Patents Assigned to Mendel Biotechnology, Inc.
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Patent number: 11566256Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.Type: GrantFiled: March 26, 2019Date of Patent: January 31, 2023Assignee: Mendel Biotechnology, Inc.Inventors: Jose Luis Riechmann, Robert Creelman, Oliver Ratcliffe, T. Lynne Reuber, Neal I. Gutterson
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Patent number: 10982218Abstract: A new and strong transcriptional activation domain was identified from the Arabidopsis protein Ethylene Response Factor 98 (AtERF98). This domain has been designated as the “EDLL domain” and has a number of highly conserved amino acid residues that are found throughout the members of the AtERF98 family from plants, including in monocot and eudicot orthologs. The EDLL domain was shown to be highly active when it was fused to transcription factors from plant and yeast, and was also shown to have activation potential comparable to the widely-used VP16 activation domain derived from Herpes simplex. The EDLL domain was also active when it was targeted to a gene promoter by a sequence-specific DNA binding protein or by protein-protein interactions. Unlike other known activation domains such as VP16 and GAL4, the EDLL domain is relatively small in size, and being of plant origin, it is favored as a strong transcriptional activation tool for application in transgenic food crops.Type: GrantFiled: November 20, 2018Date of Patent: April 20, 2021Assignee: Mendel Biotechnology, Inc.Inventors: Roger Canales, Shiv Tiwari, T. Lynne Reuber, Karen S. Century, Oliver J. Ratcliffe
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Patent number: 10815493Abstract: Polynucleotides incorporated into nucleic acid constructs have been introduced into plants and were ectopically expressed. The encoded polypeptides of the invention have been shown to confer at least one regulatory activity and confer earlier flowering, longer floral organ retention, increased cold tolerance, greater tolerance to water deprivation, altered carbon-nitrogen balance sensing, increased low nitrogen tolerance, and/or increased tolerance to hyperosmotic stress as compared to a control plant.Type: GrantFiled: February 7, 2019Date of Patent: October 27, 2020Assignees: Mendel Biotechnology, Inc., Monsanto Technology LLCInventors: Jose Luis Riechmann, Oliver J. Ratcliffe, T. Lynne Reuber, Katherine Krolikowski, Jacqueline E. Heard, Omaira Pineda, Cai-Zhong Jiang, Robert A. Creelman, Roderick W. Kumimoto, Paul S. Chomet
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Patent number: 10787677Abstract: Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered C/N sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant.Type: GrantFiled: May 7, 2018Date of Patent: September 29, 2020Assignees: Mendel Biotechnology, Inc., Monsanto Technology LLCInventors: Robert A. Creelman, Neal I. Gutterson, Oliver J. Ratcliffe, T. Lynne Reuber, Richard Eric Cerny, Kimberly Faye Zobrist Duff, Susanne Kjemtrup-Lovelace, Robert J. Meister, Marie E. Petracek, Thomas Ruff, Qingzhang Xu
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Patent number: 10597667Abstract: Transcription factor polynucleotides and polypeptides incorporated into nucleic acid constructs, including expression vectors, have been introduced into plants and were ectopically expressed. Transgenic plants transformed with many of these constructs have been shown to be more resistant to disease (in some cases, to more than one pathogen), or more tolerant to an abiotic stress (in some cases, to more than one abiotic stress). The abiotic stress may include, for example, salt, hyperosmotic stress, water deficit, heat, cold, drought, or low nutrient conditions.Type: GrantFiled: November 9, 2016Date of Patent: March 24, 2020Assignee: Mendel Biotechnology, Inc.Inventors: Peter P. Repetti, T. Lynne Reuber, Oliver Ratcliffe, Karen S. Century, Katherine Krolikowski, Robert A. Creelman, Frederick D. Hempel, Roderick W. Kumimoto, Luc J. Adam, Neal I. Gutterson, Roger Canales, Emily L. Queen, Jennifer M. Costa
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Patent number: 10407689Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.Type: GrantFiled: August 7, 2017Date of Patent: September 10, 2019Assignee: Mendel Biotechnology, Inc.Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen
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Patent number: 10273497Abstract: Polynucleotides incorporated into nucleic acid constructs have been introduced into plants and were ectopically expressed. The encoded polypeptides of the invention have been shown to confer at least one regulatory activity and confer earlier flowering, longer floral organ retention, increased cold tolerance, greater tolerance to water deprivation, altered carbon-nitrogen balance sensing, increased low nitrogen tolerance, and/or increased tolerance to hyperosmotic stress as compared to a control plant.Type: GrantFiled: September 22, 2017Date of Patent: April 30, 2019Assignees: Mendel Biotechnology, Inc., Monsanto Technology LLCInventors: Jose Luis Riechmann, Oliver J. Ratcliffe, T. Lynne Reuber, Katherine Krolikowski, Jacqueline E. Heard, Omaira Pineda, Cai-Zhong Jiang, Robert A. Creelman, Roderick W. Kumimoto, Paul S. Chomet
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Patent number: 10266575Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having improved tolerance to drought, shade, and low nitrogen conditions, as compared to wild-type or reference plants.Type: GrantFiled: November 22, 2017Date of Patent: April 23, 2019Assignee: MENDEL BIOTECHNOLOGY, INC.Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Robert A. Creelman, Oliver J. Ratcliffe, Roger D. Canales, Peter P. Repetti, Roderick W. Kumimoto, Neal I. Gutterson, T. Lynne Reuber, Omaira Pineda, Cai-Zhong Jiang, Karen S. Century, Luc Adam, James Z Zhang, Frederick D. Hempel, Jeffrey M. Libby
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Patent number: 10167480Abstract: A new and strong transcriptional activation domain was identified from the Arabidopsis protein Ethylene Response Factor 98 (AtERF98). This domain has been designated as the “EDLL domain” and has a number of highly conserved amino acid residues that are found throughout the members of the AtERF98 family from plants, including in monocot and eudicot orthologs. The EDLL domain was shown to be highly active when it was fused to transcription factors from plant and yeast, and was also shown to have activation potential comparable to the widely-used VP16 activation domain derived from Herpes simplex. The EDLL domain was also active when it was targeted to a gene promoter by a sequence-specific DNA binding protein or by protein-protein interactions. Unlike other known activation domains such as VP16 and GAL4, the EDLL domain is relatively small in size, and being of plant origin, it is favored as a strong transcriptional activation tool for application in transgenic food crops.Type: GrantFiled: November 11, 2013Date of Patent: January 1, 2019Assignee: Mendel Biotechnology, Inc.Inventors: Roger Canales, Shiv Tiwari, T. Lynne Reuber, Karen S. Century, Oliver J. Ratcliffe
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Patent number: 10093942Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference or control plant, including increased plant size, seed size, increased leaf size, lignification, water deprivation tolerance, cold tolerance, or altered flowering time. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.Type: GrantFiled: August 17, 2016Date of Patent: October 9, 2018Assignee: Mendel Biotechnology, Inc.Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Oliver J. Ratcliffe, Omaira Pineda, T. Lynne Reuber, James Z. Zhang, Gregory Nadzan
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Patent number: 9982273Abstract: Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered C/N sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant.Type: GrantFiled: January 21, 2015Date of Patent: May 29, 2018Assignees: Mendel Biotechnology, Inc, Monsanto Technology LLCInventors: Robert A. Creelman, Neal I. Gutterson, Oliver J. Ratcliffe, T. Lynne Reuber, Richard Eric Cerny, Kimberly Faye Zobrist Duff, Susanne Kjemtrup-Lovelace, Robert J. Meister, Marie E. Petracek, Thomas Ruff, Qingzhang Xu
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Patent number: 9856297Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having improved tolerance to drought, shade, and low nitrogen conditions, as compared to wild-type or reference plants.Type: GrantFiled: March 28, 2014Date of Patent: January 2, 2018Assignee: Mendel Biotechnology, Inc.Inventors: Jacqueline E Heard, Jose Luis Riechmann, Robert A Creelman, Oliver J Ratcliffe, Roger D Canales, Peter P Repetti, Roderick W Kumimoto, Neal I Gutterson, T. Lynne Reuber, Omaira Pineda, Cai-Zhong Jiang, Karen S Century, Luc Adam, James Z Zhang, Frederick D Hempel, Jeffrey M Libby
