Patents Assigned to New England Nuclear Corporation
  • Patent number: 4465676
    Abstract: 16.alpha.-Radiohalo-3,17.beta.-dihydroxy steroidal estrogens and their radiolabelled analogs are described. These steroidal estrogens have high estrogen receptor activity and are prepared by halogen exchange with the corresponding 16.beta.-bromo compound. The radiolabelled estrogens of this invention are useful in estrogen receptor assays, radioimmunoassays, in vivo imaging of tissue having estrogen receptor activity, and for therapeutic treatment of tumors having estrogen receptor activity.
    Type: Grant
    Filed: April 9, 1980
    Date of Patent: August 14, 1984
    Assignee: New England Nuclear Corporation
    Inventor: Richard B. Hochberg
  • Patent number: 4455291
    Abstract: A composition for preparing cationic lipophilic technetium complexes is described. The composition comprises an admixture of (a) an accelerator compound selected from the group of water-soluble organic bidentate ligands that are capable of coordinating with technetium to form a 4 to 6 member ring and (b) a target-seeking ligand, or aqueous salt thereof, having the structure indicated in formulas I, II or III. The accelerator compound has a weaker coordinating bond with technetium than the target-seeking ligand has with technetium.
    Type: Grant
    Filed: January 22, 1982
    Date of Patent: June 19, 1984
    Assignee: New England Nuclear Corporation
    Inventor: Michael F. Tweedle
  • Patent number: 4451450
    Abstract: A normally solid, hydrophilic compound capable of binding with Tc-99m to form a cationic complex is provided. The compound has a formula selected from: ##STR1## wherein: R, R', R", R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each independently selected from hydrogen; or substituted or unsubstituted alkyl, alkylene, aryl, alkylaryl, arylalkyl, monocycloalkyl, polycycloalkyl, heterocyclic and carbocyclic groups; and R plus R.sup.i in formula (A) may be taken together to form a cyclic compound;A, A', A", A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 and A.sup.6 are independently neutral functional elements, each having a free electron pair available for accepting a proton to provide a charged ligand and having the capability of complexing with Tc-99m to form a cationic complex;Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, Y.sup.5 and Y.sup.
    Type: Grant
    Filed: October 15, 1981
    Date of Patent: May 29, 1984
    Assignee: New England Nuclear Corporation
    Inventor: Vinayakam Subramanyam
  • Patent number: 4432877
    Abstract: Compositions in which organo-mercurial moieties are bound to glass or other inorganic substrates are useful in separating sulfhydryl-containing compounds from mixtures with other compounds, e.g., by affinity chromatography.
    Type: Grant
    Filed: October 19, 1981
    Date of Patent: February 21, 1984
    Assignee: New England Nuclear Corporation
    Inventor: Nathan R. Tzodikov
  • Patent number: 4429229
    Abstract: A method for producing various configurations of permanent magnet quadrupoles so that there is no coupling in the two transverse directions when focusing a charged particle beam is provided. Each configuration comprises a plurality of rotatable quadrupole disks, and means for rotating the quadrupole disks with respect to each other in a predetermined relationship.
    Type: Grant
    Filed: August 26, 1981
    Date of Patent: January 31, 1984
    Assignee: New England Nuclear Corporation
    Inventor: Robert L. Gluckstern
  • Patent number: 4411881
    Abstract: A stabilized composition comprising a solution of a radiolabeled compound and a diethylenetriamine is described. Preferred diethylenetriamines include, N,N-bis(2-aminoethyl) dithiocarbamic acid, di(2-dithiocarbamyl-ethyl) amine, and salts thereof.
    Type: Grant
    Filed: July 12, 1982
    Date of Patent: October 25, 1983
    Assignee: New England Nuclear Corporation
    Inventor: Nathan R. Tzodikov
  • Patent number: 4390517
    Abstract: A method of stabilizing a solution of a radiolabeled compound comprising adding to such solution a compound having a substantially insoluble backbone, to which has been bound a quaternary ammonium group; or a water soluble primary, secondary or tertiary aliphatic amine. The present invention also includes a solution of a radiolabeled compound maintained in contact with such a compound, and as an article of manufacture, a sealed vial containing such a solution.
    Type: Grant
    Filed: August 15, 1980
    Date of Patent: June 28, 1983
    Assignee: New England Nuclear Corporation
    Inventors: Robert E. O'Brien, Nathan R. Tzodikov
  • Patent number: 4377075
    Abstract: A self-contained refrigerant package and method for shipment of a perishable or degradable product is described. The shipping package comprises an insulated container having therein a predetermined quantity of dry ice and a predetermined quantity of refrigerant gel that separates the product from the dry ice to prevent contact with the dry ice. The shipping package maintains the desired temperature range for periods in excess of 48 hours thus providing a safety factor for delays in shipment of such products.
    Type: Grant
    Filed: March 9, 1981
    Date of Patent: March 22, 1983
    Assignee: New England Nuclear Corporation
    Inventor: Michael S. Russo
  • Patent number: 4358434
    Abstract: A method and kit for stabilizing solutions of radiolabelled compound by the use of insoluble quaternary ammonium containing compounds. Also described are novel insoluble compounds having quaternary ammonium and sulfide groups for use in the present invention.
    Type: Grant
    Filed: December 19, 1979
    Date of Patent: November 9, 1982
    Assignee: New England Nuclear Corporation
    Inventors: Nathan R. Tzodikov, Robert E. O'Brien
  • Patent number: 4358401
    Abstract: A liquid organic scintillation cocktail which is readily converted to a solid for disposal after use. Also disclosed are a method of disposal of radwaste employing the cocktail and a kit useful for practicing the method.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: November 9, 1982
    Assignee: New England Nuclear Corporation
    Inventors: Robert E. O'Brien, Jeanne K. Krieger
  • Patent number: 4355236
    Abstract: An adjustable strength multipole permanent magnet is disclosed that comprises a plurality of axial layers of magnetic material wherein one layer can be angularly displaced with respect to an adjacent layer, each of said axial layers comprising a plurality of segments comprising an oriented, anisotropic,, permanent magnet material arranged in a ring, each segment having a predetermined easy axis orientation that is preferably determined by the formula:.alpha.=2.theta.where .theta. is the angle between the radial symmetry line of a segment and the X-axis and .alpha. is the angle between said radial line and the easy axis of the segment.
    Type: Grant
    Filed: April 24, 1980
    Date of Patent: October 19, 1982
    Assignee: New England Nuclear Corporation
    Inventor: Ronald F. Holsinger
  • Patent number: 4337240
    Abstract: Small sized material (less than 0.2 .mu.m, preferably less than 0.1 .mu.m) comprising a complex of (1) denatured albumin, particularly human serum albumin and (2) a metal reducing agent, particularly a stannous reducing agent, preferably formed in the presence of a stabilizing ligand, which complex, when labelled with technetium-99m provides an excellent agent for imaging or otherwise evaluating reticuloendothelial systems (RES) and/or components thereof, particularly the bone marrow, liver and/or lymphatic system; methods of making and using the same; a complex (physical or chemical) of technetium-99m with such materials and methods of using such latter complex.
    Type: Grant
    Filed: March 7, 1979
    Date of Patent: June 29, 1982
    Assignee: New England Nuclear Corporation
    Inventor: Eugene L. Saklad
  • Patent number: 4330507
    Abstract: A method for generating Ga-68 from Ge-68 is provided that comprises contacting a substrate on which Ge-68 has been adsorbed with an alkaline solution having a pH of at least about 12 and thereby eluting Ga-68. Preferably the Ga-68 is eluted in the form of the gallate ion. A generator system comprises a generator column containing Ge-68 and Ga-68, a sealed eluant container having a predetermined quantity of eluant comprising an alkaline solution having a pH of at least about 12, and an evacuated eluate collection vial having a vacuum sufficient to draw the desired quantity of eluate into the eluate collection vial. The eluate collection vial can contain a neutralizing agent and also a diagnostically useful complexing agent.
    Type: Grant
    Filed: June 11, 1980
    Date of Patent: May 18, 1982
    Assignee: New England Nuclear Corporation
    Inventor: Robert E. Lewis
  • Patent number: 4315906
    Abstract: A highly purified, biologically active cold insoluble globulin (CIG) preparation is provided having specific opsonic activity of at least 1000 units per mg of CIG. Methods of purifying CIG using affinity antibody columns are described in which the biological activity of the purified CIG is greater than 95% of the activity of the starting material.The purified CIG can be radiolabelled and radiopharmaceutical preparations containing such CIG are useful as scanning agents for in vivo localizing of areas where CIG-binding determinants are expressed. Such areas include thrombi and damaged tissue such as burns, heart, liver, spleen, muscle, skin, kidney and the like. These areas of localized radiolabelled CIG can be visualized with a gamma camera.
    Type: Grant
    Filed: May 21, 1979
    Date of Patent: February 16, 1982
    Assignee: New England Nuclear Corporation
    Inventor: Frank B. Gelder
  • Patent number: 4293436
    Abstract: An improved method of enhancing the effect of weak, e.g. beta, radioactive emitters, such as tritium and carbon-14, on film by contacting the medium used to contain the radioactive emitter with a fluor dissolved or dispersed in a carboxylic acid.A new composition of matter for performing such a method, comprising a fluor dissolved or dispersed in a carboxylic acid.An article of manufacture comprising an aqueous separation medium impregnated with a fluor and a solvent.
    Type: Grant
    Filed: March 30, 1979
    Date of Patent: October 6, 1981
    Assignee: New England Nuclear Corporation
    Inventor: Dennis L. Fost
  • Patent number: 4278653
    Abstract: Methods and kits for performing a double antibody immunoassay are described. The immunoassay comprises:reacting an antigen and a labelled version of said antigen with a first antibody against said antigen and said first antibody with a second antibody against said first antibody to precipitate a complex of said antigen, said first antibody and said second antibody, andprecipitating a colored protein to form a precipitate comprised of said complex and colored protein.In a preferred embodiment, the first and second antibodies can be prereacted to simplify the assay procedure.
    Type: Grant
    Filed: February 1, 1979
    Date of Patent: July 14, 1981
    Assignee: New England Nuclear Corporation
    Inventors: S. Richard Harris, Darlene K. Bonci
  • Patent number: 4272503
    Abstract: Reductant compositions for reducing technetium to produce technetium labelled ligands comprise a substrate having attached thereto a reducing complex having sufficient redox potential to reduce technetium from the +7 oxidation state. Preferably the reducing complex comprises a reducing agent for technetium and a chelating ligand therefor. Technetium labelled ligands are prepared by mixing such ligands with pertechnetate in the presence of the reductant of this invention and separating the reductant from the resulting labelled ligand. Technetium labelled ligands that are substantially free from reducing agent used in their preparation may be made in this manner.
    Type: Grant
    Filed: May 25, 1978
    Date of Patent: June 9, 1981
    Assignee: New England Nuclear Corporation
    Inventors: Leopoldo L. Camin, Maria P. Liteplo
  • Patent number: 4226846
    Abstract: Microaggregates of a complex of (1) albumin, particularly human serum albumin and (2) a metal reducing agent, particularly a stannous reducing agent, preferably formed in the presence of a stabilizing ligand, which complex, when labelled with technetium-99m provides an excellent agent for imaging reticuloendothelial systems (RES), particularly the liver, spleen, and bone marrow; methods of making and using the same; a complex (physical or chemical) of technetium-99m with such microaggregates and methods of using such latter complex.
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: October 7, 1980
    Assignee: New England Nuclear Corporation
    Inventor: Eugene L. Saklad
  • Patent number: 4136159
    Abstract: Novel folic acid derivatives useful in processes for analysis of biological fluids for folic acid or its metabolites comprising components of the formula: ##STR1## wherein R is hydrogen or radioactive iodine.
    Type: Grant
    Filed: February 28, 1977
    Date of Patent: January 23, 1979
    Assignee: New England Nuclear Corporation
    Inventor: Marcia J. Stone
  • Patent number: 4124527
    Abstract: Liquid scintillation counting compositions which include certain polyethoxylated poly(oxypropylene) emulsifiers allow stable dispersion of aqueous or other samples merely by shaking. Preferred are mixtures of such emulsifiers, which give homogeneous, monophasic-appearing dispersions over wide ranges of temperature and aqueous sample content. Certain of these emulsifiers, without being mixed, are of particular advantage when used in analysis of samples obtained through radioimmunoassay techniques, which are extremely difficult to disperse. Certain of these emulsifiers, also without being mixed, uniformly give homogeneous, monophasic appearing aqueous counting samples over much wider ranges of aqueous sample content and temperature than prior sample emulsifiers.
    Type: Grant
    Filed: December 15, 1975
    Date of Patent: November 7, 1978
    Assignee: New England Nuclear Corporation
    Inventor: Joel M. Kauffman