Patents Assigned to National Institute of Advanced Industrial Science and Technology
  • Publication number: 20200190537
    Abstract: The present invention enables simultaneous and stable expression of a plurality of foreign genes by using a stealthy RNA gene expression system that is a complex that does not activate the innate immune mechanism and is formed from an RNA-dependent RNA polymerase, a single-strand RNA binding protein, and negative-sense single-strand RNAs including the following (1) to (8) : (1) a target RNA sequence that codes for any protein or functional RNA; (2) an RNA sequence forming a noncoding region and derived from mRNA expressed in animal cells; (3) a transcription initiation signal sequence recognized by the RNA-dependent RNA polymerase; (4) a transcription termination signal sequence recognized by the polymerase; (5) an RNA sequence containing a replication origin recognized by the polymerase; (6) an RNA sequence that codes for the polymerase and of which codons are optimized for the species from which an introduction target cell is derived; (7) an RNA sequence that codes for a protein for regulating the activity
    Type: Application
    Filed: November 22, 2019
    Publication date: June 18, 2020
    Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, TOKIWA-BIO INC.
    Inventors: Mahito Nakanishi, Minoru Iijima
  • Patent number: 10686043
    Abstract: [Object] To provide a FeFET and a method of its manufacture, the FeFET having a ferroelectric whose film thickness (dr) is made small and so nanofine as to range in: 59 nm<dr<150, without impairing the data retention property of not less than 105 seconds and the data rewrite withstand property of not less than 108 times, of those that have hitherto been developed, and the FeFET allowing data to be written with a writing voltage whose absolute value is not more than 3.3 volts. [Means for Solving] In methods of making a device in which an insulator, a film made of constituent elements of a bismuth layered perovskite crystalline ferroelectric and a metal are sequentially formed in the indicated order on a semiconductor substrate and thereafter are annealed for ferroelectric crystallization, thereby preparing the device composed of the semiconductor, insulator, ferroelectric and metal, a method of making a semiconductor ferroelectric memory element in which the film is composed of Ca.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: June 16, 2020
    Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, WACOM R&D CORPORATION
    Inventors: Shigeki Sakai, Mitsue Takahashi, Masaki Kusuhara, Masayuki Toda, Masaru Umeda, Yoshikazu Sasaki
  • Publication number: 20200181181
    Abstract: The present invention provides a method for producing a cyclometalated iridium complex, the method including producing a cyclometalated iridium complex by reacting a cyclometalated iridium complex raw material including an organoiridium compound with an aromatic heterocyclic bidentate ligand capable of forming an iridium-carbon bond and an iridium-nitrogen bond, and using as the raw material an organoiridium compound including a substructure represented by the following General Formula (1). The present invention is capable of producing a cyclometalated iridium complex with a high yield without by-production of a halogen-crosslinked iridium dimer. (in General Formula (1), Ir represents an iridium atom, and O represents an oxygen atom).
    Type: Application
    Filed: December 4, 2017
    Publication date: June 11, 2020
    Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, TANAKA KIKINZOKU KOGYO K.K.
    Inventors: Hideo KONNO, Junichi TANIUCHI, Rumi KOBAYASHI, Yasushi MASAHIRO
  • Publication number: 20200173044
    Abstract: A method for producing a transparent electrode for oxygen production having a Ta nitride layer on a transparent substrate, including: a step of forming a Ta nitride precursor layer on the transparent substrate; and a step of nitriding the Ta nitride precursor layer with a mixed gas containing ammonia and a carrier gas.
    Type: Application
    Filed: February 7, 2020
    Publication date: June 4, 2020
    Applicants: Mitsubishi Chemical Corporation, THE UNIVERSITY OF TOKYO, JAPAN TECHNOLOGICAL RESEARCH ASSOCIATION OF ARTIFICIAL PHOTOSYNTHETIC CHEMICAL PROCESS, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hiroshi NISHIYAMA, Tomohiro HIGASHI, Yutaka SASAKI, Taro YAMADA, Kazunari DOMEN, Yohichi SUZUKI, Seiji AKIYAMA
  • Patent number: 10669159
    Abstract: Provided is a complex oxide that has a high hydrogen content, contains almost no impurity phase, and is suitable for proton conductivity. The complex oxide is represented by a chemical formula Li7-xHxLa3M2O12 (M represents Zr and/or Hf, and 3.2<x?7) and is a single phase of a garnet type structure belonging to a cubic system. A method for producing the complex oxide includes an exchange step of bringing a raw material complex oxide represented by a chemical formula Li7-xHxLa3M2O12 (M represents Zr and/or Hf, and 0?x?3.2) and a compound having a hydroxy group or a carboxyl group into contact with each other to exchange at least some of lithium of the raw material complex oxide and hydrogen of the compound having a hydroxy group or a carboxyl group.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: June 2, 2020
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Junji Akimoto, Naoki Hamao, Kunimitsu Kataoka
  • Publication number: 20200166497
    Abstract: An analysis apparatus (100) includes an image acquisition unit (110) and an analysis unit (120). The image acquisition unit (110) acquires image data of a microfossil in a sample collected from a stratum. The analysis unit (120) analyzes the image data acquired by the image acquisition unit (110) using a machine learning result to analyze a taxon or kind of the microfossil in the image data.
