Patents Assigned to Mitsui Norin Co., Ltd.
  • Patent number: 8652533
    Abstract: Contemplated compositions and methods include a catechin at a concentration effective to inactivate SARS at least by a factor of 2 log 10 units when the formulation is applied to a surface. Preferably, the catechins are provided as a complex mixture, and most preferably as a near-native catechin preparation from green tea.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: February 18, 2014
    Assignee: Mitsui Norin Co., Ltd.
    Inventors: Yukihiko Hara, Paul Wegener
  • Patent number: 8338476
    Abstract: Contemplated methods and compositions further increase susceptibility of sensitized MRSA against various antibiotic drugs. Most preferably, the MRSA is already sensitized with a galloylated catechin (e.g., ECG), and further sensitization is achieved by exposure to a non-galloylated catechin (e.g., EC), and most preferably the corresponding non-galloylated catechin.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: December 25, 2012
    Assignees: Mitsui Norin Co, Ltd., The School of Pharmacy, University of London
    Inventors: Paul Stapleton, Yukihiko Hara, Peter Taylor
  • Patent number: 8138359
    Abstract: Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the 3-hydroxyflavan. Such adducts exhibit markedly increased stability towards oxidation as compared to the unmodified 3-hydroxyflavan. Particularly preferred 3-hydroxyflavans include green tea catechins, and especially EGCG, while especially preferred reducing agents include NAC and glutathione.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: March 20, 2012
    Assignee: Mitsui Norin Co., Ltd.
    Inventors: Yukihiko Hara, Hiroshi Hojo, Slobodan Jovanovic
  • Patent number: 8128967
    Abstract: Contemplated compositions and methods utilize a combination of a polyphenol and a non-polyphenol cyclooxygenase-2 inhibitor. Preferably, the compositions are pharmaceutical and/or nutraceutical compositions and formulated in a dosage form and amount such that the polyphenol and the non-polyphenol cyclooxygenase-2 inhibitor are effective to reduce tumor incidence and/or multiplicity. In preferred aspects, the polyphenol is epigallocatechin gallate, epigallocatechin, epicatechin gallate, epicatechin, and/or a mixture of polyphenols isolated from a plant (e.g., polyphenon E), and the cyclooxygenase-2 inhibitor is rofecoxib, celecoxib, and/or valdecoxib.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: March 6, 2012
    Assignee: Mitsui Norin Co., Ltd.
    Inventor: Yukihiko Hara
  • Patent number: 8124141
    Abstract: Topical compositions, and particularly hydrophobic compositions include an essential oil in an amount effective to achieve substantially complete absorption of the composition in the skin without leaving a greasy residue. Especially preferred topical compositions may also include pharmaceutically active agents (e.g., polyphenol), additional essential oils, stabilizers, etc. In further preferred aspects, contemplated compositions may delay onset, or even prevent viral eruptions on the skin, and where applied as a lipstick, will increase reddening of the lip as well as reduce chapping.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: February 28, 2012
    Assignees: Mitsui Norin Co., Ltd., Epitome Pharmaceuticals Limited
    Inventors: Paul T. Wegener, Yukihiko Hara
  • Patent number: 7763291
    Abstract: The objective of the present invention is to provide a tea polyphenol composition that has reduced bitterness and astringency while containing catechins with high purity. The present invention provides a tea polyphenol composition, (A) comprising 85% by weight to 95% by weight of catechins, (B) wherein the catechins contains epigallocatechin gallate and gallocatechin gallate at a ratio of 65% by weight to 80% by weight and (C) wherein the ratio given by (epigallocatechin gallate+gallocatechin gallate)/(epicatechin+catechin+epigallocatechin+gallocatechin+epicatechin gallate+catechin gallate) is from 2 to 4.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: July 27, 2010
    Assignee: Mitsui Norin Co., Ltd.
    Inventors: Yukihiko Hara, Ryota Seto
  • Publication number: 20100069476
    Abstract: Compositions and methods are provided in which a topical hydrophilic formulation includes a catechin and a hydrophilic antioxidant in a hydrophilic composition at a ratio of between 2.3 to 1.7 (by weight), ad wherein the catechin and the antioxidant are present in an amount such that application of the composition to skin will deposit the catechin at a dosage of between 0.7 mg/cm2 and 1.3 mg/cm2. Especially preferred catechins include green tea catechins, and particularly EGCG, while preferred antioxidants include ascorbic acid and derivatives thereof.
