Patents Assigned to National Centre for Cell Science
  • Publication number: 20210338611
    Abstract: The present invention pertains to a synergistic combination comprising histone deacetylase inhibitors (HDACi) in combination with estrogen receptor (ER) antagonist for treating gliomas. The present invention also discloses composition containing the combination, and a method of use of the combination and the composition of the present invention and method of treatment using the combination.
    Type: Application
    Filed: September 5, 2019
    Publication date: November 4, 2021
    Applicant: NATIONAL CENTRE FOR CELL SCIENCE
    Inventor: Padma SHASTRY
  • Publication number: 20210196718
    Abstract: The present invention relates to compounds and pharmaceutical composition having antiviral effects. Over 1200 molecules were screened and 55 molecules having statistically significant anti-HIV activity were identified and selected. The compound Methotrexate (MTX-HYD) and its analogues, the combinations thereof and their combination with other anti-retrovirals were selected for repurposing the compounds as anti-HIV drugs. The present invention may further relate to pharmaceutical composition comprising compounds in combination with active drugs having anti-HIV activity.
    Type: Application
    Filed: May 10, 2019
    Publication date: July 1, 2021
    Applicant: NATIONAL CENTRE FOR CELL SCIENCE
    Inventors: Debashis MITRA, Jay TRIVEDI
  • Patent number: 10429393
    Abstract: The present invention provides a method for concurrent resolution of the cancer stem cell (CSC) derived hierarchy, genetic instability, differentially cycling cells and host cells recruited for performing tumor growth supporting functions; and (ii) quantification, monitoring and analysis of these populations. The first level of analysis can be carried out using either CSC- and progenitor-specific markers or a marker-free approach based on label-chase to resolve the tumor regenerative hierarchy. The next level involves combinatorial quantification of differential DNA-RNA contents to identify recruited host and tumor cell variants resulted from genetic instability and differential cycling within the tumor.
    Type: Grant
    Filed: January 17, 2015
    Date of Patent: October 1, 2019
    Assignee: NATIONAL CENTRE FOR CELL SCIENCE
    Inventors: Sharmila A. Bapat, Rutika R. Naik
  • Publication number: 20190175700
    Abstract: The present invention discloses a novel therapeutic intervention for osteoporosis. The present invention discloses that Interleukin-3 (IL-3) can be utilized as a therapeutic intervention against osteoporosis and for regulating bone homeostasis. The present invention also provides a method for determining the pre-disposition of a subject for osteoporosis by measuring the RANKL/OPG level.
    Type: Application
    Filed: December 3, 2018
    Publication date: June 13, 2019
    Applicant: NATIONAL CENTRE FOR CELL SCIENCE
    Inventors: Kanupriya Singh, Mohan Ramchandra Wani
  • Publication number: 20170067901
    Abstract: The present invention provides a method for concurrent resolution of the cancer stem cell (CSC) derived hierarchy, genetic instability, differentially cycling cells and host cells recruited for performing tumor growth supporting functions; and (ii) quantification, monitoring and analysis of these populations. The first level of analysis can be carried out using either CSC- and progenitor-specific markers or a marker-free approach based on label-chase to resolve the tumor regenerative hierarchy. The next level involves combinatorial quantification of differential DNA-RNA contents to identify recruited host and tumor cell variants resulted from genetic instability and differential cycling within the tumor.
    Type: Application
    Filed: January 17, 2015
    Publication date: March 9, 2017
    Applicant: National Centre for Cell Science
    Inventors: Sharmila A. BAPAT, Rutika R. NAIK
  • Patent number: 8865237
    Abstract: A method of preparing dialysed aqueous extract of fenugreek seeds comprising washing the fenugreek seeds is distilled water, sterilizing the said seeds, subjecting the sterilized seeds to the step of grinding to form powder, suspending the said powder in phosphate buffered saline (PBS), subjecting the said suspension to the step of filtration to obtain the filtrate, treating the filtrate with activated charcoal to obtain clear supernatant, subjecting the supernatant to the step of lyophilization and the powder thus obtained was dissolved in phosphate buffered saline (PBS), dialyzing the aqueous extract of fenugreek seeds to obtain dialysed fenugreek seed extract (FSE) which was aliquoted and stored.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: October 21, 2014
    Assignees: Department of Biotechnology, National Centre For Cell Science
    Inventors: Manoj Kumar Bhat, Maleppillil Vavachen Vijayakumar
  • Patent number: 8519163
    Abstract: A novel chemical moiety triterpenoid AECHL-1 isolated from root bark of Ailanthus excelsa having the structure:
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: August 27, 2013
    Assignees: National Centre for Cell Science, Department of Biotechnology
    Inventors: Sandhya Sitasawad, Manish Lavhale, Santosh Kumar, Shrihari Mishra
  • Patent number: 8420100
    Abstract: Chimeric tumor suppressor activating peptides derived from matrix attachment region binding protein (MARBP) SMARI unique in their sequence comprising a arginine rich motif flanked by serine residues wherein from the stretch of four consecutive serine residues the first serine residue gets phosphorylated by the protein kinase C family of serine threonine kinases being indispensable for its functionality, the phosphorylation being directly correlated to the phosphorylation of p53 at serine 15 residue thereby stabilizing it, wherein the peptide activates p53 by modifying it post translationally which allow phosphorylation and translocation of p53 to the nucleus.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: April 16, 2013
    Assignees: Department of Biotechnology, National Centre for Cell Science
    Inventors: Samit Chattopadhyay, Archana Jalota-Badhwar
  • Publication number: 20110046342
    Abstract: Chimeric tumor suppressor activating peptides derived from matrix attachment region binding protein (MARBP) SMARI unique in their sequence comprising a arginine rich motif flanked by serine residues wherein from the stretch of four consecutive serine residues the first serine residue gets phosphorylated by the protein kinase C family of serine threonine kinases being indispensable for its functionality, the phosphorylation being directly correlated to the phosphorylation of p53 at serine 15 residue thereby stabilizing it, wherein the peptide activates p53 by modifying it post translationally which allow phosphorylation and translocation of p53 to the nucleus.