    Type: Application
    Filed: May 10, 2018
    Publication date: May 28, 2020
    Applicants: NEC CORPORATION, JAPAN AGENCY FOR MARINE-EARTH SCIENCE AND TECHNOLOGY, NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Yousuke TAIRA, Naoki KUWAMORI, Tatsuhiko HOSHINO, Jonaotaro ONODERA, Tatsuhiko YAMAGUCHI, Kyoko TOMIOKO, Takuya ITAKI
  • Patent number: 10663385
    Abstract: A measurement apparatus for carrying out an indentation creep test on a specimen, including a measurement control apparatus that includes a load measurement device, a constant-load compression device configured to compress a tip of a transparent indenter to a surface of the specimen, and an image capturing device configured to optically capture an image including a contact area portion which is a part of the specimen to which the load is applied by the constant-load compression device. The apparatus also includes an information processing apparatus that includes an image analysis unit configured to analyze a contact area, and a physical property value calculation unit. The physical property value calculation unit conducts linear regression with respect to a plot of a logarithmic value of the contact stress and a logarithmic value of the contact strain rate so as to determine a creep index n and creep constant k.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: May 26, 2020
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventor: Tatsuya Miyajima
  • Patent number: 10663456
    Abstract: The present invention provides means for evaluating harmfulness of a chemical substance before occurrence of cell death, that is, more quickly and sensitively compared to conventional methods wherein the remaining viable cell count is determined using a reductive coloring reagent after a period of time required for occurrence of cell death due to the chemical substance. A double-stranded RNA probe comprising an RNA strand labeled with a fluorescent dye A that emits fluorescence, and an RNA strand labeled with a fluorescent dye B that quenches emission from a fluorescent dye in the vicinity thereof, wherein the fluorescence is quenched in a double-stranded state due to occurrence of fluorescence resonance energy transfer (FRET) between the two kinds of fluorescent dyes.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: May 26, 2020
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hidenori Tani, Masaki Torimura, Hiroaki Sato
  • Patent number: 10661267
    Abstract: Provided is an electric pipette system, including: an operating condition receiving milt configured to receive an operating condition of a manipulation operation to foe occur next; a suction/discharge operating unit configured to perform at least any one of a suction operation and a discharge operation of a liquid by an electric pipette based cm the operating condition; an information collecting unit configured to collect various types of information during the suction operation or the discharge operation of the liquid; and an information recording unit configured to record the information.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: May 26, 2020
    Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, KABUSHIKI KAISHA YASKAWA DENKI, ROBOTIC BIOLOGY INSTITUTE INC.
    Inventors: Toru Natsume, Naoyuki Sasaki, Kenji Matsukuma, Makoto Umeno, Tatsuro Ipposhi
  • Publication number: 20200157571
    Abstract: The present invention enables simultaneous and stable expression of a plurality of foreign genes by using a stealthy RNA gene expression system that is a complex that does not activate the innate immune mechanism and is formed from an RNA-dependent RNA polymerase, a single-strand RNA binding protein, and negative-sense single-strand RNAs including the following (1) to (8): (1) a target RNA sequence that codes for any protein or functional RNA; (2) an RNA sequence forming a noncoding region and derived from mRNA expressed in animal cells; (3) a transcription initiation signal sequence recognized by the RNA-dependent RNA polymerase; (4) a transcription termination signal sequence recognized by the polymerase; (5) an RNA sequence containing a replication origin recognized by the polymerase; (6) an RNA sequence that codes for the polymerase and of which codons are optimized for the species from which an introduction target cell is derived; (7) an RNA sequence that codes for a protein for regulating the activity o
    Type: Application
    Filed: December 4, 2019
    Publication date: May 21, 2020
    Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, TOKIWA-BIO INC.
