Patents Assigned to National Research Development Corporation
  • Patent number: 9198896
    Abstract: A pharmaceutical composition and treatment method to reduce the proliferation of cancerous or tumor cells, in which the combined active agents are methylglyoxal, ascorbic acid, creatine and melatonin.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: December 1, 2015
    Assignee: NATIONAL RESEARCH DEVELOPMENT CORPORATION
    Inventor: Manju Ray
  • Patent number: 8835145
    Abstract: The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolorizing, purifying and dialyzing.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: September 16, 2014
    Assignees: National Research Development Corporation, India and Malladi Drugs Pharmaceuticals Ltd.
    Inventors: Subrahamanyam Chivukula Sekar, Sundaramurthy Suresh Babu, Sita Mahadevan
  • Patent number: 7776574
    Abstract: The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolourizing, purifying and dialyzing.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: August 17, 2010
    Assignees: National Research Development Corporation, Malladi Drugs & Pharmaceuticals Ltd.
    Inventors: Perurmadom Ramaiyer Mahadevan, Sita Mahadevan, legal representative, Subrahmanyam Chivukula Sekar, Sundaramurthy Suresh Babu
  • Publication number: 20100130452
    Abstract: Use of doxycycline, a non specific matrix metalloproteinase inhibitor, for treatment of idiopathic pulmonary fibrosis and a pharmaceutical composition comprising doxycycline or its congener in combination with another compound selected from the drug listed for treatment of idiopathic pulmonary fibrosis in a standard dose.
    Type: Application
    Filed: February 25, 2008
    Publication date: May 27, 2010
    Applicant: NATIONAL RESEARCH DEVELOPMENT CORPORATION
    Inventor: Parthasarathi Bhattacharyya
  • Publication number: 20090285793
    Abstract: The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolourizing, purifying and dialyzing.
    Type: Application
    Filed: October 12, 2007
    Publication date: November 19, 2009
    Applicants: National Research Development Corporation, Malladi Drugs & Pharmaceuticals Ltd.
    Inventors: Perurmadom Ramaiyer Mahadevan, Sita Mahadevan, Subrahamanyam Chivukula Sekar, Sundaramurthy Suresh Babu
  • Patent number: 7585661
    Abstract: A process for producing herbicides from a fungus Alternaria alteranata f.sp. lantanae deposited as a pure culture as MTCC 5432 and ITCC-4896, comprising culturing the fungus in a liquid broth; subjecting the broth to the step of filtration to separate the broth containing phytotoxins from mycelium; extracting the phytotoxins from said broth to obtain the phytotoxins; and subjecting the phytotoxins to chemical characterization.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: September 8, 2009
    Assignee: National Research Development Corporation
    Inventor: Sanjai Saxena
  • Publication number: 20050260704
    Abstract: The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolourizing, purifying and dialyzing.
    Type: Application
    Filed: May 20, 2004
    Publication date: November 24, 2005
    Applicants: National Research Development Corporation, Malladi Drugs & Pharmaceuticals Ltd.
    Inventors: Perurmadom Mahadevan, Sita Mahadevan, Subrahamanyam Sekar, Sundaramurthy Babu
  • Patent number: 6939567
    Abstract: The present invention relates to a process on ayurvedic preparation comprising in the steps of subjecting silver, mercury, sulphur and arsenic trisulphide to the steps of detoxification, grinding the detoxified mercury and silver in the presence of a citrus juice and then adding detoxified sulphur and again subjecting to the step of grinding to obtain a greyish black powder, adding detoxified arsenic trisulphide thereto and subjecting to the step of grinding, imparting a shape such as a ball thereto, coating the ball with detoxified sulphur in the presence of a citrus juice and subjecting the coated ball to the step of slow firing, adding detoxified arsenic trisulphide and firing, repeating said step of addition and firing ground in a citrus juice such that the weight of the ball is reduced by at least 10% to obtain an intermediate, adding serpentive and delphenium root thereto.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: September 6, 2005
    Assignees: National Research Development Corporation, Anusandhan Vikas, Central Council for Research in Ayurveda and Siddha
    Inventor: Vaidya Balendu Prakash
  • Patent number: 6617861
