Patents Assigned to National University Corporation Tokyo Medical and Dental University
  • Publication number: 20220307019
    Abstract: A double-stranded nucleic acid complex is a double-stranded nucleic acid complex including a first nucleic acid strand and a second nucleic acid strand bonded to each other, the second nucleic acid strand including a complementary region having a base sequence complementary to the first nucleic acid strand; the first nucleic acid strand including natural nucleosides and non-natural nucleosides; some of the nucleosides in at least one nucleic acid strand selected from the group consisting of the first nucleic acid strand and the second nucleic acid strand being bonded together by bonds including asymmetric phosphorus atoms; and absolute configurations of the asymmetric phosphorus atoms being regulated.
    Type: Application
    Filed: March 25, 2020
    Publication date: September 29, 2022
    Applicants: National University Corporation Tokyo Medical and Dental University, Wave Life Sciences Ltd
    Inventors: Takanori YOKOTA, Takeshi WADA, Mamoru SHIMIZU
  • Publication number: 20220296143
    Abstract: A biomagnetism measurement apparatus includes a memory and a processor configured to set a curved surface as a region-of-interest based on a morphological image including a portion to be evaluated of a subject, the morphological image being acquired by an image acquisition apparatus, and the curved surface being a surface on which an anterior-posterior position of the subject changes in a cranial-caudal direction and in a left-right direction along a position of a nerve to be evaluated. The processor is further configured to estimate current distribution in the region-of-interest based on magnetic data, the magnetic data being acquired by measuring a magnetic field with a magnetic measurement instrument, and the magnetic field being generated by an electrical activity of a nerve in the portion to be evaluated.
    Type: Application
    Filed: March 14, 2022
    Publication date: September 22, 2022
    Applicants: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental University
    Inventors: Koki ISHIDA, Taishi WATANABE, Shigenori KAWABATA, Jun HASHIMOTO
  • Patent number: 11443717
    Abstract: A biometric information display device includes a display controller configured to display a morphological image indicative of a morphology of a subject, on a display, an input controller configured to receive a designation of a specified position on the morphological image, a pathway generating section configured to generate a pathway based on the specified position on the morphological image, and a current extracting section configured to extract current components at a plurality of positions along the pathway, based on current information reconstructed based on magnetic field measurement data generated by the subject. The display controller displays the current components extracted along the pathway on the display.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: September 13, 2022
    Assignees: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental University
    Inventors: Yoichiro Takahashi, Taishi Watanabe, Shigenori Kawabata
  • Patent number: 11433089
    Abstract: The present invention provides a composition and a method for efficiently delivering a nucleic acid agent to the central nervous system and/or the retina and bringing about antisense effects. Provided is a composition for reducing the expression level of a target transcription product in the central nervous system and/or retina of a subject, the composition including a nucleic acid complex that includes a first nucleic acid strand and a second nucleic acid strand, wherein: the first nucleic acid strand comprises a base sequence capable of hybridizing with at least part of the target transcription product and has an antisense effect on the target transcription product; the second nucleic acid strand comprises a base sequence complementary to the first nucleic acid strand and is conjugated to tocopherol, cholesterol, or an analog thereof; and the first nucleic acid strand is annealed to the second nucleic acid strand.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: September 6, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Takanori Yokota, Tetsuya Nagata
  • Patent number: 11412945
    Abstract: The present invention addresses the problem of providing a muscle activity measurement device and a muscle activity measurement method which make it possible to measure the muscle activity of an object to be sensed with increased accuracy. The muscle activity measurement device is provided with a magnetic sensor unit which senses a magnetic field generated from a living body. The muscle activity measurement device identifies an installed direction of the muscle activity measurement device, and includes an indication, on a surface of a container, which comprises identification information for installing the muscle activity measurement device in such a way that a magnetism sensing direction X of the magnetic sensor unit and the direction in which the muscle fibers of the living body as the object to be sensed extend are substantially orthogonal to each other.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: August 16, 2022
    Assignees: National University Corporation Tokyo Medical and Dental University, TDK CORPORATION
    Inventors: Shigenori Kawabata, Shuichi Okawa, Shuta Ushio
  • Publication number: 20220233656
    Abstract: The present invention relates to an antibacterial composition and the like having antibacterial property against Acinetobacter. The present invention provides an antibacterial composition comprising a complex of lysozyme and chitosan bound together, with antibacterial property against Acinetobacter; and a pharmaceutical composition for treating or preventing an Acinetobacter infection, comprising a complex of lysozyme and chitosan bound together.
