Patents Assigned to Michigan Biotechnology Institute
  • Patent number: 6495657
    Abstract: A polyamide and a process for preparing the polyamide are disclosed.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: December 17, 2002
    Assignee: Michigan Biotechnology Institute
    Inventors: William F. McDonald, Zhi Heng Huang, Stacy C. Wright, Morris Danzig, Andrew C. Taylor
  • Patent number: 6410077
    Abstract: A stable mixture of milk, juice, and polysaccharide/cereal is disclosed. In a preferred version of the present invention, composition containing an amino acid, an organic or inorganic acid and a metal ion is added to further stabilize the milk proteins in the mixture.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: June 25, 2002
    Assignee: Michigan Biotechnology Institute
    Inventors: Joel I. Dulebohn, Ronald J. Carlotti, James A. Richter
  • Patent number: 6399714
    Abstract: A crosslinked polyamide material and a process for preparing the crosslinked polyamide material are disclosed. The crosslinked polyamide material comprises a crosslinked chemical combination of (1) a polyamide of the formula: wherein n is between about 50 and 10,000, wherein each R is between 1 and 50 carbon atoms alone and is optionally substituted with heteroatoms, oxygen, nitrogen, sulfur, or phosphorus and combinations thereof, wherein multiple of the R are in vertically aligned spaced relationship along a backbone forming the polyamide, and wherein two or more of the R contain an amino group; and (2) a crosslinking agent containing at least two functional groups capable of reacting with the amino groups of the polyamide. In one embodiment of the invention, the crosslinking agent is an aliphatic or aromatic isocyanate compound having 2 or more —N═C═O groups.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: June 4, 2002
    Assignee: Michigan Biotechnology Institute
    Inventors: Zhi H. Huang, William F. McDonald, Stacy C. Wright, Andrew C. Taylor
  • Patent number: 6284904
    Abstract: Disclosed is a cost-effective method for purifying and acidifying carboxylic acids, including organic acids and amino acids. The method involves removing impurities by allowing the anionic form of the carboxylic acid to bind to an anion exchange column and washing the column. The carboxylic anion is displaced as carboxylic acid by washing the resin with a strong inorganic anion. This method is effective in removing organic carboxylic acids and amino acids from a variety of industrial sources, including fermentation broths, hydrolysates, and waste streams.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: September 4, 2001
    Assignee: Michigan Biotechnology Institute
    Inventor: Elankovan Ponnampalam
  • Patent number: 5723322
    Abstract: A fermentation process for making succinic acid in high concentrations employs a bacteria obtained from the rumen contents of cattle. A preferred bacteria is Bacterium 130Z (ATCC No. 55618).
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: March 3, 1998
    Assignee: Michigan Biotechnology Institute
    Inventors: Michael V. Guettler, Mahendra K. Jain, Bhupendra K. Soni
  • Patent number: 5618467
    Abstract: The present invention relates to luminescent materials, phosphors, and compositions containing phosphors and methods of their use. More particularly, it relates to organic phosphors which are amino acid salts and methods of using those phosphors and compositions to make objects photo-luminescent.
    Type: Grant
    Filed: October 26, 1995
    Date of Patent: April 8, 1997
    Assignee: Michigan Biotechnology Institute
    Inventors: Richard S. Turk, Joel I. Dulebohn
  • Patent number: 5573931
    Abstract: A method for producing succinic acid in high concentration by fermentation employs a variant of strain 130Z which is resistant to concentrations of about 1 g/l to about 8 g/l of sodium monofluoroacetate. The variant produces succinic acid in concentrations of about 80 g/l to about 110 g/l and the fermentation product contains less formic and acetic acids than the product obtained using the parent strain under identical conditions. The novel variants and a method of obtaining such variants also are described.
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: November 12, 1996
    Assignee: Michigan Biotechnology Institute
    Inventors: Michael V. Guettler, Mahendra K. Jain, Denise Rumler
  • Patent number: 5525365
    Abstract: A method for processing food, and particularly fruit, wherein the leaching discharge stream is separated, for example by desalting electrodialysis, into reusable brine and residual solutions. First, the fruit is brined using conventional techniques. The fruit is then leached or flushed with water to reduce the concentration of brine materials. The discharge stream from the leaching process is separated into a sugar solution and a brine solution, preferably through desalting electrodialysis. The dilute sugar solution is returned to the leaching process to return the natural sugar and color to the fruit. The brine solution preferably is returned to the brining process.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: June 11, 1996
    Assignees: Gray & Company, Michigan Biotechnology Institute
    Inventor: Ponnampalam Elankovan
  • Patent number: 5521075
    Abstract: A method for making succinic acid employs a fluoroacetate resistant variant of Anaerobiospirillum succiniciproducens. The fluoroacetate variant produces a succinic acid product which contains less acetic acid than the product obtained using the parent strain under identical conditions. A preferred variant FA-10 is obtained from A. succiniciproducens (ATCC No. 29305). A method of obtaining the variant also is described.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: May 28, 1996
    Assignee: Michigan Biotechnology Institute
    Inventors: Michael V. Guettler, Mahendra K. Jain
  • Patent number: 5504004
    Abstract: A fermentation process for making succinic acid in high concentrations employs a bacteria obtained from the rumen contents of cattle. A preferred bacteria is Bacterium 130Z (ATCC No. 55618).
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: April 2, 1996
    Assignee: Michigan Biotechnology Institute
    Inventors: Michael V. Guettler, Mahendra K. Jain, Bhupendra K. Soni
  • Patent number: 5490634
    Abstract: A method for reducing the size of coal particles includes the steps of inoculating a coal sample with an anaerobic bacteria or decarboxylating enzyme therefrom and incubating the inoculated sample. The microbes and/or decarboxylating enzymes biochemically modify the coal to reduce the size of the coal to ultra-fine particles. The biotreatment modifies the coal so as to improve its dispersibility in coal-water slurries.
    Type: Grant
    Filed: February 10, 1993
    Date of Patent: February 13, 1996
    Assignee: Michigan Biotechnology Institute
    Inventors: Mahendra K. Jain, Ramani Narayan, Ohantaek Han
  • Patent number: 5464651
    Abstract: The present invention relates to phosphors, composition containing phosphors and methods of their use. More particularly, it relates to organic phosphors which are amino acid salts compositions containing the phosphors and methods of using those phosphors and compositions to make objects photo-luminescent.
    Type: Grant
    Filed: November 18, 1993
    Date of Patent: November 7, 1995
    Assignee: Michigan Biotechnology Institute
    Inventors: Richard Turk, Paul Nowaczyk
  • Patent number: 5266475
    Abstract: A genetically engineered glucose isomerase with improved affinity for D-glucose and the method of preparation of such a glucose isomerase are disclosed. The glucose isomerase is obtained by mutagenizing the gene of a naturally occurring glucose isomerase such that a smaller amino acid replaces a larger amino acid in the catalytic site. In an especially advantageous embodiment of the present invention, the Clostridium glucose isomerase sequence is mutated and the residue replaced with a smaller amino acid is either Trp.sub.139 or Val.sub.186.
    Type: Grant
    Filed: September 19, 1991
    Date of Patent: November 30, 1993
    Assignee: Michigan Biotechnology Institute
    Inventors: Chanyong Lee, Michael Bagdasarian, J. Gregory Zeikus, Menghsiao Meng
  • Patent number: 5229161
    Abstract: Salts containing lysine, chloride ion and succinic acid in which the lysine is present in greater molar concentration than the chloride or succinic acid possess a salty flavor making them useful as table salt substitutes and flavor enhancers. Low sodium and low potassium salts containing sodium or potassium in addition to the lysine, chloride ion and succinic acid also are disclosed.
