Patents Assigned to National Cerebral and Cardiovascular Center
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Patent number: 11149252Abstract: The present disclosure aims to provide a method of efficiently manufacturing a cell mass, a cell structure, or a three-dimensional tissue body using a culturing surface coated with a temperature-responsive polymer or a temperature-responsive polymer composition. The manufacturing method of a cell mass, a cell structure, or a three-dimensional tissue body of the present disclosure includes seeding and culturing cells on a culturing surface coated with a temperature-responsive polymer or a temperature-responsive polymer composition.Type: GrantFiled: January 27, 2017Date of Patent: October 19, 2021Assignee: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTERInventors: Yasuhide Nakayama, Ryosuke Iwai, Yasushi Nemoto
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Publication number: 20210100790Abstract: Provided is a drug superior for preventing and/or treating dementia. It contains a carbostyril derivative of the following formula (1) (wherein R is a cycloalkyl group, A is a lower alkyl group, and a single bond or a double bond is present between the 3-position and the 4-position of the carbostyril nucleus) and dihydroquercetin.Type: ApplicationFiled: December 18, 2020Publication date: April 8, 2021Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBEInventors: Tadamasa MATSUMOTO, Masafumi IHARA, Satoshi SAITO, Masanori FUKUSHIMA
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Patent number: 10898098Abstract: A myocardial excitation determining apparatus which can support the determination of excitation dynamics of the myocardium during atrial fibrillation is provided. A myocardial excitation determining apparatus has: an acquiring section 2 which acquires an intracardiac electrocardiogram of a subject; a processing section 3 which computes to produce visualized data indicating a state of excitation in the myocardium, based on the intracardiac electrocardiogram; and a determining section 4 which determines the type of excitation dynamics of the myocardium based on the visualized data.Type: GrantFiled: March 14, 2017Date of Patent: January 26, 2021Assignees: SHIGA UNIVERSITY OF MEDICAL SCIENCE, NIHON KOHDEN CORPORATION, Takeshi TSUCHIYA, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTERInventors: Takashi Ashihara, Koji Takizawa, Tatsuo Nishihara, Nobuhiro Suzuki, Yuuho Iwanaga, Akio Ota, Takeshi Tsuchiya, Kazuo Nakazawa, Shin Inada
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Publication number: 20200305731Abstract: Provided is a cerebral blood flow measurement method of quantitatively measuring cerebral blood flow, the measurement method including: a tracer introducing step of introducing a tracer into a blood vessel; a light applying step of applying measurement light including an absorption wavelength of the tracer to a head; a light detecting step of detecting the measurement light propagating in the head and generating a detection signal based on light intensity of the measurement light; and a calculation step of calculating cerebral blood flow on the basis of a relative change over time ?Q of a concentration of the tracer in a brain tissue which is acquired on the basis of the detection signal and a predetermined relationship between a change over time of a concentration Pa of the tracer in an artery of the head and cerebral blood flow.Type: ApplicationFiled: October 24, 2018Publication date: October 1, 2020Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, HAMAMATSU PHOTONICS K.K.Inventors: Kenji YOSHITANI, Shinya KATO, Mariko EZAKA, Takeo OZAKI
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Publication number: 20200197446Abstract: The purpose of the present invention is to provide a novel medical application of pluripotent stem cells (muse cells) in regeneration medicine. The present invention provides a cell preparation and a pharmaceutical composition which are for amelioration and treatment of brain disorders resulting from fetal growth retardation, such as abnormal motor quality or abnormal neurological development, and which contain SSEA-3 positive pluripotent stem cells isolated from a mesenchymal tissue from a live body or cultured mesenchymal cells. It is assumed that this cell preparation is based on a mechanism where muse cells that are administered to objects having the disorders are engrafted on an impaired brain tissue, thereby ameliorating or treating the disorders.Type: ApplicationFiled: June 20, 2018Publication date: June 25, 2020Applicants: National University Corporation Nagoya University, TOHOKU UNIVERSITY, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, Life Science Institute, Inc.Inventors: Yoshiaki SATO, Yuma KITASE, Shinobu SHIMIZU, Masaaki MIZUNO, Masahiro HAYAKAWA, Mari DEZAWA, Masahiro TSUJI
