Patents Assigned to Novozymes Biotech, Inc.
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Publication number: 20090142447Abstract: The present invention provides processes for producing a brewers wort comprising forming a mash from a grist, and contacting said mash with a pullulanase.Type: ApplicationFiled: December 2, 2008Publication date: June 4, 2009Applicants: Novozymes A/S, Novozymes Biotech, Inc.Inventors: Niels Elvig, Per Linaa Joergensen, Michael Thomas
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Publication number: 20080193982Abstract: The present invention relates to a process of producing desired enzyme(s) in a host cell, comprising cultivating said host cell capable of producing the desired enzyme(s) under conditions conducive for production of the desired enzyme(s) using a substrate for the host cell comprising liquefied and/or saccharified starch-containing plant material.Type: ApplicationFiled: May 18, 2006Publication date: August 14, 2008Applicants: Novozymes Biotech, Inc., Novozymes North America, Inc.Inventors: Mads Peter Torry Smith, Guillermo Coward-Kelly, Keith Charles McFarland, Derek Scott Akerhielm
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Patent number: 7387888Abstract: The present invention relates to isolated strains of a Streptomyces spp. which are endophytes of dicotyledonous plants and to methods for selecting such strains. The present invention also relates to a biologically active compound called coronamycin obtained from endophytic Streptomycetes isolated from higher plants. The present invention further relates to compositions of such compounds and to methods of protecting plants against attack by a plant pathogen and methods of inhibiting bacterial growth, fungal growth, viral infection, growth of parasitic organisms, and cancer cell growth with such compositions.Type: GrantFiled: February 24, 2005Date of Patent: June 17, 2008Assignees: Montana State University, Novozymes Biotech Inc.Inventors: Gary A. Strobel, Debbie S. Yaver, Uvidelio F. Castillo, David Ezra
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Publication number: 20060005279Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated nucleic acids encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acids as well as methods for producing and using the polypeptides.Type: ApplicationFiled: February 4, 2005Publication date: January 5, 2006Applicant: Novozymes Biotech, Inc.Inventors: William Dotson, Jennifer Greenier, Hanshu Ding
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Publication number: 20050233423Abstract: The present invention relates to methods for converting plant cell wall polysaccharides into one or more products, comprising: treating the plant cell wall polysaccharides with an effective amount of a spent whole fermentation broth of a recombinant microorganism, wherein the recombinant microorganism expresses one or more heterologous genes encoding enzymes which degrade or convert the plant cell wall polysaccharides into the one or more products.Type: ApplicationFiled: March 10, 2005Publication date: October 20, 2005Applicant: Novozymes Biotech, Inc.Inventors: Randy Berka, Joel Cherry
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Patent number: 6951749Abstract: The present invention relates to polypeptides having carboxypeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to methods of obtaining protein hydrolysates useful as flavor improving agents.Type: GrantFiled: November 13, 2000Date of Patent: October 4, 2005Assignees: Novozymes Biotech, Inc., Novozymes A/SInventors: Alexander Blinkovsky, Randy Berka, Michael Rey, Elizabeth Golightly, Alan Klotz, Thomas Erik Mathisen, Claus Dambmann
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Publication number: 20050214920Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: October 28, 2004Publication date: September 29, 2005Applicant: Novozymes Biotech, Inc.Inventors: Paul Harris, Elizabeth Golightly
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Publication number: 20050210548Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: February 9, 2005Publication date: September 22, 2005Applicant: Novozymes Biotech, Inc.Inventors: Debbie Yaver, Paul Harris, Suzanne Otani, Janine Lin, Haiyan Ge
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Patent number: 6942973Abstract: The present invention relates to methods for isolating a gene encoding an enzyme, comprising: (a) adding a mixture of labeled first nucleic acid probes from a microbial strain cultured on medium without the substrate, and labeled second nucleic acid probes from a microbial strain cultured on medium with the substrate, to an array of random nucleic acid fragments of the microbial strain where the labeled nucleic acids hybridize to complementary sequences of the genomic fragments in the array, wherein the first nucleic acid probes are labeled with a first reporter and the second nucleic acid probes are labeled with a second reporter; (b) examining the array under conditions wherein the relative expression of the genes of the microbial strain is determined by the observed hybridization reporter signal of each spot in the array; and (c) isolating a gene from the microbial strain that encodes an enzyme that degrades the substrate. The present invention also relates to isolated genes obtained by such methods.Type: GrantFiled: March 12, 2002Date of Patent: September 13, 2005Assignee: Novozymes Biotech, Inc.Inventors: Debbie S. Yaver, Randy M. Berka
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Publication number: 20050191736Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: January 28, 2005Publication date: September 1, 2005Applicant: Novozymes Biotech, Inc.Inventors: Kimberly Brown, Paul Harris, Elizabeth Zaretsky, Edward Re, Elena Vlasenko, Keith McFarland, Alfredo Lopez de Leon
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Publication number: 20050181480Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the polypeptide, wherein (i) the mutant cell comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes involved in the production of a trichothecene and (ii) the mutant produces less of the trichothecene than the parent filamentous fungal cell when cultured under the same conditions; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells. The present invention also relates to isolated trichodiene synthases and isolated nucleic acid sequences encoding the trichodiene synthases.Type: ApplicationFiled: March 31, 2005Publication date: August 18, 2005Applicant: Novozymes Biotech, Inc.Inventors: John Royer, Lynne Christianson, Gregory Gambetta, Howard Brody, Suzanne Otani, Wendy Yoder
