Patents Assigned to Ohio State Innovation Foundation
  • Patent number: 10363599
    Abstract: A piston, particularly a piston for use in a diesel engine, particularly a heavy duty diesel engine, is formed from a billet of metal, such that the finished piston has a mass that is at least 50%, and, more preferably, up to about 62%, of the mass of the billet. Other than finishing steps, the piston is formed with a closed gallery, without loss of mass through machining processes.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: July 30, 2019
    Assignee: Ohio State Innovation Foundation
    Inventor: Rajiv Shivpuri
  • Publication number: 20190224298
    Abstract: Disclosed herein are methods and platforms for increasing utility and efficacy of a cellular vaccine. Specifically, disclosed are steps that optimize ex vivo B cell expansion and boost host in vivo immunity. Also disclosed is a platform for enhancing effectiveness of antigen presentation and antigen-specific immune responses. Also disclosed is a method for enhancing effectiveness of APCs in a subject. Also disclosed are vaccines and kits based on the platform.
    Type: Application
    Filed: July 13, 2017
    Publication date: July 25, 2019
    Applicant: OHIO STATE INNOVATION FOUNDATION
    Inventors: Thomas L. CHERPES, Nirk E. QUISPE CALLA, Rodolfo Daniel VICETTI MIGUEL
  • Patent number: 10357151
    Abstract: Systems and methods for using an interocular inhibition procedure (IIP) for discriminating between anisometropic amblyopia and myopia, two disorders commonly confused in visual examination without proper optical correction. Opaque and translucent patching are positioned over the fellow (or untested) eye resulting in different contrast sensitivities in the amblyopic (or tested) eye. A pinhole aperture may be used for identifying amblyopia and myopia/hyperopia.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: July 23, 2019
    Assignees: OHIO STATE INNOVATION FOUNDATION, ADAPTIVE SENSORY TECHNOLOGY, BEIJING JUEHUA MEDICAL TECHNOLOGY CO., LTD., INSTITUTE OF PSYCHOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: Zhong-Lin Lu, Chang-Bing Huang, Wuli Jia, Luis A. Lesmes, Jiawei Zhou
  • Patent number: 10357543
    Abstract: Disclosed are methods and compositions related to treatment and prevention of sarcopenia and/or nerve injury by increasing survival motor neuron (SMN) levels in an individual in need thereof.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: July 23, 2019
    Assignees: Ohio State Innovation Foundation, The Research Institute At Nationwide Children's Hospital
    Inventors: Arthur Burghes, William Arnold, Brian Kaspar, Vicki McGovern
  • Patent number: 10358494
    Abstract: Disclosed herein are chimeric antigen receptors (CAR) that can specifically recognize tumor-associated antigens (TAA) on multiple myeloma (MM) cells. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with MM that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: July 23, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Jianhua Yu, Craig Hofmeister, Jianhong Chu
  • Publication number: 20190218553
    Abstract: Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor (VWF). Pharmaceutical compositions comprising these aptamers are also provided. Methods of preventing blood clot formation in a subject by administering the aptamers are provided and methods of treating a blood clot by administering a VWF-targeting agent are also provided.
    Type: Application
    Filed: September 18, 2017
    Publication date: July 18, 2019
    Applicants: DUKE UNIVERSITY, OHIO STATE INNOVATION FOUNDATION
    Inventors: Shahid M. NIMJEE, George A. PITOC, Juliana LAYZER, Bruce SULLENGER
  • Patent number: 10345408
    Abstract: A low-cost magnetic resonance imaging (MRI) apparatus that may be used for, e.g., Cardiac MRI (CMR). CMR is a clinical imaging tool that can investigate a wide range of cardiac conditions by exploring changes in the anatomy, physiology, or dynamics of the heart. The applications of CMR include, but are not limited to, the evaluation of congenital heart disease, coronary heart disease, ischemic heart disease, cardiac masses, the pericardium, cardiomyopathy, hibernating myocardium, and valvular and ventricular function. Generally, the MRI apparatus is a low-field (˜0.5T) system equipped with a high-end data processing unit (DPU) to enable the implementation of structure aware (SA) recovery in clinically relevant times.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: July 9, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Rizwan Ahmad, Lee C. Potter, Adam Rich, Orlando P. Simonetti, Samuel T. Ting
  • Publication number: 20190206057
    Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.