    Type: Application
    Filed: September 10, 2007
    Publication date: February 24, 2011
    Applicants: Department of Biotechnology, National Centre for Cell Science
    Inventors: Samit Chattopadhyay, Archana Jalota-Badhwar
  • Publication number: 20100311987
    Abstract: A novel chemical moiety triterpenoid AECHL-1 isolated from root bark of Ailanthus excelsa having anti-cancer properties exhibiting remarkable activity in treatment of various forms of tumors with specificity wherein it blocks the growth of four tumor cell lines with distinct origins and of different p53 status (B16F10 mouse melanoma, PC3 human prostate cancer, MCF-7 and MDA-MB-231 human breast cancer), having following characteristic IR, NMR and mass spectra IR (KBr): 3425, 3419 (hydroxyl group), 2972, 2966, 2923, 2873 (alkyl C—H stretch), 1733 (? lactone), 1718 (Bi acetyl), 1680 (C?O conjugation with alkene), 1652 (—C?C stretching), 1600 (aromatic), 1492, 1454, 1394 (methyl stretching), 1222 (? lactone), 1184, 1110, 1051, 1031 (acetals), 1018 nm (alkanes). 1H-NMR (DMSO, 400 Hz) ?: 0.95 (3H, t, 4?-CH3), ?:1.15 (3H, d, H-24), ?:1.235 (3H, d, 5?-CH3), ?: 1.5 (2H, ddd, 5?-CH2), ?: 1.73 (3H, ddd, H-21), ?: 1.83 (1H, s, H-9), ?: 1.87 (1H, s, H-14), ?: 1.9 (2H, s, H-18), ?: 2.16 (3H, s, H-18), ?: 2.
    Type: Application
    Filed: December 2, 2008
    Publication date: December 9, 2010
    Applicants: National Centre For Cell Science, Department of Biotechnology
    Inventors: Sandhya Sitasawad, Manish Lavhale, Santosh Kumar, Shrihari Mishra
  • Publication number: 20090305325
    Abstract: Maintenance of quiescent hematopoietic stem and progenitor cells (HSPC) in culture without the addition of exogenous growth factors is an important aspect in clinical hematology. A recent report described the ability of Flt3 receptor-interacting lectin (FRIL) in the maintenance of cord blood (CB) derived progenitors in vitro. Since FRIL is a mannose binding lectin, the effectiveness of four such lectins of well-characterized specificities on the preservation of HSPC of CB origin have been examined. The HSPC preservation activity of lectins was assessed by in vitro colony forming unit (CFU) and long-term culture initiating cell (LTC-IC) assays. It was found that all four lectins had a HSPC preservation activity at least up to 30 days in culture without addition of exogenous growth factors. The results indicate that use of such lectins may provide a cost effective method of HSPC maintenance for clinical use.
    Type: Application
    Filed: June 27, 2006
    Publication date: December 10, 2009
    Applicants: DEPARTMENT OF BIOTECHNOLOGY, NATIONAL CENTRE FOR CELL SCIENCE, INDIAN INSTITUTE OF SCIENCES
    Inventors: Vaijayanti P. Kale, Lalita S. Limaye, Ashwini Hinge, Avadhesha Surolia
  • Patent number: 7604980
    Abstract: The present invention relates to proteomics, especially downstream processing of proteins. The present invention also relates to novel expression cassettes having unique cleavage sites for efficient removal of purification tags. The invention further provides expression systems and a methods for purifying and isolating proteins.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: October 20, 2009
    Assignee: National Centre for Cell Science
    Inventors: Sanjeev Galande, Prabhat K. Purbey, Peter C. Jayakumar, Milind S. Patole
  • Publication number: 20090226554
    Abstract: A method of preparing dialysed aqueous extract of fenugreek seeds comprising washing the fenugreek seeds is distilled water, sterilizing the said seeds, subjecting the sterilized seeds to the step of grinding to form powder, suspending the said powder in phosphate buffered saline (PBS), subjecting the said suspension to the step of filtration to obtain the filtrate, treating the filtrate with activated charcoal to obtain clear supernatant, subjecting the supernatant to the step of lyophilization and the powder thus obtained was dissolved in phosphate buffered saline (PBS), dialyzing the aqueous extract of fenugreek seeds to obtain dialysed fenugreek seed extract (FSE) which was aliquoted and stored.
    Type: Application
    Filed: June 27, 2006
    Publication date: September 10, 2009
    Applicant: National Centre for Cell Sciences
    Inventors: Manoj Kumar Bhat, Maleppillil Vavachen Vijayakumar
  • Publication number: 20070037251
    Abstract: The present invention relates to proteomics, especially downstream processing of proteins. The present invention also relates to novel expression cassettes having unique cleavage sites for efficient removal of purification tags. The invention further provides expression systems and a methods for purifying and isolating proteins.
    Type: Application
    Filed: February 2, 2006
    Publication date: February 15, 2007
    Applicant: National Centre for Cell Sciences
    Inventors: Sanjeev Galande, Prabhat Purbey, Peter Jayakumar, Milind Patole
  • Publication number: 20050037434
    Abstract: The present invention relates to a monoclonal antibody directed against the 150 kDa protein M150 on activated macrophages.
    Type: Application
    Filed: August 13, 2004
    Publication date: February 17, 2005
    Applicant: National Centre for Cell Science
    Inventors: Durbaka Prasad, Pradeep Parab, Gyan Mishra