Abstract: Compositions comprising therapeutic oligonucleotide miR-3151 compounds that target the expression of genes associated with tumorigenesis or cell transformation are provided.
Type:
Application
Filed:
February 12, 2016
Publication date:
June 16, 2016
Applicant:
The Ohio State University
Inventors:
Albert de la Chapelle, Ann-Kathrin Eisfeld
Abstract: The novel omp-1 gene cluster encoding twenty one Ehrlichia ewingii (EE) proteins was isolated and sequenced completely. This invention relates to isolated E. ewingii (EE) polypeptides, isolated polynucleotides encoding EE polypeptides, probes, primers, isolated antibodies and methods of their production, immunogenic compositions and vaccines, as well as methods of using the EE polypeptides, antibodies, probes, and primers for the purpose of diagnosis, therapy and production of vaccines against E. ewingii.
Type:
Grant
Filed:
June 11, 2014
Date of Patent:
June 7, 2016
Assignee:
The Ohio State University Research Foundation
Abstract: Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.
Type:
Grant
Filed:
May 12, 2011
Date of Patent:
June 7, 2016
Assignees:
Wisconsin Alumni Research Foundation, The Ohio State University Research Foundation
Inventors:
Margaret Clagett-Dame, Robert W. Curley, Jr., Joel R. Walker, Hussein Abou-Issa, Galal A. Alshafie
Abstract: Magnetic resonance reconstruction includes motion compensation. Inverse-consistent non-rigid registration is used to determine motion between shots. The motion is incorporated into reconstruction. The incorporation compensates for the motion resulting from the period over which the MR data is acquired.
Type:
Grant
Filed:
March 7, 2012
Date of Patent:
May 17, 2016
Assignees:
Siemens Corporation, Siemens Medical Solutions USA, Inc., Siemens Aktiengesellschaft, Ohio State University
Inventors:
Hui Xue, Christoph Guetter, Yu Ding, Marie-Pierre Jolly, Orlando P. Simonetti, Jens Guehring, Sven Zuehlsdorff, Arne Littmann
Abstract: Described herein are methods for diagnosing ovarian cancer. In particular, certain microRNAs are useful to the response to chemotherapy of ovarian cancer patients.
Abstract: Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed.
Type:
Grant
Filed:
August 18, 2015
Date of Patent:
March 29, 2016
Assignee:
The Ohio State University Research Foundation
Abstract: Methods and solutions for fabricating a superhydrophobic, optically transparent surface on a substrate. A dip coating technique is employed in which a solution comprising hydrophobic nanoparticles, a resin binder and a solvent is provided. The substrate is dipped and then withdrawn from the solution. As the substrate is withdrawn, a precursor coating of the solution is formed on a surface of the substrate. The solvent in the precursor coating is allowed to evaporate (is otherwise removed), immediately resulting in a superhydrophobic, optically transparent coating on the substrate surface. The hydrophobic nanoparticles can be metal oxide nanoparticles (such as SiO2, ZnO, and ITO) that are surface functionalized to be hydrophobic. Substrate types include glass and polymer substrates such as PC and PMMA.
Abstract: Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
Type:
Application
Filed:
May 29, 2015
Publication date:
February 25, 2016
Applicants:
Board of Regents of the University of Texas System, The Ohio State University Research Foundation
Inventors:
Mauro Ferrari, Ennio Tasciotti, Jason Sakamoto
Abstract: Described herein is a system which uses a gene therapy particle that includes at least one gene, cDNA, fragment or analogue of at least one neurotropin that binds to the trkB receptor or the trkB receptor itself. The gene therapy particle is capable of being delivered to a subject in need thereof for therapy of a metabolic disorder. In a particular aspect, this invention is directed to an inventive method that demonstrates a remarkable efficacy on lowering body weight.
Abstract: It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein.
Abstract: An artificial skin for use on a radar mannequin exposed to electromagnetic radiation having a predetermined frequency and a radar mannequin having the artificial skin are provided. The artificial skin and the radar mannequin with the artificial skin are configured to produce a radar cross section that closely approximates the radar cross section of a human. The artificial skin includes a conductive layer of material and a shielding layer of material. The conductive layer and the shielding layer are configured to reflect electromagnetic radiation at a level of an electromagnetic response of human skin exposed to the electromagnetic radiation. The shielding layer also electromagnetically shields an inside surface of the artificial skin from electromagnetic radiation.
Type:
Grant
Filed:
December 27, 2013
Date of Patent:
February 16, 2016
Assignees:
Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Jidosha Kabushiki Kaisha, The Ohio State University, Indiana University Research and Technology Corporation
Inventors:
Chi-Chih Chen, Stanley Yung-Ping Chien, Rini Sherony, Hiroyuki Takahashi
Abstract: A hermetically-sealed, ohmic heating packet for storing, heating and sterilizing food and beverage items. The packet is formed of a multilayer laminate material having interior and exterior polymer layers and an intermediate metallic foil layer. Conductive tags on the exterior of the packet are electrically connected to electrodes on the interior of the packet through reverse-patched regions of the packet's sidewalls. The configuration of the electrical connection prevents current from leaking into the metallic foil layer of the packet during heating, thereby mitigating the risk of a short circuit condition in the packet. The rectangular prism geometry of the packet and the parallel configuration of the electrodes within the packet facilitate uniform heating of the packet's contents.
Type:
Grant
Filed:
September 9, 2011
Date of Patent:
February 16, 2016
Assignee:
The Ohio State University
Inventors:
Sudhir K. Sastry, Brian F. Heskitt, Soojin Jun, Romel Somavat
Abstract: An electrical capacitance tomography sensor comprised of a sensor having a plurality of electrodes, where each electrode is further comprised of a plurality of capacitance segments. Each of the capacitance segments of each electrode can be individually addressed to focus the electric field intensity or sensitivity to desired regions of the electrodes and the sensor.
Type:
Grant
Filed:
October 4, 2012
Date of Patent:
February 16, 2016
Assignee:
THE OHIO STATE UNIVERSITY
Inventors:
Qussai Mohammad Marashdeh, Liang-Shih Fan
Abstract: Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided.
Type:
Application
Filed:
November 11, 2014
Publication date:
February 4, 2016
Applicants:
Board of Regents of the University of Texas System, The Ohio State University Research Foundation
Abstract: Described herein are methods for diagnosing ovarian cancer. In particular, certain microRNAs are useful to the response to chemotherapy of ovarian cancer patients.
Abstract: The present invention is directed to a method of isolating fractions of anthocyanin molecules from anthocyanin-containing vegetable and fruit juices and extracts, or combinations thereof, at a select pH based on differences in polarity of the anthocyanin molecules in the anthocyanin-containing vegetable and fruit juices and extracts.
Type:
Application
Filed:
March 14, 2014
Publication date:
January 21, 2016
Applicants:
THE OHIO STATE UNIVERSITY, MARS, INCORPORATED
Inventors:
Rebecca J. Robbins, J. Christopher Johnson, Thomas M. Collins, Neda Ahmadiani, M. Monica Giusti
Abstract: The present invention is directed to natural blue anthocyanin-containing colorants comprising fractions of anthocyanin molecules separated from anthocyanin-containing vegetable and fruit juices and extracts. Anthocyanin fractions are separated at a select pH based on differences in polarity of the anthocyanin molecules in the anthocyanin-containing vegetable and fruit juices and extracts. The invention is directed to the anthocyanin fractions providing color characteristics similar to those provided by the synthetic blue colorant, FD&C Blue No. 1. The present invention is also directed to natural green colorants comprising the natural blue anthocyanin-containing colorant and a natural yellow colorant. The present invention is further directed to edible products comprising the natural blue anthocyanin-containing colorants.
Type:
Application
Filed:
March 14, 2014
Publication date:
January 21, 2016
Applicants:
THE OHIO STATE UNIVERSITY, MARS, INCORPORATED
Inventors:
Rebecca J. Robbins, J. Christopher Johnson, Thomas M. Collins, Neda Ahmadiani, M. Monica Giusti
Abstract: It is disclosed herein that miR-221 and miR-222 down-regulate PTEN and TIMP3 tumor suppressors, resulting in TRAIL resistance. The present invention provides research, diagnostic, and therapeutic tools and methods related to this discovery. Diagnostics, prognostics and treatments for human hepatocellular cancer and non-small cell lung carcinoma having a TRAIL resistance are particularly described herein.
Abstract: A p-channel tunneling field effect transistor (TFET) is selected from a group consisting of (i) a multi-layer structure of group IV layers and (ii) a multi-layer structure of group III-V layers. The p-channel TFET includes a channel region comprising one of a silicon-germanium alloy with non-zero germanium content and a ternary III-V alloy. An n-channel TFET is selected from a group consisting of (i) a multi-layer structure of group IV layers and (ii) a multi-layer structure of group III-V layers. The n-channel TFET includes an n-type region, a p-type region with a p-type delta doping, and a channel region disposed between and spacing apart the n-type region and the p-type region. The p-channel TFET and the n-channel TFET may be electrically connected to define a complementary field-effect transistor element. TFETs may be fabricated from a silicon-germanium TFET layer structure grown by low temperature (500 degrees Centigrade) molecular beam epitaxy.
Abstract: Modified expression vectors, including Tobacco Mosaic Virus (TMV) expression vectors, methods for modifying such vectors, and uses of the same are disclosed.
Type:
Application
Filed:
December 12, 2014
Publication date:
December 3, 2015
Applicant:
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION