Abstract: The present invention relates compounds of the formula (I): wherein X represents hydrogen, C1-4alkyl optionally substituted by a hydroxy, methoxy or benzyloxy group, or CO2(C1-2alkyl); Z is —CR9R10CH2— or —CH2CR9R10—; and R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.

Abstract: The present invention relates to laser-markable plastics of which a feature is that they comprise as dopant at least one metal powder and/or semimetal powder selected from the group consisting of aluminum, boron, titanium, magnesium, copper, tin, silicon and zinc and one or more effect pigments based on phyllosilicates.

Abstract: A stopper debris separator useful for removing unwanted debris from stoppers utilized to seal bottles of IV pharmaceutical compositions at the manufacturing process. Debris-containing stopper in the stopper injection hopper are drawn through the stopper duct into the cyclone separator tube by the vacuum wherein the debris on the stoppers is separated therefrom and drawn through the vacuum duct into the vacuum filter.

Abstract: The invention provides a method, system, and computer program device for an embedded search with site search summary. The search provides an easy-to-navigate user interface that is also intuitive for healthcare professionals, for specifying the search request, and for displaying the search results together with a site search summary. In order to specify the search request, the user enters the keyword or phrase of interest and chooses a category of resources in which to search, where the categories correspond to physician-intuitive groupings of types of resources. A search specific results page including a site search summary box and initially indicating search results within category is returned, both of which thereby provide a number of possibilities for drill down.

Abstract: The invention provides a method, system, and computer program device for an interactive continuing education system, for managing and/or providing continuing education activities, especially useful for healthcare professionals. The invention may provide a personal profile, to provide a snapshot of the user's CE activities vis-à-vis CE requirements; a curriculum manager, to provide details on CE activities in a user's curriculum; a catalog browser, for reviewing/searching a catalog of available CE activities; a transcript manager for tracking completed activities and providing customizable transcripts; a showcase of selected CE activities; and a CE assistant feature, for notifying a user of new CE activities which fit the user's preference. The system accommodates a catalog of available CE activities, and enable a user to easily launch and automatically track CE activities. Each user has a curriculum of on-going CE activities, and a transcript of completed CE activities.

Abstract: The invention provides a method, system, and computer program device for a medical information portal, providing a key to medical content on the internet. The invention may include one or more of the following sets of tools, in which various resources are organized in a manner which is intuitive for a healthcare professional: diagnostic tools for research of diseases, learning tools for professional development, patient tools for patient resources, technology tools on using health technology, news and updates tools, quick-reference tools, and/or electronic assistant tools. According to an aspect of the present invention, healthcare resources may be accessed via the Internet. Optionally, the system includes user registration data for each user, and certain resources may be restricted to appropriate users.

Abstract: The invention describes a method of preparing alpha- or beta-tricalcium phosphate, brushite (CaHPO4.2H2O), calcium pyrophosphate (Ca2P2O7) or hydroxyapatite (Ca5(PO4)3(OH)) or mixtures thereof in the form of morsels or granules via gelatin processing. These morsels or granules can be used as bone or tooth fillers or bone substitutes in applications, especially when higher rates of resorption or taking part in the bone remodelling processes of the implanted material are desired.

Abstract: The invention relates to chiral compounds of formula I, to liquid crystal mixtures comprising at least one chiral compound of formula I, to chiral linear or crosslinked liquid crystal polymers obtainable by polymerizing a polymerizable mixture comprising at least one chiral compound of formula I, to the use of chiral compound of formula I and mixtures and polymers obtained thereof in liquid crystal displays, active and passive optical elements, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic and pharmaceutical compositions, diagnostics, liquid crystal pigments, for decorative and security applications, nonlinear optics, optical information storage or as chiral dopants, and to a liquid crystal display comprising a mixture comprising at least one chiral compound of formula I.

Abstract: Indole derivatives of formula I, their salts and solvates, have valuable pharmacological properties together with good tolerability, as they have actions on the central nervous system: wherein R1 and R3 are as defined herein. The compounds have a strong affinity for 5-HT2A receptors, and furthermore exhibit 5HT2A receptor-antagonistic properties. These are therefore suitable both in veterinary and in human medicine for the treatment of functional disorders of the central nervous system and also of inflammation.

Abstract: Process for the preparation of benzo-fused heterocycles of general formula I: in which X, R1, R2, R3, R4, R5 and n are as defined in claim 1, by reacting tetrahydrobenzo-fused heterocycles of formula II: in which X, R1, R2, R3, R4, R5, n and Ac are as defined in claim 1, with a catalytic amount of a noble metal catalyst in the presence of a hydrogen acceptor and then deacylating the acylated amino group by the addition of an amine.

Abstract: The present invention is directed to 3-phenylimidazol[4,5-b]pyridine derivatives, that are selective ligands for GABAA receptors. These compounds are useful in the treatment and prevention of disorders of the central nervous system, including anxiety and convulsions.

Abstract: The invention relates to liquid-crystalline compounds of the formula I in which R1, A1, A2, Z1, Z2, a, b, L1, L2 and L3 are as defined in claim 1, and to liquid-crystalline media comprising at least compound of the formula I and to electro-optical displays containing a liquid-crystalline medium of this type.

Abstract: The present invention relates to colored interference pigments based on multicoated, platelet-shaped substrates, which are distinguished in that they comprise (A) a colored coating having a refractive index of n>1.8, (B) a colorless coating having a refractive index of n>1.8, (C) a colorless coating having a refractive index of n≦1.8, (D) a colorless coating having a refractive index of n>1.8, and optionally (E) an outer protective layer, and to their use in paints, surface coatings, printing inks, plastics, ceramic materials, glasses, for laser marking, in cosmetic formulations and for the production of pigment preparations and dry preparations.

Abstract: The present invention relates to pearlescent pigments based on substrates coated with one or more layers of nitrides or oxynitrides to a method for the production of such pigments and their use in plastics, paints, coatings, powder coatings, inks, printing inks, glasses, ceramic products, agriculture foils, for lasermarking of papers and plastics, security applications and in cosmetic formulations.

Abstract: The invention relates to a preparation having antioxidant properties, comprising at least one compound of the formula I 1

Abstract: A liquid-crystalline medium based on a mixture of polar compounds of positive dielectric anisotropy, which comprises one or more compounds of the formula I where R1, A1, A2, Z1, Z2, L1, L2 and n are as defined herein, is suitable for use in, for example, MLC, TN and STN displays.

Abstract: The invention relates to a pharmaceutical preparation comprising levothyroxine sodium, gelatine and fillers, which is free of organic solvent residues, and to processes for its production.

Abstract: The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

Abstract: Compounds of general structural formula I such as that shown in structural formula II 1

Abstract: A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.