Patents Assigned to Monsanto Company
  • Alginate and gellan gum as tablet coating
    Patent number: 6326028
    Abstract: This invention relates to coatings employed to coat medicinal tablets. Such tablets include but are not limited to small pellet(s) of medication to be taken orally. In particular this invention relates to the use of alginates and/or gellan gum, mixtures thereof and the like as tablet coatings. More in particular, this invention relates to the use of alginate and gellan gum as tablet coatings for tablets which are useful for humans including coating(s) on medicinal tablets and to a process for making such coatings.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: December 4, 2001
    Assignee: Monsanto Company
    Inventors: Thierry Nivaggioli, George Colegrove, John Flanagan
  • Polynucleotide compositions encoding Cry1Ac/Cry1F chimeric O-endotoxins
    Patent number: 6326169
    Abstract: Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and transgenic plants expressing the modified endotoxin are also aspects of the invention.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: December 4, 2001
    Assignee: Monsanto Company
    Inventors: Thomas Malvar, Amy Jelen Gilmer
  • Fungicides for the control of take-all disease of plants
    Publication number: 20010046975
    Abstract: A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula 1
    Type: Application
    Filed: May 9, 2001
    Publication date: November 29, 2001
    Applicant: Monsanto Company
    Inventors: Dennis Paul Phillion, Diane Susan Braccolino, Matthew James Graneto, Wendell Gary Phillips, Karey Alan Van Sant, Daniel Mark Walker, Sai Chi Wong
  • Antifungal polypeptide from alfalfa and methods for controlling plant pathogenic fungi
    Patent number: 6316407
    Abstract: Antifungal polypeptides, isolated from Medicago plants, are shown to control fungal damage to plants. The polypeptides can be formulated into compositions useful in controlling undesired fungi.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: November 13, 2001
    Assignee: Monsanto Company
    Inventors: Jihong Liang, Dilip Maganlal Shah, Yonnie S. Wu, Cindy A. Rosenberger, Salim Hakimi
  • Process for making optically active alpha-amino ketones and selected novel optically active alpha-amino ketones
    Patent number: 6316656
    Abstract: The invention includes selected novel optically active &agr;-ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the present invention provides a method for dehydrogenation/asymmetrical hydrogenation to obtain essentially pure antipodes of ketomethylene pseudopeptides having two chiral centers.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: November 13, 2001
    Assignee: Monsanto Company
    Inventor: John J. Talley
  • Plant fatty acid hydroxylases
    Patent number: 6310194
    Abstract: This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants. In addition, the use of genes encoding fatty acid hydroxylases or desaturases to alter the level of lipid fatty acid unsaturation in transgenic plants is described.
    Type: Grant
    Filed: February 6, 1996
    Date of Patent: October 30, 2001
    Assignees: Carnegie Institution of Washington, Monsanto Company, Ltd.
    Inventors: Chris Somerville, Pierre Broun, Frank van de Loo
  • Methods for producing poly (hydroxy) fatty acids in bacteria
    Publication number: 20010031489
    Abstract: The present invention relates to a process for the production of poly (hydroxy fatty acids) as well as recombinant bacterial strains for carrying out the process. In addition, new poly(hydroxy fatty acids) and new substrates for the production of conventional and new poly(hydroxy fatty acids) are described. Moreover, the invention also relates to a DNA fragment, which codes for a PhaE and a PhaC component of the poly(hydroxy fatty acid) synthase from Thiocapsa pfennigii, as well as the corresponding poly (hydroxy fatty acid) synthase protein.
    Type: Application
    Filed: February 8, 2001
    Publication date: October 18, 2001
    Applicant: Monsanto Company
    Inventors: Alexander Steinbuchel, Mathias Liebergesell, Henry Valentin, Andreas Pries
  • Production of hydroxylated fatty acids in genetically modified plants
    Patent number: 6291742
    Abstract: This invention relates to plant fatty acyl hydroxylases. Methods to use conserved amino acid or nucleotide sequences to obtain plant fatty acyl hydroxylases are described. Also described is the use of cDNA clones encoding a plant hydroxylase to produce a family of hydroxylated fatty acids in transgenic plants.
