Patents Assigned to Norian Corporation
  • Patent number: 6334891
    Abstract: Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of pharmacological interest.
    Type: Grant
    Filed: April 1, 1999
    Date of Patent: January 1, 2002
    Assignee: Norian Corporation
    Inventors: Brent R. Constantz, Mark Fulmer, Ira Ison
  • Patent number: 6149655
    Abstract: A system is provided for the storage, preparation and administration of calcium phosphate cements. The subject invention provides a storage means for storing a two component calcium phosphate cement having a liquid component and a dry component. Also provided is a preparation means for combining the two components of the cement while present in the storage means. The subject invention further provides a means for administering the prepared cement to a physiological site. The subject devices and methods find use in a variety of applications where the introduction of a flowable material capable of setting to a solid calcium phosphate mineral to a physiological site is desired, including dental and orthopedic applications.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: November 21, 2000
    Assignee: Norian Corporation
    Inventors: Brent R. Constantz, Ben Clawson
  • Patent number: 6083229
    Abstract: A system is provided for the storage, preparation and administration of calcium phosphate cements. The subject invention provides a storage means for storing a two component calcium phosphate cement having a liquid component and a dry component. Also provided is a preparation means for combining the two components of the cement while present in the storage means. The subject invention further provides a means for administering the prepared cement to a physiological site. The subject devices and methods find use in a variety of applications where the introduction of a flowable material capable of setting to a solid calcium phosphate mineral to a physiological site is desired, including dental and orthopedic applications.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: July 4, 2000
    Assignee: Norian Corporation
    Inventors: Brent R. Constantz, Ben Clawson
  • Patent number: 6053970
    Abstract: Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: April 25, 2000
    Assignee: Norian Corporation
    Inventors: Ira C. Ison, Mark T. Fulmer, Bryan M. Barr, Brent R. Constantz
  • Patent number: 6005162
    Abstract: Methods are provided for repairing bone. In the subject methods, a flowable composition capable of setting under physiological conditions into an physiologically acceptable calcium phosphate mineral is administered to a bone repair site. Following administration, the composition is allowed to harden, whereby the bone is repaired.
    Type: Grant
    Filed: January 29, 1997
    Date of Patent: December 21, 1999
    Assignee: Norian Corporation
    Inventor: Brent R. Constantz
  • Patent number: 6002065
    Abstract: Setting times of calcium phosphate cement compositions are enhanced by the addition of phosphate or carbonate lubricant compositions. Methods for preparing the cement compositions are provided.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: December 14, 1999
    Assignee: Norian Corporation
    Inventors: Brent R. Constantz, Mark T. Fulmer, Bryan M. Barr
  • Patent number: 5968253
    Abstract: A flowable, paste-like composition capable of setting in a clinically relevant period of time into an antimicrobial agent loaded apatitic product having sufficient compressive strength to serve as a cancellous bone structural material is provided. The subject compositions are prepared by combining dry ingredients with a physiologically acceptable lubricant and an antimicrobial agent, where the dry ingredients comprise at least two different calcium phosphates. The subject compositions find use in a variety of different applications, including orthopaedic, dental and cranio-maxillofacial applications.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: October 19, 1999
    Assignee: Norian Corporation
    Inventors: Robert Poser, Mark Fulmer, Brent R. Constantz
  • Patent number: 5964932
    Abstract: Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calciumim phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion.
    Type: Grant
    Filed: July 7, 1998
    Date of Patent: October 12, 1999
    Assignee: Norian Corporation
    Inventors: Ira C. Ison, Mark T. Fulmer, Bryan M. Barr, Brent R. Constantz
  • Patent number: 5962028
    Abstract: Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: October 5, 1999
    Assignee: Norian Corporation
    Inventor: Brent R. Constantz
  • Patent number: 5952010
    Abstract: Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like.
    Type: Grant
    Filed: December 9, 1997
    Date of Patent: September 14, 1999
    Assignee: Norian Corporation
    Inventor: Brent R. Constantz
  • Patent number: 5900254
    Abstract: Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: May 4, 1999
    Assignee: Norian Corporation
    Inventor: Brent R. Constantz
  • Patent number: 5885540
    Abstract: Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: March 23, 1999
    Assignee: Norian Corporation
    Inventors: Mark Fulmer, Brent R. Constantz, Ira C. Ison, Bryan M. Barr
  • Patent number: 5846312
    Abstract: Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: December 8, 1998
    Assignee: Norian Corporation
    Inventors: Ira C. Ison, Mark T. Fulmer, Bryan M. Barr, Brent R. Constantz
  • Patent number: 5820632
    Abstract: Setting times of calcium phosphate cement compositions are enhanced by the addition of phosphate or carbonate lubricant compositions. Methods for preparing the cement compositions are provided.
    Type: Grant
    Filed: April 1, 1994
    Date of Patent: October 13, 1998
    Assignee: Norian Corporation
    Inventors: Brent R. Constantz, Mark T. Fulmer, Bryan M. Barr
  • Patent number: 5782971
    Abstract: Calcium phosphate cements are provided. The subject cements comprise amorphous calcium phosphate, at least one additional calcium source, usually an additional calcium phosphate, and a liquid component, such as a physiologically acceptable lubricant. Upon combination of the cement components, a flowable composition capable of setting in vivo into a solid calcium phosphate mineral product, such as hydroxyapatite, is produced. The subject cement compositions find use in a variety of applications, including the treatment of injured or compromised hard tissue.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: July 21, 1998
    Assignee: Norian Corporation
    Inventors: Brent R. Constantz, Bryan M. Barr
  • Patent number: 5709742
    Abstract: Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.
    Type: Grant
    Filed: May 15, 1996
    Date of Patent: January 20, 1998
    Assignee: Norian Corporation
    Inventors: Mark Fulmer, Brent R. Constantz, Ira C. Ison, Bryan M. Barr
  • Patent number: 5697981
    Abstract: Methods and compositions for use in bone repair are provided. The subject methods employ a two component calcium phosphate cement having a dry component and a lubricant, wherein the dry component of the cement comprises basic calcium phosphate particles at least partially coated with a partially neutralized acidic calcium phosphate. In the subject methods, the dry component and lubricant of the cement are combined to produce a moldable paste which is capable of hardening into a solid mass. The moldable paste may be introduced at a bone repair site and allowed to harden in situ. Alternatively the paste may be allowed to harden and then shaped to obtain a preformed object useful in bone repair.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 16, 1997
    Assignee: Norian Corporation
    Inventors: Ira C. Ison, Mark T. Fulmer, Bryan M. Barr, Brent R. Constantz
  • Patent number: 5683667
    Abstract: Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.
    Type: Grant
    Filed: December 11, 1995
    Date of Patent: November 4, 1997
    Assignee: Norian Corporation
    Inventors: Mark Fulmer, Brent R. Constantz, Ira C. Ison, Bryan M. Barr
  • Patent number: 5683496
    Abstract: Two component, storage stable apatitic cement compositions, as well as methods for their production, are provided. The dry component of subject apatitic cements comprises basic calcium source particles at least partially coated with a partially neutralized acidic calcium phosphate. The dry component of subject compositions is prepared by combining basic calcium source particles with dissolved acidic phosphate in at least a partially aqueous medium, whereby the basic calcium source particles become partially coated with a partially neutralized acidic calcium phosphate. The reaction is terminated prior to completion of the reaction between the acidic phosphate and the basic calcium source by removing the available water from the reaction mixture. In a first mode, the subject cement may be produced by mechanically mixing an acidic phosphate source with basic calcium source particles in the presence of an aqueous solvent and stopping the reaction between the acid and base prior to completion.
    Type: Grant
    Filed: May 14, 1996
    Date of Patent: November 4, 1997
    Assignee: Norian Corporation
    Inventors: Ira C. Ison, Mark T. Fulmer, Bryan M. Barr, Brent R. Constantz
  • Patent number: 5580623
    Abstract: Methods and compositions are provided for preparing storage stable partially neutralized acid compositions. The partially neutralized acid compositions are amenable to prolonged periods of storage. Following storage, the acids can be neutralized with a calcium neutralizing source and combined with a lubricant to form a rapidly setting calcium phosphate mineral suitable for a variety of purposes, e.g. bone replacement.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 3, 1996
    Assignee: Norian Corporation
    Inventors: Mark Fulmer, John Ross, Brent Constantz