    Type: Application
    Filed: September 13, 2017
    Publication date: July 4, 2019
    Applicants: Ohio State Innovation Foundation, The Penn State Research Foundation, University of North Carolina, University of San Francisco
    Inventors: Skyler Cranmer, Bruce Desmarais, Shankar Bhamidi, James Wilson, Matthew Denny, Zhong-Lin Lu, Paul Stillman
  • Patent number: 10322379
    Abstract: Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a gas permeable support layer, an inorganic layer disposed on the support, the inorganic layer comprising a plurality of discreet nanoparticles having an average particle size of less than 1 micron, and a selective polymer layer disposed on the inorganic layer, the selective polymer layer comprising a selective polymer having a CO2:N2 selectivity of at least 10 at 57° C. In some embodiments, the membrane can be selectively permeable to an acidic gas. The membranes can be used, for example, to separate gaseous mixtures, such as flue gas.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: June 18, 2019
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: W. S. Winston Ho, Prabir Dutta, Kartik Ramasubramanian, Michael Severance
  • Patent number: 10323235
    Abstract: Disclosed are compositions comprising an engineered intein designed such that the self-cleaving activity of the intein can be modulated by a zinc-binding motif as well as methods and systems for making and using the compositions.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: June 18, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Buyong Ma, David F. Nellis, Jianwei S. Zhu, David W. Wood
  • Patent number: 10324355
    Abstract: Disclosed herein are various improvements in optical switching engines. In one aspect, a range of switching engines includes various multiple bounce, multiple image devices, such as, for example, the Herriott Cell and the Robert Cell. In another aspect, liquid crystal spatial light modulators (SLMs) are used in the switching engine of an optical cross-connect. In another aspect, polarization gratings (PGs) are used in the switching engine. In another aspect, a switching engine includes a Fourier cell using SLMs with more than two states. Alternative imaging optics in a Fourier cell implementing a multiple-bounce, multiple image device are also disclosed.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: June 18, 2019
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: David Rabb, Betty Lise Anderson
  • Patent number: 10307520
    Abstract: An example assembly for use with a vacuum system and an esophageal positioning device esophageal positioning device includes an introducer, in which the esophageal positioning device includes a handle, a first segment, a second segment and an articulation driving mechanism. The first segment being coupled to the handle. The second segment being pivotally connected to the first segment. The articulation driving mechanism being configured to pivot the second segment about the first segment upon articulation.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 4, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Veeral M. Oza, Adam Hensel, Emile Daoud, Nishaki Mehta
  • Publication number: 20190160123
    Abstract: Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides an oncolytic virus capable of killing target cells, such as tumor cells. In various embodiments presented herein, the oncolytic viruses described herein are suitable for treatment of several types of cancer, including glioblastoma.
    Type: Application
    Filed: January 30, 2019
    Publication date: May 30, 2019
    Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., Ohio State Innovation Foundation
    Inventors: Hiroshi Nakashima, Ennio Antonio Chiocca
  • Patent number: 10302864
    Abstract: An example method of forming a deterministic thin film from a crystal substrate is described herein. The method can include implanting ions into a surface of the crystal substrate to form a thin film crystal layer, and bonding the crystal substrate and a handle substrate to form a bilayer bonding interface between the crystal substrate and the handle substrate. The method can also include exfoliating the thin film crystal layer from the crystal substrate, patterning the thin film crystal layer to define a deterministic thin film, etching one or more trenches in the thin film crystal layer, etching the bilayer bonding interface via the one or more trenches, and releasing the deterministic thin film from the handle substrate.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: May 28, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Ronald M. Reano, Li Chen
  • Publication number: 20190152778
    Abstract: A reactor configuration is proposed for selectively converting gaseous, liquid or solid fuels to a syngas specification which is flexible in terms of H2/CO ratio. This reactor and system configuration can be used with a specific oxygen carrier to hydro-carbon fuel molar ratio, a specific range of operating temperatures and pressures, and a co-current downward moving bed system. The concept of a CO2 stream injected in-conjunction with the specified operating parameters for a moving bed reducer is claimed, wherein the injection location in the reactor system is flexible for both steam and CO2 such that, carbon efficiency of the system is maximized.
