
    Filed: June 24, 1987
    Date of Patent: November 14, 1989
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: Raymond P. Warrell, Jr.
  • Patent number: 4791371
    Abstract: Apparatus are described which is useful in continuous operation of magnetic resonance imaging studies. The apparatus permits examination of subjects without repositioning of the subject and produces more accurate studies than previously possible.
    Type: Grant
    Filed: November 17, 1986
    Date of Patent: December 13, 1988
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: George S. Krol
  • Patent number: 4773909
    Abstract: A surgically implantable, multi-lumen, high profile mammary implant includes a first, flexible, lumen at least partly and filled with a soft gel material and having a front wall approximating the shape of a human breast and a second, firmer flexible lumen elastic within the first lumen and connected thereto solely at the rear wall of the first lumen. The second lumen has a volume which is less than the volume of the first lumen and at least partly filled with a second soft gel material. A third lumen preferably inflatably surrounds the first lumen and is inflated with saline solution.
    Type: Grant
    Filed: December 9, 1986
    Date of Patent: September 27, 1988
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: Toros A. Chaglassian
  • Patent number: 4671254
    Abstract: This invention relates to a method for the non-surgical treatment of tumors. The method of this invention involves the use of shock waves to effect subcellular destruction of tumor cells, to alter their tumorigenic potential, and to suppress tumor growth.
    Type: Grant
    Filed: March 1, 1985
    Date of Patent: June 9, 1987
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: William R. Fair
  • Patent number: 4650487
    Abstract: A surgically implantable, multi-lumen, high profile mammary implant includes a first, flexible, elastic lumen at least partly filled with a soft gel material and having a front wall approximating the shape of a human breast and a second, firmer, flexible lumen within the first lumen and connected thereto solely at the rear wall of the first lumen. The second lumen has a volume which is less than the volume of the first lumen and is at least partly filled with a second soft gel material. A third lumen preferably inflatably surrounds the first lumen and is inflated with saline solution.
    Type: Grant
    Filed: October 6, 1981
    Date of Patent: March 17, 1987
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: Toros A. Chaglassian
  • Patent number: 4646258
    Abstract: An N-path filter has a number N of parallel resistive-capacitive filter sections. A switching arrangement connects each filter section periodically into an input signal path through the filter. The switching arrangement also triggers a sample and hold network to sample the filtered input signal for a portion of the time each filter section is connected into the input signal path through the filter and then hold the sampled, filtered input signal. The sampling time is preferably selected to be an initial portion of the time each filter section is connected as the signal path through the filter when variations in the charging rates of the capacitors in the filter sections have the least effect. The sampled N-path filter technique thus reduces the need to match the filter section components.
    Type: Grant
    Filed: October 4, 1985
    Date of Patent: February 24, 1987
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: Saul Miodownik
  • Patent number: 4570639
    Abstract: A discontinuity detector detects a sudden change or discontinuity in a medium moving relative to the detector such as a liquid plug in a gas flowing along a conduct, an air bubble in a liquid, or a change form one liquid or gas to another. It has a sensor which senses the discontinuity and a circuit which compensates for gradual changes in the medium or sensor, but responds to the sensed discontinuity. The preferred circuit also determines that the sensor is functioning properly and is properly set up for sensing the discontinuity. The preferred circuit is an analog-to-digital delta modulator which periodically resets a clock pulse counter until a discontinuity is sensed. The clock pulses then increment the counter to a higher-than-normal count to signal the discontinuity. The preferred embodiments are intended for detecting discontinuities in patient gas or liquid supplies in a medical diagnostic or therapeutic instrument.
    Type: Grant
    Filed: December 30, 1982
    Date of Patent: February 18, 1986
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: Saul Miodownik
  • Patent number: 4493892
    Abstract: A process and reagent for determining the presence of fecal occult blood in a test sample using a guaiac-peroxidase test matrix and a means for inhibiting peroxidase enzyme interferences which combines the partial denaturing of peroxidase enzyme protein using a protein-hydrogen bond cleaving agent, with the removal of metals necessary for efficient peroxidase enzyme activity wherein the improvement comprises dissolving said reagent for cleaving protein-hydrogen bonds in an alcohol-water solvent before adding said reagent to the sample.
