Patents Assigned to Momenta Pharmaceuticals, Inc.
  • Publication number: 20110076729
    Abstract: Methods of making LMWH compositions are provided to provide the LMWH compositions at a yield of at least about 10%.
    Type: Application
    Filed: February 19, 2009
    Publication date: March 31, 2011
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Zainab Sirajbhai Mamuwala, Ganesh Venkataraman
  • Patent number: 7888072
    Abstract: The invention provides recombinant B. thetaiotaomicron GAG lyase polypeptides. The invention also provides nucleic acid molecules encoding such polypeptides, recombinant expression vectors containing B. thetaiotaomicron GAG lyase nucleic acid molecules, and host cells into which the expression vectors have been introduced. Characterization, diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: February 15, 2011
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventor: James Myette
  • Patent number: 7884187
    Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: February 8, 2011
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
  • Publication number: 20100331266
    Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.
    Type: Application
    Filed: September 15, 2010
    Publication date: December 30, 2010
    Applicant: Momenta Pharmaceuticals, Inc. a Massachusetts corporation
    Inventors: Yanjie Jiang, Peter James Ahern, James Eric Anderson, Corinne Bauer, Xiangping Zhu, Zachary Shriver
  • Publication number: 20100324276
    Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Application
    Filed: April 16, 2010
    Publication date: December 23, 2010
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Mallikarjun SUNDARAM, Takashi Kei KISHIMOTO, Sucharita ROY
  • Publication number: 20100316640
    Abstract: Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Application
    Filed: June 15, 2010
    Publication date: December 16, 2010
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Mallikarjun SUNDARAM, Takashi Kei KISHIMOTO, Sucharita ROY
  • Publication number: 20100298260
    Abstract: Preparations of polysaccharides lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
    Type: Application
    Filed: November 3, 2008
    Publication date: November 25, 2010
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Mallikarjun Sundaram, Takashi Kei Kishimoto, Sucharita Roy
  • Publication number: 20100279306
    Abstract: The present disclosure provides technologies for enriching, detecting, and/or quantifying phosphorylated glycans and/or glycoconjugates (e.g., glycopeptides, glycolipids, proteoglycans, etc.). Specifically, the present disclosure provides methods that utilize immobilized metal affinity chromatography (IMAC) to isolate and/or to characterize phosphorylated glycans. The present disclosure particularly provides methods for distinguishing sulfated and phosphorylated glycans.
    Type: Application
    Filed: April 15, 2008
    Publication date: November 4, 2010
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Carlos J. Bosques, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons
  • Publication number: 20100279269
    Abstract: The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.
    Type: Application
    Filed: April 15, 2008
    Publication date: November 4, 2010
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Jonathan Lansing, Daniela Beccati, Scott Bailey, Carlos J. Bosques
  • Patent number: 7816144
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: October 19, 2010
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • Patent number: 7811827
    Abstract: The invention provides methods and apparatus for characterizing complex polymeric mixture of interest. Candidate solutions are eliminated from a solution space using one or more experimental measurements of a polymeric mixture of interest. The elimination step can be repeated one or more times using different experimental measurements produced by various chemical and physical protocols, so that the remaining candidate solutions converge to describe the actual polymeric mixture under investigation. Once the composition of the complex polymeric mixture has been characterized, the information thus generated can be used to facilitate, for example, the manufacture of a bio-equivalent of the complex polymeric mixture.
    Type: Grant
    Filed: July 1, 2008
    Date of Patent: October 12, 2010
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventor: Sasisekharan Raguram
  • Patent number: 7790466
    Abstract: Methods for analyzing mixtures of polysaccharides, for example heparin such as unfractionated heparin and enoxaparin are described. In some instances, the mixtures are analyzed using fast performance liquid chromatography (FPLC) and high liquid performance chromatography (HPLC), e.g., strong anion exchange HPLC.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: September 7, 2010
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Zachary Shriver, Daniela Beccati, Ishan Capila, Nur Sibel Gunay, Jennifer Ozug, Steve Wudyka
  • Publication number: 20100196940
    Abstract: The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
    Type: Application
    Filed: April 15, 2008
    Publication date: August 5, 2010
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Brian Edward Collins, Carlos J. Bosques, Xiangping Zhu, Dorota A. Bulik, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Venkataraman
  • Patent number: 7767420
    Abstract: The invention provides recombinant B. thetaiotaomicron HSGAG lyase polypeptides. The invention also provides nucleic acid molecules encoding such polypeptides, recombinant expression vectors containing B. thetaiotaomicron HSGAG lyase nucleic acid molecules, and host cells into which the expression vectors have been introduced. Characterization, diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: August 3, 2010
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventor: James Myette
  • Publication number: 20100188084
    Abstract: The present disclosure provides a method for determining the relative conformations of a protein provided in different protein preparations, comprising steps of: (i) obtaining a first 2D NOESY NMR spectrum of a first protein preparation; (ii) obtaining a second 2D NOESY NMR spectrum of a second protein preparation; and (iii); determining whether a protein has a different conformation in the first and second protein preparations by comparing one or more cross-peaks in the first 2D NOESY NMR spectrum with one or more corresponding cross-peaks in the second 2D NOESY NMR spectrum.
    Type: Application
    Filed: April 15, 2008
    Publication date: July 29, 2010
    Applicant: Momenta Pharmaceuticals,Inc.
    Inventors: Ian Christopher Parsons, Jonathan Lansing, Carlos J. Bosques, Daniela Beccati
  • Publication number: 20100151584
    Abstract: A multi-dimensional chromatographic method for the separation of N-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged N-glycan. The glycan preparation is then separated by anion-exchange chromatography and at least one secondary chromatographic technique.
    Type: Application
    Filed: April 15, 2008
    Publication date: June 17, 2010
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Ian Christopher Parsons, Ting Zheng, Nur Sibel Gunay, Carlos J. Bosques
  • Publication number: 20100151499
    Abstract: The present disclosure provides strategies for analyzing protein-linked glycans, and particularly for analyzing glycans on cell surface glycoproteins.
    Type: Application
    Filed: April 15, 2008
    Publication date: June 17, 2010
    Applicant: Momenta Pharmaceuticals, Inc.
    Inventors: Brian Edward Collins, Dorota A. Bulik, Carlos J. Bosques, Ian Christopher Parsons
  • Publication number: 20100144553
    Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
    Type: Application
    Filed: November 20, 2009
    Publication date: June 10, 2010
    Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, MOMENTA PHARMACEUTICALS, INC.
    Inventors: Carlos Bosques, Nishla Keiser, Aravind Srinivasan, Rahul Raman, Karthik Viswanathan, Ram Sasisekharan, Pankaj Gandhe, Sasi Raguram
  • Publication number: 20100136599
    Abstract: The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information regarding the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation on protein function. Such methods are also provided. Methods are also provided to assess protein production processes, to assess the purity of proteins produced, and to select proteins with the desired glycosylation.
    Type: Application
    Filed: October 6, 2009
    Publication date: June 3, 2010
    Applicants: Massachusetts Institute of Technology, Momenta Pharmaceuticals, Inc.
    Inventors: Pankaj Gandhe, Sasi Raguram, Carlos Bosques, Nishla Keiser, Aravind Srinivasan, Ram Sasisekharan
  • Publication number: 20100133430
    Abstract: The present disclosure provides, among other things, methods for the identification of sulfated glycans in a mixture of glycans.
    Type: Application
    Filed: April 15, 2008
    Publication date: June 3, 2010
    Applicant: MOMENTA PHARMACEUTICALS, INC.
    Inventors: Carlos J. Bosques, Nathaniel J. Washburn, Xiangping Zhu, Ian Christopher Parsons