Patents Assigned to Mochida Pharmaceutical Co., Ltd.
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Patent number: 10668038Abstract: Novel compositions comprising omega-3 fatty acids and uses thereof are disclosed.Type: GrantFiled: June 23, 2017Date of Patent: June 2, 2020Assignee: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Omar Abdelfattah Abu-Baker, Donald MacKenzie, Rennan Pan
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Patent number: 10669239Abstract: The present invention aims to provide a compound having a TrkA inhibitory action, a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition containing the same as an active ingredient, and a preventive and/or therapeutic agent for medicinal use, in particular for a disease in which TrkA in involved (pain, cancers, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, endometriosis, renal diseases, osteoporosis, and the like).Type: GrantFiled: July 17, 2019Date of Patent: June 2, 2020Assignee: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Fumihiko Saitoh, Hiroshi Nagasue
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Publication number: 20200069726Abstract: The present invention provides a ready-to-use sterile alginate aqueous solution preparation which is packed in a sealed container or an airtight container and which has storage stability, comprising: (a) a low-endotoxin monovalent metal salt of alginic acid having a weight average molecular weight of 50,000 to 400,000 by a GPC-MALS method; (b) a salt selected from a monovalent metal salt and an ammonium salt; and (c) water, wherein a concentration of the component (a) is 1.5% by mass or more, a concentration of the component (b) is 0.5 to 2% by mass, and a viscosity measured at 20° C. using a rotational viscometer is 2700 mPa·s or more, and a method of producing the same. This alginate aqueous solution preparation is a ready-to-use aqueous solution preparation of a low-endotoxin monovalent metal salt of alginic acid.Type: ApplicationFiled: March 6, 2018Publication date: March 5, 2020Applicant: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Shuichi ENDO, Motoi NAKAHARA
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Patent number: 10576053Abstract: Provided are: a composition containing 96-99 area % of eicosapentaenoic acid alkyl ester, the composition having an arachidonic acid alkyl ester content of 0.7 area % or less, and an eicosapentaenoic-acid-alkyl-ester mono-trans isomer content of 2.5 area % or less; and a method for producing a composition containing a high concentration of eicosapentaenoic acid alkyl ester, the method including performing precision distillation on a composition containing eicosapentaenoic acid alkyl ester, obtained by alkyl esterification of a raw material oil containing eicosapentaenoic acid, under a vacuum of 0.2 Torr or lower and a temperature of 190° C. or lower in the entire column, and performing a concentration treatment on the precision-distilled composition using chromatography.Type: GrantFiled: September 18, 2018Date of Patent: March 3, 2020Assignees: NIPPON SUISAN KAISHA, LTD., MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Nobushige Doisaki, Shingo Arato, Takuro Fukae
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Publication number: 20200046672Abstract: This invention provides a self-emulsifying composition comprising 50 to 95% by weight in total of at least one compound selected from the group consisting of ?3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; and 5 to 50% by weight of an emulsifier having a hydrophilic lipophilic balance of at least 10. The composition has no or reduced ethanol content, and exhibits excellent self-emulsifying property, dispersibility in the composition, emulsion stability, and absorption property. The composition is adapted for use as a drug.Type: ApplicationFiled: October 18, 2019Publication date: February 13, 2020Applicant: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Hirosato FUJII, Motoo YAMAGATA
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Publication number: 20200030367Abstract: The present invention has an objective of providing a novel composition for treating a fibrocartilaginous tissue injury. The present invention provides a composition for treating a fibrocartilaginous tissue injury, which is to be applied to an injured fibrocartilaginous tissue part of a target and which comprises a monovalent metal salt of alginic acid, more preferably a low endotoxin monovalent metal salt of alginic acid.Type: ApplicationFiled: March 1, 2018Publication date: January 30, 2020Applicants: Mochida Pharmaceutical Co., Ltd, National University Corporation Hokkaido UniversityInventors: Eiji KONDO, Norimasa IWASAKI, Tomohiro ONODERA, Wooyoung KIM, Yasuyuki KAWAGUCHI