    Type: Grant
    Filed: December 20, 1982
    Date of Patent: January 15, 1985
    Assignee: Memorial Hospital for Cancer & Allied Diseases
    Inventor: Martin Fleisher
  • Patent number: 4492124
    Abstract: A sampling system for stool analysis provides an elongated handle and a cylindrical coring device, said handle including means for releasibly holding said coring device. The coring device is inserted into the stool to collect a representative sample. The sample is removed for analysis, as required.
    Type: Grant
    Filed: July 30, 1982
    Date of Patent: January 8, 1985
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventors: Martin Fleisher, Sidney J. Winawer
  • Patent number: 4484582
    Abstract: A system for measuring the flow rate of electrolytic fluids includes a flow cell which has a cylindrical flow channel receptive of the fluid flow to be measured and a pair of spaced apart electrodes configured to conform to the cylindrical surface of the flow channel and to be flushed therewith. The electrodes are electrically conductive and inert to the fluid of the flow and a channel is configured to effect contact of the electrodes with the fluid flow for a desired range of flow measurement. A monopolar pulse train is applied across the electrodes to effect a cell impedance across the electrodes which is inversely proportional to the rate of flow.
    Type: Grant
    Filed: September 15, 1981
    Date of Patent: November 27, 1984
    Assignee: Memorial Hospital for Cancer & Allied Diseases
    Inventors: David A. Rottenberg, Saul Miodownik, William E. Epifanio, II
  • Patent number: 4450838
    Abstract: A jet ventilator control system produces a periodic pulse signal either asynchronous or synchronous with a patient's pulse rate. It is proportional in frequency to the number of jet ventilation pulses to be applied to the patient per unit time and is digitally programmable to adjust the delay and duty cycle of the pulse signal within the period defined by the produced pulse. The duration and duty cycle adjusted pulse signals effect the application of jet ventilation pulses corresponding thereto to the patient.
    Type: Grant
    Filed: February 10, 1981
    Date of Patent: May 29, 1984
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: Saul Miodownik
  • Patent number: 4440176
    Abstract: A delta modulator has its feedback loop components selected to put the delta modulator into slope overload in response to the QRS wave of an EKG signal for detecting the same.
    Type: Grant
    Filed: August 9, 1982
    Date of Patent: April 3, 1984
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: Saul Miodownik
  • Patent number: 4425914
    Abstract: A humidifier-injector for use with a jet ventilator.
    Type: Grant
    Filed: February 10, 1981
    Date of Patent: January 17, 1984
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventors: Cole Ray, John Vincent, Clifford Small
  • Patent number: 4325382
    Abstract: A process and apparatus for measuring the catheter fluid pressure of a patient wherein a pressure transducer is used to convert the pressure into an electrical signal and a pressure indicator indicates the pressure corresponding to the electrical signal. A turnable active filter is disposed in the signal path between the transducer and the pressure indicator and the frequency parameters of the filter are adapted to that of the catheter in real time.
    Type: Grant
    Filed: May 15, 1980
    Date of Patent: April 20, 1982
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventor: Saul Miodownik
  • Patent number: 4198982
    Abstract: A method and a surgical stapling instrument for the stapling together of the free ends of two hollow organs. The instrument comprises an elongated tubular body, a base unit concentrically connected to the body and a head unit mounted to the body and concentric therewith for relative movement with respect to the head unit over a range wherein the inner end thereof is spaced apart from the outer end of the base unit and wherein the inner end of the head unit is substantially adjacent to the outer end of the base unit. Holding elements are mounted on the base and head units and project outwardly from the outer and inner ends thereof respectively to extend between the base and head units and are disposed inwardly from the outer periphery of the ends of the base and head units for holding the free ends of the hollow organs inwardly of actuatable stapling and cutting mechanisms to maintain the free ends in position on the base and head portions while the base and head units are moved towards one another.
    Type: Grant
    Filed: March 31, 1978
    Date of Patent: April 22, 1980
    Assignee: Memorial Hospital for Cancer and Allied Diseases
    Inventors: Joseph G. Fortner, Dimitrios Papachristou