Patents Assigned to National Institute of Radiological Sciences
  • Patent number: 9919164
    Abstract: According to one embodiment, a medical image processing apparatus, includes: a first acquisition unit; a second acquisition unit; and a part-removed image generation unit, wherein the first acquisition unit is adapted to acquire a first radiograph that is a virtual radiograph generated to have a specified part or a predetermined part, among parts included in volume data indicative of a three-dimensional structure of an inside of a body of a patient, being emphasized, the second acquisition unit is adapted to acquire a second radiograph of the inside of the body of the patient, and the part-removed image generation unit is adapted to generate a part-removed image by removing the specified or predetermined part or parts other than the specified or predetermined part from the second radiograph with reference to the first radiograph.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: March 20, 2018
    Assignees: KABUSHIKI KAISHA TOSHIBA, National Institute of Radiological Sciences
    Inventors: Yasunori Taguchi, Yukinobu Sakata, Ryusuke Hirai, Kyoka Sugiura, Tomoyuki Takeguchi, Shinichiro Mori, Fumi Maruyama
  • Publication number: 20160253455
    Abstract: A viewer part 38b accesses an image viewer web server 14 by a user terminal 16, in which a medical image display program 38 is installed, to acquire at least medical image data 13a, input data accepted in a touch input part 21a is transmitted in an input transmission part 31 and is transferred to the image viewer web server 14, the medical image data 13a outputted from the image viewer web server 14 is acquired in a capture acquisition part 34, at least a medical image data 13a portion is subjected to image conversion in an image conversion part 35, and image data for display after conversion is outputted to a display part 23 by an output part 36. Accordingly, there is provided a medical image display device that can display a medical image in proper gradation without using color management by hardware, and without performing modification corresponding to gradation correction to an individual application having a display function of the medical image.
    Type: Application
    Filed: January 29, 2014
    Publication date: September 1, 2016
    Applicant: National Institute of Radiological Sciences
    Inventors: Shin HASEGAWA, Yasuo OKUDA
  • Patent number: 9382303
    Abstract: This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phospholylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: July 5, 2016
    Assignees: KYOTO UNIVERSITY, NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
    Inventors: Haruhisa Inoue, Hiroki Takeuchi, Ryosuke Takahashi, Makoto Higuchi, Bin Ji, Tetsuya Suhara
  • Publication number: 20160155228
    Abstract: A medical image generation apparatus includes: a three-dimensional image acquisition unit that acquires a three-dimensional image in which a space including a patient is captured; an imparting unit that imparts, to each of voxels constituting the three-dimensional image, a living-body likelihood coefficient indicating a likelihood of being a living-body region of the patient; an updating unit that updates a luminance value of the voxel in which the imparted living-body likelihood coefficient shows a given value, through predetermined processing; a virtual viewpoint setting unit that sets a virtual viewpoint for transforming the three-dimensional image into a two-dimensional radiation image; and a radiation image generation unit that calculates a luminance value of a pixel constituting the radiation image based on the luminance value of the voxel existing along a line connecting each of the corresponding pixels and the virtual viewpoint.
    Type: Application
    Filed: November 27, 2015
    Publication date: June 2, 2016
    Applicants: KABUSHIKI KAISHA TOSHIBA, National Institute of Radiological Sciences
    Inventors: Yukinobu SAKATA, Ryusuke HIRAI, Kyoka SUGIURA, Yasunori TAGUCHI, Tomoyuki TAKEGUCHI, Shinichiro MORI, Fumi MARUYAMA
  • Publication number: 20160136458
    Abstract: According to one embodiment, a medical image processing apparatus, includes: a first acquisition unit; a second acquisition unit; and a part-removed image generation unit, wherein the first acquisition unit is adapted to acquire a first radiograph that is a virtual radiograph generated to have a specified part or a predetermined part, among parts included in volume data indicative of a three-dimensional structure of an inside of a body of a patient, being emphasized, the second acquisition unit is adapted to acquire a second radiograph of the inside of the body of the patient, and the part-removed image generation unit is adapted to generate a part-removed image by removing the specified or predetermined part or parts other than the specified or predetermined part from the second radiograph with reference to the first radiograph.
    Type: Application
    Filed: November 18, 2015
    Publication date: May 19, 2016
    Applicants: Kabushiki Kaisha Toshiba, National Institute of Radiological Sciences
    Inventors: Yasunori TAGUCHI, Yukinobu SAKATA, Ryusuke HIRAI, Kyoka SUGIURA, Tomoyuki TAKEGUCHI, Shinichiro MORI, Fumi MARUYAMA
  • Publication number: 20160029934
    Abstract: A suction drain device of a disclosed liquid collecting apparatus actively pushes and pulls blood. This achieves liquid collection at high speed even under decreased pressure depending on a physiological state of an animal. Moreover, the liquid collecting apparatus includes a First flow path and a second flow path having a given length. Accordingly, the flow path with a given length set in advance and thus a known volume allows collection of a given amount volume of blood without measuring a length and an amount of blood using a volume measuring device. Accordingly, no need of the measuring device allows reduction in size of the liquid collecting apparatus. Consequently, the liquid collecting apparatus can be installed adjacent to the animal to achieve reduction in dead volume. Moreover, blood is flown to a fourth flow path branched with a connecting terminal, and is also flown to the second flow path branched with a connecting terminal.
