Patents Assigned to National University Corporation Kagoshima University
-
Patent number: 11701440Abstract: Described is a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH (SEQ ID NO: 2) wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.Type: GrantFiled: April 15, 2019Date of Patent: July 18, 2023Assignees: NIHON MEDI-PHYSICS CO., LTD., NATIONAL UNIVERSITY CORPORATION KAGOSHIMA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITYInventors: Shota Komoto, Yu Ogawa, Yoshinari Shoyama, Tadashi Hatano, Yuji Ito, Yasushi Arano, Hiroyuki Suzuki, Tomoya Uehara
-
Publication number: 20210170058Abstract: The present invention relates to a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and provides a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.Type: ApplicationFiled: April 15, 2019Publication date: June 10, 2021Applicants: NIHON MEDI-PHYSICS CO., LTD., National University Corporation Kagoshima University, National University Corporation Chiba UniversityInventors: Shota KOMOTO, Yu OGAWA, Yoshinari SHOYAMA, Tadashi HATANO, Yuji ITO, Yasushi ARANO, Hiroyuki SUZUKI, Tomoya UEHARA
-
Method for concentrating viruses, method for concentrating cells or bacteria, and magnetic composite
Patent number: 9464281Abstract: A method for concentrating viruses includes applying a magnetic force to a mixture containing: sugar chain-immobilized magnetic metal nano-particles each having a structure in which a sugar chain-immobilized metal nano-particle is bound to a first magnetic nano-particle; second magnetic particles with mean particle size larger than that of the sugar chain-immobilized magnetic metal nano-particles; and a specimen. Each sugar chain-immobilized metal nano-particle has a structure where a ligand-conjugate is bound to a metal nano-particle via sulfur atoms. The ligand-conjugate has a structure where a linker compound's amino group is connected to a sugar chain having a reducing terminal. The linker compound includes, in molecules thereof, an amino group, sulfur atoms, and a hydrocarbon chain having carbon-nitrogen bonds.Type: GrantFiled: July 27, 2010Date of Patent: October 11, 2016Assignees: SUDx-Biotec Corporation, National University Corporation Kagoshima University, Neat Co., Ltd.Inventors: Yasuo Suda, Masahiro Wakao, Takashi Kodama -
Publication number: 20140295566Abstract: A novel ligand conjugate which is effectively utilizable for analyzing a function of a protein; a ligand-supporting object; and a method of analyzing a protein. The ligand conjugate has a structure which comprises: a linker compound having a structure represented by the following General Formula (1): (wherein n and p each is an integer of 0 to 6) in which X is a structure comprising one, two, or three hydrocarbon derivative chains which have an aromatic amino group at the end and may have a carbon-nitrogen bond in the main chain, Y is a hydro-carbon structure containing one or more sulfur atoms, and Z is a straight-chain structure comprising a carbon-carbon bond or carbon-oxygen bond; and a sugar which has a reducing end and is bonded to the linker compound through the aromatic amino group.Type: ApplicationFiled: May 9, 2014Publication date: October 2, 2014Applicants: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventor: Yasuo SUDA
-
Patent number: 8765384Abstract: A novel ligand conjugate which is effectively utilizable for analyzing a function of a protein; a ligand-supporting object; and a method of analyzing a protein. The ligand conjugate has a structure which comprises: a linker compound having a structure represented by the following General Formula (1): (wherein n and p each is an integer of 0 to 6) in which X is a structure comprising one, two, or three hydrocarbon derivative chains which have an aromatic amino group at the end and may have a carbon-nitrogen bond in the main chain, Y is a hydro-carbon structure containing one or more sulfur atoms, and Z is a straight-chain structure comprising a carbon-carbon bond or carbon-oxygen bond; and a sugar which has a reducing end and is bonded to the linker compound through the aromatic amino group.Type: GrantFiled: February 18, 2005Date of Patent: July 1, 2014Assignees: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventor: Yasuo Suda
-
Patent number: 8575131Abstract: An object of the present invention is to provide a uronic acid-containing glucan or a modified product thereof. The glucuronic acid-containing glucan of the present invention is a glucuronic acid-containing glucan in which a glucuronic acid residue is bound to at least one non-reducing end of a glucan, and the glucan is a branched ?-1,4 glucan or a linear ?-1,4 glucan. The glucuronic acid-containing glucan of the present invention can be provided by allowing ?-glucan phosphorylase derived from Aquifex aeolicus VF5 to act on glucuronic acid-1-phosphate to thereby transfer a glucuronic acid residue to the non-reducing end of the receptor glucan.Type: GrantFiled: May 10, 2010Date of Patent: November 5, 2013Assignees: National University Corporation Kagoshima University, Ezaki Glico Co., Ltd.Inventors: Junichi Kadokawa, Takeshi Takaha, Akiko Kubo, Michiyo Yanase, Kayo Hosoya
-