    Type: Grant
    Filed: August 4, 1992
    Date of Patent: July 20, 1993
    Assignee: Michigan Biotechnology Institute
    Inventor: Richard Turk
  • Patent number: 5192673
    Abstract: A biologically pure asporogenic mutant of Clostridium acetobutylicum is produced by growing sporogenic C. acetobutylicum ATCC 4259 and treating the parent strain with ethane methane sulfonate. The mutant which as been designated C. acetobutylicum ATCC 55025 is useful in an improved ABE fermentation process, and produces high concentrations of butanol and total solvents.
    Type: Grant
    Filed: April 30, 1990
    Date of Patent: March 9, 1993
    Assignee: Michigan Biotechnology Institute
    Inventors: Mahendra K. Jain, Daniel Beacom, Rathin Datta
  • Patent number: 5167799
    Abstract: An apparatus for simulating the operation of a full-scale belt filter press consists of a support base, a filter belt and a press belt each anchored at one end to the support base and passing over a static curved pressure face and a winch for exerting a pulling force on the press belt against the static curved press face to remove water from a sample of slurry on or within the belts. An improvement in the method of removing liquid from a slurry with a belt filter press also is disclosed which consists of pulling the pair of belts containing a slurry against a static curved pressure face to force liquid out of the slurry.
    Type: Grant
    Filed: August 1, 1991
    Date of Patent: December 1, 1992
    Assignee: Michigan Biotechnology Institute
    Inventors: Blaine F. Severin, Daniel J. Wagner, Hans E. Grethlein, Robert F. Hickey
  • Patent number: 5166069
    Abstract: A thermostable lipase is produced by aerobically culturing a microorganism having the identifying characteristics of Bacillus sp.A30-1 ATCC No. 53841 on a nutrient medium under growth conditions until a recoverable lipolytic activity is detectable and thereafter isolating the thermostable lipase. The thermostable lipase has an optimum temperature of about 60.degree. C. and an optimum pH of about 9.5.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: November 24, 1992
    Assignee: Michigan Biotechnology Institute
    Inventors: Gwo-Jenn Shen, Kailash C. Srivastava, Yongxiang Wang, Henry Y. Wang
  • Patent number: 5034105
    Abstract: A process for preparing a carboxylic acid of high purity comprises preparing an undersaturated solution of a salt of the carboxylic acid; subjecting the undersaturated salt solution to water-splitting electrodialysis to form base and a supersaturated solution of the carboxylic acid; and, then crystallizing the carboxylic acid from the supersaturated solution. In the preferred embodiment, the undersaturated solution is a fermentation broth containing sodium succinate and the carboxylic acid obtained is succinic acid.
    Type: Grant
    Filed: July 27, 1989
    Date of Patent: July 23, 1991
    Assignee: Michigan Biotechnology Institute
    Inventors: Kris A. Berglund, Ponnampalam Elankovan, David A. Glassner
  • Patent number: 4997665
    Abstract: Dietary fiber of enhanced functional properties and a novel antioxidant activity is prepared by mixing a slurry of a lignocellulose plant fiber while heating it and maintaiing it as a liquid until the functional properties of the fiber are enhanced and the fiber acquires an antioxidant property.
    Type: Grant
    Filed: October 5, 1989
    Date of Patent: March 5, 1991
    Assignee: Michigan Biotechnology Institute
    Inventor: Hans Grethlein
  • Patent number: 4885247
    Abstract: A process for producing, recovering and purifying lactate from a fermentation broth so that it can be efficiently and economically converted to lactic acid is disclosed. The process comprises growing a high lactate producing, microorganism on an inexpensive substrate until a whole broth containing about 75 to about 90 grams of lactate salt is obtained. The whole broth including the viable cells is then electrodialyzed in a unit having anionic-permeable and cationic-permeable membranes to cause the lactate salt to concentrate in an aqueous liquid which can be treated to convert the lactate salt to lactic acid.
    Type: Grant
    Filed: April 19, 1988
    Date of Patent: December 5, 1989
    Assignee: Michigan Biotechnology Institute
    Inventor: Rathin Datta