Patents Assigned to Merck Patent Gesellschaft Mit Beschraenkter Haftung
  • Publication number: 20130131037
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R4 and R5 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.
    Type: Application
    Filed: January 11, 2013
    Publication date: May 23, 2013
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
    Inventor: MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
  • Patent number: 8435981
    Abstract: Compounds of the formula (I) in which R1, R2, R3, R4 and R5 have the meanings indicated in claim 1 are inhibitors of tyrosine kinases, in particular of met kinase and can be employed inter alia for the treatment of tumors.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: May 7, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Dieter Dorsch, Oliver Schadt, Andree Blaukat, Frank Stieber
  • Patent number: 8426397
    Abstract: Compounds of the formula (I), in which R1, R2, R3, R3?, R4 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumors.
    Type: Grant
    Filed: November 26, 2009
    Date of Patent: April 23, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Dieter Dorsch, Oliver Schadt, Frank Stieber, Andree Blaukat
  • Patent number: 8415352
    Abstract: The present invention relates to quinoxalinone derivatives of formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined herein, as insulin secretion stimulators. Specific such quinoxaline compounds are also an aspect of the invention. The invention also relates to the preparation and use of these quinoxalinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: April 9, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Gérard Botton, Eric Valeur, Micheline Kergoat, Christine Charon, Samer Elbawab
  • Patent number: 8414983
    Abstract: The invention relates to a method of aligning reactive mesogens (RM) on a substrate subjected to particle beam treatment, to RM's oriented by said method, especially in form of thin layers, to oriented polymers and polymer films obtained from such oriented RM's and RM layers, and to the use of the RM's, layers, polymers and films in optical, electronic and electrooptical applications.
    Type: Grant
    Filed: August 10, 2007
    Date of Patent: April 9, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Owain Llyr Parri, Alison Linda May, Julian Vaughan-Spickers, Karl Skjonnemand, Oleg Yaroshchuck
  • Patent number: 8399073
    Abstract: The invention relates to a liquid-crystalline medium having negative dielectric anisotropy which comprises at least one compound of the formula I in which R1, R1* and a have the meanings indicated in Claim 1, and to the use thereof for an active-matrix display, in particular based on the VA, PS-VA, PALC, FFS or IPS effect.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: March 19, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Melanie Klasen-Memmer, Matthias Bremer, Konstantin Schneider, Detlef Pauluth
  • Patent number: 8394292
    Abstract: The present invention relates to dielectrically positive liquid-crystalline media comprising a dielectrically neutral or slightly positive component, component A, comprising one or more dielectrically neutral or slightly positive compounds of the formula I in which the parameters have the meaning indicated in the specification, and a dielectrically positive component, component B, comprising one or more dielectrically positive compounds, and optionally a second dielectrically neutral component, component C, and to liquid-crystal displays containing these media, especially active-matrix displays and in particular TN, IPS and FFS displays.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 12, 2013
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Michael Wittek, Brigitte Schuler, Volker Reiffenrath
  • Patent number: 8389554
    Abstract: Novel imidazo[2,1-b][1,3,4]thiadiazole derivatives of formula (I) wherein R1 and R2 have the meaning according to claim 1, are inhibitors of TGF-beta receptor I kinase, and can be employed, inter alia, for the treatment of tumors.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: March 5, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Guenter Hoelzemann, Hartmut Greiner, Emilie Rossignol, Dominique Swinnen
  • Patent number: 8383679
    Abstract: The present invention relates to a novel crystal form of calcium 3-acetylaminopropane-1-sulfonate, to a process for the preparation thereof, and to the use thereof in medicaments.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: February 26, 2013
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Antje Ernst, Clemens Kuehn, Matthias Bartels, Christoph Saal, Nathalie Bosc
  • Patent number: 8383838
    Abstract: The present invention relates to novel compounds of general formula (I) and uses thereof.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: February 26, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Christoph Saal, Lars Burgdorf, Ulrich Emde, Norbert Beier, Johannes Gleitz, Christine Charon
