Patents Assigned to National University Corporation Tokyo Medical and Dental University
  • Publication number: 20240228972
    Abstract: An object of the present invention is to provide an ever-better method for producing sinusoidal endothelial cells. The present invention provides a method for producing sinusoidal endothelial cells from sinusoidal endothelial progenitor cells, the method comprising the step of culturing the sinusoidal endothelial progenitor cells in a medium containing one or more substances selected from the interleukin 6 (IL-6) family, for example, oncostatin M (OSM), interleukin 6 (IL-6), or interleukin 11 (IL-11).
    Type: Application
    Filed: April 27, 2022
    Publication date: July 11, 2024
    Applicants: National University Corporation Tokyo Medical and Dental University, Takeda Pharmaceutical Company Limited
    Inventors: Takanori TAKEBE, Norikazu SAIKI
  • Publication number: 20240212103
    Abstract: To provide an information processing apparatus and the like that are capable of dividing an image indicating movement of a subject into a chest region and an abdominal region along anatomical knowledge. The information processing apparatus inputs time-series distance image data acquired by measuring a distance from a subject during a breathing exercise. The apparatus calculates a standard deviation image indicating a standard deviation of values for each pixel in a distance image indicated by the time-series distance image data. The apparatus executes division processing of dividing the standard deviation image into the chest region and the abdominal region of the subject by using a differential value in a direction of an intersection line between a sagittal plane and a frontal plane of the subject with respect to the standard deviation image. The apparatus outputs a result of the division processing by superimposing the result on the standard deviation image.
    Type: Application
    Filed: December 21, 2023
    Publication date: June 27, 2024
    Applicants: NEC CORPORATION, National University Corporation Tokyo Medical and Dental University
    Inventors: Makoto YASUKAWA, Keisuke SUZUKI, Shuhei NOYORI, Akimoto NIMURA, Koji FUJITA, Takuya IBARA
  • Publication number: 20240206769
    Abstract: An information processing apparatus and the like capable of calculating a respiratory feature amount necessary for evaluating a breathing motor function of a subject is provided. The information processing apparatus inputs time-series distance image data acquired by measuring a distance from the subject during a breathing exercise and division position data indicating a position at which a chest region and an abdominal region of the subject are divided in the time-series distance image data. The information processing apparatus calculates a standard deviation image indicating a standard deviation of values for each pixel in a distance image indicated by the time-series distance image data. The information processing apparatus calculates a respiratory feature amount indicating a feature of breathing of the subject, based on a divided standard deviation image acquired by dividing the standard deviation image for each divided region being divided at a position indicated by the division position data.
    Type: Application
    Filed: December 26, 2023
    Publication date: June 27, 2024
    Applicants: NEC CORPORATION, National University Corporation Tokyo Medical and Dental University
    Inventors: Makoto YASUKAWA, Shuhel NOYORI, Akimoto NIMURA, Koji FUJITA, Takuya IBARA
  • Patent number: 12004915
    Abstract: Removable denture data of a removable denture is produced, and disk frame data of a disk frame in which the removable denture is accommodated is produced, thereby building the disk frame based on the disk frame data. Next, a resin disk in which artificial teeth are embedded is produced by arranging the artificial teeth in the disk frame and curing a base resin, and a denture base is milled by milling the resin disk based on the removable denture data, thereby manufacturing the removable denture in which a base side of the artificial teeth is embedded in the denture base. As a result, artificial teeth having an excellent aesthetics may be used, it is possible to firmly join the artificial teeth and the denture base to each other, and it is possible to manufacture a removable denture with a favorable restoration accuracy of the artificial teeth.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: June 11, 2024
    Assignee: National University Corporation Tokyo Medical and Dental University
    Inventors: Manabu Kanazawa, Yumika Soeda, Maiko Iwaki, Toshio Arakida, Tamaki Hada, Shunsuke Minakuchi
  • Publication number: 20240158790
    Abstract: A method of reducing the level of a transcription product in a cell comprising contacting with the cell a composition comprising a double-stranded nucleic acid complex comprising a first nucleic acid strand annealed to a second nucleic acid strand, wherein: (i) the first nucleic acid strand hybridizes to the transcription product and comprises (a) a region consisting of at least 4 consecutive nucleotides that are recognized by RNase H when the strand is hybridized to the transcription product, (b) one or more nucleotide analogs located on 5? terminal side of the region, (c) one or more nucleotide analogs located on 3? terminal side of the region and (d) a total number of nucleotides and nucleotide analogs ranging from 8 to 35 nucleotides and (ii) the second nucleic acid strand comprises (a) nucleotides and optionally nucleotide analogs and (b) at least 4 consecutive RNA nucleotides.
