Patents Assigned to National University of Singapore
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Patent number: 11679132Abstract: The present invention relates to a method of using a receptor (e.g., chimeric antigen receptor—CAR) that activates an immune response upon binding a cancer cell ligand in conjunction with a target-binding molecule that targets a protein or molecule for removal or neutralization to generate enhanced anti-cancer immune cells. The present invention also relates to engineered immune cells having enhanced therapeutic efficacy and uses thereof.Type: GrantFiled: July 12, 2022Date of Patent: June 20, 2023Assignee: NATIONAL UNIVERSITY OF SINGAPOREInventors: Dario Campana, Takahiro Kamiya
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Patent number: 11673955Abstract: The present invention relates to targeted prevention of vertical transmission of infection between mother and foetus. More particularly, the invention relates to methods of preventing neonatal Fc receptor (FcRn)-mediated transmission of virus, preferably flavivirus, more preferably Zika virus (ZIKV), from a mother immune to a cross-reactive virus e.g. Dengue virus (DENY) to her foetus, and to reagents that block or inhibit said FcRN-mediated transmission of virus.Type: GrantFiled: May 10, 2018Date of Patent: June 13, 2023Assignee: National University of SingaporeInventor: Ashley St. John
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Publication number: 20230175120Abstract: Methods of depositing an adamantane film are described, which may be used in the manufacture of integrated circuits. Methods include processing a substrate in which an adamantane seed layer is deposited on a substrate, converting to a diamond nuclei layer having an increased crystallinity relative to the adamantane seed layer and then grown into full nanocrystalline diamond film from the diamond nuclei layer.Type: ApplicationFiled: December 5, 2022Publication date: June 8, 2023Applicants: Applied Materials, Inc., National University of SingaporeInventors: Sze Chieh Tan, Vicknesh Sahmuganathan, Eswaranand Venkatasubramanian, Abhijit Basu Mallick, John Sudijono, Jiteng Gu, Kian Ping Loh
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Publication number: 20230170217Abstract: Methods to manufacture integrated circuits are described. Nanocrystalline diamond is used as a hard mask in place of amorphous carbon. Provided is a method of processing a substrate in which nanocrystalline diamond is used as a hard mask, wherein processing methods result in a smooth surface. The method involves two processing parts. Two separate nanocrystalline diamond recipes are combined—the first and second recipes are cycled to achieve a nanocrystalline diamond hard mask having high hardness, high modulus, and a smooth surface. In other embodiments, the first recipe is followed by an inert gas plasma smoothening process and then the first recipe is cycled to achieve a high hardness, a high modulus, and a smooth surface.Type: ApplicationFiled: January 25, 2023Publication date: June 1, 2023Applicants: Applied Materials, Inc., National University of SingaporeInventors: Vicknesh Sahmuganathan, Jiteng Gu, Eswaranand Venkatasubramanian, Kian Ping Loh, Abhijit Basu Mallick, John Sudijono, Zhongxin Chen
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Patent number: 11662239Abstract: A dispenser (100, 500, 900) for granules is disclosed herein. In a specific embodiment, the dispenser comprises a granular reservoir (1); a selector disk comprising (a) a feeder disk (2, 22, 52) comprising at least one protruding member (3, 23); and (b) a dispensing disk (8, 58) arranged to rotate in concert with the feeder disk (2, 22, 52). The dispensing disk further comprises at least one dispensing aperture (9) and a non-dispensing portion (103), the at least one dispensing aperture (9) being in registration with the at least one protruding member (3, 23).Type: GrantFiled: October 5, 2021Date of Patent: May 30, 2023Assignee: National University of SingaporeInventor: Veit Frederik Kepler
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Publication number: 20230157896Abstract: The present invention relates to a device for repair of a region within an ear via a natural orifice, the device comprising a body. The body comprises a first port for visibly identifying the region to be sealed, the region being inside the ear; and a second port through which a seal can be introduced into the ear through the device. The region comprises a perforation of a tympanic membrane of the ear and the device is a speculum. The present invention also relates to method for repairing a perforation in a tympanic membrane using the same device.Type: ApplicationFiled: March 11, 2021Publication date: May 25, 2023Applicants: National University of Singapore, Hadasit Medical Research Services And Development Ltd, Yissum Research Development Company of the Hebrew University of Jerusalem LtdInventors: Menachem Gross, Shlomo Magdassi, Yin Chiang Boey, Ngeow Khing Chia
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Publication number: 20230159990Abstract: The present invention relates to signalling catalytic nucleic acid nanostructures that are responsive to polymerase activity, methods of their use, devices and kits comprising the same. More specifically, the present invention provides a catalytic signalling nanostructure comprising a DNAzyme/RNAzyme, such as G-quadruplex hemin, and a polymerase—responsive element. Polymerase elongation of the polymerase-responsive element eliminates catalytic activity of the DNAzyme/RNAzyme. The catalytic nucleic acid nanostructure can be used alone or paired with a target recognition nanostructure which can transduce molecular signals into polymerase activity, in an integrated circuit.Type: ApplicationFiled: April 7, 2021Publication date: May 25, 2023Applicants: National University of Singapore, Agency for Science, Technology and ResearchInventors: Huilin Shao, Yuan Chen, Noah Riandiputra Sundah, Rui Yuan Nicholas Ho
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Patent number: 11655451Abstract: The present disclosure relates to methods for culturing human epidermal keratinocytes. When keratinocytes are cultured on plates coated with a laminin containing an alpha-4 chain or an alpha-5 chain, in a xeno-free, chemically defined cell culture medium, they expand efficiently in vitro. Useful cell culture kits for culturing keratinocytes are also described herein, as are methods of using such cells for treatment of burns or chronic wounds.Type: GrantFiled: May 4, 2018Date of Patent: May 23, 2023Assignees: NATIONAL UNIVERSITY OF SINGAPORE, SINGAPORE HEALTH SERVICES PTE LTDInventors: Karl Tryggvason, Monica Suryana Tjin, Alvin Wen Choong Chua
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Patent number: 11659779Abstract: Various embodiments may provide a memory cell. The memory cell may include an active electrode including an active electrode material. The memory cell may also include a first noble electrode contact with the active electrode, the first noble electrode being a patterned electrode including a noble electrode material. The memory cell may further include a resistive switching layer in contact with the active electrode and the first noble electrode. The memory cell may additionally include a second noble electrode including a noble electrode material, the second noble electrode in contact with the resistive switching layer.Type: GrantFiled: March 8, 2019Date of Patent: May 23, 2023Assignees: Agency for Science, Technology and Research, National University of SingaporeInventors: Wen Xiao, Wendong Song, Jun Ding, Ernult Franck Gerard
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Publication number: 20230151038Abstract: Molybdenum(0) coordination complexes comprising an arene ligand and one or more neutral ligands which coordinate to the metal center by carbon, nitrogen or phosphorous are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.Type: ApplicationFiled: January 16, 2023Publication date: May 18, 2023Applicants: Applied Materials, Inc., National University of SingaporeInventors: Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
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Publication number: 20230154747Abstract: A seed layer for inducing nucleation to form a layer of material is described. In an embodiment, the seed layer comprising a layer of two-dimensional monolayer amorphous material having a disordered atomic structure adapted to create localised electronic states to form electric potential wells for bonding adatoms to a surface of the seed layer via van der Waals interaction to form the layer of material, wherein each of the electric potential wells has a potential energy larger in magnitude than surrounding thermal energy to capture adatoms on the surface of the seed layer. Embodiments in relation to a method for forming the seed layer, a heterostructure comprising the seed layer, a method for forming the heterostructure comprising the seed layer, a device comprising the heterostructure and a method of enhancing vdW interaction between adatoms and a surface of the seed layer are also described.Type: ApplicationFiled: March 9, 2021Publication date: May 18, 2023Applicant: National University of SingaporeInventors: Barbaros OEZYILMAZ, Chee Tat TOH, Irfan Haider ABIDI
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Patent number: 11651273Abstract: A machine learning method comprises: receiving input data comprising a set of feature variables each indicating features of a plurality of entities; encoding partial order relations between entities of the plurality of entities as a set of logic rules; constructing a hypergraph comprising a plurality of vertices representing the entities of the plurality of entities and a plurality of hyperlinks linking similar entities of the plurality of entities; adding directed edges to the hypergraph to represent partial order interactions between entities to form a partial order hypergraph; representing the partial order hypergraph as a set of matrices; forming an objective function using the logic rules and matrices of the set of matrices; minimizing the objective function to obtain a prediction function; and outputting an indication of the prediction function.Type: GrantFiled: April 18, 2019Date of Patent: May 16, 2023Assignee: National University of SingaporeInventors: Fuli Feng, Xiangnan He, Tat-Seng Chua
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Patent number: 11648269Abstract: The present invention provides compositions comprising a protein expression blocker or PEBL comprising a target-binding molecule and localizing domain, and methods of using such compositions in cancer therapy. PEBLs are useful as a blockade of expression of target surface receptors (peptides or antigens) in immune cells. Also provided herein are CD3/TCR??-deficient T cells and CD3/TCR??-deficient chimeric antigen receptor T cells that express such PEBLs.Type: GrantFiled: August 9, 2018Date of Patent: May 16, 2023Assignee: NATIONAL UNIVERSITY OF SINGAPOREInventors: Dario Campana, Takahiro Kamiya