    Type: Application
    Filed: September 3, 2012
    Publication date: February 4, 2016
    Applicants: SHIMADZU CORPORATION, NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY, NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
    Inventors: Nobuya HASHIZUME, Keishi KITAMURA, Takahiro NISHIMOTO, Yuichi KIMURA, Hiroshi TOYAMA, Takashi YAMADA
  • Patent number: 9226717
    Abstract: A helmet-type PET device includes a helmet portion (hemispherical detector) and an added portion (jaw portion detector, an ear portion detector, or a neck portion detector). The helmet portion includes a PET detector so as to cover a parietal region of an examination target. The added portion is positioned to dispose a PET detector at a part other than the parietal region of the examination target. PET measurement is performed using both an output from the PET detector at the helmet portion and an output from the PET detector at the added portion.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: January 5, 2016
    Assignee: NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
    Inventors: Hideaki Tashima, Taiga Yamaya
  • Patent number: 9176237
    Abstract: In a coincidence determination of a PET device, the PET device uses a scintillator of radioactive isotope containing background noise due to intrinsic radioactivity as a radiation detector. The PET device counts a pair of annihilation radiations that is assumed to occur from a same nuclide. The annihilation radiations are detected within a predetermined coincidence time window by a plurality of radiation detectors. The method includes determining a coincidence with a wide energy window that allows detecting the background noise due to intrinsic radioactivity as multiple coincidences; removing the multiple coincidences; and using an energy window narrower than the wide energy window to limit a coincidence event to a coincidence event in a photopeak from a positron nuclide only.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: November 3, 2015
    Assignee: NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
    Inventors: Eiji Yoshida, Taiga Yamaya
  • Publication number: 20150299280
    Abstract: The present invention relates to a chimeric protein formed by fusing a CPP containing a CPP-C domain in any of an FGF11, FGF12, FGF13, and FGF14 to an FGF1 or an FGF2, or DNA molecules that contain DNA sequences coding the FGF1 or the FGF2 and DNA sequences coding a CPP-C or vectors containing these DNA sequences. These chimeric protein, DNA molecules, or vectors can be used for a medicine or a method of treatment effective to a tissue on which an expression of an FGFR is low or becomes low due to any cause, a medicine or a method of treatment that can further dynamize bioactivity of the FGF1 or the FGF2 via the FGFR, or a medicine or a method of treatment that protects a stem cell against an influence from radiation exposure, a chemotherapy, or a similar treatment.
    Type: Application
    Filed: November 11, 2013
    Publication date: October 22, 2015
    Applicant: NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
    Inventors: Fumiaki NAKAYAMA, Sachiko UMEDA, Takeshi YASUDA, Mayumi FUJITA, Takashi IMAI
  • Publication number: 20150266937
    Abstract: This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phospholylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
    Type: Application
    Filed: December 30, 2014
    Publication date: September 24, 2015
    Applicants: National Institute of Radiological Sciences, Kyoto University
    Inventors: Haruhisa INOUE, Hiroki TAKEUCHI, Ryosuke TAKAHASHI, Makoto HIGUCHI, Bin JI, Tetsuya SUHARA
  • Patent number: 9029789
    Abstract: A light receiver for detecting incident time is installed on the side of a radiation source of a scintillator (including a Cherenkov radiation emitter), and information (energy, incident time, an incident position, etc.) on radiation made incident into the scintillator is obtained by the output of the light receiver. It is, thereby, possible to identify an incident position and others of radiation into the scintillator at high accuracy.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: May 12, 2015
    Assignee: National Institute of Radiological Sciences
    Inventors: Kengo Shibuya, Taiga Yamaya, Naoko Inadama, Fumihiko Nishikido, Eiji Yoshida, Hideo Murayama
  • Patent number: 9029787
    Abstract: In an open PET device including a plurality of detector rings that are arranged apart in the direction of the body axis of a subject and having a physical open field of view area, at least one of the detector rings or another imaging device arranged in parallel is configured to be movable by simple device moving means in order to change the configuration of the PET device. This improves the versatility of the open PET device for easier introduction to facilities.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: May 12, 2015
    Assignee: National Institute of Radiological Sciences
    Inventors: Taiga Yamaya, Hideo Murayama
  • Patent number: 9029790
    Abstract: In imaging on the basis of list mode data of a list of radioactive count data detected by a nuclear medicine imaging apparatus for measuring radiation in a pulse mode, the processing from the measurement to imaging of radiation is accelerated substantially to the real time level by selecting the number of count data to be used for online imaging computations on the basis of the counting rate of radiation.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: May 12, 2015
