Patents Assigned to Northwestern University
  • Publication number: 20200390700
    Abstract: Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes a ligand, an engineered glycosylation site, and an exosome-targeting domain. Exemplary extracellular vesicles may include but are not limited to exosomes.
    Type: Application
    Filed: April 20, 2020
    Publication date: December 17, 2020
    Applicant: Northwestern University
    Inventors: Joshua N. Leonard, Michelle E. Hung
  • Publication number: 20200393458
    Abstract: Disclosed are systems and methods for detecting extracellular ligands. The disclosed systems and method for detecting extracellular ligands typically comprise or utilize engineered red blood cells (eRBCs) that comprises modular extracellular sensors. The eRBCs may comprise: (i) a first exogenous extracellular sensor; the first extracellular sensor comprising: a) a ligand binding domain, b) a transmembrane domain, and c) a first fragment of a functional protein, and (ii) a second exogenous extracellular sensor; the second extracellular sensor comprising: a) a ligand binding domain, b) a transmembrane domain, and c) a second fragment of the functional protein.
    Type: Application
    Filed: August 17, 2020
    Publication date: December 17, 2020
    Applicant: Northwestern University
    Inventors: Joshua N. Leonard, Kelly A. Schwarz, Taylor B. Dolberg
  • Publication number: 20200392116
    Abstract: Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.
    Type: Application
    Filed: June 17, 2020
    Publication date: December 17, 2020
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Gary E. SCHILTZ, Atul JAIN, Huiying HAN, Sarki A. ABDULKADIR
  • Publication number: 20200390894
    Abstract: Disclosed are proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of c-MYC protein. The disclosed PROTACs typically include a first targeting moiety that binds to c-MYC (Mc-MYC) which may be derived from a substituted heterocycle that binds to c-MYC such as a substituted pyrazole. The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to an E3 ubiquitin ligase (ME3). As such, the disclosed PROTACS may be described as having a formula Mc-MYC-L-ME3 or ME3-L-Mc-MYC.
    Type: Application
    Filed: June 12, 2020
    Publication date: December 17, 2020
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Gary E. Schiltz, Atul Jain, Huiying Han, Sarki A. Abdulkadir
  • Publication number: 20200390551
    Abstract: An annuloplasty device that includes at least one helical coil usable for percutaneous implantation and activatable such that a length of the coil shortens, thereby reducing a circumference of a dilated valve annulus.
    Type: Application
    Filed: June 12, 2020
    Publication date: December 17, 2020
    Applicant: NORTHWESTERN UNIVERSITY
    Inventor: Patrick M. McCarthy
  • Patent number: 10867718
    Abstract: Provided herein are mechanically interlocked air-stable persistent organic radicals. The radical compositions may access a multiplicity of radical, cationic redox states as well as a fully cationic redox state. A composition comprises a first ring mechanically interlocked with a second ring or a salt thereof, wherein the first ring comprises a 4,4?-bipyridinium subunit or a derivative thereof and a diazapyrenium subunit or a derivative thereof and the second ring comprises a 4,4?-bipyridinium subunit or a derivative thereof. In some embodiments, the second ring further comprises a diazapyrenium subunit or a derivative thereof. Methods of preparing the compositions are also provided.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: December 15, 2020
    Assignee: Northwestern University
    Inventors: Zhichang Liu, Junling Sun, James Fraser Stoddart
  • Publication number: 20200377481
    Abstract: Disclosed are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. The disclosed compounds may be described as substituted 4-(1-pyrrolidinyl)pyrimidine compounds. The disclosed compounds are shown to inhibit the activity of nitric oxide synthases (NOSs) including neuronal NOS (nNOS) by inhibiting dimerization, and as such, the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with nNOS activity.
    Type: Application
    Filed: June 7, 2017
    Publication date: December 3, 2020
    Applicant: Northwestern University
    Inventors: Richard B. Silverman, Sana Ma
  • Patent number: 10851082
    Abstract: Disclosed are substituted aromatic N-heterocyclic compounds. The disclosed compounds typically exhibit kinase inhibition activity, for example, and inhibit Mnk1 kinase and/or Mnk2 kinase. The disclosed compounds may be used in pharmaceutical compositions and methods for treating diseases or disorders associated with Mnk1 kinase activity and/or Mnk2 kinase activity, such as cancers, diabetes, autism, and fragile X syndrome.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: December 1, 2020
    Assignee: Northwestern University
    Inventors: Gary E. Schiltz, Javier Izquierdo-Ferrer, Purav Vagadia, Matthew R. Clutter, Rama K. Mishra, Leonidas C. Platanias
  • Publication number: 20200370133
    Abstract: The present invention features methods for characterizing mutational profiles in patients with bladder cancer.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 26, 2020
    Applicants: The Broad Institute, Inc., The General Hospital Corporation, Baylor College of Medicine, The Brigham and Women?s Hospital, Inc., Northwestern University, The Johns Hopkins University, United States Government as represented by the U.S. Department of Veterans Affairs
    Inventors: Jaegil Kim, Gad Getz, Seth Paul Lerner, David Kwiatkowski, Joshua Meeks, Joaquim Bellmunt, David McConkey
  • Publication number: 20200368258
    Abstract: A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The antiviral activity of the compound includes inhibiting formation of an associative complex or disrupting formation of an associative complex. The associative complex comprises an L-domain motif of the enveloped virus and at least one cellular polypeptide, or fragment thereof, capable of binding the L-domain motif of the enveloped virus.
    Type: Application
    Filed: August 5, 2020
    Publication date: November 26, 2020
    Applicants: Northwestern University, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Jonathan Leis, Carol Carter
  • Patent number: 10843195
    Abstract: Provided herein are devices, systems, and methods for specimen preparation by employing a combination of capillary and centrifugal forces. For example, provided herein are devices, systems, and methods that collect a sample by capillary force, separate components of the collected sample by centrifugal force, and isolate one or more of the separated components by further capillary force.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: November 24, 2020
    Assignee: Northwestern University
    Inventors: David M. Kelso, Robert Elghanian
  • Publication number: 20200362001
    Abstract: Disclosed are compositions comprising myokines and their methods of preparation and use. The disclosed myokine compositions and methods may comprise myokines having a molecular weight of greater than about 10 kDa such as myostatin and metrnl. The disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders. In particular, the disclosed myokine compositions and methods may be utilized for treating and/or preventing cell proliferative and metabolic diseases and disorders, such as cancer, and metabolic diseases and disorders, such as diabetes, non-alcoholic fatty liver disease, and heart disease.
    Type: Application
    Filed: May 18, 2020
    Publication date: November 19, 2020
    Applicant: Northwestern University
    Inventors: Hemant K. Roy, Vadim Backman
  • Publication number: 20200363437
    Abstract: Nanostructures having an inorganic core and a lipid layer capable of binding a lecithin:cholesterol acyltransferase (LCAT) activator such as an apolipoprotein are provided herein. Methods of using the nanostructures and related devices and compositions for assessing the risk of developing a disease or condition or treating the disease or condition are also provided.
    Type: Application
    Filed: June 30, 2020
    Publication date: November 19, 2020
    Applicant: Northwestern University
    Inventors: C. Shad Thaxton, Rohun U. Palekar, Kaylin M. McMahon
  • Patent number: 10835311
    Abstract: An electroporation apparatus and the method of using same are provided. The apparatus allows for the ablation of an area of tissue of arbitrary volume. The apparatus includes a plurality of conductive electrodes attached to a base plate and electrically connected to a pulse generator to allow individual electrical actuation of the electrodes. In use, the electrodes are inserted into an area of tissue to be ablated, such that the electrodes are in a first position. Predetermined ones of the electrodes are then activated to ablate tissue surrounding the activated electrodes, while leaving other ones of the electrodes un-activated. The electrodes are then moved to a second position which is different than the first position, and predetermined ones of the electrodes are then activated to ablate tissue surrounding the activated electrodes, while leaving other ones of the electrodes un-activated.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: November 17, 2020
    Assignee: Northwestern University
    Inventors: Alan V. Sahakian, Yearnchee C. Wang
  • Patent number: 10836708
    Abstract: Provided herein are processes, compounds and compositions for making (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid. Also provided herein a pharmaceutical compositions containing (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: November 17, 2020
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Richard B. Silverman, Matthew Moschitto
  • Patent number: 10840536
    Abstract: The present invention provides electronic systems, including device arrays, comprising functional device(s) and/or device component(s) at least partially enclosed via one or more containment chambers, such that the device(s) and/or device component(s) are at least partially, and optionally entirely, immersed in a containment fluid. Useful containment fluids for use in containment chambers of electronic devices of the invention include lubricants, electrolytes and/or electronically resistive fluids. In some embodiments, for example, electronic systems of the invention comprise one or more electronic devices and/or device components provided in free-standing and/or tethered configurations that decouple forces originating upon deformation, stretching or compression of a supporting substrate from the free standing or tethered device or device component.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: November 17, 2020
    Assignees: The Board of Trustees of the University of Illinois, Northwestern University
    Inventors: John A. Rogers, Sheng Xu, Jonathan A. Fan, Yonggang Huang, Yihui Zhang, Lin Jia
  • Patent number: 10830639
    Abstract: Certain examples disclose systems and methods for imaging a target. An example method includes: a) activating a subset of light-emitting molecules in a wide field area of a target using an excitation light; b) capturing one or more images of the light emitted from the subset of the molecules illuminated with the excitation light; c) localizing one or more activated light emitting molecules using one or more single molecule microscopic methods to obtain localization information; d) simultaneously capturing spectral information for the same localized activated light emitting molecules using one or more spectroscopic methods; e) resolving one or more non-diffraction limited images of the area of the target using a combination of the localization and spectral information for the localized activated light emitting molecules; and f) displaying the one or more non-diffraction limited images.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: November 10, 2020
    Assignee: Northwestern University
    Inventors: Ben Urban, Hao F. Zhang, Cheng Sun, Biqin Dong
  • Patent number: 10830747
    Abstract: Systems and methods include a predictor module configured to receive an input, e.g., composition parameters and processing parameters. A processor processes the input to predict a material property, e.g., fatigue strength, of an alloy based on the input. The processor outputs the predicted fatigue strength of the alloy for display.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: November 10, 2020
    Assignee: Northwestern University
    Inventors: Ankit Agrawal, Alok Choudhary
  • Patent number: 10829393
    Abstract: A bio-inspired method for detoxifying contaminated water is disclosed. In the method, polydopamine, a mussel-inspired adhesive catecholamine was used as an adsorbent to effectively remove from contaminated water three major classes of toxic agents: heavy metal ions (e.g., Cr, Hg, Pb, Cu, and Cd), toxic organic species (e.g., 4-aminopyridine), and radioisotopes (e.g., Lutetium-177). Furthermore, the polydopamine adsorbent was regenerated by treatment with acid or hydrogen peroxide.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: November 10, 2020
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Haeshin Lee
  • Patent number: 10829795
    Abstract: Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: November 10, 2020
    Assignees: Northwestern University, Cornell University
    Inventors: Michael Christopher Jewett, Jessica Carol Stark, Matthew P. DeLisa, Thapakorn Jaroentomeechai