Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.
Type:
Grant
Filed:
February 5, 2016
Date of Patent:
September 3, 2019
Assignees:
University of Washington, Oricula Therapeutics LLC, Fred Hutchinson Cancer Research Center
Inventors:
Julian Simon, Graham Johnson, Edwin W. Rubel, David W. Raible, Mario D. Gonzalez, Peter C. Meltzer, Weishi Miao
Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.
Type:
Grant
Filed:
February 5, 2016
Date of Patent:
November 15, 2016
Assignees:
University of Washington, Oricula Therapeutics LLC, Fred Hutchinson Cancer Research Center
Inventors:
Julian Simon, Graham Johnson, Edwin Rubel, David Raible, Mario D. Gonzalez, Peter C. Meltzer, Weishi Miao