Patents Assigned to National University Corporation Tottori University
  • Patent number: 10780127
    Abstract: The present invention provides fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity. The present invention also provides a method for producing fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity and a method for producing Tyr-Pro, each of which is characterized by comprising fermenting milk with a mushroom.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: September 22, 2020
    Assignees: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITY
    Inventors: Kenji Okamoto, Toru Nabika
  • Publication number: 20200289592
    Abstract: The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a recombinant vaccinia virus lacking functions of VGF and O1L and having a gene encoding B5R in which an SCR domain has been deleted. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12; a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12; and use of the two vaccinia viruses in combination.
    Type: Application
    Filed: April 30, 2020
    Publication date: September 17, 2020
    Applicants: Astellas Pharma Inc., National University Corporation Tottori University
    Inventors: Takafumi Nakamura, Hajime KUROSAKI, Motomu NAKATAKE
  • Patent number: 10758427
    Abstract: The present invention aims at providing a disposable diaper having excellent maintainability of a surface space and capable of being easily produced.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: September 1, 2020
    Assignees: Daio Paper Corporation, National University Corporation Tottori University
    Inventors: Bin Nakayama, Yoshiko Suyama, Kaori Fujii, Nobutada Nishiura, Aya Ohshima
  • Patent number: 10729926
    Abstract: The method for detoxifying asbestos disclosed here includes: preparing an asbestos-containing substance that contains at least one type of asbestos; preparing an asbestos treatment agent that contains a mineral acid, N-methyl-2-pyrrolidone and a fluoride; and bringing the asbestos-containing substance into contact with the asbestos treatment agent so as to detoxify asbestos in the asbestos-containing substance. Due to this configuration, asbestos in the asbestos-containing substance can be favorably detoxified.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: August 4, 2020
    Assignees: KOKIGUMI CO., LTD., NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY
    Inventors: Toshimitsu Myoga, Koichi Takahashi, Kazuhiro Iizuka, Yuhei Matsubara, Toshiyuki Tanaka, Hisaki Okamoto
  • Patent number: 10722742
    Abstract: The method for detoxifying asbestos disclosed here includes: preparing an asbestos-containing substance that contains at least one type of asbestos; preparing an asbestos treatment agent that contains a mineral acid and N-methyl-2-pyrrolidone; and bringing the asbestos-containing substance into contact with the asbestos treatment agent so as to detoxify asbestos in the asbestos-containing substance. Due to this configuration, asbestos in the asbestos-containing substance can be favorably detoxified.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: July 28, 2020
    Assignees: KOKIGUMI CO., LTD, NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY
    Inventors: Toshimitsu Myoga, Koichi Takahashi, Kazuhiro Iizuka, Yuhei Matsubara, Toshiyuki Tanaka, Hisaki Okamoto
  • Patent number: 10631759
    Abstract: According to an aspect, a testing instrument that is used for testing an airway protection function includes: a pipe portion continuous from an inlet port to an outlet port, the pipe portion having a plurality of holes penetrating the pipe portion from an outer surface of the pipe portion to an inner surface of the pipe portion, the holes being provided for guiding a reagent gas mixture to the inside of the pipe portion; and a guide portion covering all of the holes to form a closed space and guiding the reagent gas mixture to the closed space from an inflow port.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: April 28, 2020
    Assignees: National University Corporation Tottori University, Chest M.I., Incorporated
    Inventors: Kazunori Fujiwara, Katsuyuki Kawamoto, Masaru Ueki, Kazutake Uehara, Hiroya Kitano
  • Patent number: 10597398
    Abstract: To obtain a novel therapeutic drug for a malignant tumor or fibrosis. Used is a compound represented by formula (1), a salt thereof, or a solvate thereof. Also used is a therapeutic drug for a malignant tumor or a therapeutic drug for fibrosis, comprising a compound represented by formula (1), a salt thereof, or a solvate thereof.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: March 24, 2020
    Assignees: National University Corporation Tottori University, KanonCure, Inc.
    Inventors: Goshi Shiota, Noriko Itaba, Minoru Morimoto, Hiroyuki Oka, Kenichiro Abe, Hiroki Shimizu, Yohei Kouno, Satoshi Yokogi
  • Publication number: 20200029539
    Abstract: In this application, the provided are: a Down syndrome rat model characterized in that a rat gene homologous to at least one gene present on a human chromosome 21 or fragment thereof is a trisomy and is transmittable to progeny; or a Down syndrome rat model characterized in that it comprises a human chromosome 21 or fragment thereof, or an exogenous rat chromosome or fragment thereof on which a rat gene homologous to the human chromosome 21 or fragment thereof is present, wherein at least one gene on the human chromosome 21 or fragment thereof or on the exogenous rat chromosome or fragment thereof is added to endogenous rat genes homologous to the at least gene so as to become a trisomy and to be transmittable to progeny: and a method for producing the Down syndrome rat model.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 30, 2020
    Applicants: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, TRANS CHROMOSOMICS, INC.
