Patents Assigned to Neuroindx, Inc.
  • Patent number: 11579068
    Abstract: The invention relates to a system (10) adapted to measure multiple biophysical characteristics of cells, the system (10) comprising: a microfluidic chip (12) provided with a microfluidic channel (14) which allows cells to flow through, the microfluidic channel (14) having an inlet (14a), an outlet (14b), and a lateral opening (14c) situated between the inlet (14a) and the outlet (14b); and a capacitive sensor (30) integrated in the microfluidic chip, adapted to obtain biophysical characteristics of a single cell in the microfluidic channel (14) by directly manipulating the single cell by sensor elements (31, 32) through the lateral opening (14c) of the microfluidic channel (14), the sensor (30) comprising a stationary part and an electrostatically driven movable part which is movable relative to the stationary part, the stationary part being fixed to the microfluidic chip (12), the movable part being arranged in the lateral opening (14c) of the microfluidic channel (14), wherein a portion of the sensor elemen
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: February 14, 2023
    Assignees: Centre National de la Recherche Scientifique (CNRS), Neuroindx, Inc., The Foundation for the Promotion of Industrial Science
    Inventors: Dominique Collard, Hiroyuki Fujita, Stanislav Karsten
  • Patent number: 10845333
    Abstract: An object is to make a bridge of DNA expanding between a pair of electrodes, and to characterize the bridge of DNA, to thereby detect DNA easily and surely without employing any marker or labeling substances, such as fluorescent reagents. A method of detecting DNA using a detection device with at least a couple of electrodes, the method comprising immobilizing a primer on the electrodes; making a bridge of the DNA expanded between the electrodes, by immersing the electrodes in a solution including circular templates of single stranded DNA, annealing the circular templates, and generating single stranded DNA product utilizing RCA (Rolling Circle Amplification), with impressing a designated voltage between the electrodes; and characterizing the bridge of DNA which includes multiple single stranded DNA molecules between the electrodes.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: November 24, 2020
    Assignees: The Foundation for the Promotion of Industrial Science, Neuroindx, Inc., Centre National de la Recherche Scientifique (CNRS)
    Inventors: Hiroyuki Fujita, Stanislav L. Karsten, Dominique Collard, Momoko Kumemura