Patents Assigned to New Horizons Diagnostics Corp.
  • Patent number: 7232576
    Abstract: A lozenge for the treatment of Streptococcus Group A infections of the mouth, throat, and nasal passage is disclosed which comprises a lytic enzyme composition specific for Streptococcus Group A and a lozenge carrier for delivering the lytic enzyme.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: June 19, 2007
    Assignees: New Horizons Diagnostics Corp, Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 7169408
    Abstract: The present invention discloses a composition for dermatological infections by the use of a lytic enzyme in a carrier suitable for topical application to dermal tissues. The method for the treatment of dermatological infections comprises administering a composition comprising effective amount of a therapeutic agent, with the therapeutic agent comprising a lytic enzyme produced by infecting a bacteria with phage specific for that bacteria.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: January 30, 2007
    Assignees: New Horizons Diagnostics Corp., Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 7141241
    Abstract: The present invention relates to an oral delivery system containing a bacteriophage associated lysin enzyme for the treatment of [Streptococcus pneumoniae and] Hemophilus influenzae sinus/nasal infections.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: November 28, 2006
    Assignees: New Horizons Diagnostics Corp, Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 7063837
    Abstract: The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for that bacteria and an appropriate carrier for delivering the lytic enzyme into a patient. The injection can be done intramuscularly, subcutaneously, or intravenously.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: June 20, 2006
    Assignees: New Horizons Diagnostics Corp, Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 7014850
    Abstract: A nasal spray for treating a streptococcal infection is disclosed. The spray comprises an effective amount of a lysin enzyme genetically coded for by a C1 bacteriophage capable of infecting a group C Streptococcal bacteria, and a nasal spray carrier for delivering said lysin enzyme to a mouth, throat, or nasal passage.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: March 21, 2006
    Assignees: New Horizons Diagnostics Corp, Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6936244
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
    Type: Grant
    Filed: May 14, 2002
    Date of Patent: August 30, 2005
    Assignees: New Horizons Diagnostics Corp, Rockefeller University
    Inventors: Vincent Fiochetti, Lawrence Loomie
  • Patent number: 6893635
    Abstract: A method for treating a streptococcal infection is disclosed using a nasal spray. The spray comprises an effective amount of a lysin enzyme genetically coded for by a C1 bacteriophage capable of infecting a group C Streptococcal bacteria, and a nasal spray carrier for delivering said lysin enzyme to a mouth, throat, or nasal passage.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: May 17, 2005
    Assignees: New Horizons Diagnostics Corp, Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6881403
    Abstract: A tampon for treatment of Streptococcus Group B infections of the vagina is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering the lytic enzyme.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: April 19, 2005
    Assignees: New Horizons Diagnostic, Corp, Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6875431
    Abstract: A method for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The composition may be in the form of an isotonic solution.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: April 5, 2005
    Assignees: New Horizons Diagnostics Corp., Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6752988
    Abstract: A method for the prophylactic and therapeutic treatment of bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of a native or modified version of a lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria. The lytic enzyme is selected from a group consisting of shuffled lytic enzymes, chimericlytic enzymes, wherein the lytic enzyme is in an environment having a pH which allows for activity of said lytic enzyme; and a carrier for delivering said lytic enzyme. Additionally, a holin enzyme for puncturing the membrane may be included in the composition. This method, and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, and burns, vaginal infections, eye infections, intestinal disorders and dental problems.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: June 22, 2004
    Assignees: New Horizons Diagnostic Corp, Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6685937
    Abstract: A chewing gum composition produced by mixing an effective amount of lysin enzyme produced by group C streptococcal bacteria infected with a C1 bacteriophage and a carrier for delivering said lysin enzyme to a mouth, throat, or nasal passage.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: February 3, 2004
    Assignees: New Horizons Diagnostics Corp., Rockefeller University
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6432444
    Abstract: A bandage for treating a bacterial infection of skin is disclosed wherein the bandage contains a composition produced by the method of obtaining an effective amount of at least one lytic enzyme genetically coded for by a specific bacteriophage specific for a bacteria infecting the skin, wherein the bacteria to be treated is selected from the group consisting of Staphylococcus, Pseudomonas, Streptococcus, and combinations thereof. This lytic enzyme is specific for and has the ability to digest a cell wall of one of the bacteria and is coded for by the same bacteriophage capable of infecting the bacteria being digested. The enzyme produced is mixed with a topical carrier.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 13, 2002
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6428784
    Abstract: A composition for treatment of bacterial infections of the vagina is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The lytic enzyme is which is specific for the group B Streptococcus, is genectically coded for by a specific bacteriophage.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 6, 2002
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6406692
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: June 18, 2002
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6399098
    Abstract: The present invention discloses a method for treating baterial dental caries caused by Streptococcus mutans, comprising administering a composition comprising an effective amount of at least one lytic enzyme produced by a bacteriophage specific for Streptococcus mutans, with the lytic enzyme having the ability to exclusively digest a cell wall of the Streptococcus mutans infecting all or part of a mouth or teeth, and a toothpaste for delivering the enzyme to the mouth and teeth.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: June 4, 2002
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6395504
    Abstract: A method for the use of a phage associated lysing enzyme for the detecting the presence and determining the quantity of bacteria present in or on a wide variety of substances is described. The total concentration of microbes is determined by adding or incorporating a phage associated lytic agent to a disposable test system device with the luminescent reagents luciferin and luciferase, and introducing the disposable test system into a luminometer that can read the luminescence. Other systems can be used with the lytic enzymes for the quantitative and qualitative determination for the presence of bacteria.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: May 28, 2002
    Assignee: New Horizons Diagnostics Corp.
    Inventor: David Trudil
  • Patent number: 6238661
    Abstract: Compositions and methods for the prophylactic and therapeutic treatment of bacterial infections are disclosed which comprise administering to an individual an effective amount of a composition comprising an effective amount of lytic enzyme and a carrier for delivering the lytic enzyme. This method and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, burns, vaginal infections, eye infections, intestinal disorders and dental problems.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: May 29, 2001
    Assignee: New Horizons Diagnostics Corp.
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 6056954
    Abstract: A method for the prophylactic and therapeutic treatment of bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of a lytic enzyme composition specific for the infecting bacteria, with the lytic enzyme comprising an effective amount of lytic enzyme, wherein the lytic enzyme is in an environment having a pH which allows for activity of said lytic enzyme; and a carrier for delivering said lytic enzyme. This method, and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, and burns, vaginal infections, eye infections, intestinal disorders and dental problems.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: May 2, 2000
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent A. Fischetti, Lawrence Loomis
  • Patent number: 5985271
    Abstract: The present invention relates to an oral delivery system containing a group c streptococcal phage associated lysin enzyme for the prophylactic and therapeutic treatment of Streptococcal A throat infections, commonly known as strep throat.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: November 16, 1999
    Assignee: New Horizons Diagnostics Corp.
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Patent number: 5624810
    Abstract: A method for determining the presence and concentration of total microbial contamination or the presence and concentration of a specific microbial species on a surface is described. The method consists of a means of a collection device and fluid for removing the microbes from the surface and suspending them in a fluid phase. An aliquot of the fluid phase is introduced into a disposable test device which allows filtration of the sample to remove extraneous substances including somatic cells, and concentration of the microbes. The total concentration of microbes is determined by adding a bacterial releasing reagent and a luminescent reagent to the disposable test device and introducing the disposable test device into a luminometer that can read the luminescence from the side wall.
    Type: Grant
    Filed: January 9, 1995
    Date of Patent: April 29, 1997
    Assignee: New Horizons Diagnostics Corp.
    Inventors: C. David Miller, Lawrence Loomis