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Publication number: 20200190590Abstract: Provided is a method for predicting probability of ischemic stroke onset. A method for predicting a risk of ischemic stroke onset, the method comprising: a detection step of detecting presence or absence of a RNF213 p.R4810K gene variant in a sample derived from a test subject who does not develop ischemic stroke; and a determination step of determining whether a probability of ischemic stroke onset of the test subject is high or not, based on the presence or absence of the RNF213 p.R4810K gene variant in the detection step, and gender information of the test subject. A genetic marker for predicting a risk of ischemic stroke onset using gender information, comprising a RNF213 p.R4810K gene variant. A biomarker for predicting a risk of ischemic stroke onset using gender information, comprising a polypeptide encoded by a RNF213 p.R4810K gene variant.Type: ApplicationFiled: December 10, 2019Publication date: June 18, 2020Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, SHIMADZU CORPORATIONInventors: Masafumi IHARA, Shuhei OKAZAKI, Daisuke KAWAKAMI
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Patent number: 10624555Abstract: A myocardial excitation complementation/visualization apparatus includes an acquiring section that acquires intracardiac electrocardiograms of a subject, the intracardiac electrocardiograms being recorded by a recording unit having a plurality of electrodes, a processing section that performs a computation for completing and visualizing a state of excitation in a myocardium of the subject based on the intracardiac electrocardiograms, and a displaying section that displays the state of excitation in the myocardium of the subject based on an output of the processing section. The processing section includes a first generating section, a correcting section, a second generating section, and a third generating section. The displaying section displays a change of the state of excitation in the myocardium of the subject based on the visualized data.Type: GrantFiled: March 15, 2016Date of Patent: April 21, 2020Assignees: SHIGA UNIVERSITY OF MEDICAL SCIENCE, NIHON KOHDEN CORPORATION, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTERInventors: Takashi Ashihara, Koji Takizawa, Tatsuo Nishihara, Nobuhiro Suzuki, Yuuho Iwanaga, Akio Ota, Takeshi Tsuchiya, Kazuo Nakazawa, Shin Inada
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Patent number: 10550153Abstract: To provide a peptide that selectively activates type 2 neuromedin U receptor and is chemically stable under physiological conditions. A peptide represented by Formula (1) described in the specification.Type: GrantFiled: January 19, 2018Date of Patent: February 4, 2020Assignees: TOKYO UNIVERSITY OF PHARMACY & LIFE SCIENCES, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, KYOTO PHARMACEUTICAL UNIVERSITYInventors: Yoshio Hayashi, Kentaro Takayama, Mikiya Miyazato, Kenji Kangawa, Kenji Mori, Akira Yamamoto, Toshiyasu Sakane
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Publication number: 20190365944Abstract: Provided is a use for a peptide in surface-treating a medical device or medical material to be used in contact with blood, with which it is possible to obtain a medical device or medical material that can achieve highly efficient vascular endothelialization through the use of a peptide uniquely binding to vascular endothelial cells. Also provided are: a peptide suitable for use in said surface treatment; a method for producing a medical device or medical material surfaced-treated with said peptide and to be used in contact with blood; and a surface treatment agent including said peptide, said agent to be used in surface-treating a medical device or medical material to be used in contact with blood. In the present invention, a medical device or medical material is surface-treated using a peptide that includes any one of ten specific amino acid sequences and uniquely binds to the surface of endothelial progenitor cells.Type: ApplicationFiled: January 30, 2018Publication date: December 5, 2019Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, JMS CO., LTD.Inventors: Tetsuji YAMAOKA, Maria MUNISSO, Atsushi MAHARA, Takashi YAMAMOTO
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Publication number: 20190343892Abstract: An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysin and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.Type: ApplicationFiled: July 11, 2019Publication date: November 14, 2019Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE, HYOGO COLLEGE OF MEDICINE, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, KANEKA CORPORATIONInventors: Kenichi YAMAHARA, Akihiko TAGUCHI, Toshihiro SOMA, Shunsuke OHNISHI, Akira KOBAYASHI
