Abstract: Disclosed is a pharmaceutical composition having circulation ameliorating effect and antiulcer effect containing a prostaglandin I.sub.2 analogue represented by the formula shown below or a non-toxic salt or a cyclodextrin inclusion compound thereof as the effective ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cycloalkyl group having 4 to 7 carbon atoms or a phenyl group, A represents a pentyl group, a cyclopentyl group, a cyclohexyl group, a 1-methyl-3-hexynyl group, a 2-methyl-3-hexynyl group, a 1-methylhexyl group, a 2-phenethyl group, a 1,1-dimethylpentyl group, a 2-methylpentyl group, a 1-cyclohexylethyl group, a 2-methylhexyl group, a 1-methyl-3-pentynyl group or a 2,6-dimethyl-5-heptenyl group; the double bond between the carbon atoms at 4- and 5-positions is E or Z or a mixture thereof; the asymmetric center in the substituent represented by A is in the R-configuration or the S-configuration or a mixture thereof.

Abstract: A .gamma.-butyrolactone derivative represented by the following formula: ##STR1## wherein R.sup.1 represents a hydrogen atom, a straight or branched alkyl group having 1-8 carbon atoms, a phenyl group; R.sup.2 and R.sup.3 may be the same or different and each represents a hydrogen atom, a straight or branched alkyl group having 1-8 carbon atoms, a cycloalkyl group having 3-10 carbon atoms, a benzyl group, a phenyl group, a phenyl group substituted with a substituent selected from the group consisting of a halogen atom, an alkoxy group, a nitro group, an amino group, an alkyl group having 1-4 carbon atoms, a nitrile group and an alkoxycarbonyl group; R.sup.2 and R.sup.3 may be linked to form an alkylene group having 4-6 carbon atoms; X represents a hydrogen atom, a straight or branched alkyl group having 1-8 carbon atoms, a cycloalkyl group having 3-10 carbon atoms, a benzyl group or a substituent represented by the formula ##STR2## (wherein R.sup.

Abstract: There are presented novel quinazoline derivatives, namely 2-(4-substituted-carbamoyl-piperazin-1-yl)quinazoline derivatives, 2-(4-substituted-carbamoyl-homopiperazin-1-yl)quinazoline derivatives, 2-(4-substituted-thiocarbamoyl-piperazin-1-yl)quinazoline derivatives and 2-(4-substituted-thiocarbamoyl-piperazin-1-yl)quinazoline derivatives, having excellent antihypertensive activities.

Abstract: This invention relates to an anticholesteremic containing a main ingredient of an anion exchange resin which is a copolymer of an imidazole compound modified with a halomethyl oxirane compound and a polyfunctional epoxy resin, and has an imidazolium salt as the functional group in the main chain.

Abstract: There is provided a cholesterol reducing agent which contains as an active ingredient an anion exchange resin having a functional group of an imidazolium salt represented by the formula: ##STR1## wherein the substituents R.sub.1a through R.sub.4a and X.sup..crclbar. are as defined in the specification and claims.The cholesterol reducing agent according to the present invention has a high selectivity for the adsorption of bile acids and has no bad smell.

Abstract: There are provided a novel compound, i.e., a 2-piperazino-4-substituted-5,6-alkylenepyrimidine derivative represented by the formula: ##STR1## wherein Y, Z and n are defined in the specification and claims, and a pharmaceutically acceptable acid addition salt thereof.The compounds of the present invention show, an anti-inflammatory effect, a blood sugar level lowering effect, a blood platelet aggregation suppressive effect, an anorexigenic action and a Serotonin effect.

Abstract: New polysaccharide named M-30-C produced by cultivation of new strain Pseudomonas polysaccharogenes M-30 and having utility as hypocholesterol agents.

Abstract: Novel ester derivatives of quinolopyran-4-one-2-carboxylic acids and the tautomers thereof are provided, the ester groups being specified and restricted. These novel compounds are especially useful as antiallergic antasthmatics or remedies for asthma, and can be administered orally with long duration of action.

Abstract: New polysaccharide named M-30-C produced by cultivation of new strain Pseudomonas polysaccharogenes M-30 and having utility as hypocholesterol agents.

Abstract: Novel quinazoline compounds and antihypertensive compositions containing said compounds are disclosed; said compounds having the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or an alkyl group having 1-5 carbon atoms;R.sup.2 is a group of the formula ##STR2## in which Y is a hydrogen atom, an alkyl group of 1-5 carbon atoms, an alkoxy group of 1-5 carbon atoms, an alkenyloxy group, a methylenedioxy group, a nitro group, a halogen atom, a trifluoromethyl group, an acyloxy group, a hydroxy group, an unsubstituted or substituted amino group or a condensed benzene nucleus and m is an integer of 1-3 inclusive, or a group of the formula ##STR3## in which X is an oxygen atom, a sulfur atom or a carbon-nitrogen double bond and Z is a hydrogen atom, an alkyl group of 1-5 carbon atoms, an alkoxy group of 1-5 carbon atoms, a nitro group or a halogen atom; and n is an integer of 2-3 inclusive;provided that, when R.sup.2 is the said group ##STR4## n is 2 and R.sup.1 is a hydrogen atom or, when R.sup.

Abstract: Substituted pyrimido[5,6-b]quinoxaline-4(3H)-one-2-carboxylic acid compounds each represented by the formula ##STR1## wherein: R designates a member selected from the group consisting of hydrogen, alkyl groups having 1 to 4 carbon atoms, benzyl group, and phenyl group; and each of R.sup.1, R.sup.2, R.sup.3, and R.sup.4 independently designates a member selected from the group consisting of hydrogen, alkyl group having 1 to 4 carbon atoms, alkoxy groups having 1 to 4 carbon atoms, halogens, benzyloxy group, hydroxyl group, alkylthio groups having 1 to 4 carbon atoms, and alkylenedioxy groups having 1 to 4 carbon atoms and formed by the bonding of two of R.sup.1, R.sup.2, R.sup.3, and R.sup.4, or pharmacologically acceptable salts of said compounds.

Abstract: Quinolopyran-4-one-2-carboxylic acid derivatives and salts thereof are provided as novel compounds and as medicines for treatment of allergic asthma, each of the derivatives being represented by the general formula ##STR1## wherein X designates a member selected from the group consisting of alkyl groups having 1 to 5 carbon atoms, alkoxy groups having 1 to 5 carbon atoms, halogen atoms, aryl-substituted alkoxy groups having 7 to 10 total carbon atoms, alkoxycarbonyl groups having 2 to 6 total carbon atoms, and aryl groups having 6 to 10 carbon atoms, and n is any one of the integers 1 through 4, X being the same group or different groups in the case where n is at least 2.

Abstract: Novel substituted phenylacetic acid derivatives having the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or lower alkyl radical and R.sub.3 represents an alkenyl or alkynyl radical having 3 - 4 carbon atoms with excellent anti-inflammatory and analgesic activities.