    Type: Application
    Filed: May 27, 2020
    Publication date: July 28, 2022
    Applicants: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, WAKO FILTER TECHNOLOGY CO., LTD.
    Inventors: Yasunari MIYAZAKI, Hiroki KAGESHIMA, Akira SAITO
  • Patent number: 11375934
    Abstract: A biomagnetic measurement apparatus includes a table on which a subject is placed; a biomagnetic detector configured to detect a biomagnetic field of the subject; a supporter configured to support a detection target region from which the biomagnetic field of the subject is detected; a radiation detector provided below the supporter; and a position changer configured to change relative positions of the biomagnetic detector and the detection target region. The supporter has a surface shape that corresponds to a surface of the biomagnetic detector.
    Type: Grant
    Filed: November 23, 2018
    Date of Patent: July 5, 2022
    Assignees: Ricoh Company, Ltd., NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Yoshinori Okada, Yoshihisa Naijo, Hiroshi Deguchi, Taishi Watanabe, Yuki Miyano, Shigenori Kawabata
  • Publication number: 20220202371
    Abstract: A biological-data processing apparatus includes a processor; and a memory that includes instructions, which when executed, cause the processor to execute performing an addition-averaging process every time an addition count of biological data reaches a predetermined count, the biological data being measured in response to a trigger signal associated with a stimulus applied to one or more parts; storing, in a storage, addition-average data resulting from the addition-averaging process performed for each of the stimulated one or more parts, in association with the addition count in the addition-average data; and performing a biological data process based on the biological data, by using the addition-average data corresponding to each of the stimulated one or more parts, the addition-average data being acquired by referring to the storage based on the addition count that is specified.
    Type: Application
    Filed: December 22, 2021
    Publication date: June 30, 2022
    Applicants: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental University
    Inventors: Fumikazu HOSHI, Yuki Miyano, Hideaki Yamagata, Shigenori Kawabata, Nobuyori Nagaoka, Taishi Watanabe
  • Publication number: 20220177922
    Abstract: One of the purposes of the present invention is to provide a method for producing a gene-edited tissue stem cell in an undifferentiated state within a short period of time. Another one of the purposes of the present invention is to provide a method for treating and/or preventing a disease using a gene-edited tissue stem cell in an undifferentiated state. A gene-edited tissue stem cell is produced by a method comprising a step for editing the gene sequence of a target gene in tissue stem cells, and a step for selecting the tissue stem cells having an edited gene sequence, and optionally, further comprising a step for adding a tag to the gene sequence of the target gene and/or a step for activating gene expression of the target gene in the tissue stem cells. The tissue stem cell thus produced is used in treating/preventing diseases.
    Type: Application
    Filed: March 9, 2020
    Publication date: June 9, 2022
    Applicants: National University Corporation Tokyo Medical and Dental University, SYSMEX CORPORATION
    Inventors: Hiroshi ASAHARA, Ryota KURIMOTO, Takahide MATSUSHIMA, Hiroki TSUTSUMI
  • Publication number: 20220175817
    Abstract: A nucleic acid complex that exhibits an excellent antisense effect in the skeletal muscle and/or heart muscle, and a composition for treating or preventing a muscle disease that develops in the skeletal muscle, heart muscle, and the like having the nucleic acid complex as an active ingredient is disclosed. Also provided is a double-stranded nucleic acid complex in which a first nucleic acid strand that hybridizes to the transcription product of a target gene and has an antisense effect on the transcription product is annealed with a second nucleic acid strand that has a base sequence complementary to the first nucleic acid strand and is bound to cholesterol or analog thereof.
    Type: Application
    Filed: April 8, 2020
    Publication date: June 9, 2022
    Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Takanori YOKOTA, Tetsuya NAGATA
  • Publication number: 20220167904
    Abstract: An atrial fibrillation analysis device includes: a hardware processor that: acquires P-wave data from only one of either: a first electrocardiogram in a lead of one direction on a plane including a body-axis direction and a left-right direction with respect to a subject, or a second electrocardiogram in leads of two directions orthogonal to each other on the plane; extracts P-wave fragments from the acquired P-wave data; and analyzes a possibility of development of atrial fibrillation based on at least one of a number of the P-wave fragments and a duration of the P-wave fragments.
    Type: Application
    Filed: December 23, 2019
    Publication date: June 2, 2022
    Applicants: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, KONICA MINOLTA, INC.
    Inventors: Tetsuo Sasano, Kanae Sasaki
  • Publication number: 20220160779
    Abstract: The present inventors have clarified that activin has an activity of promoting the proliferation of MSCs and an activity of promoting the regeneration of meniscus or cartilaginous tissue without affecting differentiation multipotency. Further, the present inventors have also found that the use of activin makes it possible to treat and prevent meniscus damage or cartilage disorders, including suppression of degenerative degeneration of cartilage and pain.
    Type: Application
    Filed: March 19, 2020
    Publication date: May 26, 2022
    Applicant: National University Corporation Tokyo Medical and Dental University
    Inventors: Kunikazu TSUJI, Miyoko OJIMA, Takeshi MUNETA, Hideyuki KOGA, Ichiro SEKIYA
  • Publication number: 20220155309
    Abstract: The present invention provides a fusion protein of an antigen-binding protein and a fluorescent protein or a fluorescence-labeled tag protein. The present invention provides a fusion protein of an antigen-binding protein and a fluorescent protein or a fluorescence-labeled tag, wherein the antigen-binding protein is an antigen-binding protein having a helix structure or a ?-sheet structure at a terminus, the fluorescent protein or the fluorescence-labeled tag is a fluorescent protein or a fluorescence-labeled tag having a helix structure or a ?-sheet structure at a terminus, and the helix at the terminus and the helix at the terminus are linked, or the ?-sheet structure at the terminus and the ?-sheet structure at the terminus are linked.
    Type: Application
    Filed: February 26, 2020
    Publication date: May 19, 2022
    Applicant: National University Corporation Tokyo Medical and Dental University
    Inventors: Sumio TERADA, Keisuke SATO, Nori NAKAI, Kenta SAITO, Masahiko KAWAGISHI
  • Publication number: 20220157412
    Abstract: A clinical trial matching apparatus according to an embodiment includes processing circuitry. The processing circuitry receives patient information. The processing circuitry retrieves a clinical trial matching the patient from clinical trials based on the patient information, by referring to storage circuitry that stores data for associating a clinical trial in which medication conditions are set with the results of the clinical trial, for the clinical trials. The processing circuitry presents the retrieved clinical trial. The processing circuitry collects, and stores in the storage circuitry, the results obtained by conducting the retrieved clinical trial on the patient and patient's clinical information. The processing circuitry updates the conditions of the retrieved clinical trial based on the clinical information, when there is clinical information that can identify a significant difference in drug efficacy in the collected clinical information.
    Type: Application
    Filed: January 31, 2022
    Publication date: May 19, 2022
    Applicants: National University Corporation Tokyo Medical and Dental University, CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Sadakatsu IKEDA, Eri ISHIBASHI, Kei MORI, Fuminori FUJITA, Shoichi KANAYAMA, Kimiko YOKOTA, Naoki OOWAKI
  • Publication number: 20220154185
    Abstract: Provided is a nucleic acid inhibiting a function of a target miRNA. Provided is a double-stranded nucleic acid complex comprising a first nucleic acid strand of 6 to 30 nucleotide length that hybridizes to a target miRNA to inhibit a function of the target miRNA, and a second nucleic acid strand complementary to the first nucleic acid strand, wherein the first nucleic acid strand is a mixmer comprising a natural nucleoside and a non-natural nucleoside, and the second nucleic acid strand comprises at least one of one or more modified internucleoside linkages and one or more sugar modified nucleosides.