    Type: Application
    Filed: April 12, 2017
    Publication date: May 23, 2019
    Applicant: Ohio State Innovation Foundation
    Inventors: Liang-shih FAN, Abbey EMPFIELD, Mandar KATHE, Charles FRYER, Elena BLAIR
  • Patent number: 10292832
    Abstract: A spinal fixation device includes an outer housing and an end plate assembly coupled with the outer housing. The outer housing defines an aperture and a longitudinal axis. At least a portion of the end plate assembly is slidably received within the outer housing. The end plate assembly includes a first end plate configured to engage a vertebral body, wherein the end plate assembly is selectively movable between a first position in which the first end plate is spaced apart from the outer housing and a second position in which the first end plate is adjacent the outer housing. Further, the first end plate is selectively adjustable to an angular orientation of a plurality of angular orientations with respect to the longitudinal axis of the outer housing.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 21, 2019
    Assignees: Ohio State Innovation Foundation, K2M, Inc.
    Inventors: Chester Evan Sutterlin, III, Ehud Mendel, Michael Finn, Clint Boyd, Scott Jones, Todd Wallenstein, Jacob M. Buchowski
  • Patent number: 10292891
    Abstract: A robotic walker and associated method are provided. The robotic walker includes a housing containing a control unit operatively connected to a drive unit. The drive unit is operatively connected to a pair of motorized drive wheels. The robotic walker includes first and second winches, each winch having a strap that can be retracted by its respective winch, each winch is operatively connected to the drive unit, each strap having an end adapted to be removably connected to a pair of leg braces worn by a user. The first and second winches may retract a portion of each respective strap to move the legs of the user forward. A first control button is operatively connected to the control unit. The control unit is configured to operate the robotic walker in at least one control mode and the first control button being operable to start the at least one control mode.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: May 21, 2019
    Assignee: Ohio State Innovation Foundation
    Inventors: Yuan Fang Zheng, Hongfei Wang
  • Patent number: 10293234
    Abstract: A portable, impact-absorbing apparatus having a striking portion, an energy-absorbing portion, and a mounting portion. The striking portion may be a padded plate and the mounting portion may be a collar that may mount to the vertical frame member of a squat rack. The energy-absorbing portion may be an insert that slides into the barrel of a hollow sleeve in which a spring is disposed. The sleeve may have slots in the top and bottom for bolts or pins, which are inserted therethrough for attachment to the insert, to define the longitudinal limits of the insert's extension.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: May 21, 2019
    Assignee: Ohio State Innovation Foundation
    Inventor: Anthony Schlegel
  • Patent number: 10286068
    Abstract: A vaccine composition is disclosed that contains a vaccine antigen and a neutrophil inhibitor in amounts effective to promote an IgA response to the antigen in a subject. Also disclosed is a method for enhancing immune response to a vaccine antigen in a subject that involves co-administering to the subject the vaccine antigen and an adjuvant composition comprising a neutrophil inhibitor in an amount effective to promote an IgA response to the vaccine antigen in the subject.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: May 14, 2019
    Assignee: Ohio State Innovation Foundation
    Inventor: Prosper Boyaka
  • Publication number: 20190133159
    Abstract: Described herein are natural food colorant compositions that includes acylated anthocyanins extracted from black goji and at least one buffer solution, methods of making, and products using the same.
    Type: Application
    Filed: May 18, 2017
    Publication date: May 9, 2019
    Applicant: Ohio State Innovation Foundation
    Inventors: Monica M. Giusti, Peipei Tang