Patents Assigned to Organ Technologies Inc.
  • Publication number: 20190201579
    Abstract: The object of the present invention is to provide an artificial skin having hair follicles, sebaceous glands, and hair pores. The present invention provides a method for manufacturing artificial skin having hair follicles, sebaceous glands, and hair pores, characterized in that it comprises each of the following steps: (A): a step of preparing an artificial skin having dermal and epidermal layers or an artificial skin having only a dermal layer; and (B): a step of transplanting isolated hair follicles to the artificial skin prepared in step (A); wherein said isolated hair follicle comprises a sebaceous gland, and said isolated hair follicle is transplanted to said artificial skin so that the surface of said dermal Layer of said artificial skin is in alignment with the position of the hair pore portion of said isolated hair follicle.
    Type: Application
    Filed: June 19, 2017
    Publication date: July 4, 2019
    Applicants: Organ Technologies, Inc., Riken
    Inventors: Takashi TSUJI, Koh-ei TOYOSHIMA, Miho OGAWA
  • Publication number: 20190170726
    Abstract: The purpose of the present invention is to propose a method for measuring the level of health of a subject, with which it is possible: to perform health examination that is non-invasive to the human body and that employs a simple method; to provide highly reliable analysis results having a scientific basis; and to, additionally, provide appropriate solutions to the subject. Another purpose of the present invention is to propose a health-level determining apparatus employing said method and a new business model employing said method. The present invention is a method for measuring the level of health of a subject, including a hair analyzing step (A) for analyzing hair of the subject. It is preferable that the aforementioned hair analyzing step (A) include a step (A-1) for analyzing hair in the occipital region. In addition, it is preferable that the aforementioned hair analyzing step (A) include a step (A-2) for analyzing hair in a site other than the occipital region.
    Type: Application
    Filed: August 8, 2017
    Publication date: June 6, 2019
    Applicants: ORGAN TECHNOLOGIES INC., RIKEN
    Inventors: Takashi TSUJI, Koh-ei TOYOSHIMA
  • Publication number: 20190133904
    Abstract: The present invention is directed to a hair growth agent for external use comprising chiro-inositol, which is provided as an excellent hair growth agent.
    Type: Application
    Filed: April 27, 2017
    Publication date: May 9, 2019
    Applicants: KOBAYASHI PHARMACEUTICAL CO., LTD., ORGAN TECHNOLOGIES INC.
    Inventors: Kosuke TANAKA, Mihoko KAWASAKI, Hironori TOMI, Takashi TSUJI
  • Publication number: 20180355315
    Abstract: To provide a method of efficiently producing full thickness skin having skin accessory organs. [Solution] This method of producing full thickness skin having skin accessory organs is characterized by involving the following steps (a) to (d): (a) a step for stimulating an embryoid body with a physiologically active substance that can activate the Wnt pathway, (b) a step for preparing a conjugate that includes all or part of the embryoid body stimulated in step (a) and a scaffolding material, (c) a step for transplanting the conjugate prepared in step (b) into an animal, and (d) a step for producing, in the animal, full thickness skin derived from said conjugate.
    Type: Application
    Filed: September 7, 2015
    Publication date: December 13, 2018
    Applicant: Organ Technologies, Inc.
    Inventors: Takashi Tsuji, Koh-ei Toyoshima
  • Patent number: 10022205
    Abstract: The object of the present invention is to provide an implant that enables functional periodontium formation around the implant after transplantation of a dental implant. In some aspects of the present invention, a tooth germ tissue-derived or a periodontal membrane tissue-derived cell mass is placed on the surface of the implant, and the surface of the implant on which the cell mass is placed is the whole or a part of the surface which is surrounded by the alveolar bone of the recipient at the time of implant transplantation.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: July 17, 2018
    Assignee: ORGAN TECHNOLOGIES, INC.
    Inventors: Takashi Tsuji, Masamitsu Oshima
  • Patent number: 9982238
    Abstract: A method for producing a regenerative organ germ for transplantation includes using regenerative organ germ for transplantation ensuring continuity with a recipient after transplantation and facilitating transplantation procedures. A method for producing a regenerative organ germ provided with a guide for transplantation includes preparing a regenerative organ germ by closely contacting a first cell mass, which substantially consists of mesenchymal cells, and a second cell mass, which substantially consists of epithelial cells, culturing these cell masses within a support, and inserting the guide into the regenerative organ germ.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: May 29, 2018
    Assignee: Organ Technologies, Inc.
    Inventors: Koh-ei Toyoshima, Takashi Tsuji
  • Patent number: 9877474
    Abstract: The object of the present invention is to provide a technology that enables long-term preservation while maintaining the function of an organ or tissue for transplantation. A further object is utilizing this technology to provide a technology for suppressing tissue disorder accompanying warm ischemia and reperfusion as well as restoring an organ from a cardiac arrest donor to a level compatible for transplantation. A method that employs perfusion by a perfusate etc. is provided, comprising each of the following steps of: (a) connecting a perfusate instream cannula for streaming said perfusate into said “organ or tissue,” (b) connecting a perfusate outstream cannula for streaming said perfusate out from said “organ or tissue,” and (c) perfusing a perfusate comprising an oxygen carrier and a blood coagulation inhibitor into said organ or tissue.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: January 30, 2018
    Assignee: Organ Technologies, Inc.
    Inventors: Takashi Tsuji, Masamitsu Oshima
  • Patent number: 9321998
    Abstract: A method for producing a regenerative hair follicle germ for transplantation, in which a color of hair that grows after transplantation is controlled, includes preparing a first cell mass containing mesenchymal cells; preparing a second cell mass containing epithelial cells; preparing a cell mass containing pigment stem cells; binding the cell mass containing the pigment stem cells to at least one among the first cell mass and the second cell mass, and closely contacting the first cell mass and the second cell mass, at least one of which has been bound to the cell mass containing the pigment stem cells, and culturing them within a support.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: April 26, 2016
    Assignee: Organ Technologies Inc.
    Inventors: Koh-ei Toyoshima, Takashi Tsuji
  • Publication number: 20150366916
    Abstract: The object of the present invention is to provide a method for manufacturing multiple teeth from one isolated tooth germ in order to increase the absolute number of tooth germs that can be employed for transplantation. The present invention relates to a method for manufacturing a tooth. More specifically, the present invention provides a method for manufacturing multiple teeth from one isolated tooth germ comprising the epithelial and mesenchymal tissue layers characterized in that it comprises the steps of: (a) completely or partially splitting one isolated tooth germ comprising the epithelial and mesenchymal tissue layers, wherein said splitting is characterized in splitting so that each splitted tooth germ portion respectively comprises a portion of said epithelial tissue layer and a portion of said mesenchymal tissue layer, and (b) culturing said splitted tooth germs in vitro or culturing in vivo in a living animal other than humans to form multiple teeth.
    Type: Application
    Filed: February 7, 2014
    Publication date: December 24, 2015
    Applicant: ORGAN TECHNOLOGIES, INC.
    Inventors: Takashi Tsuji, Masamitsu Oshima
  • Patent number: 8927284
    Abstract: A method for producing a tooth having a desired length in one direction includes the steps of: placing a first cell aggregate and a second cell aggregate in the inside of a support while bringing the first and the second cell aggregates into close contact with each other; and culturing the first and the second cell aggregates in the inside of the support, in which the first cell aggregate is composed of one of mesenchymal cells or epithelial cells and the second cell aggregate is composed of the other, and the size of the tooth is controlled by adjusting the length of contact between the first cell aggregate and the second cell aggregate in one direction.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: January 6, 2015
    Assignee: Organ Technologies, Inc.
    Inventors: Takashi Tsuji, Kazuhisa Nakao
  • Publication number: 20140356797
    Abstract: The purpose of the present invention is to provide a dental implant which enables the formation of a functional periodontal tissue around the implant after the implantation of the implant. The dental implant according to the present invention is characterized in that a cell mass originated from a tooth germ tissue or a periodontal ligament tissue is placed on the surface of the implant and the surface of the implant on which the cell mass is to be placed is the whole or a part of a surface that is surrounded by an alveolar bone of a recipient during the implantation of the implant.
    Type: Application
    Filed: January 28, 2013
    Publication date: December 4, 2014
    Applicant: Organ Technologies, Inc.
    Inventors: Takashi Tsuji, Masamitsu Oshima
  • Publication number: 20140256027
    Abstract: Disclosed are a perfusion culture method and a perfusion culture device whereby a perfusate can be delivered to all parts of an organ or tissue so that the organ or tissue can be preserved while sufficiently maintaining the function thereof. Specifically disclosed is a method for perfusion culture of an organ or tissue removed from a mammal, said organ or tissue having been removed together with a second organ or tissue connected to the aforesaid organ or tissue in vivo, which comprises a step for fixing said second organ or tissue so as to hang the aforesaid organ or tissue and a step for perfusing blood vessels in the aforesaid organ or tissue with a perfusate.
    Type: Application
    Filed: May 21, 2014
    Publication date: September 11, 2014
    Applicant: Organ Technologies, Inc.