    Type: Application
    Filed: February 2, 2022
    Publication date: May 19, 2022
    Applicant: National University Corporation Tokyo Medical and Dental University
    Inventors: Takanori Yokota, Kotaro Yoshioka
  • Publication number: 20220143263
    Abstract: Provided is a thrombin-carrying hemostatic sheet that is suitable for hemostasis during surgery, in particular, for hemostasis during spine surgery, that is convenient without preparation before use, and that is bioabsorbable and can be embedded in the body as it is. The hemostatic sheet is composed of a gelatin sponge carrying an effective amount of thrombin, wherein (A) the density is 30 to 55 mg/cm3, and (B) the shape maintaining angle in wet conditions is 55 to 120°.
    Type: Application
    Filed: March 19, 2020
    Publication date: May 12, 2022
    Applicants: Astellas Pharma Inc., National University Corporation Tokyo Medical and Dental University
    Inventors: Makoto OGINO, Keiichi YOSHIHARA, Yasuharu KIMURA, Megumi AOKI, Toshitaka YOSHII, Satoru EGAWA
  • Publication number: 20220135972
    Abstract: An object of the present invention is to provide a double-stranded nucleic acid complex having a reduced number of PS modifications in an antisense strand and maintaining an antisense effect. An optimal PS modification pattern for double-stranded nucleic acid complexes is disclosed. Such a nucleic acid complex comprising an antisense strand having an optimal PS modification pattern has a characteristic of having low toxicity and high bioavailability. The double-stranded nucleic acid complex comprising an antisense strand having an optimal PS modification pattern according to the present invention is useful when used as a nucleic acid drug that utilizes inhibition of expression of a specific gene (knockdown), activity that changes the function of coating or non-coding RNA for a specific gene, or activity that changes the function of RNA by inducing exon skipping during processing of pre-mRNA for a specific gene.
    Type: Application
    Filed: February 20, 2020
    Publication date: May 5, 2022
    Applicant: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Takanori YOKOTA, Rintaro HARA, Tetsuya NAGATA, Hideki KIZAWA, Koh TAKAGI
  • Patent number: 11317843
    Abstract: The objective of the present invention is to provide a biomagnetism measuring device capable of accurately detecting biomagnetism regardless of the object to be measured. This biomagnetism measuring device (1) is provided with: a plurality of magnetic sensors (11) which detect biomagnetism of a living body (100); a retaining portion (12) including retaining holes (12a) which retain the plurality of magnetic sensors (11) with freedom to move individually; and a movement mechanism which moves the magnetic sensors (11) individually in a contacting/separating direction causing the magnetic sensors (11) to come into contact with or separate from the living body (100). As movement mechanisms there may be mentioned, for example, a pneumatic/hydraulic mechanism (20), a resilient body mechanism (30), a screw mechanism (40) and a gear mechanism (50).
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: May 3, 2022
    Assignees: National University Corporation Tokyo Medical and Dental University, TDK CORPORATION
    Inventors: Shigenori Kawabata, Takato Fukui, Tomohiko Shibuya
  • Patent number: 11298372
    Abstract: The present invention provides novel compositions for suppressing or improving hair loss, and compositions for suppressing or improving graying. More specifically, it provides agents that stabilize type XVII collagen expression, preferably agents that suppress the degradation of type XVII collagen by ELANE inhibitors and such, and compositions comprising a DNA repair-promoting agent or a DNA damage-suppressing agent as an active ingredient. Advantageous suppressive effects of hair loss and graying can be obtained when a composition comprising as an active ingredient a suppressive agent of type XVII collagen degradation such as an ELANE inhibitor is administered to a mammal. For the ELANE inhibitors, suppressive agents of type XVII collagen degradation and DNA repair-promoting agents, low-molecular compounds, polypeptides, proteins, antibodies, or nucleic acid medicine such as antisense oligos or siRNAs may be used.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: April 12, 2022
    Assignee: National University Corporation Tokyo Medical and Dental University
    Inventors: Emi Nishimura, Hiroyuki Matsumura
  • Patent number: 11260085
    Abstract: There is provided a salt-tolerant Lactobacillus having high foodstuff suitability, being easily produced, and having an immunostimulatory action. Salt-tolerant Lactobacillus having an immunostimulatory action with viability and activation potency of B cells.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: March 1, 2022
    Assignees: ICHIBIKI CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi