Patents Assigned to Mendel Biotechnology, Inc.
  • Patent number: 11566256
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: January 31, 2023
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jose Luis Riechmann, Robert Creelman, Oliver Ratcliffe, T. Lynne Reuber, Neal I. Gutterson
  • Patent number: 10982218
    Abstract: A new and strong transcriptional activation domain was identified from the Arabidopsis protein Ethylene Response Factor 98 (AtERF98). This domain has been designated as the “EDLL domain” and has a number of highly conserved amino acid residues that are found throughout the members of the AtERF98 family from plants, including in monocot and eudicot orthologs. The EDLL domain was shown to be highly active when it was fused to transcription factors from plant and yeast, and was also shown to have activation potential comparable to the widely-used VP16 activation domain derived from Herpes simplex. The EDLL domain was also active when it was targeted to a gene promoter by a sequence-specific DNA binding protein or by protein-protein interactions. Unlike other known activation domains such as VP16 and GAL4, the EDLL domain is relatively small in size, and being of plant origin, it is favored as a strong transcriptional activation tool for application in transgenic food crops.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: April 20, 2021
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Roger Canales, Shiv Tiwari, T. Lynne Reuber, Karen S. Century, Oliver J. Ratcliffe
  • Patent number: 10815493
    Abstract: Polynucleotides incorporated into nucleic acid constructs have been introduced into plants and were ectopically expressed. The encoded polypeptides of the invention have been shown to confer at least one regulatory activity and confer earlier flowering, longer floral organ retention, increased cold tolerance, greater tolerance to water deprivation, altered carbon-nitrogen balance sensing, increased low nitrogen tolerance, and/or increased tolerance to hyperosmotic stress as compared to a control plant.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: October 27, 2020
    Assignees: Mendel Biotechnology, Inc., Monsanto Technology LLC
    Inventors: Jose Luis Riechmann, Oliver J. Ratcliffe, T. Lynne Reuber, Katherine Krolikowski, Jacqueline E. Heard, Omaira Pineda, Cai-Zhong Jiang, Robert A. Creelman, Roderick W. Kumimoto, Paul S. Chomet
  • Patent number: 10787677
    Abstract: Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered C/N sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: September 29, 2020
    Assignees: Mendel Biotechnology, Inc., Monsanto Technology LLC
    Inventors: Robert A. Creelman, Neal I. Gutterson, Oliver J. Ratcliffe, T. Lynne Reuber, Richard Eric Cerny, Kimberly Faye Zobrist Duff, Susanne Kjemtrup-Lovelace, Robert J. Meister, Marie E. Petracek, Thomas Ruff, Qingzhang Xu
  • Patent number: 10597667
    Abstract: Transcription factor polynucleotides and polypeptides incorporated into nucleic acid constructs, including expression vectors, have been introduced into plants and were ectopically expressed. Transgenic plants transformed with many of these constructs have been shown to be more resistant to disease (in some cases, to more than one pathogen), or more tolerant to an abiotic stress (in some cases, to more than one abiotic stress). The abiotic stress may include, for example, salt, hyperosmotic stress, water deficit, heat, cold, drought, or low nutrient conditions.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: March 24, 2020
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Peter P. Repetti, T. Lynne Reuber, Oliver Ratcliffe, Karen S. Century, Katherine Krolikowski, Robert A. Creelman, Frederick D. Hempel, Roderick W. Kumimoto, Luc J. Adam, Neal I. Gutterson, Roger Canales, Emily L. Queen, Jennifer M. Costa
  • Patent number: 10407689
    Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: September 10, 2019
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen
  • Patent number: 10273497
    Abstract: Polynucleotides incorporated into nucleic acid constructs have been introduced into plants and were ectopically expressed. The encoded polypeptides of the invention have been shown to confer at least one regulatory activity and confer earlier flowering, longer floral organ retention, increased cold tolerance, greater tolerance to water deprivation, altered carbon-nitrogen balance sensing, increased low nitrogen tolerance, and/or increased tolerance to hyperosmotic stress as compared to a control plant.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: April 30, 2019
    Assignees: Mendel Biotechnology, Inc., Monsanto Technology LLC
    Inventors: Jose Luis Riechmann, Oliver J. Ratcliffe, T. Lynne Reuber, Katherine Krolikowski, Jacqueline E. Heard, Omaira Pineda, Cai-Zhong Jiang, Robert A. Creelman, Roderick W. Kumimoto, Paul S. Chomet
  • Patent number: 10266575
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having improved tolerance to drought, shade, and low nitrogen conditions, as compared to wild-type or reference plants.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: April 23, 2019
    Assignee: MENDEL BIOTECHNOLOGY, INC.
    Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Robert A. Creelman, Oliver J. Ratcliffe, Roger D. Canales, Peter P. Repetti, Roderick W. Kumimoto, Neal I. Gutterson, T. Lynne Reuber, Omaira Pineda, Cai-Zhong Jiang, Karen S. Century, Luc Adam, James Z Zhang, Frederick D. Hempel, Jeffrey M. Libby
  • Patent number: 10167480
    Abstract: A new and strong transcriptional activation domain was identified from the Arabidopsis protein Ethylene Response Factor 98 (AtERF98). This domain has been designated as the “EDLL domain” and has a number of highly conserved amino acid residues that are found throughout the members of the AtERF98 family from plants, including in monocot and eudicot orthologs. The EDLL domain was shown to be highly active when it was fused to transcription factors from plant and yeast, and was also shown to have activation potential comparable to the widely-used VP16 activation domain derived from Herpes simplex. The EDLL domain was also active when it was targeted to a gene promoter by a sequence-specific DNA binding protein or by protein-protein interactions. Unlike other known activation domains such as VP16 and GAL4, the EDLL domain is relatively small in size, and being of plant origin, it is favored as a strong transcriptional activation tool for application in transgenic food crops.
    Type: Grant
    Filed: November 11, 2013
    Date of Patent: January 1, 2019
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Roger Canales, Shiv Tiwari, T. Lynne Reuber, Karen S. Century, Oliver J. Ratcliffe
  • Patent number: 10093942
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference or control plant, including increased plant size, seed size, increased leaf size, lignification, water deprivation tolerance, cold tolerance, or altered flowering time. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: October 9, 2018
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Oliver J. Ratcliffe, Omaira Pineda, T. Lynne Reuber, James Z. Zhang, Gregory Nadzan
  • Patent number: 9982273
    Abstract: Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the invention have been shown to confer at least one regulatory activity and confer increased yield, greater height, greater early season growth, greater canopy coverage, greater stem diameter, greater late season vigor, increased secondary rooting, more rapid germination, greater cold tolerance, greater tolerance to water deprivation, reduced stomatal conductance, altered C/N sensing, increased low nitrogen tolerance, increased low phosphorus tolerance, or increased tolerance to hyperosmotic stress as compared to the control plant as compared to a control plant.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: May 29, 2018
    Assignees: Mendel Biotechnology, Inc, Monsanto Technology LLC
    Inventors: Robert A. Creelman, Neal I. Gutterson, Oliver J. Ratcliffe, T. Lynne Reuber, Richard Eric Cerny, Kimberly Faye Zobrist Duff, Susanne Kjemtrup-Lovelace, Robert J. Meister, Marie E. Petracek, Thomas Ruff, Qingzhang Xu
  • Patent number: 9856297
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having improved tolerance to drought, shade, and low nitrogen conditions, as compared to wild-type or reference plants.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: January 2, 2018
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jacqueline E Heard, Jose Luis Riechmann, Robert A Creelman, Oliver J Ratcliffe, Roger D Canales, Peter P Repetti, Roderick W Kumimoto, Neal I Gutterson, T. Lynne Reuber, Omaira Pineda, Cai-Zhong Jiang, Karen S Century, Luc Adam, James Z Zhang, Frederick D Hempel, Jeffrey M Libby
  • Patent number: 9783819
    Abstract: Polynucleotides incorporated into nucleic acid constructs have been introduced into plants and were ectopically expressed. The encoded polypeptides of the invention have been shown to confer at least one regulatory activity and confer earlier flowering, longer floral organ retention, increased cold tolerance, greater tolerance to water deprivation, altered carbon-nitrogen balance sensing, increased low nitrogen tolerance, and/or increased tolerance to hyperosmotic stress as compared to a control plant.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: October 10, 2017
    Assignees: Mendel Biotechnology, Inc., Monsanto Technology LLC
    Inventors: Jose Luis Riechmann, Oliver J. Ratcliffe, T. Lynne Reuber, Katherine Krolikowski, Jacqueline E. Heard, Omaira Pineda, Cai-Zhong Jiang, Robert A. Creelman, Roderick W. Kumimoto, Paul S. Chomet
  • Patent number: 9758791
    Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: September 12, 2017
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen
  • Patent number: 9725728
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: August 8, 2017
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Bradley K. Sherman, Jose Luis Riechmann, Cai-Zhong Jiang, Jacqueline E. Heard, Volker Haake, Robert A. Creelman, Oliver J. Ratcliffe, Luc J. Adam, T. Lynne Reuber, James S. Keddie, Pierre E. Broun, Marsha L. Pilgrim, Arnold N. DuBell, III, Omaira Pineda, Guo-Liang Yu
  • Patent number: 9676831
    Abstract: Transcription factor polynucleotides and polypeptides incorporated into nucleic acid constructs, including expression vectors, have been introduced into plants and were ectopically expressed. Transgenic plants transformed with many of these constructs have been shown to have increased tolerance to an abiotic stress (in some cases, to more than one abiotic stress), increased growth, and/or increased biomass. The abiotic stress may include, for example, salt, hyperosmotic stress, water deficit, heat, cold, drought, and/or low nutrient conditions.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: June 13, 2017
    Assignees: SweTree Technologies AB, Mendel Biotechnology, Inc.
    Inventors: T. Lynne Reuber, Oliver J. Ratcliffe, Frederick D. Hempel, Luc J. Adam, Cai-Zhong Jiang, Robert A. Creelman, Jose Luis Riechmann, Jacqueline E. Heard, Raymond R. Samaha, Pierre E. Broun, Magnus Hertzberg, Torgny Näsholm
  • Patent number: 9476039
    Abstract: The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference plant. Sequence information related to these polynucleotides and polypeptides can also be used in bioinformatic search methods and is also disclosed.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: October 25, 2016
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jose Luis Riechmann, Robert Creelman, Oliver Ratcliffe, T. Lynne Reuber, Neal I. Gutterson
  • Patent number: 9447425
    Abstract: The invention relates to plant homeobox (HB) protein family polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of using the polynucleotides and polypeptides to produce transgenic plants having advantageous properties compared to a reference or control plant, including increased yield.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: September 20, 2016
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Jacqueline E. Heard, Jose Luis Riechmann, Oliver Ratcliffe, Omaira Pineda, T. Lynne Reuber, James Zhang, Gregory Nadzan
  • Patent number: 9175051
    Abstract: The invention is directed to transgenic plants transformed with nucleic acids that encode a plant transcription factor that increases the transgenic plant's size and yield and/or delays flowering in the plant, and methods of using and producing the transgenic plants.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: November 3, 2015
    Assignee: Mendel Biotechnology, Inc.
    Inventors: Robert A. Creelman, Luc J. Adam, Jose Luis Riechmann, Jacqueline E. Heard, Omaira Pineda, Cai-Zhong Jiang, Oliver J. Ratcliffe, T. Lynne Reuber
  • Publication number: 20150052633
    Abstract: The application describes producing polynucleotide variants of the AtHB 17 clade members and introducing the mutant variants into plants to improve plant traits. The mutant polynucleotides encode polypeptides that comprise mutations in the EAR motifs.
    Type: Application
    Filed: April 8, 2013
    Publication date: February 19, 2015
    Applicant: Mendel Biotechnology, Inc.
    Inventors: Robert A. Creelman, Marjorie R. Lundgren, Suqin Cai, Hans E. Holtan, Graham J. Hymus, Oliver J. Ratcliffe, T. Lynne Reuber, Amanda J. Burek, Shiv B. Tiwari, Luc J. Adam, Colleen M. Marion, Megan Lau, Bonnie R. Brayton, Yu Shen