    Type: Grant
    Filed: September 20, 1995
    Date of Patent: September 18, 2001
    Assignees: Carnegie Institution of Washington, Monsanto Company Inc.
    Inventors: Chris Somerville, Pierre Broun, Frank van de Loo
  • Fungicidal compositions and methods of making thereof
    Patent number: 6291513
    Abstract: The fungicidal compound 4,5-dimethyl-N-2-propenyl-2-(trimethylsilyl)-3-thiophenecarboxamide (Formula (I)) has shown superior and unexpected control of the growth of the soil-borne fungus Gaeumannomyces graminis (Gg). The present invention provides a novel compound for synthesizing the compound of Formula (I) which uses the compound 4-hydroxy-4,5-dimethyl-2-trimethylsilanyl-dihydrothiophene-3-carboxylic acid allylamide (Formula (II)) as well as novel compounds of synthesizing the allylamide. In addition, Formula (II) itself has unexpectedly been found to provide control of Gg.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: September 18, 2001
    Assignee: Monsanto company
    Inventors: Wendell G. Phillips, Michael K. Mao, Chun Ma, Thomas L. Fevig
  • Deoxygalactonojirimycin derivatives
    Patent number: 6291657
    Abstract: Novel N-alkyl derivatives of deoxygalactonojirimycin are provided in which said alkyl contains from 3-6 carbon atoms. These novel compounds are useful for selectively inhibiting glycolipid synthesis.
    Type: Grant
    Filed: August 5, 1993
    Date of Patent: September 18, 2001
    Assignee: Monsanto Company
    Inventors: Frances M. Platt, Gabrielle R. Neises, Raymond A. Dwek, Terry D. Butters
  • Method of creating transformed rice plant
    Patent number: 6288312
    Abstract: A method of transforming rice is disclosed. The method begins with the preparation of copies of a nucleic acid construct that are coated onto biologically inert carrier particles. In one embodiment, the nucleic acid-coated carrier particles are physically accelerated toward immature rice embryos. In another embodiment, the nucleic acid-coated carrier particles are accelerated toward discs excised from the meristem region of a rice seedling. Both the bombarded embryos and discs are cultivated to produce shoots. These shoots are cultivated into whole sexually mature plants, some of which are transformed. The presence of the nucleic acid construct is verified in either the shoots or the sexually mature plants. A particularly advantageous embodiment of the invention is a transformed Indica rice plant.
    Type: Grant
    Filed: October 26, 1993
    Date of Patent: September 11, 2001
    Assignee: Monsanto Company
    Inventors: Paul Christou, Tameria L. Ford, Matt Kofron
  • Insect-resistant plants comprising a Bacillus thuringiensis gene
    Patent number: 6284949
    Abstract: A method for producing genetically transformed plants exhibiting toxicity to Coleopteran insects is disclosed. In another aspect, the present invention embraces chimeric plant genes, genetically transformed cells and differentiated plants which exhibit toxicity to Coleopteran insects. In yet another aspect, the present invention embraces bacterial cells and plant transformation vectors comprising a chimeric plant gene encoding a Coleopteran toxin protein of Bacillus thuringiensis.
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: September 4, 2001
    Assignee: Monsanto Company
    Inventors: David A. Fischhoff, Roy L. Fuchs, Paul B. Lavrik, Sylvia A. McPherson, Frederick J. Perlak
  • Broad-spectrum insect resistant transgenic plants
    Patent number: 6281016
    Abstract: Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and transformation of suitable host cells. Transformed host cells and tansgenic plants expressing the modified endotoxin are also aspects of the invention.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: August 28, 2001
    Assignee: Monsanto Company
    Inventors: Thomas Malvar, Amy Jelen Gilmer
  • Expression of sucrose phosphorylase on plants
    Publication number: 20010016953
    Abstract: Introducing sucrose phosphorylase activity into plants by transformation with a gene for the enzyme increases the rate of sucrose hydrolysis, leading to increased starch, oil, and protein levels. The preferred gene is from Streptococcus mutans. Surprisingly, in potatoes transformed to express this gene in tubers, reduced bruise discoloration susceptibility and increased uniformity of starch deposition throughout the tuber are achieved.
    Type: Application
    Filed: March 1, 2001
    Publication date: August 23, 2001
    Applicant: Monsanto Company.
    Inventors: Gerard Francis Barry, Jan Willem de Weerd, Ganesh Murthy Kishore, Marcia Lee Weldon
  • Highly concentrated aqueous glyphosate compositions
    Patent number: 6277788
    Abstract: A herbicidal composition is provided comprising an aqueous solution of N-phosphonomethylglycine, predominantly in the form of the monoethanolammonium salt thereof, at a concentration of about 30% to about 48% N-phosphonomethylglycine acid equivalent by weight. In a particular embodiment, a herbicidal composition comprises water; N-phosphonomethylglycine predominantly in the form of the monoethanolammonium salt thereof in solution in the water in an amount of about 360 to about 570 g a.e./l of the composition; and a surfactant component in solution or stable dispersion in the water, comprising one or more surfactants in a total amount of about 20 to about 200 g/l of the composition, this surfactant component being selected such that the composition has a cloud point not lower than about 50° C.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: August 21, 2001
    Assignee: Monsanto Company
    Inventor: Daniel R. Wright
  • Continuous process for the preparation of N-(phosphonomethyl)iminodiacetic acid
    Patent number: 6278017
    Abstract: A process for the continuous production of N-(phosphonomethyl)glycine is provided. In the process, N-(acetyl)iminodiacetic acid is formed in an amidocarboxymethylation reactor system. The N-(acetyl)iminodiacetic acid product stream is either: (1) reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid; or (2) deacylated and cyclized to form a 2,5-diketopiperazine, and then reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid. In either case, the N-(phosphonomethyl)iminodiacetic acid product is recovered and converted to N-(phosphonomethyl)glycine.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: August 21, 2001
    Assignee: Monsanto Company
    Inventors: Michael K. Stern, Todd J. Johnson, Amy L. Jorgenson, Michael D. Rogers, Thaddeus S. Franczyk, II
  • Method of preparing amino carboxylic acids
    Patent number: 6265605
    Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: July 24, 2001
    Assignee: Monsanto Company
    Inventors: Todd J. Johnson, Michael K. Stern, David A. Morgenstern, Michael D. Rogers, Yvette M. Fobian, Jeffrey A. Levine
  • Cyclic sulfone containing retroviral protease inhibitors
    Patent number: 6265583
    Abstract: The present invention relates to cyclic sulfone moiety-containing hydroxyethylamine protease inhibitor compounds and pharmaceutical or method of use therefor, particularly as an inhibitor of HIV protease.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: July 24, 2001
    Assignees: G. D. Searle & Co., Monsanto Company
    Inventors: Deborah E. Bertenshaw, Daniel Getman, Robert M. Heintz, John J. Talley, Kathryn L. Reed, Robert Alan Chrusciel, Michael Clare
  • Heat regenerative oxidizer and method of operation
    Patent number: 6261093
    Abstract: The present invention relates to regenerative thermal or catalytic oxidizers and methods of operation thereof for oxidizing combustible components of feed gas mixtures. In accordance with the disclosed invention, operation of the heater used to supply supplemental heat to regenerative heat transfer oxidizers is controlled such that the input load to the heater is varied between a maximum input load and a nominal input load in response to a measured control temperature. The present invention provides improved temperature uniformity across the system for more efficient operation.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: July 17, 2001
    Assignee: Monsanto Company
    Inventors: Yurii S. Matros, Grigori A. Bunimovich, Christopher A. Roach
  • Chimeric genes for transforming plant cells using viral promoters
    Patent number: 6255560
    Abstract: In one aspect the present invention relates to the use of viral promoters in the expression of chimeric genes in plant cells. In another aspect this invention relates to chimeric genes which are capable of being expressed in plant cells, which utilize promoter regions derived from viruses which are capable of infecting plant cells. One such virus comprises the cauliflower mosaic virux (CaMV). Two different promoter regions have been derived from the CaMV genome and ligated to heterologous coding sequences to form chimeric genes. These chimeric genes have been shown to be expressed in plant cells. This invention also relates to plant cells, plant tissue, and differentiated plants which contain and express the chimeric genes of this invention.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: July 3, 2001
    Assignee: Monsanto Company
    Inventors: Robert T. Fraley, Robert Bruce Horsch, Stephen Gary Rogers