Patents Assigned to National Research Council of Canada
  • Humanized antibodies transmigrating the blood-brain barrier and uses thereof
    Patent number: 10738115
    Abstract: The present invention relates to antibodies and fragments thereof derived by humanization of an existing antibody, and methods of making them. The humanized antibodies of the present invention show enhanced binding to the brain endothelial antigen, improved transmigration across the blood-brain barrier, and increased thermal stability relative to the parent non-humanized antibody.
    Type: Grant
    Filed: July 4, 2017
    Date of Patent: August 11, 2020
    Assignee: National Research Council of Canada
    Inventors: Danica Stanimirovic, Kristin Kemmerich, Yves Durocher, Traian Sulea
  • Radiation curable polymer formulation and methods for the preparation thereof
    Patent number: 10738143
    Abstract: Disclosed is a radiation curable polymer formulation and methods of producing a dielectric film having such a formulation. The radiation curable polymer formulation includes an acrylic monomer; a cross linking agent; and a photoinitiator. The polymer formulation is insoluble with an organic solvent, which is preferable in low cost high volume manufacturing of thin film transistors for flexible electronics.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: August 11, 2020
    Assignee: National Research Council of Canada
    Inventors: Marius G. Ivan, Yanguang Zhang
  • Peristaltic Pump Microfluidic Separator
    Publication number: 20200238217
    Abstract: A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.
    Type: Application
    Filed: December 23, 2019
    Publication date: July 30, 2020
    Applicants: National Research Council of Canada, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Kebin LI, Teodor VERES, Tohid Fatanat DIDAR, Maryam TABRIZIAN
  • METHOD FOR PREPARING POWDERS FOR A COLD SPRAY PROCESS, AND POWDERS THEREFOR
    Publication number: 20200238375
    Abstract: A method for enabling cold spray of steels, particularly transformation hardenable steels including tool steels, has been made possible by: heat treating steel powder while agitating the powder to limit agglomeration and particle growth; cooling it slowly enough to avoid retransformation hardening; and protecting the powder from cold working or retransformation hardening until cold sprayed. Surprisingly the softening, as well as the agglomerated morphology of powders, has been found to allow for deposition of steel powders. Furthermore, the cooling has been found to be possible within 8 hour heat treatments, and high density, and reasonably high deposition efficiencies have been achieved. Water- and gas-atomized starting powders have been treated and cold sprayed.
    Type: Application
    Filed: July 20, 2018
    Publication date: July 30, 2020
    Applicant: National Research Council of Canada
    Inventors: Dominique POIRIER, Paul-Émile MONGEON, Yannig THOMAS, Eric IRISSOU
  • Cannabichromenic acid synthase from
    Patent number: 10724009
    Abstract: Nucleic acid molecules from cannabis have been isolated and characterized and encode polypeptides having cannabichromenic acid synthase activity. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: July 28, 2020
    Assignee: National Research Council of Canada (NRC)
    Inventors: Jonathan E. Page, Jason M. Stout
  • Joined incompatible metallic parts and method of joining
    Patent number: 10724561
    Abstract: A technique for joining parts of incompatible metals involves cold spraying a 150-900 micron thick layer of a metal compatible with the second part onto the first part, and friction stir joining the parts by lap welding while keeping a tool of the FSJ tool at least 300 microns away from the first part (less layer) throughout the joining, to avoid damaging the cold spray to first part interface, and formation of intermetallics. Fatigue resistance was tested, with and without a sealant.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: July 28, 2020
    Assignee: National Research Council of Canada
    Inventors: Sofiene Amira, Patrick Gougeon, Jean-Gabriel Legoux, Francois Nadeau
  • TGF-B-RECEPTOR ECTODOMAIN FUSION MOLECULES AND USES THEREOF
    Publication number: 20200231652
    Abstract: The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-beta) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.
    Type: Application
    Filed: August 31, 2016
    Publication date: July 23, 2020
    Applicant: National Research Council of Canada
    Inventors: John C. Zwaagstra, Traian Sulea, Maria Jaramillo, Maureen D. O'Connor, Anne E.G. Lenferink
  • Systems and methods for the production of diphtheria toxin polypeptides
    Publication number: 20200231635
    Abstract: An expression system and process for the production of Diphtheria toxin polypeptides or mutated forms thereof, such as the toxoid CRM197 polypeptide, in genetically-modified E. coli with high yield is described. The system and process is based on the uncoupling of biomass growth from recombinant protein induction, i.e. using an inducer of protein production that cannot be used as a carbon source for growth by the bacteria. The use of specific components and conditions that improve protein yields are also described.