    Type: Application
    Filed: December 21, 2023
    Publication date: May 16, 2024
    Applicants: National University Corporation Tokyo Medical and Dental University, Osaka University
    Inventors: Takanori Yokota, Kazutaka Nishina, Satoshi Obika, Hidehiro Mizusawa
  • Publication number: 20240158740
    Abstract: The present invention provides the following method as an approach for enriching desired cells, particularly, yolk sac mesoderm cells or amniotic ectoderm cells, contained in an embryogenesis region-specific micropattern structure of a cell cluster formed by differentiation-inducing factors from a colony of pluripotent stem cells such as iPS cells: a method for producing a cell cluster enriched in desired cells from pluripotent stem cells, comprising the step of two-dimensionally culturing the pluripotent stem cells under Wnt signal regulation.
    Type: Application
    Filed: March 8, 2022
    Publication date: May 16, 2024
    Applicants: National University Corporation Tokyo Medical and Dental University, Takeda Pharmaceutical Company Limited
    Inventors: Takanori TAKEBE, Norikazu SAIKI
  • Patent number: 11980493
    Abstract: An image processing apparatus includes a processor programmed to obtain a first radiation image of a subject captured from a first direction, obtain a second radiation image of the subject captured from a second direction that intersects the first direction, and either correct one of the first radiation image and the second radiation image based on positional information of a device for capturing the one of the first radiation image and the second radiation image, or correct another one of the first radiation image and the second radiation image based on information on a position of a specific region of the subject obtained from the one of the first radiation image and the second radiation image.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: May 14, 2024
    Assignees: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental University
    Inventors: Taishi Watanabe, Akira Kinoshita, Masahiro Takada, Shigenori Kawabata
  • Publication number: 20240117346
    Abstract: In an embodiment, an object of the present invention is to provide a double-stranded nucleic acid complex having a novel structure. In an embodiment, the present invention relates to a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein said first nucleic acid strand: (1) is capable of hybridizing to at least a part of a target transcriptional product; (2) has an antisense effect on the target transcriptional product; and (3) is a gapmer comprising a central region, and a 5? wing region and a 3? wing region, said second nucleic acid strand comprises at least one sugar-unmodified central region (first exposed region) consisting of one sugar-unmodified ribonucleoside or two or three contiguous sugar-unmodified ribonucleosides linked by an internucleoside bond, which is or are complementary to a part of said first nucleic acid strand, and said first nucleic acid strand is annealed to said second nucleic acid strand.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 11, 2024
    Applicants: National University Corporation Tokyo Medical and Dental University, Takeda Pharmaceutical Company Limited
    Inventors: Takanori Yokota, Tetsuya Nagata, Hiroki Yamada, Hideki Furukawa, Takatoshi Yogo, Kenichi Miyata, Akio Uchida, Naoki Tomita
  • Publication number: 20240081980
    Abstract: A vocalization assistance device includes: a mounting body that is mounted in an oral cavity of a person and that has a facing portion facing a palate of the person; a diaphragm that is provided at the facing portion and that is capable of outputting a sound recorded by a device having a recording function, as an original sound; and a passage that is provided at the facing portion and that is configured to transmit the original sound output from the diaphragm to a rear side of the oral cavity.
    Type: Application
    Filed: January 25, 2022
    Publication date: March 14, 2024
    Applicant: National University Corporation Tokyo Medical and Dental University
    Inventors: Haruka TOHARA, Taishi YAMADA, Kazuharu NAKAGAWA, Kohei YAMAGUCHI, Daiki MIZUGUCHI
  • Publication number: 20240050189
    Abstract: A biomagnetic field measurement device includes an irradiation unit configured to irradiate a subject with radiation; an imaging unit having a light-receiving surface for receiving radiation, the imaging unit being configured to image the subject based on the radiation from the irradiation unit; a marker part configured to absorb the radiation from the irradiation unit; and a processing circuit configured to output biological information based on third position information of the marker part and an imaged result of the subject by the imaging unit, the third position information of the marker part being calculated from first position information of the marker part, second position information of the irradiation unit, and a captured image of the marker part imaged by the imaging unit.
    Type: Application
    Filed: August 8, 2023
    Publication date: February 15, 2024
    Applicants: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental University
    Inventors: Masahiro Takada, Shigenori Kawabata, Akira Kinoshita
  • Publication number: 20240034836
    Abstract: A coating agent including a polyrotaxane represented by Formula (1): wherein R1 is a hydrogen atom or a methyl group, m is 1 to 2000, and n is 10 to 500, is a cyclodextrin in which at least one hydroxyl group is modified with R2, and R2 is a C1-6 alkyl group.
    Type: Application
    Filed: November 10, 2021
    Publication date: February 1, 2024
    Applicants: DENKA COMPANY LIMITED, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Ruriko AOYAMA SEKIYA, Nobuhiko YUI, Yoshinori ARISAKA, Tetsuya YODA, Hiroki MASUDA
  • Publication number: 20240023862
    Abstract: A diagnostic support apparatus includes a computing unit that computes a decreasing rate of a current intensity of an inward current flowing into a nerve pathway, based on magnetic field data obtained by measuring a magnetic field generated by a subject.
    Type: Application
    Filed: January 11, 2022
    Publication date: January 25, 2024
    Applicants: Ricoh Company, Ltd., National University Corporation Tokyo Medical and Dental University
    Inventors: Nobuyori NAGAOKA, Taishi WATANABE, Shigenori KAWABATA
  • Patent number: 11877764
    Abstract: The present invention provides a coronary artery bypass surgery treatment tool or the like including a flexible tube, a suction cup in which an opening portion is formed to communicate with the flexible tube and which is provided at a distal end of the flexible tube, a joint portion which has a suction path, a male connector which is provided in one of a proximal end of the flexible tube and a distal end of the suction path of the joint portion, and a female connector which is provided in the other thereof and is detachably connected to the male connector.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: January 23, 2024
    Assignees: SUMITOMO BAKELITE CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Hirokuni Arai, Toshifumi Sakate, Akira Kawamata, Shinetsu Harata
  • Publication number: 20230414669
    Abstract: There are provided a production method for a therapeutic agent for arthrosis, in which a population including a plurality of mesenchymal stem cells being cultured is imaged to acquire a cell image, the cell image is analyzed to derive density information on the mesenchymal stem cells in the cell image, colonies, which are formed by the mesenchymal stem cells in the population, are detected based on the density information, and the population is sorted based on at least one of an average colony size or a colony forming unit, which is derived from the detected colonies, and provided a therapeutic agent for arthrosis, which is produced by the production method for a therapeutic agent for arthrosis.
    Type: Application
    Filed: September 8, 2023
    Publication date: December 28, 2023
    Applicants: FUJIFILM Corporation, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Kentaro NAKAMURA, Shunsuke TOMINAGA, Ichiro SEKIYA, Mitsuru MIZUNO, Hisako KATANO, Nobutake OZEKI
  • Publication number: 20230414765
    Abstract: A polymer represented by the following formula (I): wherein each symbol is as described in the specification, is useful as a drug carrier in effectively delivering a drug to a target site.
