Patents Assigned to National University Corporation Chiba University
  • Publication number: 20220127415
    Abstract: A liquid composition includes a thiophene polymer; and at least one polymerization component selected from the group including a monomer and an oligomer.
    Type: Application
    Filed: September 28, 2021
    Publication date: April 28, 2022
    Applicants: FUJIFILM Business Innovation Corp., National University Corporation Chiba University
    Inventors: Wataru YAMADA, Satoya SUGIURA, Natsumi KANEKO, Katsuyoshi HOSHINO
  • Patent number: 11309741
    Abstract: A resonance oscillator circuit is provided to include first and second oscillators. The first oscillator includes a first LC resonator circuit and an amplifier element, and oscillates by shifting a phase of an output voltage with a predetermined phase difference and feeding the output voltage back to the amplifier element. The second oscillator oscillates by generating a gate signal, which has a frequency identical to that of the output voltage, and drives the amplifier element, by shifting the phase of the output voltage with the phase difference and feeding the gate signal back to an input terminal of the amplifier element, by using the amplifier element as a switching element and using the first oscillator as a feedback circuit. The phase difference is a value substantially independent of an inductance of the first LC resonator circuit and a load, to which the output voltage is applied.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: April 19, 2022
    Assignees: OMRON CORPORATION, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Taichi Mishima, Shingo Nagaoka, Takeshi Uematsu, Hiroo Sekiya
  • Patent number: 11304611
    Abstract: An image processing apparatus includes a processor including hardware. The processor is configured to: acquire video data; estimate a spatial distribution of a predetermined biological component for which a component spectrum temporally varies with respect to image data of a predetermined frame among a plurality of frames included in the video data; generate biological component video data in which the biological component is extracted from the video data based on the estimated spatial distribution of the biological component in the image data of the predetermined frame; and generate periodic variation video data of the biological component by applying, to the biological component video data, a filter for extracting a predetermined frequency component.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: April 19, 2022
    Assignees: OLYMPUS CORPORATION, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Munenori Fukunishi, Norimichi Tsumura, Koki Kurita
  • Patent number: 11285168
    Abstract: Tumor growth was found to be significantly suppressed in vivo by inhibiting both miRNA containing 5?-AACACUG-3? as a seed sequence and miRNA containing 5?-AAUACUG-3? as a seed sequence. The inhibition significantly altered the proportion of subpopulations of tumor cells and reduced the tumorigenicity in all subpopulations. The inhibition also exerted a remarkable tumor-shrinking effect on already-formed tumors. The present invention provides novel therapeutic potential against tumor.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: March 29, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Hideo Iba, Takeshi Haraguchi
  • Publication number: 20220075573
    Abstract: An information processing apparatus includes circuitry and a memory, the circuitry performing perceptual image conversion of converting two image data generated from one color image data respectively into perceptual images based on human visual characteristics, collation of determining whether the two perceptual images converted by the perceptual image conversion are same, and comparison result outputting of outputting the comparison result by the collation.
    Type: Application
    Filed: September 8, 2021
    Publication date: March 10, 2022
    Applicants: Ricoh Company, Ltd., National University Corporation Chiba University
    Inventors: Takahiko Horiuchi, Ren Nakamura, Midori Tanaka, Shoko Imaizumi, Tsuyoshi Sakamoto, Tatsuroh Yoshioka, Kazuhiro Miyabe
  • Publication number: 20220071929
    Abstract: Provided is a novel compound having rapid and long-lasting therapeutic effects on diseases exhibiting depressive symptoms. Specifically, provided are an agent for prevention and/or treatment of a depressive symptom, consisting of R(?)-ketamine or a pharmacologically acceptable salt thereof, and a pharmaceutical composition for prevention and/or treatment of a depressive symptom, comprising R(?)-ketamine or a pharmacologically acceptable salt thereof in an effective amount for reducing a depressive symptom, and being substantially free of S(+)-ketamine, and a pharmacologically acceptable salt thereof.
    Type: Application
    Filed: November 16, 2021
    Publication date: March 10, 2022
    Applicant: National University Corporation Chiba University
    Inventor: Kenji HASHIMOTO
  • Patent number: 11207279
    Abstract: Provided is a novel compound having rapid and long-lasting therapeutic effects on diseases exhibiting depressive symptoms. Specifically, provided are an agent for prevention and/or treatment of a depressive symptom, consisting of R(?)-ketamine or a pharmacologically acceptable salt thereof, and a pharmaceutical composition for prevention and/or treatment of a depressive symptom, comprising R(?)-ketamine or a pharmacologically acceptable salt thereof in an effective amount for reducing a depressive symptom, and being substantially free of S(+)-ketamine, and a pharmacologically acceptable salt thereof.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: December 28, 2021
    Assignee: National University Corporation Chiba University
    Inventor: Kenji Hashimoto
  • Patent number: 11193948
    Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4?-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: December 7, 2021
    Assignees: Tokyo University of Science, National University Corporation Chiba University, JEOL Ltd.
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Publication number: 20210373032
    Abstract: The present invention provides a method for acquiring data relating to the onset of cerebral infarction, characterized in that the method includes determining the level of an antibody to DIDO1 protein or a portion thereof, and/or the level of an antibody to CPSF2 protein or a portion thereof, the antibody or antibodies being present in a body fluid sample collected from a living body. The invention also provides a kit for acquiring data for carrying out the method of the present invention. The invention can accurately discern signs linked to the onset of cerebral infarction.
    Type: Application
    Filed: November 22, 2018
    Publication date: December 2, 2021
    Applicants: FUJIKURA KASEI CO., LTD., NATIONAL CANCER CENTER, UNIVERSITY OF TSUKUBA, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, OSAKA UNIVERSITY
    Inventors: Hideyuki KURODA, Rika NAKAMURA, Go TOMIYOSHI, Takaki HIWASA, Kazumasa YAMAGISHI, Shoichiro TSUGANE, Norie SAWADA, Hiroyasu ISO
  • Patent number: 11167050
    Abstract: Described are: [1] a compound or the like represented by the formula (1); [2] a compound or the like having a target molecule recognition element bound to the compound or the like described in the above [1]; and [3] a metal complex compound or the like having a metal selected from the group consisting of a radioactive metal and a radioactive atom-labeled metal, and the compound or the like described in the above [1] or [2] coordinated to the metal. Also described are uses of the compound or the like described in the above [1] or [2] or the metal complex compound or the like described in the above [3] in a radioactive drug, a radiotherapeutic agent or a radioactive diagnostic imaging agent.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: November 9, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Yasushi Arano, Tomoya Uehara, Hiroyuki Suzuki
  • Publication number: 20210301250
    Abstract: The purpose of the present invention is to provide a composition containing, as an active ingredient, a substance having rich history of use in foods or an ingestion experience in human and having an effect of inhibiting Fc?RI expression on a pDC. This purpose can be achieved by a composition for activating plasmacytoid dendritic cell comprising: at least one active ingredient selected from the group consisting of a bacterial cell, a bacterial component, and a culture of Pediococcus lactic acid bacteria, and a product obtained by treating any one of them, and having an effect of inhibiting Fc?RI expression on a plasmacytoid dendritic cell.
    Type: Application
    Filed: August 8, 2019
    Publication date: September 30, 2021
    Applicants: KIKKOMAN CORPORATION, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Yuki ISHIKAWA, Tadaomi KAWASHIMA, Masaki ADACHI, Naoki SHIMOJO
  • Publication number: 20210285863
    Abstract: The objective of the present invention is to provide a particle detection device and a particle detection method that can individually and continuously detect a wide range of particles. The objective is achieved by a particle detection device including: a particle separation channel through which particles are separated according to particle sizes in a perpendicular direction to the flow of fluid; and two or more particle recovery channels that are connected to and branched from the particle separation channel, in which each of the particle recovery channels includes a particle detection unit that includes an aperture and an electric detector.
    Type: Application
    Filed: February 13, 2018
    Publication date: September 16, 2021
    Applicants: TOSOH CORPORATION, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Kazuki IIJIMA, Toshinobu TOYOSHIMA, Kotohiro FURUKAWA, Koji KATAYAMA, Naotaka JIN, Minoru SEKI
  • Patent number: 11118158
    Abstract: Provided are a functional microbial material and a method for producing a fermentation product, wherein the functional microbial material and the fermentation product are environment-friendly and improve the quality of crops. The present invention relates to a microbial material and a method for producing a fermentation product wherein the microbial material and the fermentation product are obtained by fermentation of a fermentation raw material including a plant-derived raw material and an animal-derived raw material using a population of microorganisms including a plurality of species of thermophilic microorganisms, and lead to a remedy for soil and water pollution and to the inhibition of greenhouse gas generation, as well as contribute to improvements in the functionality of plants, particularly the expression of genes involved in biophylaxis and resistant to high-temperature disorder, and an increase in antioxidant components.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: September 14, 2021
    Assignees: JAPAN ECO SCIENCE CO., LTD., NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, MIROKU CO., LTD., KEIYO PLANT ENGINEERING CO., LTD.
    Inventors: Hirokuni Miyamoto, Hiroaki Kodama, Hisashi Miyamoto, Takumi Nishiuchi, Kazuto Ishikawa, Kazuo Ogawa, Toshiyuki Ito, Takuya Kamitai, Kenshiro Oshima, Wataru Suda, Masahira Hattori
  • Publication number: 20210277098
    Abstract: The present invention aims to obtain an anti-repulsive guidance molecule a (RGMa) antibody having a high binding activity and few side effects which can be used as a medicine for preventing, treating, or preventing the relapse of neurological or immunological diseases. The problem is solved by providing an isolated RGMa binding protein which does not inhibit binding between RGMa and neogenin but neutralizes the neurite outgrowth inhibiting activity of RGMa, preferably by providing an anti-RGMa antibody which has complementarity determining regions having amino acid sequences of SEQ ID NOS: 30-35 or SEQ ID NOS: 36-40 in Sequence Listing, and SFG.
    Type: Application
    Filed: May 17, 2021
    Publication date: September 9, 2021
    Applicants: MITSUBISHI TANABE PHARMA CORPORATION, OSAKA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Motonori HASHIMOTO, Toshihide YAMASHITA
  • Patent number: 11091668
    Abstract: A film having a metallic luster that is easier to manufacture and exhibits little degradation over time, an article having the film formed thereon, and a manufacturing method for the film having a metallic luster. The film, which has a metallic luster, is characterized by containing a thiophene polymer. The manufacturing method for the film which has a metallic luster is characterized by a thiophene being polymerized using an oxidizing agent and made into a solution containing the thiophene polymer, and then coating and drying the solution containing the thiophene polymer on an article. The article having the film, which has a metallic luster formed thereon, is characterized by containing a thiophene polymer.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: August 17, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Katsuyoshi Hoshino, Reo Tagawa
  • Publication number: 20210229341
    Abstract: A manufacturing method for manufacturing a colored product, where using inkjet heads which are a plurality of color ink heads, and an inkjet head, which is a colorless ink head, a plurality of coloring regions are formed in an overlapping manner in a normal direction, a surface side colored region, which is a region located closest to the surface of the colored product is formed using at least the color ink ejected from any of the inkjet heads, and an inner colored region, which is a region located farther from the surface of the colored product than the surface side colored region is formed using at least the color ink ejected from any of the inkjet heads and the colorless ink ejected from the inkjet head.
    Type: Application
    Filed: January 19, 2021
    Publication date: July 29, 2021
    Applicants: MIMAKI ENGINEERING CO., LTD., NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Wataru ARAI, Kunio Hakkaku, Norimichi Tsumura, Keita Hirai, Junki Yoshii
  • Publication number: 20210226111
    Abstract: A thermoelectric conversion element includes: a thermoelectric conversion layer containing a thiophene polymer, in which a peak intensity of a diffraction angle (2?) of 7.9° is 5 times or more a peak intensity of a diffraction angle (2?) of 25.8° in an X-ray diffraction spectrum of the thermoelectric conversion layer.
    Type: Application
    Filed: January 11, 2021
    Publication date: July 22, 2021
    Applicants: FUJI XEROX CO., LTD., NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Satoya SUGIURA, Wataru YAMADA, Katsuyoshi HOSHINO
  • Publication number: 20210179773
    Abstract: A composition for forming a metallic luster film, includes: a thiophene polymer, in which a total content of an Fe atom, a Cu atom, an Mn atom, a Cr atom, and a Ce atom in the composition for forming a metallic luster film is 1500 ppm or less with respect to the thiophene polymer.
    Type: Application
    Filed: December 8, 2020
    Publication date: June 17, 2021
    Applicants: FUJI XEROX CO., LTD., NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Wataru YAMADA, Satoya SUGIURA, Katsuyoshi HOSHINO, Rihito TAMURA, Kenta HORIKOSHI, Minako TACHIKI
  • Publication number: 20210170058
    Abstract: The present invention relates to a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and provides a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.
    Type: Application
    Filed: April 15, 2019
    Publication date: June 10, 2021
    Applicants: NIHON MEDI-PHYSICS CO., LTD., National University Corporation Kagoshima University, National University Corporation Chiba University
    Inventors: Shota KOMOTO, Yu OGAWA, Yoshinari SHOYAMA, Tadashi HATANO, Yuji ITO, Yasushi ARANO, Hiroyuki SUZUKI, Tomoya UEHARA
  • Patent number: 11008388
    Abstract: The present invention aims to obtain an anti-repulsive guidance molecule a (RGMa) antibody having a high binding activity and few side effects which can be used as a medicine for preventing, treating, or preventing the relapse of neurological or immunological diseases. The problem is solved by providing an isolated RGMa binding protein which does not inhibit binding between RGMa and neogenin but neutralizes the neurite outgrowth inhibiting activity of RGMa, preferably by providing an anti-RGMa antibody which has complementarity determining regions having amino acid sequences of SEQ ID NOS: 30-35 or SEQ ID NOS: 36-40 in Sequence Listing, and SFG.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: May 18, 2021
    Assignees: MITSUBISHI TANABE PHARMA CORPORATION, OSAKA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
    Inventors: Motonori Hashimoto, Toshihide Yamashita