    Abstract: A highly accurate instantaneous numerical analysis software assists on on-line and nondestructive in situ measurement method and instrument for the measurement of complex permittivity of materials in solid, semisolid, granular, sheet, thin and thick films, as well as materials in the liquid state. Such materials may include ceramics, polymer, semiconductor, or dielectric materials used in a circuit board and integrated Circuit manufacturing materials. The measuring instrument is a near field, non-contract apparatus in the form of one from the group of microstrip, coplanar waveguide and asymmetric inhomogeneous stripline. The frequency range may be 50 MHz onwards. The instrument includes a sweep oscillator, a resonator, a detector, a power meter to measure transmitted power with respect to the input signal frequency, a computer and an interface device.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: September 9, 2003
    Assignee: National Research Development Corporation
    Inventor: Kalpana Joshi
  • Patent number: 6424671
    Abstract: A process for making steel in an electric arc furnace includes providing a molten charge which is a melt composed of a high carbon ferrous metal in the electric arc furnace by one of preparing the melt in the furnace or introducing the melt into the furnace, the high carbon ferrous metal being composed of less than 3% carbon, less than 0.2% silicon, and less than 0.2% manganese, and the melt having a temperature of at least 1375° C.; adding to the molten charge provided in the furnace a solid metallic charge composed of least one material selected from the group consisting of scrap steel, hot briquetted iron, direct reduced iron, and iron ore to provide a charge mixture; refining the charge mixture by melting in the absence of gaseous oxygen to provide a molten steel; and superheating, finishing and tapping the molten steel into a ladle for subsequent casting thereof.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: July 23, 2002
    Assignee: National Research Development Corporation
    Inventor: Shilowbhadra Banerjee
  • Patent number: 6407555
    Abstract: An instrument and process for measuring moisture content of an article. A microstrip resonator receives a signal from a microwave sweep oscillator. A holder holds the article wherein the article under test is placed over a substrate of the resonator and covers the resonator and provides orientation to the article under test in a desired direction to the sample. A detector receives transmitted as well as reflected signals from a resonator sensor for measurement of Q factor and frequency shift of the resonator. The moisture content of the article is determined by the change in effective permittivity of a cross-section of the miscorstrip.
    Type: Grant
    Filed: February 26, 2001
    Date of Patent: June 18, 2002
    Assignee: National Research Development Corporation
    Inventors: Kalpana Keshav Joshi, Rohini Chandrashekhar Aiyer, Ravi Narhar Karekar, Mahesh Pandurang Abegaonkar
  • Patent number: 6368509
    Abstract: The present invention relates to a device for dialysis, desalting, purification or concentration of proteins. The device includes an upper hollow chamber, a middle detachable air-tight seal and a lower semipermeable membrane sac. The upper and lower parts are connected to each other by one or more apertures situated in the detachable air-tight seal.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: April 9, 2002
    Assignee: National Research Development Corporation
    Inventors: Parikshit Bansal, Krishan Lal Bhatia
  • Patent number: 6333058
    Abstract: A process for preparing a spermicidal agent from neem oil includes (a) mixing neem oil with an aliphatic hydrocarbon solvent so that a precipitate forms, and filtering the mixture to separate the filtrate solution from the precipitate; (b) contacting the filtrate solution of step (a) with a polar extractant solvent whereby a spermicidal agent is extracted from the filtrate solution into the polar extractant solvent; and (c) removing solvent from the polar extractant solvent to produce a concentrated solution containing extract a spermicidal agent.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: December 25, 2001
    Assignee: National Research Development Corporation
    Inventors: Govindaswamy Ilavazhagan, Chakra Devakumar
  • Patent number: 6294017
    Abstract: A method and apparatus for growing single crystal of GaAs, etc uses the Czochralski techniques. Control of crystal (1) diameter is by a closed loop (9, 10, 24, 7, 6) control of melt (4) temperature in response to crystal weight signals (9) W or dW/dt. The invention injects a test signal St (22, 26) into the control loop and performs a signal processing (21), e.g. cross correlation, on St and crystal weight signal. Peak amplitude of correlation values is related to the growing crystal shape. This is used by comparison with reference values (24) to control the growing-out phase from seed diameter (16) to full diameter of the crystal (1).
    Type: Grant
    Filed: February 22, 1993
    Date of Patent: September 25, 2001
    Assignee: The National Research Development Corporation
    Inventors: Donald Thomas James Hurle, Gordon Charles Joyce, Kathryn Elizabeth McKell
  • Patent number: 6083506
    Abstract: A process for the preparation of spermicidal agents and other biologically active materials from neem oil or extractives by subjecting a neem feed obtained from neem oil to the step of enrichment. Such a step of enrichment is carried out in a chromatographic column containing a sorbant, and the feed is eluted with a non polar followed by a polar solvent or mixtures thereof. In accordance with one embodiment, the feed is formed by subjecting neem oil to the step of solvent partition, the precipitate being removed therefrom and the filterate forming the feed. In accordance with another embodiment, the feed is formed by adding a polar solvent to the filterate of the first embodiment, the lower layer formed therefrom being subjected to the step of distillation for removal of the solvent to obtain a feed.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: July 4, 2000
    Assignee: National Research Development Corporation
    Inventors: Govindaswamy Ilavazhagan, Chakra Devakumar
  • Patent number: 5863996
    Abstract: A solution polymerization process for the preparation of a polymeric material having a weight average molecular weight from 5,000 to 20,000,000 and comprising cross-linked particles which are capable of forming a sol in the reaction solvent, which process comprises:(i) polymerizing one or more monomers, the or at least one of which is a cross-linking agent, in a solvent which (a) has a solubility parameter from 2.5 cal.sup.1/2 ml.sup.-3/2 below to 1.0 cal.sup.1/2 ml.sup.-3/2 above the solubility parameter of the bulk polymeric material and (b) is of the same or adjacent hydrogen bonding group as the bulk polymeric material;(ii) monitoring the polymerization until polymeric material as herein defined is obtained; and(iii) terminating the polymerization before gelation is observed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 26, 1999
    Assignee: National Research Development Corporation
    Inventor: Neil Bonnette Graham
  • Patent number: 5723207
    Abstract: Material transparent at infra red wavelengths, 3-5 and 8-14 .mu.m is formed of ZrN, YN, CeN, TLN, or EuN. The material can be used as a self supporting material or as a coating on substrates such as infra red transparent material e.g. Ge, ZnS, ZnSe, As.sub.2 S.sub.3, As.sub.2 Se.sub.3, optically transparent materials e.g. sodium glass, or reflecting surfaces such as metal surfaces, e.g. Al or silvered surfaces. For some substrates e.g. Ge a thin, e.g. 10-1,000 Angstrom bonding layer may be used to improve adhesion. Bonding layers may be Ge, Si, Ge.sub.x C.sub.1-x, Si.sub.x C.sub.1-x (0<x<1). The coating may be produced by sputtering in a glow discharge chamber using Ar and N gases.
    Type: Grant
    Filed: July 23, 1990
    Date of Patent: March 3, 1998
    Assignee: The National Research Development Corporation
    Inventors: Alan H Lettington, Colin Smith
  • Patent number: 5601821
    Abstract: An immunogen comprising a residue of a histamine-releasing peptide comprising a cationic N-terminal head and a hydrophobic C-terminal tail, together with a residue capable of eliciting antibodies against said peptide while inhibiting histamine release by said peptide is useful in anti-allergy treatment. Preferably the histamine-releasing peptide is of formula:Lys-Thr-Lys-Gly-Ser-Gly-Phe-Phe-Val-Phe, SEQ ID NO: 6optionally amidated at the C terminal.Antibodies to the histamine-releasing peptide are useful for passive immunization.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 11, 1997
    Assignee: National Research Development Corporation
    Inventors: Denis R. Stanworth, Ian V. Lewin, Sarita Nayyar, Valerie Jones
  • Patent number: 5439966
    Abstract: A temperature- and/or polar fluid-sensitive device which comprises a mechanically strained semi-crystalline hydrophilic polymer.
    Type: Grant
    Filed: January 7, 1993
    Date of Patent: August 8, 1995
    Assignee: National Research Development Corporation
    Inventors: Neil B. Graham, Marion E. McNeill
  • Patent number: 5395838
    Abstract: The invention relates to quinazoline derivatives, or pharmaceutically-acceptable salts thereof, which possess anti-tumour activity; to processes for their manufacture; and to pharmaceutical compositions containing them.The invention provides a quinazoline of the formula: ##STR1## wherein R.sup.1 is hydrogen or amino, or alkyl or alkoxy each of up to 6 carbon atoms; or R.sup.1 is substituted alkyl or alkoxy each of up to 3 carbon atoms;R.sup.2 is hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, halogenoalkyl or cyanoalkyl each of up to 6 carbon atoms;Ar is phenylene or heterocyclene;L is a group of the formula --CO.NH--, --NH.CO--, --CO.NR.sup.3 --, --NR.sup.3.CO--, --CH.dbd.CH--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 S--, --SCH.sub.2 --, --CO.CH.sub.2 --, --CH.sub.2.CO-- or --CO.O--, wherein R.sup.3 is alkyl of up to 6 carbon atoms; andY is aryl or heteroaryl or a hydrogenated derivative thereof; orY is a group of the formula --A--Y.sup.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: March 7, 1995
    Assignees: Imperial Chemical Industries PLC, National Research Development Corporation
    Inventors: Andrew J. Barker, Leslie R. Hughes, Peter R. Marsham, John Oldfield, Stephen J. Pegg