Patent number: 8067393Abstract: It is intended to provide a stable novel sugar-immobilized metal nanoparticle capable of easily immobilizing a sugar chain, a method for measuring sugar-protein interaction easily and at a low cost using the same without labeling, and a method for simply recovering a protein from a sugar-protein interactant. A maltose-immobilized gold nanoparticle was obtained by binding a ligand complex, in which maltose and a linker compound had been bound to each other, to a gold nanoparticle. By adding this maltose-immobilized gold nanoparticle to a dilution series of concanavalin A, a sugar-protein interactant of maltose and ConA was formed, and red-purple color derived from a colloidal solution of maltose-immobilized gold nanoparticle disappeared. That is, sugar-protein interaction could be confirmed by visual observation without labeling.Type: GrantFiled: May 26, 2006Date of Patent: November 29, 2011Assignees: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventors: Yasuo Suda, Tomoaki Nishimura, Yuko Kishimoto, Hiromi Nakagawa
-
METHOD FOR CONCENTRATING VIRUSES, METHOD FOR CONCENTRATING CELLS OR BACTERIA, AND MAGNETIC COMPOSITE
Publication number: 20110027854Abstract: A method for concentrating viruses includes applying a magnetic force to a mixture containing: sugar chain-immobilized magnetic metal nano-particles each having a structure in which a sugar chain-immobilized metal nano-particle is bound to a first magnetic nano-particle; second magnetic particles with mean particle size larger than that of the sugar chain-immobilized magnetic metal nano-particles; and a specimen. Each sugar chain-immobilized metal nano-particle has a structure where a ligand-conjugate is bound to a metal nano-particle via sulfur atoms. The ligand-conjugate has a structure where a linker compound's amino group is connected to a sugar chain having a reducing terminal. The linker compound includes, in molecules thereof, an amino group, sulfur atoms, and a hydrocarbon chain having carbon-nitrogen bonds.Type: ApplicationFiled: July 27, 2010Publication date: February 3, 2011Applicants: SUDx-Biotec Corporation, National University Corporation Kagoshima University, Neat Co., Ltd.Inventors: Yasuo SUDA, Masahiro Wakao, Takashi Kodama -
Patent number: 7838549Abstract: The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.Type: GrantFiled: February 4, 2005Date of Patent: November 23, 2010Assignees: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventors: Yasuo Suda, Akio Arano, Shoichi Kusumoto, Michael Sobel, Masahiro Wakao
-
Publication number: 20090151240Abstract: An apparatus for carrying out algae intensive-cultivation while conducting an environmental control most suitable for growth of algae in an artificial environment including dissolved gas, light, temperature, nutrient source and sanitary atmosphere; and a method of intensive cultivation therewith.Type: ApplicationFiled: April 18, 2005Publication date: June 18, 2009Applicant: NATIONAL UNIVERSITY CORPORATION KAGOSHIMA UNIVERSITYInventors: Hiroyuki Kayama, Shusaku Kadowaki
-
Patent number: 7320867Abstract: A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a carbon-nitrogen bond in a backbone.Type: GrantFiled: September 8, 2003Date of Patent: January 22, 2008Assignees: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventors: Yasuo Suda, Akio Arano, Shoichi Kusumoto, Michael Sobel
-
Publication number: 20070287195Abstract: A novel ligand conjugate which is effectively utilizable for analyzing a function of a protein; a ligand-supporting object; and a method of analyzing a protein. The ligand conjugate has a structure which comprises: a linker compound having a structure represented by the following General Formula (1): (wherein n and p each is an integer of 0 to 6) in which X is a structure comprising one, two, or three hydrocarbon derivative chains which have an aromatic amino group at the end and may have a carbon-nitrogen bond in the main chain, Y is a hydro-carbon structure containing one or more sulfur atoms, and Z is a straight-chain structure comprising a carbon-carbon bond or carbon-oxygen bond; and a sugar which has a reducing end and is bonded to the linker compound through the aromatic amino group.Type: ApplicationFiled: February 18, 2005Publication date: December 13, 2007Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, NATIONAL UNIVERSITY CORPORATION KAGOSHIMA UNIVERSITYInventor: Yasuo Suda
-
Publication number: 20070213523Abstract: The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.Type: ApplicationFiled: February 4, 2005Publication date: September 13, 2007Applicants: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventors: Yasuo Suda, Akio Arano, Shoichi Kusumoto, Michael Sobel, Masahiro Wakao
-
Patent number: 7183067Abstract: A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof. With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility. Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.Type: GrantFiled: August 6, 2003Date of Patent: February 27, 2007Assignees: Japan Science and Technology Agency, National University Corporation Kagoshima UniversityInventors: Yasuo Suda, Akio Arano, Hideki Hayashi, Shoichi Kusumoto, Michael Sobel