Patents Assigned to Nihon Medi-Physics Co., Ltd.
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Patent number: 11318216Abstract: Provided is a method for producing a radiohalogen-labeled compound, the method comprises: a step in which a radiohalogen-labeling precursor compound (S-L) having a leaving group (L) capable of being nucleophilically substituted by a radioactive halide ion (X?) is subjected to a radiohalogenation reaction to obtain a reaction mixture RM1 which contains the radiohalogen-labeling precursor compound (S-L) and a reaction product (S—X) resulting from the radiohalogenation reaction; a step in which the reaction mixture RM1 is mixed with a polyvalent acid or a salt thereof to obtain a reaction mixture RM2; and a step in which the reaction product (S—X) is purified from the reaction mixture RM2 by a solid phase extraction method.Type: GrantFiled: May 28, 2018Date of Patent: May 3, 2022Assignee: NIHON MEDI-PHYSICS CO., LTD.Inventors: Yuki Okumura, Daisaku Nakamura, Masato Kiriu, Hiroaki Ichikawa, Gota Tonoya, Naomi Sugimoto
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Patent number: 11266753Abstract: Provided are a compound represented by the following formula (1): wherein X1 represents a hydrogen atom or a halogen atom, X2 represents a fluorine atom or a nitrile group, and X3 represents a radioactive halogen atom, or a salt thereof, and a medicament including the same.Type: GrantFiled: December 20, 2018Date of Patent: March 8, 2022Assignees: NIHON MEDI-PHYSICS CO., LTD., NATIONAL HOSPITAL ORGANIZATIONInventors: Akihiro Izawa, Yuki Okumura, Yurie Fukui, Hiroaki Ichikawa, Yoshifumi Maya, Miho Ikenaga, Hiroyuki Okudaira, Yoshihiro Doi, Mitsuhide Naruse
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Publication number: 20220051828Abstract: Provided is a target transport system which is advantageous in simplifying and downsizing a configuration in production of radio-isotopes using an accelerator and in which components are hardly affected to be damaged by radiation. The target transport system includes: a transport pipeline through which a target body is transported; a target holding part that holds the target body and allows the target body to be irradiated with particle beams; and a pump, the transport pipeline, and a target entry port that transport the target body to the target holding part by a cooling water. The pump, the transport pipeline, and the target entry port cause the cooling water to flow in the transport direction, and the target body is recovered from the transport pipeline by the cooling water.Type: ApplicationFiled: September 6, 2019Publication date: February 17, 2022Applicant: Nihon Medi-Physics Co., Ltd.Inventor: Taku ITO
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Publication number: 20210338852Abstract: The RI-labeled anti-MUC5AC humanized antibody of the present invention is a conjugate of a chelating agent chelated with a radionuclide and an antibody (the radionuclide is a metal nuclide that emits ? particle or positron, and the antibody is a humanized antibody specifically binding to MUC5AC), and is superior in specificity for MUC5AC and accumulation in tumor. Therefore, it is extremely useful for the treatment and/or diagnosis of diseases in which MUC5AC is overexpressed, particularly cancer.Type: ApplicationFiled: July 2, 2021Publication date: November 4, 2021Applicants: NIHON MEDI-PHYSICS CO., LTD., SUMITOMO DAINIPPON PHARMA CO., LTD.Inventors: Norihito Nakata, Nobuya Kobashi, Yoshinari Shoyama, Mitsuhiro Matono, Yasushi Ochiai, Takayuki Murakami
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Publication number: 20210322582Abstract: The present invention provides a radiolabeled compound represented by the following formula (1), which is a radioactive imidazothiadiazole derivative compound having an affinity for CA-IX, or a salt thereof. wherein n is an integer of 1 to 4, and L represents a radionuclide or a mono- to tetravalent group containing a radionuclide.Type: ApplicationFiled: August 30, 2019Publication date: October 21, 2021Applicants: Nihon Medi-Physics Co., Ltd., Kyoto UniversityInventors: Masato KIRIU, Norihito NAKATA, Tsutomu ABE, Masahiro ONO
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Patent number: 11083804Abstract: It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.Type: GrantFiled: May 11, 2018Date of Patent: August 10, 2021Assignee: NIHON MEDI-PHYSICS CO., LTD.Inventors: Osamu Ito, Akio Hayashi, Fumie Kurosaki, Masahito Toyama, Toshiyuki Shinmura, Arinori Harano
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Publication number: 20210170058Abstract: The present invention relates to a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and provides a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.Type: ApplicationFiled: April 15, 2019Publication date: June 10, 2021Applicants: NIHON MEDI-PHYSICS CO., LTD., National University Corporation Kagoshima University, National University Corporation Chiba UniversityInventors: Shota KOMOTO, Yu OGAWA, Yoshinari SHOYAMA, Tadashi HATANO, Yuji ITO, Yasushi ARANO, Hiroyuki SUZUKI, Tomoya UEHARA
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Patent number: 10953112Abstract: It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.Type: GrantFiled: April 20, 2020Date of Patent: March 23, 2021Assignee: NIHON MEDI-PHYSICS CO., LTD.Inventors: Osamu Ito, Akio Hayashi, Fumie Kurosaki, Masahito Toyama, Toshiyuki Shinmura, Arinori Harano
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Publication number: 20210060186Abstract: Provided are a compound represented by the following formula (1): wherein X1 represents a hydrogen atom or a halogen atom, X2 represents a fluorine atom or a nitrile group, and X3 represents a radioactive halogen atom, or a salt thereof, and a medicament including the same.Type: ApplicationFiled: December 20, 2018Publication date: March 4, 2021Applicants: Nihon Medi-Physics Co., Ltd., National Hospital OrganizationInventors: Akihiro IZAWA, Yuki OKUMURA, Yurie FUKUI, Hiroaki ICHIKAWA, Yoshifumi MAYA, Miho IKENAGA, Hiroyuki OKUDAIRA, Yoshihiro DOI, Mitsuhide NARUSE
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Patent number: 10857245Abstract: There is provided a diagnostic imaging agent for early bone metastasis from cancer, containing trans-1-amino-[18F]fluorocyclobutanecarboxylic acid or a pharmaceutically acceptable salt thereof as an active ingredient.Type: GrantFiled: June 1, 2016Date of Patent: December 8, 2020Assignee: NIHON MEDI-PHYSICS CO., LTD.Inventors: Shuntaro Oka, Masaru Kanagawa, Akiharu Otaka, Masako Teramachi, Satoshi Watanabe, Toshie Nagatomo
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Patent number: 10703726Abstract: A simple method for producing a clinically applicable radiopharmaceutical composition containing 1-(2,2-dihydroxymethyl-3-[18F]fluoropropyl)-2-nitroimidazole ([18F]DiFA) or a salt thereof as an active ingredient, is provided which includes a synthesis step of obtaining a crude product of [18F]DiFA from a labeling precursor compound for [18F]DiFA; and a purification step of purifying the crude product, in which the purification step includes purifying [18F]DiFA using two or more different types of reverse phase solid phase extraction cartridges.Type: GrantFiled: February 28, 2019Date of Patent: July 7, 2020Assignees: NIHON MEDI-PHYSICS CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Masato Kiriu, Soichi Nakamura, Yuji Kuge, Norifumi Abo
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Publication number: 20200121811Abstract: Provided is a method for producing a radiohalogen-labeled compound, the method comprises: a step in which a radiohalogen-labeling precursor compound (S-L) having a leaving group (L) capable of being nucleophilically substituted by a radioactive halide ion (X?) is subjected to a radiohalogenation reaction to obtain a reaction mixture RM1 which contains the radiohalogen-labeling precursor compound (S-L) and a reaction product (S—X) resulting from the radiohalogenation reaction; a step in which the reaction mixture RM1 is mixed with a polyvalent acid or a salt thereof to obtain a reaction mixture RM2; and a step in which the reaction product (S—X) is purified from the reaction mixture RM2 by a solid phase extraction method.Type: ApplicationFiled: May 28, 2018Publication date: April 23, 2020Applicant: NIHON MEDI-PHYSICS CO., LTD.Inventors: Yuki OKUMURA, Daisaku NAKAMURA, Masato KIRIU, Hiroaki ICHIKAWA, Gota TONOYA, Naomi SUGIMOTO
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Publication number: 20200009273Abstract: There is provided a labeling precursor compound represented by the general formula (2): wherein S represents a substrate, L represents a straight alkyl group having 1 to 6 carbon atoms which may contain an ether group, R1 and R2 each independently represent a straight or branched alkyl group having 1 to 30 carbon atoms, or a substituted or unsubstituted monocyclic or condensed polycyclic aryl group, R3 each independently represent an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms, and p represents an integer of 0 to 4.Type: ApplicationFiled: March 5, 2018Publication date: January 9, 2020Applicants: NIHON MEDI-PHYSICS CO., LTD., TOKYO INSTITUTE OF TECHNOLOGYInventors: Masato KIRIU, Hiroaki ICHIKAWA, Yuki OKUMURA, Hiroshi TANAKA
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Patent number: 10472338Abstract: Provided is a method for producing flutemetamol including the steps of: reacting a precursor compound represented by a predetermined general formula with a radioactive fluoride to obtain a 18F labeling compound represented by a predetermined general formula; allowing a strong base to act on the reaction mixture of the above step containing the precursor compound and the 18F labeling compound; after the above step, purifying the 18F labeling compound using a reverse phase solid phase extraction cartridge; and removing a protective group to obtain [18F]flutemetamol.Type: GrantFiled: October 17, 2016Date of Patent: November 12, 2019Assignees: GE HEALTHCARE LIMITED, NIHON MEDI-PHYSICS CO., LTD.Inventors: Yuki Okumura, Gota Tonoya, Tomoyuki Matsunami
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Publication number: 20190276411Abstract: A simple method for producing a clinically applicable radiopharmaceutical composition containing 1-(2,2-dihydroxymethyl-3-[18F]fluoropropyl)-2-nitroimidazole ([18F]DiFA) or a salt thereof as an active ingredient, is provided which includes a synthesis step of obtaining a crude product of [18F]DiFA from a labeling precursor compound for [18F]DiFA; and a purification step of purifying the crude product, in which the purification step includes purifying [18F]DiFA using two or more different types of reverse phase solid phase extraction cartridges.Type: ApplicationFiled: February 28, 2019Publication date: September 12, 2019Applicants: Nihon Medi-Physics Co., Ltd., National University Corporation Hokkaido UniversityInventors: Masato Kiriu, Soichi Nakamura, Yuji Kuge, Norifumi Abo
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Patent number: 10395364Abstract: One embodiment of the present invention addresses the problem of reducing the influence of physiological accumulation in monitoring nuclear medical image data. To solve this problem, the embodiment includes: extracting a bone area from CT image data having been positioned with nuclear medical image data; in the nuclear medical image data, displaying the data of an area overlapping the bone area extracted above; and, in the nuclear medical image data, not displaying the data of an area not overlapping the bone area extracted above.Type: GrantFiled: October 29, 2015Date of Patent: August 27, 2019Assignee: Nihon Medi-Physics Co., Ltd.Inventors: Kazuo Hamada, Hiromitsu Daisaki, Kazumasa Nishida
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Publication number: 20190255199Abstract: The present invention addresses the problem of providing a technique for detecting a lesion of a heart disease in a non-invasive manner. The present invention provides a non-invasive diagnostic imaging agent for a heart disease, which contains a radioactively labeled compound capable of binding to an aldosterone synthase or a salt thereof as an active ingredient.Type: ApplicationFiled: June 9, 2017Publication date: August 22, 2019Applicant: Nihon Medi-Physics Co., Ltd.Inventor: Yoshifumi MAYA
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Patent number: 10366479Abstract: [Problem to be Solved] To improve stability of automatic normalization of a bone scintigraphy image. [Solution] A preferred embodiment includes: creating a pixel value histogram of image data representing a bone scintigraphy image; setting a plurality of thresholds related to pixel values based on the pixel value histogram; calculating respective average pixel values for the set thresholds; arranging the calculated average pixel values in order from the largest value; and determining a reference value for normalizing the image data based on at least part of a set of the average pixel values arranged in the order. The determining the reference value includes: determining one straight line that approximates a region of small average pixel values out of the set of the average pixel values arranged in the order; and calculating the reference value based on the straight line.Type: GrantFiled: March 3, 2016Date of Patent: July 30, 2019Assignee: Nihon Medi-Physics Co. Ltd.Inventor: Kazuhiro Nishikawa
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Patent number: 10358434Abstract: Provided is a medicament comprising the compound represented by the following general formula (1) or a salt thereof: In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined. Methods for producing various radioactive compounds are also provided.Type: GrantFiled: December 6, 2018Date of Patent: July 23, 2019Assignees: NIHON MEDI-PHYSICS CO., LTD., KYOTO UNIVERSITY, NATIONAL HOSPITAL ORGANIZATIONInventors: Akihiro Izawa, Kei Akama, Yuki Okumura, Yurie Fukui, Nobuya Kobashi, Tsutomu Abe, Yoshihiro Doi, Miho Ikenaga, Hideo Saji, Hiroyuki Kimura, Mitsuhide Naruse
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Publication number: 20190169169Abstract: Provided is a medicament comprising the compound represented by the following general formula (1) or a salt thereof: In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined. Methods for producing various radioactive compounds are also provided.Type: ApplicationFiled: December 6, 2018Publication date: June 6, 2019Applicants: NIHON MEDI-PHYSICS CO., LTD., Kyoto University, National Hospital OrganizationInventors: Akihiro IZAWA, Kei AKAMA, Yuki OKUMURA, Yurie FUKUI, Nobuya KOBASHI, Tsutomu ABE, Yoshihiro DOI, Miho IKENAGA, Hideo SAJI, Hiroyuki KIMURA, Mitsuhide NARUSE