Patents Assigned to NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
  • Patent number: 8796219
    Abstract: The present invention relates to a target-activated cell/tissue-penetrating peptide for delivery of impermeable compounds (Target Activated Cell/tissue Translocation peptide for Impermeable Compound Strategy (TACTICS)), and the use thereof, and more particularly to a target-activated cell/tissue-penetrating peptide, which comprises (a) a protein transduction domain (PTD), (b) a masking domain and (c) a spacer having a cleavage site specific for a target cell/tissue enzyme and is provided with target selectivity so as to penetrate specifically into a target tissue, and to a conjugate of the peptide with a drug or drug-containing particles for imaging or therapeutic applications.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: August 5, 2014
    Assignee: Nano Intelligent Biomedical Engineering Corporation Co. Ltd
    Inventors: Yoon-Jeong Park, Chong-Pyoung Chung, Victor C. Yang
  • Publication number: 20140187743
    Abstract: The present invention relates to a membrane having bound thereto an antibacterial peptide that binds to collagen, and more particularly to a collagen membrane comprising a fusion peptide of a collagen-binding peptide and an antibacterial peptide, fixed to the collagen surface. The present invention provides a collagen membrane having surface activity by a fusion peptide bound to the surface thereof. When the collagen membrane is transplanted in vivo, the retention time of the fusion peptide in a local region can increase, and the fusion peptide can promote the cell migration, proliferation and differentiation associated with bone tissue regeneration, thereby maximizing the ability to regenerate bone tissue. Thus, the collagen membrane contributes to the development of therapeutic technology for bone induction and regeneration. Also, the fusion peptide may be applied to other types of graft materials made of collagen.
    Type: Application
    Filed: December 16, 2011
    Publication date: July 3, 2014
    Applicant: Nano Intelligent Biomedical Engineering Corporation Co., Ltd.
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee, In Kyong Shim, Hyun Jung Park
  • Patent number: 8546529
    Abstract: The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: October 1, 2013
    Assignees: Nano Intelligent Biomedical Engineering Corporation Co., Ltd., Seoul National University Industry Foundation
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee
  • Publication number: 20130210736
    Abstract: The present invention relates to a peptide having bone tissue regeneration capacity and binding to surface of apatite, and more particularly, to a peptide having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral, and a composition for bone tissue regeneration, containing the peptide.
    Type: Application
    Filed: March 9, 2011
    Publication date: August 15, 2013
    Applicant: NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Sang Hoon Rhee, Jue- Yeon Lee
  • Publication number: 20130210707
    Abstract: The present invention relates to a peptide having antibacterial or anti-inflammatory activity and a pharmaceutical composition containing the same as an active ingredient, and more particularly to a peptide having antibacterial or anti-inflammatory activity against dental bacteria, including periodontal pathogens, and bacteria causing atopic dermatitis, and to a pharmaceutical composition containing the peptide as an active ingredient. The inventive peptide having antibacterial or anti-inflammatory activity can be used for the treatment of both dental infectious diseases, including periodontitis or peri-implantitis, and inflammations, including atopy, psoriasis or arthritis.
    Type: Application
    Filed: June 13, 2011
    Publication date: August 15, 2013
    Applicant: Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee
  • Publication number: 20110213036
    Abstract: The present invention relates to a composition for prevention of tooth hypersensitivity, and more particularly to a composition for prevention of tooth hypersensitivity, which comprises an adhesive polymer for coating teeth, an active ingredient for prevention of hypersensitivity, a substance for promoting the penetration of the active ingredient for prevention of hypersensitivity, a desensitizing active ingredient, and a pH-adjusting agent. The composition for prevention of tooth hypersensitivity according to the invention can rapidly show the effect of preventing tooth hypersensitivity while maintaining the sensory feel of conventional tooth desensitizers, and it can maintain the tooth hypersensitivity-preventing effect for a long time.
    Type: Application
    Filed: October 8, 2009
    Publication date: September 1, 2011
    Applicants: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
    Inventors: Yoon-Jeong Park, Chong-Pyoung Chung, Jue-Yeon Lee, Hyun Jung Park
  • Publication number: 20100317587
    Abstract: The present invention relates to an injectable bone regeneration material containing a bone formation enhancing peptide, and more particularly, to an injectable bone regeneration material, in which a bone formation enhancing peptide essentially containing one and more amino acid sequences among SEQ ID NO: 1 to SEQ ID NO: 28 is bonded or mixed to a gel-forming base material selected from the group consisting of chitosan, alginic acid, silk fibroin, propylene glycol, propylene glycol alginic acid, poloxamer, chondroitin sulphate, and the combination thereof. The injectable bone regeneration material according to the present invention can increase differentiation of bone marrow stromal cells and osteoblasts into bone tissue, thus maximizing tissue regeneration by a peptide capable of promoting differentiation of bone tissue and periodontal tissue regeneration. The injectable bone regeneration material is in the form of a gel, and thus can be applied to a surface of various medical devices such as implant etc.
    Type: Application
    Filed: June 5, 2008
    Publication date: December 16, 2010
    Applicants: SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION, NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
    Inventors: Chong-Pyoung Chung, Yoon-Jeong Park, Jue-Yeon Lee