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Patent number: 10493052Abstract: This invention provides a self-emulsifying composition comprising 50 to 95% by weight in total of at least one compound selected from the group consisting of ?3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; and 5 to 50% by weight of an emulsifier having a hydrophilic lipophilic balance of at least 10. The composition has no or reduced ethanol content, and exhibits excellent self-emulsifying property, dispersibility in the composition, emulsion stability, and absorption property. The composition is adapted for use as a drug.Type: GrantFiled: August 29, 2018Date of Patent: December 3, 2019Assignee: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Hirosato Fujii, Motoo Yamagata
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Publication number: 20190358186Abstract: A medical composition for reducing the rate of new-onset diabetes caused by administration of a statin or for inhibiting an increase in blood glucose level by administration of a statin, the composition containing at least one ingredient selected from the group consisting of icosapentaenoic acid and pharmaceutically acceptable salts or esters thereof as an inactive ingredient.Type: ApplicationFiled: August 13, 2019Publication date: November 28, 2019Applicant: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Masahiko OHTA, Shinichi OIKAWA, Mitsuhiro YOKOYAMA, Hideki ORIGASA, Masunori MATSUZAKI, Yuji MATSUZAWA, Yasushi SAITO
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Publication number: 20190337897Abstract: The present invention aims to provide a compound having a TrkA inhibitory action, a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition containing the same as an active ingredient, and a preventive and/or therapeutic agent for medicinal use, in particular for a disease in which TrkA in involved (pain, cancers, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, endometriosis, renal diseases, osteoporosis, and the like).Type: ApplicationFiled: July 17, 2019Publication date: November 7, 2019Applicant: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Fumihiko SAITOH, Hiroshi NAGASUE
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Patent number: 10441560Abstract: The disclosure provides for a method for treating a fatty liver disorder in a subject in need thereof, comprising selecting a subject having or suspected of having a fatty liver disease or disorder, wherein the subject is non diabetic, pre-diabetic, mildly diabetic, or has normal or substantially normal biliary tract function; and administering a therapeutically effective amount of a pharmaceutical composition comprising ethyl eicosapentanoate (EPA-E). In some cases EPA-E present may be at least 40% by weight in total of the fatty acids and their derivatives.Type: GrantFiled: March 13, 2014Date of Patent: October 15, 2019Assignee: Mochida Pharmaceutical Co., LTD.Inventors: Tsuyoshi Harada, Hideo Kanehiro, Kiyoshi Mizuguchi
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Patent number: 10399945Abstract: The present invention aims to provide a compound having a TrkA inhibitory action, a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition containing the same as an active ingredient, and a preventive and/or therapeutic agent for medicinal use, in particular for a disease in which TrkA in involved (pain, cancers, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, endometriosis, renal diseases, osteoporosis, and the like).Type: GrantFiled: September 21, 2018Date of Patent: September 3, 2019Assignee: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Fumihiko Saitoh, Hiroshi Nagasue
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Publication number: 20190231731Abstract: A self-emulsifying composition contains: 70 to 90% by weight in total of one or more compounds selected from the group consisting of ?3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 1 to 29% by weight of an emulsifying agent selected from among a polyoxyethylene sorbitan fatty acid ester, a sorbitan fatty acid ester, a glycerin fatty acid ester and a polyoxyl castor oil; and 0.5 to 6% by weight of water when the composition is defined to be 100% by weight as a whole. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.Type: ApplicationFiled: April 10, 2019Publication date: August 1, 2019Applicant: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Shigeru KIMURA, Hiromitsu ITO, Hirosato FUJII, Motoo YAMAGATA
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Publication number: 20190209260Abstract: [Problem] An adhesion-preventing material having a high adhesion-preventing effect has been demanded. [Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.Type: ApplicationFiled: July 13, 2017Publication date: July 11, 2019Applicant: Mochida Pharmaceutical Co., Ltd.Inventors: Taichi ITO, Seiichi OHTA, Norihiro KOKUDO, Mitsuko ISAJI, Satoshi SHIMIZU
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Publication number: 20190167802Abstract: A self-emulsifying composition contains: 70 to 90% by weight of at least one compound selected from the group consisting of ?3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; 0.5 to 6% by weight of water; 1 to 29% by weight of a polyoxyethylene sorbitan fatty acid ester as an emulsifier (optionally including a polyoxyl castor oil, and not including lecithin); and lecithin in an amount of 3 to 40 parts by weight in relation to 100 parts by weight of ?3 polyunsaturated fatty acids and the like. The self-emulsifying composition is excellent in self-emulsifying property, composition dispersibility, emulsion stability, and absorbability, is free from ethanol and polyhydric alcohols or only has such an alcohol added thereto at a reduced concentration, and is useful for foods and pharmaceuticals.Type: ApplicationFiled: February 11, 2019Publication date: June 6, 2019Applicant: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Hiromitsu ITO, Hirosato FUJII, Motoo YAMAGATA, Daichi TANAKA
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Publication number: 20190083678Abstract: A non-tubular material for nerve regeneration induction, which can be used for the regeneration of a damaged part in a nerve, and which comprises: (A) a crosslinked form produced by crosslinking a low-endotoxin bioabsorbable polysaccharide having a carboxyl group in the molecule with at least one crosslinkable reagent selected from a compound represented by general formula (I) and a salt thereof via covalent bonds; and (B) a bioabsorbable polymer. R1HN—(CH2)n—NHR2 (I) [wherein R1 and R2 independently represent a hydrogen atom or a group represented by formula: —COCH(NH2)—(CH2)4—NH2, and n represents an integer of 2 to 18]. Thus, a medical material that can induce the regeneration of a damaged part in a nerve is provided.Type: ApplicationFiled: March 14, 2017Publication date: March 21, 2019Applicants: Tazuke Kofukai, Mochida Pharmaceutical Co., Ltd.Inventors: Yoshihisa SUZUKI, Masao TANIHARA, Mitsuko ISAJI
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Publication number: 20190071441Abstract: The present invention provides a method for manufacturing a compound represented by formula (I). With this method, provided are a method for manufacturing a 4-heteroaryl-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxylic acid amide derivative; and an intermediate for this manufacturing method.Type: ApplicationFiled: November 6, 2018Publication date: March 7, 2019Applicant: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Tsutomu SATOH, Takashi KUDOH, Tetsuo IWAMA
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Patent number: 10208010Abstract: The present invention provides a type I crystal of (E)-2-(7-trifluoromethyl-chroman-4-ylidene)-N-((7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide having excellent TRPV1 antagonistic activity, a drug and a pharmaceutical composition containing this crystal, and a method for producing the crystal. The present invention provides a type I crystal of (E)-2-(7-trifluoromethyl-chroman-4-ylidene)-N-((7R)-7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide that is excellent in at least one feature selected from the group consisting of storage stability, photostability and thermodynamic stability, that can be preferably obtained with industrially high reproducibility, yield and purity, and that is useful as a crystal of an active pharmaceutical ingredient.Type: GrantFiled: May 30, 2018Date of Patent: February 19, 2019Assignee: MOCHIDA PHARMACEUTICAL CO., LTD.Inventor: Tsutomu Satoh
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Patent number: 10201531Abstract: The present invention provides a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof or a solvate of these. A compound having Nrf2 activation ability is provided by the present invention.Type: GrantFiled: August 10, 2016Date of Patent: February 12, 2019Assignee: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Fumihiko Saitoh, Tomoyuki Kamino, Motoi Nakahara
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Publication number: 20190023657Abstract: The present invention aims to provide a compound having a TrkA inhibitory action, a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition containing the same as an active ingredient, and a preventive and/or therapeutic agent for medicinal use, in particular for a disease in which TrkA in involved (pain, cancers, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, endometriosis, renal diseases, osteoporosis, and the like).Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicant: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Fumihiko SAITOH, Hiroshi NAGASUE
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Patent number: 10174025Abstract: The present invention provides a method for manufacturing a compound represented by formula (I). With this method, provided are a method for manufacturing a 4-heteroaryl-N-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxylic acid amide derivative; and an intermediate for this manufacturing method.Type: GrantFiled: December 13, 2017Date of Patent: January 8, 2019Assignee: MOCHIDA PHARMACEUTICAL CO., LTD.Inventors: Tsutomu Satoh, Takashi Kudoh, Tetsuo Iwama