    Type: Application
    Filed: May 17, 2005
    Publication date: March 18, 2010
    Applicant: MITSUI NORIN CO., LTD
    Inventors: Yukihiko HARA, Santosh K. Katiyar
  • Publication number: 20090028963
    Abstract: Contemplated compositions and methods utilize a combination of a polyphenol and a non-polyphenol cyclooxygenase-2 inhibitor. Preferably, the compositions are pharmaceutical and/or nutraceutical compositions and formulated in a dosage form and amount such that the polyphenol and the non-polyphenol cyclooxygenase-2 inhibitor are effective to reduce tumor incidence and/or multiplicity. In preferred aspects, the polyphenol is epigallocatechin gallate, epigallocatechin, epicatechin gallate, epicatechin, and/or a mixture of polyphenols isolated from a plant (e.g., polyphenon E), and the cyclooxygenase-2 inhibitor is rofecoxib, celecoxib, and/or valdecoxib.
    Type: Application
    Filed: March 8, 2006
    Publication date: January 29, 2009
    Applicant: MITSUI NORIN CO., LTD.
    Inventor: Yukihiko Hara
  • Publication number: 20080096959
    Abstract: Contemplated compositions and methods include a catechin at a concentration effective to inactivate SARS at least by a factor of 2 log 10 units when the formulation is applied to a surface. Preferably, the catechins are provided as a complex mixture, and most preferably as a near-native catechin preparation from green tea.
    Type: Application
    Filed: July 5, 2005
    Publication date: April 24, 2008
    Applicant: MITSUI NORIN CO., LTD.
    Inventors: Yukihiko Hara, Paul T. Wegener
  • Publication number: 20020006447
    Abstract: The present invention relates to an anti-Chlamydia agent characterized by containing tea polyphenol and to a method for preventing or treating a Chlamydia infectious disease, characterized by comprising administering a composition containing tea polyphenol in an amount effective for the therapy of a Chlamydia infectious disease on an affected part of a patient.
    Type: Application
    Filed: July 19, 2001
    Publication date: January 17, 2002
    Applicant: Mitsui Norin Co., Ltd.
    Inventors: Tsutomu Yamazaki, Yukihiko Hara
  • Patent number: 6248346
    Abstract: A chewing gum which has a preventative effect against infection by influenza virus and inhibits dissemination of influenza virus. The chewing gum comprises adding at least 0.03 weight % of at least one tea polyphenol, for a chewing gum containing no organic acids; the chewing gum comprises at least 0.01 weight % of at least one tea polyphenol for a chewing gum containing at least one organic acid.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: June 19, 2001
    Assignee: Mitsui Norin Co., Ltd.
    Inventors: Yukihiko Hara, Mikio Nakayama
  • Patent number: 6197808
    Abstract: A method for a treatment of hyperplasia caused by papilloma virus, such as Condyloma acuminata, which comprises concomitantly topically and orally administering at least one tea catechin. Tea catechins do not involve the risk of side-effects and may be easily administered by the patients themselves.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: March 6, 2001
    Assignees: Cancer Instititute (Hospital), Chinese Academy of Medical Sciences, Mitsui Norin Co., Ltd.
    Inventors: Shu Jun Cheng, De Chang Wang, Yukihiko Hara, Insu P. Lee, Woong Shick Ahn
  • Patent number: 5968973
    Abstract: A method for a treatment of hyperplasia caused by papilloma virus, such as for treating Condyloma acuminata which comprises administering tea catechin. Tea catechins do not involve the risk of side-effects and may be easily applied to or inserted in the infected area by the patients themselves.
    Type: Grant
    Filed: April 7, 1998
    Date of Patent: October 19, 1999
    Assignees: Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Mitsui Norin Co., Ltd.
    Inventors: Shu Jun Cheng, De Chang Wang, Yukihiko Hara
  • Patent number: 5929047
    Abstract: An anti-viral agent comprising as the effective component, an alkali extract of mangroves, Momordica charantia, and Aspalathus linearis belonging to Leguminosae family. The effective component is essentially consists of acidic polysaccharides and shows an antioxidant activity and free radical (reactive oxygen species)-scavenging activity.The agent is effective against retrovirus such as human immuno deficiency virus (HIV), with no side-effects on human and/or animals.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: July 27, 1999
    Assignee: Mitsui Norin Co., Ltd.
    Inventor: Masatoshi Nakano
  • Patent number: 5888527
    Abstract: The present invention provides for an antifungal, antibacterial and antiviral filter comprising in laminations a dust collecting filter and a filter impregnated with a tea extract. The filter having nonwoven fabric is impregnated with a polyphenol tea extract, which can be easily produced commercially and is capable of maintaining a high virus trapping performance, inactivating the trapped viruses and preventing them from being rescattered.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: March 30, 1999
    Assignees: Matsushita Seiko Co., Ltd., Mitsui Norin Co., Ltd.
    Inventors: Kazuo Nashimoto, Yoshikazu Tashiro
  • Patent number: 5814319
    Abstract: An anti-viral, anti-bacterial, and anti-cancer agent comprising as the effective component, an alkali extraction of Aspalathus linearis which is preferably obtained after extraction by hot water. The agent serves to treat and prevent bacterial infections; to treat and prevent cancer; and to treat or prevent viral infection, for example, infection caused by retroviruses, such as human T-cell leukemia and the AIDS virus. The agent has no side effects.
    Type: Grant
    Filed: March 22, 1996
    Date of Patent: September 29, 1998
    Assignee: Mitsui Norin Co., Ltd.
    Inventor: Masatoshi Nakano
  • Patent number: 5807564
    Abstract: A method of increasing the activity of an antibiotic against methicillin resistant Staphylococcus aureus in a patient by administering to the patient the antibiotic in combination with a catechin and/or a theaflavin.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: September 15, 1998
    Assignee: Mitsui Norin Co., Ltd.
    Inventors: Tadakatsu Shimamura, Yukihiko Hara
  • Patent number: 5804567
    Abstract: A method for treating cancer in a patient by administering to a patient an nti-cancer effective amount of an anti-metabolite selected from the group consisting of 1-.beta.-arabinofuranosylcytosine and 4-amino-4-deoxy-10-methylfolic acid and an anti-oxidant effective amount of a tea polyphenol compound selected from the group consisting of a tea catechin, a theaflavin and a combination of a tea catechin and a theaflavin.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: September 8, 1998
    Assignees: Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Mitsui Norin Co., Ltd.
    Inventors: Shu Jun Cheng, De Chang Wang, Yong Su Zhen, Hoyoku Nishino, Yukihiko Hara
  • Patent number: 5795911
    Abstract: A composition for a treatment of HPV-infected Condyloma acuminata which comprises containing tea catechin as a main component. This medication has no danger of side-effects and may be easily applied to or inserted in the infected area by the patient themselves.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: August 18, 1998
    Assignees: Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Mitsui Norin Co., Ltd.
    Inventors: Shu Jun Cheng, De Chang Wang, Yukihiko Hara
  • Patent number: 5766595
    Abstract: Method of improving the quality of an egg from a female adult fowl comprising adding an effective egg improving amount of at least one tea polyphenol to a feed composition for the fowl and administering the composition to the fowl. Eggs produced by such method have a reduced crude fat content, a reduced peroxide content, an enhanced Haugh Unit value, an enhanced degree of transparency of egg white, an enhanced foam-forming ability and a pure white color in foam and egg white when the eggs are cooked. Also provided is an improved feed composition for improving the quality of an egg from a female adult fowl, wherein the improvement comprises the feed composition containing an effective egg improving amount of at least one tea polyphenol.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: June 16, 1998
    Assignees: Nippon Formula Feed Mfg. Co., Ltd., Mitsui Norin Co., Ltd.
    Inventors: Tetsuo Yamane, Takao Tsuchida, Hisaya Gotou, Daizou Takahashi, Hidetsugu Takeda