Patents Assigned to Menarini Silicon Biosystems, Inc.
  • Molecular characterization of circulating tumor cells
    Patent number: 10365266
    Abstract: The disclosed invention includes methods and kits for the removal of white blood cells from samples of immunomagnetically enriched rare cells by treating the sample with a leukocyte marker conjugated to a hapten which adheres to the white blood cells and treating the resulting product with a second medium that adheres to the hapten of the white blood cells that are labeled with the leukocyte marker conjugated to hapten and removing the labeled white blood cells.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: July 30, 2019
    Assignee: Menarini Silicon Biosystems, Inc.
    Inventors: Galla Chandra Rao, Brad Foulk, Denis Smirnov, Karl Nielsen
  • METHODS AND COMPOSITIONS TO GENERATE UNIQUE SEQUENCE DNA PROBES, LABELING OF DNA PROBES AND THE USE OF THESE PROBES
    Publication number: 20180208998
    Abstract: The invention relates generally to the field of the identification of DNA sequences, genes or chromosomes. Methods and composition to obtain Unique Sequence DNA probes are provided. Compositions comprised of and double stranded DNA containing Unique Sequences from which the repetitive sequences are eliminated according to the method described in this invention. The invention also relates to the preservation of cells that have been identified after immunomagnetic selection and fluorescent labeling in order to further interrogate the cells of interest. Furthermore the invention relates to genetic analysis of cells that have been identified after immunomagnetic selection and fluorescent labeling.
    Type: Application
    Filed: March 23, 2018
    Publication date: July 26, 2018
    Applicant: Menarini Silicon Biosystems, Inc.
    Inventors: John Verrant, Mark Carle CONNELLY, Brad FOULK, Michael T. KAGAN, Joost F. SWENNENHUIS, Leon W.M.M. TERSTAPPEN, Arjan G.J. TIBBE
  • Methods and composition to generate unique sequence DNA probes, labeling of DNA probes and the use of these probes
    Patent number: 9957571
    Abstract: The invention relates generally to the field of the identification of DNA sequences, genes or chromosomes. Methods and composition to obtain Unique Sequence DNA probes are provided. Compositions comprises of and double stranded DNA containing Unique Sequences from which the repetitive sequences are eliminated according to the method described in this invention. The invention also relates to the preservation of cells that have been identified after immunomagnetic selection and fluorescent labeling in order to further interrogate the cells of interest. Furthermore the invention relates to genetic analysis of cells that have been identified after immunomagnetic selection and fluorescent labeling.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: May 1, 2018
    Assignee: Menarini Silicon Biosystems, Inc.
    Inventors: John Verrant, Mark Carle Connelly, Brad Foulk, Michael T Kagan, Joost F Swennenhuis, Leon W. M. M. Terstappen, Arjan G. J. Tibbe
  • MOLECULAR CHARACTERIZATION OF CIRCULATING TUMOR CELLS
    Publication number: 20180045712
    Abstract: The disclosed invention includes methods and kits for the removal of white blood cells from samples of immunomagnetically enriched rare cells by treating the sample with a leukocyte marker conjugated to a hapten which adheres to the white blood cells and treating the resulting product with a second medium that adheres to the hapten of the white blood cells that are labeled with the leukocyte marker conjugated to hapten and removing the labeled white blood cells.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 15, 2018
    Applicant: Menarini Silicon Biosystems, Inc.
    Inventors: Galla Chandra RAO, Brad FOULK, Denis SMIRNOV, Karl NIELSEN
  • Molecular characterization of circulating tumor cells
    Patent number: 9823238
    Abstract: The disclosed invention includes methods and kits for the removal of white blood cells from samples of immunomagnetically enriched rare cells by treating the sample with a leukocyte marker conjugated to a hapten which adheres to the white blood cells and treating the resulting product with a second medium that adheres to the hapten of the white blood cells that are labeled with the leukocyte marker conjugated to hapten and removing the labeled white blood cells.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 21, 2017
    Assignee: Menarini Silicon Biosystems, Inc.
    Inventors: Galla Chandra Rao, Brad Foulk, Denis Smirnov, Karl Nielsen