    Type: Application
    Filed: September 8, 2023
    Publication date: December 28, 2023
    Applicants: AGC INC., THE UNIVERSITY OF TOKYO, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Mihoko HARA, Rintaro HARA, Kanjiro MIYATA, Mitsuru NAITO, Takanori YOKOTA
  • Publication number: 20230416682
    Abstract: A coating agent for promoting osteoblast differentiation and/or adipocyte differentiation of mesenchymal stem cells, the coating agent comprising a polyrotaxane represented by Formula (1): wherein R1 is a hydrogen atom or a methyl group, m is 1 to 2000, and n is 10 to 500, is a cyclodextrin in which at least one hydroxyl group is modified with a group represented by —X—Y, X is a divalent organic group, and Y is a hydroxyl group or a sulfo group.
    Type: Application
    Filed: November 22, 2021
    Publication date: December 28, 2023
    Applicants: DENKA COMPANY LIMITED, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Ruriko AOYAMA SEKIYA, Yoshinori ARISAKA, Nobuhiko YUI, Takanori IWATA, Tetsuya YODA, Masahiro HAKARIYA, Hiroki MASUDA
  • Patent number: 11851654
    Abstract: An object of the invention is to provide a low toxicity antisense nucleic acid medicine that can modulate expression of a target transcriptional product in the central nervous system and other sites of a subject. Provided is a low toxicity composition for modulating expression of a target transcriptional product in a site such as the central nervous system of a subject, having a nucleic acid complex formed by annealing together a first nucleic acid strand having an antisense oligonucleotide region with respect to the target transcriptional product, and a second nucleic acid strand having a complementary region that is complementary to at least part of the first nucleic acid strand.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: December 26, 2023
    Assignee: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Takanori Yokota, Tetsuya Nagata, Kotaro Yoshioka
  • Patent number: 11832842
    Abstract: The present invention provides a coronary artery bypass surgery treatment tool or the like including a flexible tube, a suction cup in which an opening portion is formed to communicate with the flexible tube and which is provided at a distal end of the flexible tube, a joint portion which has a suction path, a male connector which is provided in one of a proximal end of the flexible tube and a distal end of the suction path of the joint portion, and a female connector which is provided in the other thereof and is detachably connected to the male connector.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: December 5, 2023
    Assignees: SUMITOMO BAKELITE CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Hirokuni Arai, Toshifumi Sakate, Akira Kawamata, Shinetsu Harata
  • Publication number: 20230384291
    Abstract: The present invention provides means for producing a parathyroid gland organoid. A culture method of the present invention includes a cell population containing a parathyroid gland cell in a ratio of 50% or more, and a mesenchymal cell in a ratio of 10% or more; and a step of culturing the cell population.
    Type: Application
    Filed: September 28, 2021
    Publication date: November 30, 2023
    Applicants: National University Corporation Tokyo Medical and Dental University, Takeda Pharmaceutical Company Limited
    Inventors: Takanori TAKEBE, Norikazu SAIKI
  • Patent number: 11819570
    Abstract: A sugar-responsive gel that is highly resistant to temperature changes, and a sugar-responsive drug delivery device including such a gel. The sugar-responsive gel, which comprises a gel composition including a monomer having a hydroxyl group in addition to a phenylboronic-acid-based monomer, can exhibit suitable temperature resistance. A sugar-responsive drug delivery device including such a sugar-responsive gel is less susceptible to the effects of temperature changes, and therefore can prevent undesirable excessive delivery of a drug such as insulin.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: November 21, 2023
    Assignees: National University Corporation Tokai National Higher Education and Research System, National University Corporation Tokyo Medical and Dental University
    Inventors: Takayoshi Suganami, Miyako Tanaka, Akira Matsumoto, Hiroko Matsumoto, Yuki Morooka, Yuji Miyahara