    Inventors: Yasuhiro KAZUKI, Mitsuo OSHIMURA
  • Publication number: 20190374805
    Abstract: The method for detoxifying asbestos disclosed here includes: preparing an asbestos-containing substance that contains at least one type of asbestos; preparing an asbestos treatment agent that contains a mineral acid and N-methyl-2-pyrrolidone; and bringing the asbestos-containing substance into contact with the asbestos treatment agent so as to detoxify asbestos in the asbestos-containing substance. Due to this configuration, asbestos in the asbestos-containing substance can be favorably detoxified.
    Type: Application
    Filed: July 6, 2018
    Publication date: December 12, 2019
    Applicants: KOKIGUMI CO., LTD, NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY
    Inventors: Toshimitsu MYOGA, Koichi TAKAHASHI, Kazuhiro IIZUKA, Yuhei MATSUBARA, Toshiyuki TANAKA, Hisaki OKAMOTO
  • Publication number: 20190358480
    Abstract: The method for detoxifying asbestos disclosed here includes: preparing an asbestos-containing substance that contains at least one type of asbestos; preparing an asbestos treatment agent that contains a mineral acid, N-methyl-2-pyrrolidone and a fluoride; and bringing the asbestos-containing substance into contact with the asbestos treatment agent so as to detoxify asbestos in the asbestos-containing substance. Due to this configuration, asbestos in the asbestos-containing substance can be favorably detoxified.
    Type: Application
    Filed: July 6, 2018
    Publication date: November 28, 2019
    Applicants: KOKIGUMI CO., LTD, KOKIGUMI CO., LTD, NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY
    Inventors: Toshimitsu MYOGA, Koichi TAKAHASHI, Kazuhiro IIZUKA, Yuhei MATSUBARA, Toshiyuki TANAKA, Hisaki OKAMOTO
  • Publication number: 20190343884
    Abstract: The present invention provides fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity. The present invention also provides a method for producing fermented milk having a high angiotensin converting enzyme inhibition activity, a high hypotensive activity and/or a high stroke-preventing activity and a method for producing Tyr-Pro, each of which is characterized by comprising fermenting milk with a mushroom.
    Type: Application
    Filed: June 22, 2017
    Publication date: November 14, 2019
    Applicants: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITY
    Inventors: Kenji OKAMOTO, Toru NABIKA
  • Publication number: 20190336552
    Abstract: The present invention provides a genetically recombinant vaccinia virus effective in preventing or treating cancer. Specifically, the present invention provides a recombinant vaccinia virus lacking functions of VGF and O1L and having a gene encoding B5R in which an SCR domain has been deleted. Specifically, the present invention provides a vaccinia virus comprising two polynucleotides, a polynucleotide encoding IL-7 and a polynucleotide encoding IL-12; a combination kit of two vaccinia viruses, a vaccinia virus comprising a polynucleotide encoding IL-7 and a vaccinia virus comprising a polynucleotide encoding IL-12; and use of the two vaccinia viruses in combination.
    Type: Application
    Filed: April 8, 2019
    Publication date: November 7, 2019
    Applicants: Astellas Pharma Inc., National University Corporation Tottori University
    Inventors: Takafumi Nakamura, Hajime KUROSAKI, Motomu NAKATAKE
  • Patent number: 10458881
    Abstract: This internal pressure loading system includes an internal pressure loading device and an information processing device. The internal pressure loading device is set at an inner face of a pipe, and includes a load meter which detects the load applied to the inner face of the pipe and a displacement meter which detects the deformation amount of the pipe. When the internal pressure loading device is expanded so as to increase the load to be detected by the load meter, the width of the pipe at which the displacement meter is located is reduced. On the basis of the load detected by the load meter and the deformation amount detected by the displacement meter, the information processing device evaluates the remaining strength of the pipe.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: October 29, 2019
    Assignees: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITY
    Inventors: Masahiro Hyodo, Hidehiko Ogata, Naoki Kawamura, Tsuguhiro Nonaka, Masayuki Ishii
  • Patent number: 10413546
    Abstract: A medicament for prophylactic and/or therapeutic treatment of dementia, which comprises a compound represented by the formula (I) having a xanthine oxidase inhibitory action as an active ingredient.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: September 17, 2019
    Assignees: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NIPPON MEDICAL SCHOOL FOUNDATION, NIPPON CHEMIPHAR CO., LTD.