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Patent number: 9783819Abstract: Polynucleotides incorporated into nucleic acid constructs have been introduced into plants and were ectopically expressed. The encoded polypeptides of the invention have been shown to confer at least one regulatory activity and confer earlier flowering, longer floral organ retention, increased cold tolerance, greater tolerance to water deprivation, altered carbon-nitrogen balance sensing, increased low nitrogen tolerance, and/or increased tolerance to hyperosmotic stress as compared to a control plant.Type: GrantFiled: March 23, 2015Date of Patent: October 10, 2017Assignees: Mendel Biotechnology, Inc., Monsanto Technology LLCInventors: Jose Luis Riechmann, Oliver J. Ratcliffe, T. Lynne Reuber, Katherine Krolikowski, Jacqueline E. Heard, Omaira Pineda, Cai-Zhong Jiang, Robert A. Creelman, Roderick W. Kumimoto, Paul S. Chomet
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Patent number: 9758791Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.Type: GrantFiled: April 8, 2013Date of Patent: September 12, 2017Assignee: Mendel Biotechnology, Inc.Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen
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Patent number: 9725728Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.Type: GrantFiled: August 5, 2014Date of Patent: August 8, 2017Assignee: Mendel Biotechnology, Inc.Inventors: Bradley K. Sherman, Jose Luis Riechmann, Cai-Zhong Jiang, Jacqueline E. Heard, Volker Haake, Robert A. Creelman, Oliver J. Ratcliffe, Luc J. Adam, T. Lynne Reuber, James S. Keddie, Pierre E. Broun, Marsha L. Pilgrim, Arnold N. DuBell, III, Omaira Pineda, Guo-Liang Yu
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Patent number: 9676831Abstract: Transcription factor polynucleotides and polypeptides incorporated into nucleic acid constructs, including expression vectors, have been introduced into plants and were ectopically expressed. Transgenic plants transformed with many of these constructs have been shown to have increased tolerance to an abiotic stress (in some cases, to more than one abiotic stress), increased growth, and/or increased biomass. The abiotic stress may include, for example, salt, hyperosmotic stress, water deficit, heat, cold, drought, and/or low nutrient conditions.Type: GrantFiled: March 3, 2011Date of Patent: June 13, 2017Assignees: SweTree Technologies AB, Mendel Biotechnology, Inc.Inventors: T. Lynne Reuber, Oliver J. Ratcliffe, Frederick D. Hempel, Luc J. Adam, Cai-Zhong Jiang, Robert A. Creelman, Jose Luis Riechmann, Jacqueline E. Heard, Raymond R. Samaha, Pierre E. Broun, Magnus Hertzberg, Torgny Näsholm
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Patent number: 9476039Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.Type: GrantFiled: February 4, 2013Date of Patent: October 25, 2016Assignee: Mendel Biotechnology, Inc.Inventors: Jose Luis Riechmann, Robert Creelman, Oliver Ratcliffe, T. Lynne Reuber, Neal I. Gutterson
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Patent number: 9447425Abstract: The invention relates to plant homeobox (HB) protein family polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference or control plant, including increased yield.Type: GrantFiled: October 5, 2009Date of Patent: September 20, 2016Assignee: Mendel Biotechnology, Inc.Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Oliver Ratcliffe, Omaira Pineda, T. Lynne Reuber, James Zhang, Gregory Nadzan
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Patent number: 9175051Abstract: The invention is directed to transgenic plants transformed with nucleic acids that encode a plant transcription factor that increases the transgenic plant's size and yield and/or delays flowering in the plant, and methods of using and producing the transgenic plants.Type: GrantFiled: December 23, 2010Date of Patent: November 3, 2015Assignee: Mendel Biotechnology, Inc.Inventors: Robert A. Creelman, Luc J. Adam, Jose Luis Riechmann, Jacqueline E. Heard, Omaira Pineda, Cai-Zhong Jiang, Oliver J. Ratcliffe, T. Lynne Reuber
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Publication number: 20150052633Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.Type: ApplicationFiled: April 8, 2013Publication date: February 19, 2015Applicant: Mendel Biotechnology, Inc.Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen