Patents Assigned to Nippon Chemiphar Company, Ltd.
  • Patent number: 4640835
    Abstract: Derivatives of a nonimmunogenic plasminogen activator which comprises at least one polyalkylene glycol group chemically bonded with at least one coupling agent to amino acid side chains of said plasminogen activator, wherein said polyalkylene glycol has a molecular weight of about 200-20,000 and is unsubstituted or is substituted with one or more alkyl, alkoxy or alkanoyl groups or a mixture thereof.The plasminogen activator derivatives have an extended circulating life in the mammalian bloodstream and also inhibit the formation of thrombus in the same.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: February 3, 1987
    Assignee: Nippon Chemiphar Company, Ltd.
    Inventors: Kimihiro Shimizu, Tsuguji Nakahara, Taketoshi Kinoshita, Jun Takatsuka, Michiko Igarashi