Abstract: Use of synthetic thiol-containing peptides as highly effective therapeutic and protective agents is described, in clinical and research applications where lifespan and/or viability and functioning of cells is compromised at least partially due to depletion of reduced glutathione, or where viability and functioning of cells can be improved by elevating reduced glutathione levels. More specifically, compositions and methods for treating blood disorders associated with glutathione dysregulation utilizing short thiol-containing peptides selected from the group consisting of Cys-Lys-Met-Cys (SEQ ID NO: 1), Cys-Met-Lys-Cys (SEQ ID NO: 2) and Cys-?-Ala-His-Cys (SEQ ID NO: 3) are described. Further described are compositions and methods for preserving biological samples using the peptides.
Abstract: Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.
Type:
Grant
Filed:
July 3, 2014
Date of Patent:
May 19, 2015
Assignees:
ONEDAY—BIOTECH AND PHARMA LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventors:
Josef Mograbi, Daphne Atlas, Shoshana Keynan
Abstract: Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.
Type:
Grant
Filed:
August 9, 2013
Date of Patent:
August 12, 2014
Assignees:
Oneday—Biotech And Pharma Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventors:
Josef Mograbi, Daphne Atlas, Shoshana Keynan