    Inventors: Takeshi Nishino, Shinsuke Kato, Masako Kato, Hidenori Suzuki, Ken Okamoto
  • Publication number: 20190254264
    Abstract: This application provides: a non-human animal that comprises a mouse artificial chromosome comprising a human antibody heavy chain gene or gene locus, a human antibody light chain ? gene or gene locus, and/or a human antibody light chain ? gene or gene locus, and in which endogenous antibody genes or gene loci corresponding to at least 2 human antibody genes or gene loci have been knocked out, wherein the animal can be stably retained through generations and can produce human antibodies; a method for producing the non-human animal; and a method for producing human antibodies using the non-human animal.
    Type: Application
    Filed: October 31, 2017
    Publication date: August 22, 2019
    Applicants: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, TRANS CHROMOSOMICS, INC.
    Inventors: Yasuhiro KAZUKI, Satoshi ABE, Mitsuo OSHIMURA
  • Patent number: 10370647
    Abstract: It is an object of the present invention to provide utilization of a UCA1 gene that is a host regulatory factor that enhances replication and/or propagation of a vaccinia virus, in order to effectively carry out cancer virotherapy using the vaccinia virus. The present invention relates to: a method for predicting and evaluating the cancer therapeutic effects of a vaccinia virus, which comprises measuring the expression of a UCA1 gene in the cancer cells of a cancer patient, and then predicting that a vaccinia virus exhibits cancer therapeutic effects on the patient, when the UCA1 gene has been expressed therein; and a vaccinia virus into which a UCA1 gene has been expressibly introduced.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: August 6, 2019
    Assignee: National University Corporation Tottori University
    Inventors: Takafumi Nakamura, Kousuke Horita, Hajime Kurosaki, Motomu Nakatake
  • Patent number: 10369159
    Abstract: [Problem] To provide a therapeutic agent for estrogen-dependent gynecological diseases such as endometriosis, uterine fibroids, and uterus adenomyosis. [Solution] To use an estrogen receptor ?-inhibiting ? partial agonist represented by the formula (a), a pharmaceutically-acceptable salt thereof, or a hydrate of either of the afore-mentioned, as an active ingredient.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: August 6, 2019
    Assignees: Nobelpharma Co., Ltd., National University Corporation Tottori University
    Inventors: Kenichiro Nakao, Tasuku Harada, Fuminori Taniguchi
  • Publication number: 20190210805
    Abstract: A method includes acquiring starting position information of moving bodies; acquiring destination position information of movement destinations; acquiring path information indicating paths on which the moving bodies can move; calculating, for each moving body, a minimum movement amount required for the moving body to move on a path from the starting position to each movement destination, based on the starting position information, the destination position information, and the path information; allocating a movement destination not allocated to any moving body to a moving body that has a minimum movement amount being the smallest of the minimum movement amounts and that has no allocation of any movement destination; further allocating, when there is a movement destination not allocated to the moving body on a movement route, the not-allocated movement destination to the allocated moving body; and determining movement routes of the moving bodies based on the allocation.
    Type: Application
    Filed: September 5, 2017
    Publication date: July 11, 2019
    Applicants: Ricoh Company, Ltd., NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY
    Inventors: Toshihiro OKAMOTO, Koichi KUDO, Ichiro MAEDA, Takayoshi YOKOTA, Tsubasa TAMURA
  • Patent number: 10016639
    Abstract: Provided is a dropping-type fire extinguishing body that, in fire extinguishing using a gel-like fire extinguishing agent, can allow the fire extinguishing agent to be smoothly conveyed and dropped. A dropping-type fire extinguishing body 1 to be dropped onto the fire site to extinguish the fire, wherein a gelling agent 3 is contained in a bag body 2 formed of a water-permeable material and water is permeated into the body and is mixed with the gelling agent to prepare a gel-like fire extinguishing agent, thereby filling the gel-like fire extinguishing agent into the inside of the bag body.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: July 10, 2018
    Assignees: ILUKA COLLEGE CO., LTD., NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY
    Inventors: Noriko Asayama, Yuhei Matsubara
  • Patent number: D838839
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: January 22, 2019
    Assignee: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY
    Inventors: Kazunori Fujiwara, Katsuyuki Kawamoto, Hiroya Kitano, Masaru Ueki, Kazutake Uehara