    Inventors: Takashi Tsuji, Kazuhisa Nakao
  • Patent number: 8771931
    Abstract: Disclosed are a perfusion culture method and a perfusion culture device whereby a perfusate can be delivered to all parts of an organ or tissue so that the organ or tissue can be preserved while sufficiently maintaining the function thereof. Specifically disclosed is a method for perfusion culture of an organ or tissue removed from a mammal, said organ or tissue having been removed together with a second organ or tissue connected to the aforesaid organ or tissue in vivo, which comprises a step for fixing said second organ or tissue so as to hang the aforesaid organ or tissue and a step for perfusing blood vessels in the aforesaid organ or tissue with a perfusate.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: July 8, 2014
    Assignee: Organ Technologies, Inc.
    Inventors: Takashi Tsuji, Kazuhisa Nakao
  • Patent number: 8679755
    Abstract: A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured to obtain a tooth having a specific cell placement. Preferably, after the culturing, the support carrier having both cell masses is cultured with kidney cells.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: March 25, 2014
    Assignee: Organ Technologies Inc.
    Inventors: Takashi Tsuji, Kazuhisa Nakao
  • Publication number: 20140052167
    Abstract: A method for producing a regenerative hair follicle germ for transplantation, in which a color of hair that grows after transplantation is controlled, includes preparing a first cell mass containing mesenchymal cells; preparing a second cell mass containing epithelial cells; preparing a cell mass containing pigment stem cells; binding the cell mass containing the pigment stem cells to at least one among the first cell mass and the second cell mass, and closely contacting the first cell mass and the second cell mass, at least one of which has been bound to the cell mass containing the pigment stem cells, and culturing them within a support.
    Type: Application
    Filed: February 21, 2012
    Publication date: February 20, 2014
    Applicant: ORGAN TECHNOLOGIES INC.
    Inventors: Koh-ei Toyoshima, Takashi Tsuji
  • Publication number: 20140037592
    Abstract: A method for producing a regenerative organ germ for transplantation includes using regenerative organ germ for transplantation ensuring continuity with a recipient after transplantation and facilitating transplantation procedures. A method for producing a regenerative organ germ provided with a guide for transplantation includes preparing a regenerative organ germ by closely contacting a first cell mass, which substantially consists of mesenchymal cells, and a second cell mass, which substantially consists of epithelial cells, culturing these cell masses within a support, and inserting the guide into the regenerative organ germ.
    Type: Application
    Filed: July 7, 2011
    Publication date: February 6, 2014
    Applicant: Organ Technologies Inc.
    Inventors: Koh-ei Toyoshima, Takashi Tsuji
  • Patent number: 8574904
    Abstract: The present invention provides a method for producing mesenchymal cells for production of mesenchymal cells for formation of a tooth, the method comprising: culturing totipotent stem cells in the presence of a differentiation inducer to produce a cell population after differentiation induction treatment, the cell population containing CD44-positive and CD29-positive cells or CD44-positive and CD106-positive cells; and selecting, from the cell population after the differentiation induction treatment, the CD44-positive and CD29-positive cells or CD44-positive and CD106-positive cells as the mesenchymal cells for the formation of the tooth.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: November 5, 2013
    Assignee: Organ Technologies Inc.
    Inventors: Takashi Tsuji, Ritsuko Morita
  • Publication number: 20130109093
    Abstract: A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured to obtain a tooth having a specific cell placement. Preferably, after the culturing, the support carrier having both cell masses is cultured with kidney cells.
    Type: Application
    Filed: December 18, 2012
    Publication date: May 2, 2013
    Applicant: ORGAN TECHNOLOGIES INC.
    Inventors: Takashi TSUJI, Kazuhisa NAKAO
  • Publication number: 20130101951
    Abstract: The object of the present invention is to provide a method for restoring the alveolar bone of a mammal with a missing tooth. The present invention provides a method for restoring the alveolar bone in a mammal with a missing tooth comprising a step of transplanting a regenerated tooth unit to the said missing site. The regenerated tooth unit is characterized in that it has a periodontal tissue portion in addition to a tooth crown portion.
    Type: Application
    Filed: March 15, 2011
    Publication date: April 25, 2013
    Applicant: ORGAN TECHNOLOGIES, INC.
    Inventors: Takashi Tsuji, Kazuhisa Nakao, Masamitsu Oshima
  • Publication number: 20130089827
    Abstract: A method for manufacturing a regenerated tooth unit comprising a step of disposing and culturing a regenerated tooth germ inside a spacer in vivo in the body of a mammal is provided, wherein said spacer is configured so as to enable prevention of said regenerated tooth germ being extended to more than the maximum tolerance; and configured such that the regenerated tooth germ disposed inside is communicatable with the exterior of the spacer.
    Type: Application
    Filed: March 15, 2011
    Publication date: April 11, 2013
    Applicant: ORGAN TECHNOLOGIES, INC.
    Inventors: Takashi Tsuji, Kazuhisa Nakao, Masamitsu Oshima