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Method of producing a film connective tissue body using a connective tissue body formation substrate
Patent number: 10471179Abstract: The present invention provides a connective tissue body formation substrate which can form a film connective tissue having a desired thickness and both surfaces in a desired surface condition without prolonging the time required for formation of the connective tissue. Specifically, two tissue formation surfaces 2a and 2b are faced with each other with a tissue formation space 3 being interposed therebetween. A slit 9 is formed in the tissue formation surface 2b so that the tissue formation space 3 communicates with an outside of the substrate. A connective tissue body formation substrate 1 is installed in an environment where a biological tissue material is present. A connective tissue intrudes into the tissue formation space 3 from the slit 9. Both surfaces of the film connective tissue are formed so as to match the substrate surface.Type: GrantFiled: November 13, 2015Date of Patent: November 12, 2019Assignee: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTERInventors: Yasuhide Nakayama, Tomonori Oie, Takeshi Moriwaki -
Patent number: 10441611Abstract: An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysin and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.Type: GrantFiled: August 18, 2014Date of Patent: October 15, 2019Assignees: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE, HYOGO COLLEGE OF MEDICINE, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, KANEKA CORPORATIONInventors: Kenichi Yamahara, Akihiko Taguchi, Toshihiro Soma, Shunsuke Ohnishi, Akira Kobayashi
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Patent number: 10398738Abstract: An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysin and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.Type: GrantFiled: August 18, 2014Date of Patent: September 3, 2019Assignees: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE, HYOGO COLLEGE OF MEDICINE, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, KANEKA CORPORATIONInventors: Kenichi Yamahara, Akihiko Taguchi, Toshihiro Soma, Shunsuke Ohnishi, Akira Kobayashi
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Patent number: 10351600Abstract: A peptide that enables surface treatment of a scaffold for tissue repair that makes it possible to accelerate the repair of living tissue without using a material that negatively affects the repair of living tissue, a complex containing this peptide, a scaffold for tissue repair surface treated using this peptide or this complex, a surface treatment method for a scaffold for tissue repair using this peptide or this complex, and a treatment solution or set of treatment solutions to be used in this surface treatment method. Surface treatment of a scaffold for tissue repair is conducted by combining glycosaminoglycan and a peptide containing adhesive sites and basic sites each comprising predetermined amino acid residues.Type: GrantFiled: July 28, 2017Date of Patent: July 16, 2019Assignees: National Cerebral and Cardiovascular Center, JMS Co., Ltd.Inventors: Tetsuji Yamaoka, Sachiro Kakinoki, Shunsuke Baba, Yoshiya Hashimoto
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Publication number: 20190201583Abstract: The present invention provides a method for forming a connective tissue body, which enables extending the ranges of design values in terms of shape, dimension, etc., of the connective tissue body. This method comprises: a fat treatment step for removing fat contained in a connective tissue body, which is formed in an environment where a biological tissue material is present, from the interior of the connective tissue body while the connective tissue body is being set in a molding tool, and for causing the shape of the connective tissue body to follow the shape of the molding tool; and a bioinert solution treatment step for immersing the connective tissue body, together with the molding tool, in a bioinert solution while the connective tissue body is being shaped so as to follow the shape of the molding tool after the fat treatment step.Type: ApplicationFiled: August 30, 2017Publication date: July 4, 2019Applicants: BIOTUBE CO., LTD., NATIONAL CEREBRAL AND CARDIOVASCULAR CENTERInventors: Yasuhide NAKAYAMA, Takeshi MORIWAKI, Tomonori OIE
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Publication number: 20190142820Abstract: Provided is a drug superior for preventing and/or treating dementia. It contains a carbostyril derivative of the following formula (1) (wherein R is a cycloalkyl group, A is a lower alkyl group, and a single bond or a double bond is present between the 3-position and the 4-position of the carbostyril nucleus) and dihydroquercetin.Type: ApplicationFiled: May 1, 2017Publication date: May 16, 2019Applicants: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBEInventors: Tadamasa MATSUMOTO, Masafumi IHARA, Satoshi SAITO, Masanori FUKUSHIMA
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Publication number: 20190083225Abstract: A tissue body formation device for forming a connective tissue body in an environment where a living tissue material is present is provided with: an inner member having a tissue body formation surface that serves as a surface for forming a connective tissue body; and a covering member which is provided with a covering surface that constitutes an external surface of the tissue body formation device, and that covers a part of the tissue body formation surface. The covering member further has a plurality of connection parts that connect the outer side of the tissue body formation device to the tissue body formation surface. Each of the connection parts has an opening in the covering surface. Each of the openings has a minimum dimension of at least 0.5 mm in a direction along the covering surface. The openings account for 20-40% per unit area of the covering surface.Type: ApplicationFiled: May 11, 2017Publication date: March 21, 2019Applicants: SHINKAN KOGYO K.K., NATIONAL CEREBRAL AND CARDIOVASCULAR CENTERInventors: Yasuhide NAKAYAMA, Takeshi MORIWAKI, Tomonori OIE
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Publication number: 20190076041Abstract: A myocardial excitation determining apparatus which can support the determination of excitation dynamics of the myocardium during atrial fibrillation is provided. A myocardial excitation determining apparatus has: an acquiring section 2 which acquires an intracardiac electrocardiogram of a subject; a processing section 3 which computes to produce visualized data indicating a state of excitation in the myocardium, based on the intracardiac electrocardiogram; and a determining section 4 which determines the type of excitation dynamics of the myocardium based on the visualized data.Type: ApplicationFiled: March 14, 2017Publication date: March 14, 2019Applicants: SHIGA UNIVERSITY OF MEDICAL SCIENCE, NIHON KOHDEN CORPORATION, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTERInventors: Takashi ASHIHARA, Koji TAKIZAWA, Tatsuo NISHIHARA, Nobuhiro SUZUKI, Yuuho IWANAGA, Akio OTA, Takeshi TSUCHIYA, Kazuo NAKAZAWA, Shin INADA
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Publication number: 20190040359Abstract: The present disclosure aims to provide a method of efficiently manufacturing a cell mass, a cell structure, or a three-dimensional tissue body using a culturing surface coated with a temperature-responsive polymer or a temperature-responsive polymer composition. The manufacturing method of a cell mass, a cell structure, or a three-dimensional tissue body of the present disclosure includes seeding and culturing cells on a culturing surface coated with a temperature-responsive polymer or a temperature-responsive polymer composition.Type: ApplicationFiled: January 27, 2017Publication date: February 7, 2019Applicant: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTERInventors: Yasuhide NAKAYAMA, Ryosuke IWAI, Yasushi NEMOTO
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Publication number: 20180362922Abstract: The object of the present invention is to provide a method for producing a cell population comprising mesenchymal stem cells having a high specific growth rate which are useful for promptly producing large amounts of cell formulations. The present invention provides a method for producing a cell population comprising mesenchymal stem cells, comprising: a step of treating a cell population comprising mesenchymal stem cells having different proliferative ability by physical stimulation or chemical stimulation, so as to select mesenchymal stem cells having relatively high proliferative ability, wherein the selected mesenchymal stem cells having relatively high proliferative ability are negative for CD106, and the expression level of a metallothionein family gene is increased in comparison to the expression level thereof in the cell population before the treatment by the physical stimulation or chemical stimulation.Type: ApplicationFiled: October 27, 2016Publication date: December 20, 2018Applicants: KANEKA CORPORATION, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTERInventors: Kenichi YAMAHARA, Yuta KITA, Keita INO, Akira KOBAYASHI