Patents Assigned to National University of Ireland, Galway
  • Publication number: 20230293162
    Abstract: A fistula treatment system comprises a guide such as a guide coil 1101 which is adapted to extend partially around a tissue tract and an implant element 1102. The implant element 1102 is activated to draw tissue surrounding the tract inwardly.
    Type: Application
    Filed: May 30, 2023
    Publication date: September 21, 2023
    Applicant: National University of Ireland, Galway
    Inventors: Eoin BAMBURY, Moshe ZILVERSMIT
  • Publication number: 20230277115
    Abstract: A system to determine status of a pelvic condition in a subject characterised by abnormal contractility activity of a target pelvic structure is described. The system comprises a sensing module to measure electrical activity of the subjects pelvis at a plurality of time points during the subjects hormonal cycle, a signal processing module configured to receive electrical activity measurements from the sensing module and isolate from the electrical activity measurements electrical contractility parameter measurements representative of the target pelvic structure, and a processor module operably connected to the signal processing module.
    Type: Application
    Filed: July 20, 2021
    Publication date: September 7, 2023
    Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY
    Inventors: Sinead HUGHES, Siobhan KELLEHER
  • Publication number: 20230264022
    Abstract: A gait management apparatus applies stimulation to a user suffering from a neurological disease (such as Parkinson's Disease) gait dysfunction. Motion sensors are arranged to be worn by a patient, and electrical stimulation electrodes are on the legs for stimulation. A controller receives motion sensing signals, and processes these signals to generate stimulation signals for operation of the electrodes to stimulate limb movement upon detection of a gait abnormality. There may be a user actuator for user actuation of electrical stimulation, and the inputs may be a series of taps. The controller may provide signals to prevent occurrence of freezing of gait when it senses that a patient is walking or has an intention to walk. Also, it may apply stimulation at an intensity level which is insufficient for functional muscle stimulation but sufficiently high to trigger activation of efferent nerves.
    Type: Application
    Filed: April 30, 2023
    Publication date: August 24, 2023
    Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY
    Inventors: Gearóid Ó LAIGHIN, Leo QUINLAN, Dean SWEENEY, Gavin CORLEY, James FEEHILLY, Patrick BROWNE
  • Publication number: 20230255512
    Abstract: A system to determine status of a pelvic condition in a subject characterised by abnormal contractility activity of a target pelvic structure is described. The system comprises a sensing module to measure electrical activity of the subject's pelvis at a plurality of time points during the subject's hormonal cycle, a signal processing module configured to receive electrical activity measurements from the sensing module and isolate from the electrical activity measurements electrical contractility parameter measurements representative of the target pelvic structure, and a processor module operably connected to the signal processing module.
    Type: Application
    Filed: April 11, 2023
    Publication date: August 17, 2023
    Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY
    Inventors: Sinead HUGHES, Siobhan KELLEHER
  • Publication number: 20230211120
    Abstract: An indwelling pleural catheter system comprises an indwelling catheter device (2) comprising a catheter tube (7) with a fenestrated distal end (7A) configured to reside in the pleural cavity of a subject and a connection hub (10) fluidically coupled to a proximal end (7B) of the catheter tube, a skin anchoring member (3) to anchor the connection hub (10) to the skin of the subject, and optionally a detachable ambulatory suction module (4) configured for detachable attachment to the connection hub (10). The suction module (4) comprises a fluid inlet (19) configured for fluidic coupling to the catheter tube (7) through the connection hub (10) and a fluid outlet (20) configured for detachable fluidic coupling to a pleural fluid drainage system (5) to drain pleural fluid through the detachable ambulatory suction module. The detachable ambulatory suction module is configured to exert a negative pressure in the catheter tube upon detachment of the pleural fluid drainage system from the suction module.