    Assignee: National Institute of Radiological Sciences
    Inventors: Taiga Yamaya, Eiji Yoshida
  • Patent number: 8945576
    Abstract: This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phosphorylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: February 3, 2015
    Assignees: Kyoto University, National Institute of Radiological Sciences
    Inventors: Haruhisa Inoue, Hiroki Takeuchi, Ryosuke Takahashi, Makoto Higuchi, Bin Ji, Tetsuya Suhara
  • Patent number: 8933410
    Abstract: A three-dimensional position-sensitive radiation detector is provided which has a three-dimensional array of photodetectors disposed on the surface of a scintillator block and which is capable of three-dimensionally identifying the position of light emission at which radiation has been detected within the detector. The three-dimensional position-sensitive radiation detector includes: a scintillator block including a central portion which restricts the direction of diffusion of light so as to direct the light in three axial directions and which has an optically discontinuous region, and an outer portion which is disposed on the outside of the central portion and which does not restrict the direction of diffusion of light; and photodetectors disposed on at least two outer circumferential surfaces of the scintillator block.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: January 13, 2015
    Assignees: National Institute of Radiological Sciences, Hamamatsu Photonics K.K.
    Inventors: Naoko Inadama, Hideo Murayama, Taiga Yamaya, Mitsuo Watanabe, Takahiro Moriya, Kenshi Fukumitsu, Tomohide Omura
  • Publication number: 20140299784
    Abstract: A radioactive substance detection device that detects a radioactive substance being present in a specified direction. A radiation detection element having a thickness that stops and detects a characteristic X-ray arriving from a radioactive substance being present in the specified direction that radiates both gamma rays and the characteristic X-rays, and allows the gamma ray arriving from the radioactive substance to pass through. A screening body having a thickness that screens out characteristic X-rays of radiation which arrives from directions other than the specified direction and allows gamma rays of radiation which arrives from directions other than the specified direction to pass through.
    Type: Application
    Filed: January 12, 2013
    Publication date: October 9, 2014
    Applicant: National Institute of Radiological Sciences
    Inventors: Shingo Kobayashi, Yukio Uchihori, Yoshiyuki Shirakawa
  • Patent number: 8783121
    Abstract: A blood collecting apparatus includes a cleaning solution piping. The cleaning solution piping feeds into a flow path a heparin solution which is a liquid other than blood to be measured, in order to return the blood present in the flow path to a catheter disposed upstream of a blood inlet of the flow path. Thus, the blood having flowed into the flow path in an amount more than is necessary for blood collection, which corresponds to a portion returned to the upstream catheter of the blood to be measured present in the flow path, can be used in a next blood collection. As a result, the amount of collected blood can be reduced. The liquid to be measured is separated apart by means of a gas, and the flow path is cleaned in a way to leave no impurities in the flow path, thereby preventing impurities from mixing into the liquid to be measured.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: July 22, 2014
    Assignees: Shumadzu Corporation, National Institute of Radiological Sciences
    Inventors: Nobuya Hashizume, Keishi Kitamura, Takahiro Nishimoto, Yuichi Kimura, Chie Seki, Iwao Kanno
  • Publication number: 20140186260
    Abstract: A radiopharmaceutical comprising combination of a particular radioactive dithiosemicarbazone copper complex, and a chelating agent comprising a multidentate ligand having a maximum dentate number of 2 or more to 4 or less.
    Type: Application
    Filed: December 24, 2013
    Publication date: July 3, 2014
    Applicants: NIHON MEDI-PHYSICS CO., LTD., NATIONAL CANCER CENTER, NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
    Inventors: Yukie YOSHII, Hiroki Matsumoto, Mitsuyoshi Yoshimoto
  • Publication number: 20140186261
    Abstract: An anti-tumor agent comprising combination of a radioactive diacetyl-bis(N4-methylthiosemicarbazone) copper complex and a metabolic inhibitor.
    Type: Application
    Filed: December 24, 2013
    Publication date: July 3, 2014
    Applicants: NIHON MEDI-PHYSICS CO., LTD., NATIONAL CANCER CENTER, NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
    Inventors: Yukie YOSHII, Takako Furukawa, Tsuneo Saga, Hiroki Matsumoto, Mitsuyoshi Yoshimoto
  • Patent number: 8766197
    Abstract: Disclosed is a radiation detection element which can inexpensively be manufactured. The detection element including, as a main component, a base resin not containing any fluorescent substance at all is used for radiation measurement.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: July 1, 2014
    Assignee: National Institute of Radiological Sciences
    Inventor: Hidehito Nakamura