Patents Assigned to Organ Technologies Inc.
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Patent number: 8574904Abstract: The present invention provides a method for producing mesenchymal cells for production of mesenchymal cells for formation of a tooth, the method comprising: culturing totipotent stem cells in the presence of a differentiation inducer to produce a cell population after differentiation induction treatment, the cell population containing CD44-positive and CD29-positive cells or CD44-positive and CD106-positive cells; and selecting, from the cell population after the differentiation induction treatment, the CD44-positive and CD29-positive cells or CD44-positive and CD106-positive cells as the mesenchymal cells for the formation of the tooth.Type: GrantFiled: January 18, 2008Date of Patent: November 5, 2013Assignee: Organ Technologies Inc.Inventors: Takashi Tsuji, Ritsuko Morita
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Publication number: 20130109093Abstract: A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured to obtain a tooth having a specific cell placement. Preferably, after the culturing, the support carrier having both cell masses is cultured with kidney cells.Type: ApplicationFiled: December 18, 2012Publication date: May 2, 2013Applicant: ORGAN TECHNOLOGIES INC.Inventors: Takashi TSUJI, Kazuhisa NAKAO
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Publication number: 20130101951Abstract: The object of the present invention is to provide a method for restoring the alveolar bone of a mammal with a missing tooth. The present invention provides a method for restoring the alveolar bone in a mammal with a missing tooth comprising a step of transplanting a regenerated tooth unit to the said missing site. The regenerated tooth unit is characterized in that it has a periodontal tissue portion in addition to a tooth crown portion.Type: ApplicationFiled: March 15, 2011Publication date: April 25, 2013Applicant: ORGAN TECHNOLOGIES, INC.Inventors: Takashi Tsuji, Kazuhisa Nakao, Masamitsu Oshima
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Publication number: 20130089827Abstract: A method for manufacturing a regenerated tooth unit comprising a step of disposing and culturing a regenerated tooth germ inside a spacer in vivo in the body of a mammal is provided, wherein said spacer is configured so as to enable prevention of said regenerated tooth germ being extended to more than the maximum tolerance; and configured such that the regenerated tooth germ disposed inside is communicatable with the exterior of the spacer.Type: ApplicationFiled: March 15, 2011Publication date: April 11, 2013Applicant: ORGAN TECHNOLOGIES, INC.Inventors: Takashi Tsuji, Kazuhisa Nakao, Masamitsu Oshima
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Patent number: 8361709Abstract: A first cell mass substantially containing only either one of mesenchymal cells or epithelial cells and a second cell mass substantially containing only the other one of the cells are positioned in contact with each other inside a support carrier which can maintain a condition of cell contact; and cultured to obtain a tooth having a specific cell placement. Preferably, after the culturing, the support carrier having both cell masses is cultured with kidney cells.Type: GrantFiled: May 30, 2006Date of Patent: January 29, 2013Assignee: Organ Technologies Inc.Inventors: Takashi Tsuji, Kazuhisa Nakao
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Publication number: 20130017533Abstract: Disclosed are a perfusion culture method and a perfusion culture device whereby a perfusate can be delivered to all parts of an organ or tissue so that the organ or tissue can be preserved while sufficiently maintaining the function thereof. Specifically disclosed is a method for perfusion culture of an organ or tissue removed from a mammal, said organ or tissue having been removed together with a second organ or tissue connected to the aforesaid organ or tissue in vivo, which comprises a step for fixing said second organ or tissue so as to hang the aforesaid organ or tissue and a step for perfusing blood vessels in the aforesaid organ or tissue with a perfusate.Type: ApplicationFiled: January 25, 2011Publication date: January 17, 2013Applicant: Organ Technologies, Inc.Inventors: Takashi Tsuji, Kazuhisa Nakao
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Patent number: 8349608Abstract: Disclosed is a method for producing a tooth, which comprises the steps of: positioning a first cell mass substantially comprising either one of amniotic mesenchymal cells or epithelial cells, and a second cell mass substantially comprising the other one in the inside of a support carrier while keeping them in close contact with each other without being mixed together; and culturing the first and second cell masses in the inside of the support carrier.Type: GrantFiled: February 28, 2008Date of Patent: January 8, 2013Assignees: Organ Technologies Inc., The Kitasato Gakuen Foundation, Nidek Co., Ltd.Inventors: Takashi Tsuji, Nobuo Sakuragawa