    Type: Application
    Filed: August 16, 2018
    Publication date: July 23, 2020
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Luke MASSON, Melanie ARBOUR, Marie-Anne GAURIAT
  • Genes and proteins for aromatic polyketide synthesis
    Patent number: 10718000
    Abstract: Nucleic acid molecules encoding polypeptides having polyketide synthase activity have been identified and characterized. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: July 21, 2020
    Assignees: National Research Council of Canada, University of Saskatchewan
    Inventors: Jonathan E. Page, Steve Gagne
  • BORON NITRIDE NANOTUBE (BNNT)-NANOPARTICLE COMPOSITES, METHODS FOR THE PREPARATION THEREOF AND THEIR MACROSCOPIC ASSEMBLIES
    Publication number: 20200216317
    Abstract: The present application relates to boron nitride nanotube (BNNT)-nanoparticle composites, to methods of preparing such composites and their use, for example, in metal/ceramic matrix composites and/or macroscopic assemblies. For example, the methods comprise subjecting a source of hydrogen, a source of boron, a source of nitrogen and a nanoparticle precursor to a stable induction thermal plasma and cooling the reaction mixture to obtain the composite.
    Type: Application
    Filed: September 18, 2018
    Publication date: July 9, 2020
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Keun Su KIM, Benoit SIMARD, Christopher Thomas KINGSTON, Homin SHIN
  • PHOSPHORYLATED HEPTOSE COMPOUNDS: PROCESS FOR THEIR PREPARATION AND USE
    Publication number: 20200215186
    Abstract: Processes for the preparation of phosphorylated heptose compounds are provided. Embodiments of the invention relate to the chemical synthesis of heptopyranose phosphate compounds. Also, embodiments of the invention relate to the use of compounds according to the invention in modulating an immune response in a subject.
    Type: Application
    Filed: May 11, 2018
    Publication date: July 9, 2020
    Applicants: NATIONAL RESEARCH COUNCIL OF CANADA, UNIVERSITY COLLEGE DUBLIN
    Inventors: Andrew COX, Janelle SAUVAGEAU, Stefan OSCARSON, Lorenzo GUAZZELLI
  • Centrifugal microfluidic chip control
    Patent number: 10702868
    Abstract: A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: July 7, 2020
    Assignee: National Research Council of Canada
    Inventors: Teodor Veres, Daniel Brassard, Liviu Clime, Francois Normandin
  • Stable linewidth narrowing of a coherent comb laser
    Patent number: 10707647
    Abstract: A technique for narrowing a linewidth of a plurality of lines of a coherent comb laser (CCL) concurrently comprises providing a mode-locked semiconductor coherent comb laser (CCL) adapted to output of at least 4 mode-locked lines; tapping a fraction of a power from the CCL from the laser cavity to form a tapped beam; propagating the tapped beam to an attenuator to produce an attenuated beam; and reinserting the attenuated beam into the laser cavity, where the reinserted beam has a power less than 10% of a power of the tapped beam. The reinsertion allows the CCL to be operated to output the mode-locked lines, each with a linewidth of less than 80% of the original linewidth. By propagating the tapped and attenuated beams on a solid waveguide, and ensuring that the secondary cavity is polarization maintaining, improved stability of the linewidth narrowing is ensured.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: July 7, 2020
    Assignee: National Research Council of Canada
    Inventors: Zhenguo Lu, Jiaren Liu, Philip Poole, Chunying Song, Shoude Chang
  • Stable linewidth narrowing of a coherent comb laser
    Patent number: 10707648
    Abstract: A technique for narrowing a linewidth of a plurality of lines of a coherent comb laser (CCL) concurrently comprises providing a mode-locked semiconductor coherent comb laser (CCL) adapted to output of at least 4 mode-locked lines; tapping a fraction of a power from the CCL from the laser cavity to form a tapped beam; propagating the tapped beam to an attenuator to produce an attenuated beam; and reinserting the attenuated beam into the laser cavity, where the reinserted beam has a power less than 10% of a power of the tapped beam. The reinsertion allows the CCL to be operated to output the mode-locked lines, each with a linewidth of less than 80% of the original linewidth. By propagating the tapped and attenuated beams on a solid waveguide, and ensuring that the secondary cavity is polarization maintaining, improved stability of the linewidth narrowing is ensured.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: July 7, 2020
    Assignee: National Research Council of Canada
    Inventors: Zhenguo Lu, Jiaren Liu, Philip Poole, Chunying Song, Shoude Chang
  • METHODS FOR PREPARING SUPERHYDROPHOBIC NANO-MICROSCALE PATTERNED FILMS
    Publication number: 20200199307
    Abstract: The present application discloses methods for preparing superhydrophobic nano-microscale patterned films, films pre-pared from such methods and uses of such films as superhydrophobic coatings. The superhydrophobic nano- microscale patterned films comprise high aspect ratio nanoparticles such as boron nitride nanotubes (BNNTs) and/or carbon nanotubes (CNTs).
    Type: Application
    Filed: July 4, 2018
    Publication date: June 25, 2020
    Applicant: National Research Council of Canada
    Inventors: Yadienka MARTINEZ-RUBI, Benoit SIMARD, Stéphane DÉNOMMÉE, Keun Su KIM, Fuyong CHENG
  • Sulfated-glycolipids as adjuvants for vaccines
    Patent number: 10647737
    Abstract: A synthetic charged glycolipid is described comprising a sulfated saccharide group covalently linked to the tree sn-1 hydroxyl group of the glycerol backbone of an archaeal core lipid via a beta linkage. The synthetic charged glycolipids include compounds of formula I wherein n is 0 or 1; R is hydrogen or hydroxyl; and Y is hydrogen or a sulfate group, at least one Y being a sulfate group; and including pharmaceutically acceptable salts thereof. The sulfated glycolipid produces stable archaeosomes at a mol % ratio of from 100:0 to 30:70 (sulfated glycolipid:uncharged glycolipid) and which induce a protective immune response, including CD8+ and CD4+ T cell responses. Archaeosomes comprising the sulfated glycolipids described have desirable adjuvant properties, particularly when mixed with uncharged glycolipid at a mol % ratio of about 50:50.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: May 12, 2020
    Assignee: National Research Council of Canada
    Inventors: Dennis M. Whitfield, G. Dennis Sprott, Lakshmi Krishnan
  • Methods of manufacturing printable photodetector array panels
    Patent number: 10644044
    Abstract: Methods are provided for fabricating photodetector arrays using passive matrix addressing technology. The photodetector arrays use a pair of switching diode and photo diode to overcome crosstalk issues within the passive matrix. The switching diode and the photo diode of each pixel may be connected using a cathode-to-cathode connection, or an anode-to-anode connection. The photodetector arrays are fabricated by assembling on a first substrate, an array of photodetector pixels comprising a switching diode and a photo diode, providing conductive lines for each row of the array and conductive lines for each column of the array, and attaching a second substrate to the first substrate. The photodetector array may also be fabricated by assembling on a first substrate an array of switching diodes, and assembling on a second substrate an array of photo diodes, and bonding the first and second substrates together.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: May 5, 2020
    Assignee: National Research Council of Canada
    Inventors: Zhiyi Zhang, Ye Tao, Heping Ding, Salima Alem, Shoude Chang
  • Method for polymer removal from single-walled carbon nanotubes
    Patent number: 10640381
    Abstract: Processes for selectively dispersing semi-conducting single-walled carbon nanotubes (sc-SWCNTs) in a solvent. One process comprises adding an amine either: to a conjugated polymer extraction process (CPE) of the sc-SWCNTs; or after the CPE of the sc-SWCNTs, in which the amine partially displaces the conjugate polymer associated with the sc-SWNTs dispersed in the solvent. Another process comprises adding an amine either: to a conjugated polymer extraction process (CPE) of the sc-SWCNTs; or after the CPE of the sc-SWCNTs, with the proviso that the amine excludes EDTA. Also, a process for displacement of a conjugated polymer from the surface of semi-conducting single-walled carbon nanotubes (sc-SWCNTs) dispersed in a solvent, which comprises adding an amine either: to a conjugated polymer extraction process (CPE) of the sc-SWCNTs; or after the CPE of the sc-SWCNTs.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: May 5, 2020
    Assignee: National Research Council of Canada
    Inventors: Jianfu Ding, Zhao Li, Patrick Roland Lucien Malenfant
  • Engineering of immunoglobulin domains
    Patent number: 10633430
    Abstract: The present invention provides a single domain antibody (sdAb) scaffold comprising one or more than one non-canonical disulfide bond in the framework region (FR). The one or more than one non-canonical disulfide bond may be formed between cysteines introduced by mutations in FR2 and FR3. In the case where the sdAb scaffold is a VH, the Cys may be introduced at any one of positions 47-49 and any one of positions 67-71, based on Kabat numbering; in one example, the Cys may be introduced at positions 49 and 69, based on Kabat numbering. In the case where the sdAb scaffold is a VL, the Cys residues may be introduced at any one of positions 46-49 and any one of positions 62-66, based on Kabat numbering; in one example, the Cys residues may be introduced at positions 48 and 64, based on Kabat numbering.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: April 28, 2020
    Assignee: National Research Council of Canada
    Inventors: Dae Young Kim, Jamshid Tanha
  • Methods and apparatus for perfusion and environment control of microplate labware
    Patent number: 10633624
    Abstract: Systems, methods, and apparatuses of controlling fluid flow are disclosed. An apparatus includes a first microplate having a first open portion and defining one or more first wells therein, a second microplate having a second open portion and defining one or more second wells therein, and a pneumatic lid constructed of styrene ethylene butylene styrene (SEBS). The pneumatic lid extends over the first open portion and the second open portion and includes one or more microfluidic channels that fluidly couple the one or more first wells to the one or more second wells. The pneumatic lid provides an airtight seal over the first microplate and the second microplate.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: April 28, 2020
    Assignees: ESSEN INSTRUMENTS, INC., NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Kirk S. Schroeder, Bradley D. Neagle, Eric Endsley, Daniel Appledorn, Keith Morton