    Type: Application
    Filed: May 28, 2021
    Publication date: July 6, 2023
    Applicant: National University of Ireland, Galway
    Inventors: Richard Modley, Tim Jones, Michelle Tierney
  • Patent number: 11672984
    Abstract: A gait management apparatus applies stimulation to a user suffering from a neurological disease (such as Parkinson's Disease) gait dysfunction. Motion sensors are arranged to be worn by a patient, and electrical stimulation electrodes are on the legs for stimulation. A controller receives motion sensing signals, and processes these signals to generate stimulation signals for operation of the electrodes to stimulate limb movement upon detection of a gait abnormality. There may be a user actuator for user actuation of electrical stimulation, and the inputs may be a series of taps. The controller may provide signals to prevent occurrence of freezing of gait when it senses that a patient is walking or has an intention to walk. Also, it may apply stimulation at an intensity level which is insufficient for functional muscle stimulation but sufficiently high to trigger activation of efferent nerves.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: June 13, 2023
    Assignee: National University of Ireland, Galway
    Inventors: Gearóid Ó Laighin, Leo Quinlan, Dean Sweeney, Gavin Corley, James Feehilly, Patrick Browne
  • Publication number: 20230094196
    Abstract: An implantable medical device having a soft tissue interfacing surface comprises at least one soft actuatable capsule having a soft tissue interfacing deflectable membrane configured for cyclical deflection upon actuation of the capsule to modulate the biomechanics of the soft tissue interface during use. The actuatable capsule may comprise an actuation chamber containing a first fluid, a therapeutic chamber containing a second fluid, a deflectable membrane separating the actuation chamber and therapeutic chamber, and an actuation conduit in fluidic communication with the actuation chamber for pneumatic actuation of the actuation chamber. The therapeutic chamber comprises the soft tissue interfacing deflectable membrane which is configured to cyclically deflect during actuation of the capsule and modulate the biomechanics of the soft tissue interface by altering one or more of strain, fluid flow and cellular activity in peri-implant tissue at the soft tissue interface.
    Type: Application
    Filed: June 29, 2020
    Publication date: March 30, 2023
    Applicants: NATIONAL UNIVERSITY OF IRELAND, GALWAY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Ellen ROCHE, Eimear DOLAN, Garry DUFFY, Sandra ROTHENBUCHER, William WHYTE, Claudia VARELA, Scott ROBINSON, Keegan MENDEZ
  • Publication number: 20220389112
    Abstract: Provided is an effective amount of a desialylation agent and an effective amount of an anti CD38 antibody for use in the treatment of multiple myeloma. This results in potentiated primary NK cell activity against the multiple myeloma cell. Also envisaged is a method of treating multiple myeloma in a subject in need thereof.
    Type: Application
    Filed: November 6, 2020
    Publication date: December 8, 2022
    Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY
    Inventors: Michael O'DWYER, John DALY, Sarkar SUBHASHIS
  • Patent number: 11478248
    Abstract: The present invention provides a percutaneous vascular surgical system for performing endovascular/neurovascular interventions, the system incorporating a sheath having a proximal end and a distal end and defining a main lumen extending between the proximal and distal ends, an auxiliary lumen also defined by the sheath, a reversibly inflatable balloon located about the sheath adjacent the distal end and in fluid communication with the auxiliary lumen, a syringe selectively connectable to the main lumen to create suction through the main lumen, and a vessel closure device for the closure of the arteriotomy, the surgical system and method of the invention having utility in a large number of percutaneous vascular procedures such as carotid artery stenosis or neurovascular interventions and enabling four procedures to be performed with one system, being percutaneous access, emboli removal, flow reversal and arteriotomy closure.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: October 25, 2022
    Assignee: National University of Ireland, Galway
    Inventors: Sherif Sultan, Niamh Hynes, Robert Miculas, Stefan Lohfeld, Colin Henehan
  • Patent number: 11464501
    Abstract: A biopsy device comprising: a cannula comprising an elongate cannula body extending between a cannula distal end and a cannula proximal end to define a lumen, wherein the cannula comprises a cutting portion at the cannula distal end; a stylet comprising an elongate body having a stylet distal end and a stylet proximal end, the stylet being slidably disposed within the lumen, wherein the stylet comprises a tissue sampling portion. The tissue sampling portion is formed by a notch in the body of the stylet at or near the stylet distal end. The biopsy device further comprises an actuator assembly, the actuator assembly arranged to move the cannula relative to the stylet between a retracted position in which at least part of the tissue sampling portion is exposed and an extended position in which the cannula at least partly surrounds the tissue sampling portion.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: October 11, 2022
    Assignee: NATIONAL UNIVERSITY OF IRELAND, GALWAY
    Inventors: Damien Long, Edmund Brennan, Eugene Skelton, Anthony Wright
  • Patent number: 11464564
    Abstract: A microwave ablation probe (200; 300; 400), comprising: an applicator (202; 302; 402) arranged to apply microwave radiation to heat surrounding tissue; a feeding cable (204; 304; 404) arranged to supply electromagnetic energy to the applicator; a coolant flow path (206) via which coolant is able to flow; and a choke arranged to reduce power reflected from the applicator (202; 302; 402) along the feeding cable (204; 304; 404). The choke comprises a choke member (208; 209; 308; 408) cooled by coolant flowing in the coolant flow path (206). The choke member (208; 209; 308; 408) extends between two points spaced apart in a direction having at least a component parallel to a longitudinal axis of the feeding cable. The choke member (208; 209; 308; 408) comprises one or more turns extending around the longitudinal axis of the feeding cable. The choke member may be a spiral member (208; 308; 408).
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 11, 2022
    Assignee: NATIONAL UNIVERSITY OF IRELAND, GALWAY
    Inventors: Jimmy Eaton-Evans, Giuseppe Ruvio, Martin O'Halloran, Jonathan Bouchier-Hayes, Mark Bruzzi
  • Publication number: 20220257230
    Abstract: A method of facilitating access to a neonate through a caesarean incision in the woman's abdomen by opening the incision, includes providing a supporting ring dimensioned to allow delivery of a neonate through the ring and comprising a non-adjustable pelvic-region retractor and handle fixed to the supporting ring and articulating the supporting ring to insert the non-adjustable pelvic-region retractor into the incision to cover and hold back the woman's bladder with the supporting ring disposed over the woman's abdomen. A first adjustable saddle-shaped retractor is then inserted into the incision to cup a first section of abdominal tissue on an abdominal side of the incision, before attaching the first adjustable saddle-shaped retractor to the supporting ring while it is cupping the first section of abdominal tissue at a first position spaced apart from the non-adjustable pelvic-region retractor to anchor the supporting ring to the woman and partially open the incision.
    Type: Application
    Filed: November 19, 2021
    Publication date: August 18, 2022
    Applicant: National University of Ireland, Galway
    Inventors: Padraig MAHER, Barry McCANN, Marie-Therese MAHER
  • Publication number: 20220257231
    Abstract: A method of facilitating access to a neonate through a caesarean incision in the woman's abdomen by opening the incision, includes providing a supporting ring dimensioned to allow delivery of a neonate through the ring and comprising a non-adjustable pelvic-region retractor and handle fixed to the supporting ring and articulating the supporting ring to insert the non-adjustable pelvic-region retractor into the incision to cover and hold back the woman's bladder with the supporting ring disposed over the woman's abdomen. A first adjustable saddle-shaped retractor is then inserted into the incision to cup a first section of abdominal tissue on an abdominal side of the incision, before attaching the first adjustable saddle-shaped retractor to the supporting ring while it is cupping the first section of abdominal tissue at a first position spaced apart from the non-adjustable pelvic-region retractor to anchor the supporting ring to the woman and partially open the incision.
    Type: Application
    Filed: November 19, 2021
    Publication date: August 18, 2022
    Applicant: National University of Ireland, Galway
    Inventors: Padraig MAHER, Barry McCANN, Marie-Therese MAHER
  • Patent number: 11399950
    Abstract: An implant (30) for a mammalian bone joint (3) for spacing a first bone (2) of the joint from a second bone (1) of the joint while allowing translational movement of the second bone in relation to the first bone is described. The implant comprises (a) a distal part (31) configured for intramedullary engagement with an end of the second bone, (b) a proximal part (34) having a platform (15) configured for non-engaging abutment of an end of the first bone and translational movement thereon, and (c) an articulating coupling (10, 16) provided between the distal and proximal ends allowing controlled articulation of the first and second bones. The bone-abutting platform is shaped to conform to and translate upon the end of the first bone. A kit for assembly to form the implant of the invention, and the use of the implant to treat osteoarthritis in a bone joint, are also described.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: August 2, 2022
    Assignee: National University of Ireland, Galway
    Inventors: Gerry Clarke, Brendan Boland, Mark Bruzzi, Amy L. Ladd, Arnold-Peter C. Weiss, Filip Stockmans
  • Publication number: 20220133286
    Abstract: A method of treating a vessel in a subject comprises the steps of advancing a device distally across a treatment zone in a vessel, wherein the device comprises an elongated catheter having a lumen and a distal end, and a radially expansive treatment element disposed in the lumen and configured for axial movement relative to the catheter; deploying the radially expansive treatment element proud of the distal end of the catheter to radially expand and circumferentially impress against the vessel lumen at a distal end of the treatment zone; and withdrawing the deployed radially expansive treatment element proximally along the treatment zone with the treatment element circumferentially impressed against the vessel lumen to mechanically and circumferentially denude the treatment zone of the vessel. The radially expansive treatment element is then recaptured into the lumen of the catheter, before the device is withdrawn from the treated vessel.
    Type: Application
    Filed: December 10, 2021
    Publication date: May 5, 2022
    Applicant: National University of Ireland, Galway
    Inventors: Sean CUMMINS, Nigel PHELAN, Stephen COX, Martin O'HALLORAN
  • Publication number: 20220118256
    Abstract: A gait management apparatus applies stimulation to a user suffering from a neurological disease (such as Parkinson's Disease) gait dysfunction. Motion sensors are arranged to be worn by a patient, and electrical stimulation electrodes are on the legs for stimulation. A controller receives motion sensing signals, and processes these signals to generate stimulation signals for operation of the electrodes to stimulate limb movement upon detection of a gait abnormality. There may be a user actuator for user actuation of electrical stimulation, and the inputs may be a series of taps. The controller may provide signals to prevent occurrence of freezing of gait when it senses that a patient is walking or has an intention to walk. Also, it may apply stimulation at an intensity level which is insufficient for functional muscle stimulation but sufficiently high to trigger activation of efferent nerves.
    Type: Application
    Filed: November 26, 2021
    Publication date: April 21, 2022
    Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY
    Inventors: Gearóid Ó LAIGHIN, Leo QUINLAN, Dean SWEENEY, Gavin CORLEY, James FEEHILLY, Patrick BROWNE
  • Publication number: 20220071610
    Abstract: A fistula treatment system comprises a guide such as a guide coil 1101 which is adapted to extend partially around a tissue tract and an implant element 1102. The implant element 1102 is activated to draw tissue surrounding the tract inwardly.
    Type: Application
    Filed: September 21, 2021
    Publication date: March 10, 2022
    Applicant: National University of Ireland, Galway
    Inventors: Eoin BAMBURY, Moshe ZILVERSMIT
  • Patent number: 11259791
    Abstract: A method of facilitating access to a neonate through a caesarean incision in the woman's abdomen by opening the incision, includes providing a supporting ring dimensioned to allow delivery of a neonate through the ring and comprising a non-adjustable pelvic-region retractor and handle fixed to the supporting ring and articulating the supporting ring to insert the non-adjustable pelvic-region retractor into the incision to cover and hold back the woman's bladder with the supporting ring disposed over the woman's abdomen. A first adjustable saddle-shaped retractor is then inserted into the incision to cup a first section of abdominal tissue on an abdominal side of the incision, before attaching the first adjustable saddle-shaped retractor to the supporting ring while it is cupping the first section of abdominal tissue at a first position spaced apart from the non-adjustable pelvic-region retractor to anchor the supporting ring to the woman and partially open the incision.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: March 1, 2022
    Assignee: National University of Ireland, Galway
    Inventors: Padraig Maher, Barry McCann, Marie-Therese Maher
  • Publication number: 20220054992
    Abstract: An impeller-free vortex generator apparatus for fluid mixing, including: a fluid tank including: a first fluid inlet port, the first fluid inlet port including a curved flow channel between a first sidewall segment of the fluid tank and a second sidewall segment of the fluid tank, a second fluid inlet port, and a fluid outlet port; and a first fluid intake duct in fluid communication with the first fluid inlet port; wherein the first fluid intake duct is provided substantially on a tangent to the first sidewall segment of the fluid tank and aligned to deliver a first fluid to an internal surface of the first sidewall segment.
    Type: Application
    Filed: December 21, 2018
    Publication date: February 24, 2022
    Applicant: NATIONAL UNIVERSITY OF IRELAND, GALWAY
    Inventors: Sean MULLIGAN, Eoghan CLIFFORD, Alan CARTY
  • Patent number: 11242566
    Abstract: The present invention relates to the sialyltransferase ST3GAL6 for use as a biomarker for multiple myeloma, and especially as a marker for myelomas with inferior survival rates. The inventors have shown that glycosylation gene expression is dysregulated in Multiple Myeloma and that overexpression of the sialyltransferase ST3GAL6 is associated with inferior survival rates in patients.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: February 8, 2022
    Assignee: National University of Ireland, Galway
    Inventors: Siobhan Glavey, Lokesh Joshi, Michael O'Dwyer