Patents Assigned to Northwestern University
  • Patent number: 11723961
    Abstract: The present invention provides compositions, methods, and systems for treating inflammatory conditions (e.g., by inhibiting reactive oxygen species) in or on a subject with maspin, maspin derivatives, or maspin mimetics. In some embodiments, such agents are applied to the skin of a subject (e.g., to reduce skin aging).
    Type: Grant
    Filed: July 23, 2021
    Date of Patent: August 15, 2023
    Assignee: Northwestern University
    Inventor: Ming Zhang
  • Patent number: 11719712
    Abstract: Cell deposition and staining apparatuses and methods are disclosed herein. In particular, the deposition and staining apparatuses disclosed herein provide low-volume, automated bench top systems for depositing and staining cellular samples on a cytological slide. An example deposition and staining apparatus includes a housing having an access door; a substrate processing holder located within the housing configured to hold one or more substrates and/or one or more substrate cartridges, wherein the substrate processing holder is accessible when the access door is in an open configuration; at least one opening located at least partially above at least a portion of the substrate processing holder; a spray nozzle configured to dispense a gaseous substance into the substrate processing area; a user interface configured receive an input from a user, and in response to receiving the input, cause execution of a pre-programmed protocol; and a waste and/or reagent holder element.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: August 8, 2023
    Assignees: NANOCYTOMICS, LLC, NORTHWESTERN UNIVERSITY
    Inventors: Hariharan Subramanian, Michael Verleye, Micah Litow, Justin R. Derbas, Sergey Rozhok, John Hart, Chester Henderson, Rebecca Bartel, Nathan Ray, Anthony White
  • Patent number: 11709859
    Abstract: Aspects of the present disclosure relate to data visualization, and more specifically, to technology that automatically visualizes various analytics and predictions generated for mass participation endurance events, or other mass participation events of interest.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: July 25, 2023
    Assignee: Northwestern University
    Inventors: Karen R. Smilowitz, George T. Chiampas, Taylor G. Hanken, Rachel G. Lin, Ryan W. Rose, Bruno P. Velazquez, Samuel H. Young
  • Patent number: 11705373
    Abstract: A system and method for performing in-situ measurements of semiconductor devices during chemical vapor deposition (CVD) includes disposing a chip carrier within a sealed chamber of a reactor for carrying out in-situ monitoring of partially fabricated semiconductor devices. The chip carrier includes a plurality of metallized bonding pads disposed along both peripheral edges on a same surface of the base for making electrical connections to metallized pads or contacts on the semiconductor device through bonding wires. Each of the plurality of metallized bonding pads disposed along both peripheral edges is electrically connected to each other as a pair through electrically connecting to a corresponding pair of ports which are disposed along both peripheral edges of the chip carrier. In-situ monitoring of the partially fabricated semiconductor device is performed through connecting the plurality of ports on the chip carrier to an external source-measure unit through a connector and wire harness.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: July 18, 2023
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Michael J. Moody, Lincoln J. Lauhon, Ju Ying Shang
  • Patent number: 11702501
    Abstract: Polythiourethane polymer networks that can be processed and/or recycled are provided. Also provided are methods of forming the polythiourethane polymer networks using excess thiol and/or a dual catalyst system and methods for reprocessing and recycling the polyurethane polymer networks. The polythiourethane polymer networks are based on thiourethane dynamic chemistry.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: July 18, 2023
    Assignee: Northwestern University
    Inventors: John M. Torkelson, Lingqiao Li, Xi Chen
  • Patent number: 11696896
    Abstract: Provided herein are immunomodulatory nanoparticles, compositions containing the same, and methods of use thereof, such as for the treatment of traumatic brain injury.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: July 11, 2023
    Assignee: Northwestern University
    Inventors: John A. Kessler, Sripadh B. Sharma
  • Patent number: 11692996
    Abstract: Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.
    Type: Grant
    Filed: June 13, 2022
    Date of Patent: July 4, 2023
    Assignees: Trustees of Boston University, Northwestern University
    Inventors: Ji-Xin Cheng, Junjie Li, Yuying Tan, Daniela Matei, Guangyuan Zhao
  • Patent number: 11690920
    Abstract: The present disclosure generally relates to metal-organic framework nanoparticles containing terminal phosphate-modified oligonucleotides, methods for making the same, and methods of using the same.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: July 4, 2023
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Shunzhi Wang
  • Patent number: 11691958
    Abstract: Disclosed are enantioselective cross dehydrogenative coupling reactions for synthesizing tetrahydropyran compounds. Novel tetrahydropyran compounds may be synthesized by the disclosed methods as well as tetrahydropyran precursor compounds for synthesizing various naturally occurring compounds. The enantioselective cross dehydrogenative coupling reactions utilize in situ Lewis Acid activation in combination with oxidative formation of an oxocarbenium ion to provide a highly efficient and selective coupling reaction for synthesizing tetrahydropyran compounds.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: July 4, 2023
    Assignee: Northwestern University
    Inventors: Karl A. Scheidt, Ansoo Lee, Richard C. Betori
  • Publication number: 20230203369
    Abstract: Disclosed is composition comprising: a first fluorophore moiety, and nanoparticles, wherein the nanoparticles comprise: a first plurality of a first nanoparticle, the first nanoparticle comprising: a first outer surface, a first interior bulk, and a first polymer, wherein the first polymer is covalently bonded to the first fluorophore moiety within the first interior bulk of the first nanoparticle. Also disclosed is a composition comprising: a chelate moiety, and nanoparticles, wherein the nanoparticles comprise: a plurality of a chelate nanoparticle, the chelate nanoparticle comprising: an outer surface, an interior bulk, and a polymer, wherein the polymer is covalently bonded to the chelate moiety within the interior bulk of the chelate nanoparticle. Also disclosed are methods of making such compositions and using such composition for brain mapping and tracing of axonal projections.
    Type: Application
    Filed: February 12, 2021
    Publication date: June 29, 2023
    Applicants: NORTHWESTERN UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, HOWARD HUGHES MEDICAL INSTITUTE
    Inventors: Nathan C. GIANNESCHI, Nanzhi ZANG, Massimo SCANZIANI, Dante S. BORTONE, Treffly B. DITRI, Anthony M. RUSH
  • Publication number: 20230193039
    Abstract: In an aspect, an artificial selenomelanin material comprises: one or more selenomelanin polymers; wherein the one or more selenomelanin polymers comprise a plurality of covalently bonded selenomelanin base units; and wherein a chemical formula of each of the one or more selenomelanin base units comprises at least one selenium atom. Optionally, each selenomelanin polymer is a pheomelanin. Preferably, the chemical formula of each of the one or more selenomelanin base units comprises at least one covalent bond with each of the at least one selenium atom.
    Type: Application
    Filed: October 29, 2020
    Publication date: June 22, 2023
    Applicant: Northwestern University
    Inventors: Nathan C. GIANNESCHI, Wei CAO
  • Patent number: 11680391
    Abstract: Omniphilic and superomniphilic surfaces for simultaneous vapor condensation and airborne liquid droplet collection are provided. Also provided are methods for using the surfaces to condense liquid vapor and/or capture airborne liquid droplets, such as water droplets found in mist and fog. The surfaces provide enhanced capture and transport efficiency based on preferential capillary condensation on high surface energy surfaces, thin film dynamics, and force convection.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: June 20, 2023
    Assignee: Northwestern University
    Inventors: Natalia Alvarez, Neelesh A. Patankar, Kyoo-Chul Park, Youhua Jiang
  • Patent number: 11679980
    Abstract: Inorganic compounds having the formula LiMP2Q6, where M is Ga, In, Bi, Sb, As, Al, or a combination thereof, and Q is S and/or Se, are provided. Methods and devices for detecting incident neutrons and alpha-particles using the compounds are also provided. For thermal neutron detection applications, the compounds can be enriched with lithium-6 isotope (6Li) to enhance their neutron detecting capabilities.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: June 20, 2023
    Assignees: Northwestern University, UChicago Argonne, LLC
    Inventors: Mercouri G. Kanatzidis, Daniel G. Chica, Yihui He, Duck Young Chung
  • Publication number: 20230181747
    Abstract: Aspects of the invention include a polymer comprising: a plurality of repeating units, each repeating unit comprising a polymer backbone group directly or indirectly covalently linked to one or two side chain moieties; wherein: each polymer backbone group is independently a ROMP-polymerized monomer; each one of the one or two side chain moieties independently comprises a peptide moiety or a non-peptide therapeutic moiety; wherein the polymer comprises a plurality of peptide moieties; each polymer backbone group is covalently attached to at least one other polymer backbone group; 100% of the ROMP-polymerized monomers are each individually attached to the one or two side chain moieties; and at least one side chain moiety of the polymer comprises a non-peptide therapeutic moiety, one polymer-terminating group comprises a non-peptide therapeutic moiety, and/or each of both polymer-terminating groups comprises a non-peptide therapeutic moiety.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 15, 2023
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Nathan C. GIANNESCHI, Matthew P. THOMPSON, Cassandra E. CALLMANN
  • Patent number: 11673921
    Abstract: Disclosed are compositions, methods, and kits for performing cell-free RNA transcription and/or cell-free protein synthesis (CFPS). The disclosed compositions, methods, and kits include or utilize components prepared from Vibrio species such as cellular extracts from Vibrio natriegens.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: June 13, 2023
    Assignee: Northwestern University
    Inventors: Michael Christopher Jewett, Benjamin James Des Soye, Samuel Ryan Davidson
  • Patent number: 11676773
    Abstract: In one aspect of the invention, a dye sensitized solar cell has a counter-electrode including carbon-titania nanocomposite thin films made by forming a carbon-based ink; forming a titania (TiO2) solution; blade-coating a mechanical mixture of the carbon-based ink and the titania solution onto a substrate; and annealing the blade-coated substrate at a first temperature for a first period of time to obtain the carbon-based titania nanocomposite thin films. In certain embodiments, the carbon-based titania nanocomposite thin films may include solvent-exfoliated graphene titania (SEG-TiO2) nanocomposite thin films, or single walled carbon nanotube titania (SWCNT-TiO2) nanocomposite thin films.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: June 13, 2023
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Yu Teng Liang, Baiju K. Vijayan, Kimberly A. Gray, Mark C. Hersam
  • Patent number: 11673134
    Abstract: Provided herein are devices that facilitate the magnetic separation of an analyte from a sample, and methods of use thereof. In particular embodiments, devices and methods are provided for the trans-interfacial magnetic separation (TIMS) of analytes from a sample.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: June 13, 2023
    Assignee: Northwestern University
    Inventors: David M. Kelso, Abhishek K. Agarwal, Sally M. McFall, Tom Westberg, Matthew Austin Butzler, Jennifer L. Reed
  • Patent number: 11672794
    Abstract: Disclosed are methods for methods, compounds, and compositions for treating cancers characterized by therapeutic targeting of the BAP1 histone H2A deubiquitinase (DUB) complex, otherwise referred to herein as the BAP1 complex. In particular, the methods, compounds, and compositions disclosed herein relate to the use of therapeutic agents that inhibit the biological activity of the BAP1 complex for treating cancers such as myeloid neoplasms.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: June 13, 2023
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lu Wang, Ali Shilatifard
  • Patent number: 11673197
    Abstract: Provided herein are methods of preparing tetrahexahedra nanoparticles and methods of using the tetrahexahedra nanoparticles as an oxidative catalyst.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: June 13, 2023
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Liliang Huang, Haixin Lin
  • Patent number: 11666637
    Abstract: Mesoporous zirconium metal-organic frameworks (MOFs) having insulin immobilized therein and methods of using the MOFs in insulin delivery are provided. The insulin-loaded metal-organic framework molecules include a porous zirconium metal-organic framework molecule and insulin molecules within pores of the porous zirconium metal-organic framework.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: June 6, 2023
    Assignee: Northwestern University
    Inventors: Omar K. Farha, Yijing Chen, Peng Li