  • Patent number: 8378157
    Abstract: The invention relates to a process for the preparation of bis(fluoroalkyl)phosphinyl chlorides or fluoroalkylphosphonyl dichlorides by reaction of the corresponding bis(fluoroalkyl)phosphinic acid or fluoroalkylphosphonic acid with aryltetrachlorophosphorane as chlorinating agent.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: February 19, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Nikolai (Mykola) Ignatyev, Dana Bejan, Helge Willner, Emil Aust
  • Patent number: 8367668
    Abstract: Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: February 5, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Frank Stieber, Oliver Schadt, Dieter Dorsch, Andree Blaukat
  • Patent number: 8362057
    Abstract: The invention relates to the compounds of the general formula (I): in which A, D, R, R1 and X are as defined in the description, to a process for the preparation thereof and to the therapeutic use thereof in the treatment of pathologies associated with insulin resistance syndrome.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: January 29, 2013
    Assignee: Merck Patent Gesellschaft mit beschränkter Haftung
    Inventors: Gérard Moinet, Gérard Botton, Annick Arbellot de Vacqueur
  • Patent number: 8349415
    Abstract: The present invention relates to a liquid-crystalline medium having high twist, to the use thereof for electro-optical purposes, and to displays containing this medium.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: January 8, 2013
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Akihiro Kojima, Fumio Shimano
  • Patent number: 8338507
    Abstract: The present invention relates to the use of phosphinic acids and/or phosphonic acids and salts thereof for wetting fluorine compounds, in particular fluoropolymers, to the use in coating solutions comprising fluorine compounds, and to polymerisation processes in which fluorine compounds are used and/or formed.
    Type: Grant
    Filed: November 22, 2008
    Date of Patent: December 25, 2012
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Wolfgang Hierse, Nikolai (Mykola) Ignatyev
  • Patent number: 8329738
    Abstract: The invention relates to the use of imidazole derivatives of the formula (1): in which A, R?1, R?2 and R?3 are as defined in the description, as AMPK activators. The invention also relates to processes for the preparation of the said compounds, to their uses for the preparation of medicaments for the treatment of insulin resistance, diabetes and related pathologies, and also obesity, and to the pharmaceutical compositions comprising them. Certain compounds of the formula (1) are novel and, in this respect, also form part of the invention.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: December 11, 2012
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Gerard Moinet, Dominique Marais, Sophie Hallakou-Bozec, Christine Charon
  • Patent number: 8329698
    Abstract: The present invention relates to compounds of formula (I) wherein X, Y, Z, R1, R2, R3 are as defined in claim 1, including pharmaceutical compositions thereof and for their use in the treatment and/or prevention of diabetes, metabolic syndrome, obesity, cancer, inflammation.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: December 11, 2012
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Daniel Cravo, Sophie Hallakou-Bozec, Franck Lepifre
  • Publication number: 20120295992
    Abstract: The invention relates to a process for the preparation of a separating material having improved binding capacity, and to materials prepared and to the use thereof for the separation of charged or uncharged biopolymers from liquids.
    Type: Application
    Filed: August 1, 2012
    Publication date: November 22, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
    Inventor: Matthias JOEHNCK
  • Patent number: 8313669
    Abstract: The present invention relates to a liquid-crystal (LC) display of the PS (polymer stabilized) or PSA (polymer sustained alignment) type, and to polymerizable compounds and LC media for use in PS (polymer stabilized) and PSA displays.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: November 20, 2012
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Georg Bernatz, Andreas Taugerbeck
  • Patent number: 8287756
    Abstract: The invention relates to an optically biaxial film comprising an anisotropic material with uniform helically twisted structure and a reflection wavelength below 400 nm, to methods and materials for its preparation, to its use as retardation or compensation film in optical devices like liquid crystal displays, and to compensators and liquid crystal displays comprising such a biaxial film.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: October 16, 2012
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Mark Verrall, Kim Slaney, Owain Llyr Parri, Richard Harding, Shirley Ann Marden