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Publication number: 20120149110Abstract: A method for inducing the differentiation of stem cells into tissue cells; a bioartificial organ, which contains the tissue cells; and a material for medical purposes, which contains the bioartificial organ are disclosed. Stem cells capable of proliferation, self-replication and differentiation are used and cultured by a hanging-drop method to three-dimensionally construct a cell mass of embryoid bodies, and the cell mass is cultured in the presence of HGF, GDNF, b-FGF, BMP7 and EGF. In this manner, the stem cells can be differentiated into tissue cells. A bioartificial organ can be produced using cells that have been differentiated into the tissue cells. Further, a material for medical purposes can be provided.Type: ApplicationFiled: August 11, 2010Publication date: June 14, 2012Applicant: Organ Technologies Inc.Inventors: Shinji Kitamura, Hirofumi Makino
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Publication number: 20110306135Abstract: A method for producing a tooth having a desired length in one direction includes the steps of: placing a first cell aggregate and a second cell aggregate in the inside of a support while bringing the first and the second cell aggregates into close contact with each other; and culturing the first and the second cell aggregates in the inside of the support, in which the first cell aggregate is composed of one of mesenchymal cells or epithelial cells and the second cell aggregate is composed of the other, and the size of the tooth is controlled by adjusting the length of contact between the first cell aggregate and the second cell aggregate in one direction.Type: ApplicationFiled: January 14, 2010Publication date: December 15, 2011Applicant: ORGAN TECHNOLOGIES, INC.Inventors: Takashi Tsuji, Kazuhisa Nakao
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Publication number: 20110212414Abstract: A method of producing a restorative material used to restore a tooth-deficient area in an oral cavity, the method comprising: positioning, in a support carrier, a first cell mass formed from either mesenchymal cells or epithelial cells and a second cell mass formed from the other of the mesenchymal cells or epithelial cells, one of the mesenchymal cells or epithelial cells being derived from a tooth germ and the first and second cell masses being not mixed with each other but made to closely contact each other; culturing the first and second cell masses to form a reconstructed tooth germ or tooth; and confirming directionality of the reconstructed tooth germ or tooth formed by the culturing so as to enable the reconstructed tooth germ or tooth to be embedded in the tooth-deficient area such that a tip of the tooth faces an interior of the oral cavity, the tooth germ or tooth whose directionality has been confirmed being used as a restorative material to obtain an equivalent of a missing tooth in the tooth-defType: ApplicationFiled: August 19, 2009Publication date: September 1, 2011Applicant: ORGAN TECHNOLOGIES INC.Inventors: Takashi Tsuji, Etsuko Ikeda, Hiroaki Asai
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Publication number: 20100183563Abstract: The present invention provides a dentinogenesis inducer and dentinogenesis pulp-capping material, which are effectively used for formation (regeneration) of dentin. The present invention also provides a method of producing odontoblasts useful for dental regenerative therapy and the application of the obtained odontoblasts. The dentinogenesis inducer and the dentinogenesis pulp-capping material of the present invention are both characterized by the use of an HMG-CoA reductase inhibitor as an active ingredient. Additionally, odontoblasts can be produced by culturing cells capable of differentiating into odontoblasts in the presence of the HMG-CoA reductase inhibitor.Type: ApplicationFiled: March 28, 2008Publication date: July 22, 2010Applicant: ORGAN TECHNOLOGIES, INC.Inventors: Takuo Kuboki, Mitsuaki Ono, Wataru Sonoyama, Takuo Fujisawa, Kengo Shimono, Masamitsu Oshima, Yosuke Okamoto
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Publication number: 20100129771Abstract: Disclosed is a method for producing a tooth, which comprises the steps of: positioning a first cell mass substantially comprising either one of amniotic mesenchymal cells or epithelial cells, and a second cell mass substantially comprising the other one in the inside of a support carrier while keeping them in close contact with each other without being mixed together; and culturing the first and second cell masses in the inside of the support carrier.Type: ApplicationFiled: February 28, 2008Publication date: May 27, 2010Applicants: ORGAN TECHNOLOGIES INC., THE KITASATO GAKUEN FOUNDATION, NIDEK CO., LTD.Inventors: Takashi Tsuji, Nobuo Sakuragawa
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Publication number: 20100119997Abstract: The present invention provides a method for producing mesenchymal cells for production of mesenchymal cells for formation of a tooth, the method comprising: culturing totipotent stem cells in the presence of a differentiation inducer to produce a cell population after differentiation induction treatment, the cell population containing CD44-positive and CD29-positive cells or CD44-positive and CD 106-positive cells; and selecting, from the cell population after the differentiation induction treatment, the CD44-positive and CD29-positive cells or CD44-positive and CD 106-positive cells as the mesenchymal cells for the formation of the tooth.Type: ApplicationFiled: January 18, 2008Publication date: May 13, 2010Applicant: ORGAN TECHNOLOGIES INC.Inventors: Takashi Tsuji, Ritsuko Morita