    Inventors: Mahito Nakanishi, Minoru Iijima
  • Publication number: 20200157607
    Abstract: The present invention provides a reciprocal-flow-type nucleic acid amplification device comprising: heaters capable of forming a denaturation temperature zone and an extension/annealing temperature zone; a fluorescence detector capable of detecting movement of a sample solution between the two temperature zones; a pair of liquid delivery mechanisms that allow the sample solution to move between the two temperature zones and that are configured to be open to atmospheric pressure when liquid delivery stops; a substrate on which the chip for nucleic acid amplification according to claim 2 can be placed; and a control mechanism that controls driving of each liquid delivery mechanism by receiving an electrical signal from the fluorescence detector relating to movement of the sample solution from the control mechanism; the device being capable of performing real-time PCR by measuring fluorescence intensity for each thermal cycle.
    Type: Application
    Filed: February 5, 2020
    Publication date: May 21, 2020
    Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, KYORIN PHARMACEUTICAL CO., LTD.
    Inventors: Hidenori NAGAI, Shunsuke FURUTANI, Yoshihisa HAGIHARA, Yusuke FUCHIWAKI
  • Patent number: 10655954
    Abstract: In a conventional moiré method, achieving both measurement accuracy and dynamic measurement and balancing field of view and measurement accuracy have been difficult. The present invention makes it possible to handle conventional moiré fringes as a grating for generating phase-shifted second-order moiré fringes, use a spatial phase shift method algorithm to accurately analyze the phases of the second-order moiré fringes before and after deformation, and determine shape from the phase differences between gratings projected onto the surface of an object of measurement and a reference surface and determine deformation and strain from the phase differences between the second-order moiré fringes, before and after deformation, of a repeating pattern on the object surface or a produced grating. As a result, it is possible to measure the three-dimensional shape and deformation distribution of an object accurately and with a wide field of view or dynamically and with a high degree of accuracy.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: May 19, 2020
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Qinghua Wang, Shien Ri, Hiroshi Tsuda
  • Patent number: 10647593
    Abstract: The object of the invention is to provide an adsorbent that can adsorb ammonia with no large volume change between absorption and desorption, that has a high ammonia and/or ammonium ion adsorption capacity, and that can have an additional function by gaining proper control of composition, etc. The invention makes it possible to provide an adsorbent that absorbs ammonia and/or ammonium ions through the use of a metal cyanocomplex as an ammonia adsorbent, experiences no or little volume change, exhibits high enough capacity for adsorbing ammonia and/or ammonium ions, and has a function of decomposing ammonia as well as a function of varying optical responses before and after adsorption, etc.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: May 12, 2020
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Akira Takahashi, Tohru Kawamoto, Parajuli Durga, Hisashi Tanaka, Yutaka Sugiyama, Yukiya Hakuta
  • Patent number: 10646532
    Abstract: It is an object of the present invention to provide a method for preparing a water extract of ashwagandha, which comprises increasing the amounts of withanone and withaferin A contained as active ingredients in the water extract of ashwagandha leaves. In addition, it is another object of the present invention to more economically and simply provide a pharmaceutical composition comprising ashwagandha leaves. The present invention relates to a method for preparing a water extract of ashwagandha leaves, which comprises extracting ashwagandha leaves with water in the presence of cyclodextrin, and a method for enhancing the anticancer activity of the water extract of ashwagandha leaves. The present invention also relates to a pharmaceutical composition for treating or preventing cancer, comprising the water extract of ashwagandha leaves. The present invention further relates to a pharmaceutical composition comprising dry powders of ashwagandha leaves and cyclodextrin.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: May 12, 2020
    Assignees: National Institute of Advanced Industrial Science and Technology, Kaul-Tech Co., Ltd.