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Patent number: 11642362Abstract: The disclosure provides a method of inhibiting proliferation of a cell, inhibiting m3C formation in a cell, inhibiting activity of Mettl8 in a cell, or activating ATM and p53 in a cell, the method comprising contacting the cell with a Mettl8 inhibitor. The disclosure also provides a composition comprising a cell with a reduced expression or activity of Mettl8. In another aspect, the disclosure provides methods of rendering a tumor cell sensitive to a cancer therapy.Type: GrantFiled: July 6, 2018Date of Patent: May 9, 2023Assignee: NATIONAL UNIVERSITY OF SINGAPOREInventors: Xin-Yuan Fu, Xinyu Liu, Lu Ang Xu
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Publication number: 20230129073Abstract: Molybdenum(0) coordination complexes comprising at least one cycloheptatriene ligand and optionally one or more neutral ligands which coordinate to the metal center by carbon, nitrogen or phosphorous are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.Type: ApplicationFiled: December 20, 2022Publication date: April 27, 2023Applicants: Applied Materials, Inc., National University of SingaporeInventors: Andrea Leoncini, Paul Mehlmann, Nemanja Dordevic, Han Vinh Huynh, Doreen Wei Ying Yong
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Publication number: 20230123501Abstract: The present invention relates to the metabolic engineering of a microbial host for the synthesis of value-added products from oil palm empty fruit brunches (OPEFBs). In one embodiment, the genetically engineered microorganism is Escherichia coli comprising a metabolic pathway consisting of 9 enzymes (11 genes) to utilize depolymerized lignin, namely vanillin, p-coumaric acid, p-hydroxybenzaldehyde, vanillic acid, p-hydroxybenzoic acid and ferulic acid, to produce ?-ketoadipic acid, which can be subsequently converted into commercially important derivatives such as adipic acid and levulinic acid. The enzymes are feruloyl-CoA synthetase (fcs), enoyl-CoA hydratase (ech), vanillin dehydrogenase (vdh), vanillate O-demethylase (vanA; vanA and vanB), p-hydroxy benzoate hydroxylase (pobA), protocatechuate 3,4-dioxygenase {pcaGH; pcaG and pcaH), 3-carboxy-cis, cis-muconate cycloisomerase (pcaB), 4-carboxymuconolactone decarboxylase (pcaC), and ?-ketoadipate enol-lactone hydrolase (pcaD).Type: ApplicationFiled: March 5, 2021Publication date: April 20, 2023Applicant: National University of SingaporeInventors: Tat Ming Samuel Lo, In Young Hwang, Matthew Wook Chang, Han-Saem Cho
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Publication number: 20230123431Abstract: The present invention provides for a method to increase the free lipoic acid production in an isolated genetically engineered bacteria or yeast cell. The method involves culturing in a cysteine supplemented culture medium the engineered bacteria or yeast that is transformed with a recombinant expression vector encoding polynucleotide molecules that results in the overexpression of the following genes that are linked to at least one promoter: (1) substrate protein (e.g. Gcv3p); (2) octanoyltransferase or lipoyl synthase; (3) cofactor S-adenosyl methionine synthase; and (4) lipoamidase. The invention also relates to the engineered bacteria or yeast cell thereof.Type: ApplicationFiled: March 2, 2021Publication date: April 20, 2023Applicant: National University of SingaporeInventors: Matthew Wook Chang, Binbin Chen, Jee Loon Foo, Hua Ling
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Publication number: 20230110711Abstract: A semiconductor memory device may be provided. The semiconductor memory device may include data storage patterns having respective first sides and respective second sides, a spin-orbit coupling (SOC) channel layer in common contact with the first sides of the data storage patterns, the SOC channel layer is configured to provide a spin-orbit torque to the data storage patterns, read access transistors connected between the second sides of respective ones of the data storage patterns and respective data lines, a write access transistor connected between a first end of the SOC channel layer and a source line, and a bit line connected to a second end of the SOC channel layer. Each of the data storage patterns comprises a free layer in contact with the SOC channel layer and an oxygen reservoir layer in contact with the free layer.Type: ApplicationFiled: July 21, 2022Publication date: April 13, 2023Applicants: SAMSUNG ELECTRONICS CO., LTD., NATIONAL UNIVERSITY OF SINGAPOREInventors: Rahul MISHRA, Hyunsoo YANG, Ung Hwan PI
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Publication number: 20230106519Abstract: The present invention relates to a compound of following formula (I), which is a novel prodrug of biguanide derivatives: (I). The present invention also relates to the preparation and methods of using the compound. In particular, the invention relates to prodrugs wherein metformin and phenformin are attached to AuIII cyclometalated backbone to form novel AuIII prodrugs of metformin or phenformin with improved anticancer effects.Type: ApplicationFiled: March 23, 2021Publication date: April 6, 2023Applicants: National University of Singapore, Northwestern UniversityInventors: Wee Han Ang, Maria Babak, Irina Vadimovna Balyasnikova
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Publication number: 20230099421Abstract: Disclosed herein is a salt of formula I: where R1, X, n, R, R1, Y, m, p, q, Z and o are as defined herein. Also disclosed herein are methods of using said salts in chemical synthesis, such as to prepare compounds isotopically enriched in 18F for use in PET & imaging, as well as methods to make the compounds of formula I.Type: ApplicationFiled: December 15, 2020Publication date: March 30, 2023Applicant: National University of SingaporeInventors: Rowan Drury Young, Dipendu Mandal, Richa Gupta, Amit Kumar Jaiswal