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Publication number: 20050175736Abstract: The present invention relates to polypeptides having carboxypeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to methods of obtaining protein hydrolysates useful as flavor improving agents.Type: ApplicationFiled: March 4, 2005Publication date: August 11, 2005Applicants: Novozymes A/S, Novozymes Biotech, Inc.Inventors: Alexander Blinkovsky, Randy Berka, Michael Rey, Elizabeth Golightly, Alan Klotz, Thomas Mathisen, Claus Dambmann
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Publication number: 20050164355Abstract: The present invention relates to methods for degrading a lignocellulosic material, comprising: treating the lignocellulosic material with an effective amount of one or more cellulolytic enzymes in the presence of at least one surfactant selected from the group consisting of a secondary alcohol ethoxylate, fatty alcohol ethoxylate, nonylphenol ethoxylate, tridecyl ethoxylate, and polyoxyethylene ether, wherein the presence of the surfactant increases the degradation of lignocellulosic material compared to the absence of the surfactant.Type: ApplicationFiled: January 14, 2005Publication date: July 28, 2005Applicant: Novozymes Biotech, Inc.Inventors: Elena Vlasenko, Joel Cherry, Feng Xu
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Publication number: 20050158844Abstract: The present invention relates to methods for reducing or eliminating the expression of a target gene in a filamentous fungal strain, comprising: (a) inserting into the genome of the filamentous fungal strain a double-stranded transcribable nucleic acid construct comprising a first nucleotide sequence comprising a promoter operably linked to a homologous coding region of the target gene and a second nucleotide sequence comprising the homologous coding region, or a portion thereof, of the target gene, wherein the first and second nucleotide sequences are complementary to each other and the second nucleotide sequence is in reverse orientation relative to the first nucleotide sequence; and (b) inducing production of an interfering RNA encoded by the double-stranded transcribable nucleic acid construct by cultivating the filamentous fungal strain under conditions conducive for production of the interfering RNA; wherein the interfering RNA interacts with RNA transcripts of the target gene to reduce or eliminate expType: ApplicationFiled: December 9, 2004Publication date: July 21, 2005Applicants: Novozymes Biotech, Inc., Novozymes A/SInventors: Howard Brody, Suchindra Maiyuran, Hiroaki Udagawa
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Patent number: 6903193Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the polypeptide, wherein (i) the mutant cell comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes involved in the production of a trichothecene and (ii) the mutant produces less trichothecene than the parent filamentous fungal cell when cultured under the same conditions; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells, isolated trichodiene synthases and nucleic acid sequences encoding the trichodiene synthases.Type: GrantFiled: November 10, 2000Date of Patent: June 7, 2005Assignee: Novozymes Biotech, Inc.Inventors: John C. Royer, Lynne M. Christianson, Gregory A. Gambetta, Howard Brody, Suzanne M. Otani, Wendy T. Yoder
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Patent number: 6902887Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.Type: GrantFiled: March 22, 2000Date of Patent: June 7, 2005Assignees: Novozymes Biotech, Inc., Novozymes A/SInventors: Randy M. Berka, Michael W. Rey, Jeffrey R. Shuster, Sakari Kauppinen, Ib Groth Clausen, Peter Bjarke Olsen
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Patent number: 6893839Abstract: The present invention relates to methods for producing a heterologous polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the heterologous polypeptide, wherein (i) the mutant cell comprises a nucleic acid sequence encoding the heterologous polypeptide and (ii) the mutant produces less of the cyclohexadepsipeptide than the parent filamentous fungal cell when cultured under the same conditions; and (b) isolating the heterologous polypeptide from the cultivation medium. The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells. The present invention also relates to isolated cyclohexadepsipeptide synthetases and isolated nucleic acid sequences encoding the cyclohexadepsipeptide synthetases.Type: GrantFiled: January 13, 2000Date of Patent: May 17, 2005Assignee: Novozymes Biotech, Inc.Inventors: Randy M. Berka, Michael W. Rey, Wendy T. Yoder
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Publication number: 20050074844Abstract: The present invention relates to arrays for bacterial gene expression profiling in response to treatment with antimicrobial compounds. Bacterial nucleic acid molecules are used as the hybridizable elements in various applications, such as arrays for gene expression profiling and for determining a mode of action for an antimicrobial compound. The present invention also relates to nucleic acid sequences which can be developed as targets for drug screening.Type: ApplicationFiled: September 5, 2003Publication date: April 7, 2005Applicant: Novozymes Biotech, Inc.Inventors: Debbie Yaver, Alan Sloma
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Publication number: 20050069934Abstract: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.Type: ApplicationFiled: September 24, 2004Publication date: March 31, 2005Applicant: Novozymes Biotech, Inc.Inventors: Randy Berka, Elena Bashkirova, Michael Rey
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Publication number: 20050048635Abstract: The present invention relates to isolated polypeptides having oxaloacetate hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: ApplicationFiled: August 6, 2004Publication date: March 3, 2005Applicant: Novozymes Biotech, Inc.Inventors: Debbie Yaver, Barbara Cherry, Jeffrey Murrell