    Inventors: Renu Wadhwa, Sunil Kaul
  • Patent number: 10640122
    Abstract: A driving consciousness estimation device includes a driving readiness estimation unit configured to estimate a driving readiness relating to a driving consciousness of the driver from a driver's reaction to the travelling environment, a driving task demand estimation unit configured to estimate a driving task demand which is an index required for the driver with respect to the driving readiness from the travelling environment, and an attention awakening unit configured to execute awakening of attention for the driver relating to the driving of the vehicle based on the result of comparison between the driving readiness and the driving task demand.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: May 5, 2020
    Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hiroshi Kishi, Masakazu Akutsu, Motoyuki Akamatsu, Toshihisa Sato
  • Patent number: 10632533
    Abstract: A raw material for a magnet, which comprises Sm and Fe. A magnet is obtained by nitriding this raw material for a magnet. In particular, a raw material for a magnet comprises an Sm—Fe binary alloy as a main component. An intensity ratio of an Sm2Fe17 (024) peak to an SmFe7 (110) peak is less than 0.001 as measured by an X-ray diffraction method.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: April 28, 2020
    Assignees: Murata Manufacturing Co., Ltd., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Satoshi Oga, Kenta Takagi, Kimihiro Ozaki
  • Patent number: 10634563
    Abstract: A count processor counts a zero crossing detection count C. A fraction processor for calculating a fraction Fj (j=1 to L) of the zero crossing detection count on the basis of the digital signal at sampling timings immediately before a zero crossing specifying and when the zero crossing specifying, and computing a fraction processing parameter Gj=Nj?Fj using a zero crossing detection number Nj(0?Nj?N?1) in a period corresponding to a sampling count N necessary for averaging determined in advance. The averaging is performed according to the following formula, where C is the output of the count processor at the end of an averaging period and Gj (j=1 to L) is L fraction processing parameters (L indicates the number of Gj included between the averaging counts N) computed by the fraction processor, and the phase of the digital signal is computed, whereby the phase is calculated on the basis of an input signal digital value obtained by an AD converter.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: April 28, 2020
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventor: Wataru Kokuyama
  • Patent number: 10632590
    Abstract: The work processing apparatus of the present invention comprises: a processing section for processing or treating a work; and a liquid chemical supplying section for supplying a liquid chemical to the processing section. The liquid chemical supplying section includes: a plurality of liquid chemical bags for storing the liquid chemical; a bag holding part in which the liquid chemical bags are attached and held; and a liquid feeding part, to which the liquid chemical bags are detachably connected, for feeding the liquid chemical from the liquid chemical bags to the processing section. Each of the liquid chemical bags is produced by overlapping flexible resin sheets with each other and welding their edge parts to form into a bag. Each of the liquid chemical bags has a port part communicating with an outside. A joint with a valve is attached to each of the port parts.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: April 28, 2020
    Assignees: FUJIKOSHI MACHINERY CORP., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Masayuki Tsukada, Kazutaka Shibuya, Takayuki Fuse, Yoshio Nakamura, Shiro Hara
  • Patent number: 10636751
    Abstract: A semiconductor device 100 of the present invention includes a front end and back ends A and B, each including a plurality of layers. Further, in the plurality of layers of the back end B, (i) circuits 22, 23, and 24 having a security function are provided in at least one layer having a wiring pitch of 100 nm or more, (ii) a circuit having a security function is provided in at least one wiring layer in M5 or higher level (M5, M6, M7, . . . ), (iii) a circuit having a security function is provided in at least one layer, for which immersion ArF exposure does not need to be used, or (iv) a circuit having a security function is provided in at least one layer that is exposed by using an exposure wavelength of 200 nm or more.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: April 28, 2020
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE & TECHNOLOGY
    Inventors: Yohei Hori, Yongxun Liu, Shinichi Ouchi, Tetsuji Yasuda, Meishoku Masahara, Toshifumi Irisawa, Kazuhiko Endo, Hiroyuki Ota, Tatsuro Maeda, Hanpei Koike, Yasuhiro Ogasahara, Toshihiro Katashita, Koichi Fukuda
  • Publication number: 20200124669
    Abstract: A high-frequency characteristic inspection apparatus includes a pair of high-frequency probes that inspect an electrical characteristic of a plane circuit including a signal region and a ground region formed apart from each other by an S parameter obtained by pushing a tip against a surface of the plane circuit and discharging a high frequency and a measurement apparatus. The high-frequency probe includes a ground terminal that is in contact with the ground region at its tip and a signal terminal that is in contact with the signal region simultaneously with the ground terminal at its tip. The pair of high-frequency probes are configured to contact with a surface of the plane circuit at the same time while facing each other at a certain interval.
    Type: Application
    Filed: April 12, 2017
    Publication date: April 23, 2020
    Applicant: National Institute of Advanced Industrial Science and Technology
    Inventor: Ryo Sakamaki