Abstract: Shelf stable formulations of 2-CdA in water are disclosed which contain benzyl alcohol, m-cresol, a buffer and sodium chloride or a solubilizing agent such as propylene glycol or polyethylene glycol.

Abstract: The 4-[(thien-2-yl)methyl]-imidazoles of the formulae: ##STR1## wherein R is hydrogen or methyl,X is hydrogen, C.sub.1-4 alkyl, bromine or chlorine, andY is hydrogen, C.sub.1-4 alkyl, bromine or chlorine;with the proviso that X and Y are not both simultaneously hydrogen.have exceptional analgesic activity.

Abstract: A protective packaging system that will house a fragile object during transport or mailing without using bulky packaging materials. The package is essentially flat and conforms in overall dimensions to a standard mailing envelope while providing heightened protection for the object contained therein. The protective packaging system includes an envelope and a receptacle received within the envelope for the transport of generally thin, flat, flexible, yet fragile goods. In accordance with a presently preferred embodiment, the protective packaging system is designed to safely transport medical test specimens such as dried blood spots (DBSs) or other dried bodily fluids borne by a test card constructed as a flexible substrate. The envelope and receptacle combination are flexible enough to pass through the automated equipment of the United States Postal Service (or other carrier service) yet rigid enough to withstand the handling encountered in the mails so as to avoid damage to the package's contents.

Abstract: A method and apparatus are provided for tracking information associated with a plurality of test cards. Each of the test cards is anonymously associated with a patient such that the patient's identity is unknown to a central monitoring system. A first set of unique personal identification numbers (PINs) is stored in a PIN database in the central monitoring system, and a first digital signal representing PINs from the first set of unique PINs is provided to a test kit assembler. A second digital signal, representing test kits actually assembled, is received from the test kit assembler in the central monitoring system. Each of the test kits actually assembled includes a test card having one of the unique PINs from the first set of unique PINs associated therewith. The first set of unique PINs is tracked by updating the PIN database in response to the second digital signal.

Abstract: This reagent strip is comprised of a testing portion which contains an absorbent cotton pad. This absorbent cotton pad may be placed in the mouth on the tongue to collect an oral fluid sample. A plastic frame surrounds the pad to help hold the fluid thereon. This testing strip contains at its opposite end a sealing mechanism for sealing engagement with a preservative pouch, and an oversized handle with a patient identifying mechanism. The preservative pouch of the present invention contains a pair of seals. The first seal, located proximally to the user, enables a preservative which is maintained within the pouch to be sealed during shipment of the pouch to the user. Thereafter, the user punctures the first seal upon placement of the reagent pad into the pouch. The sealing mechanism contained on the reagent pad then seals at the opening in the pouch to maintain the reagent pad in sealing arrangement within the pouch. At its distal end, the pouch contains a second sealing mechanism.

Abstract: The 4-arylcyclopenta[c]pyrroles of the following formula are effective analgesics: ##STR1## including stereoisomers and pharmaceutically acceptable salts thereof, wherein ##STR2## with the proviso that where there is a 4-position hydroxy then such is trans to the 3a and 6a hydrogens.

Abstract: This invention relates to a substantially circular tablet dispenser component system which may be adapted for a variable day start of a prescribed periodic tablet regimen. Also provided are a tablet dispenser kit, a tablet package adapted for filling the tablet dispenser system, methods of filling the tablet dispenser of the invention and methods of administering a prescribed regimen of medication using the tablet dispenser system of the invention.

Abstract: This invention relates to a substantially circular tablet dispenser component system which may be adapted for a variable day start of a prescribed periodic tablet regimen. Also provided are a tablet dispenser kit, a tablet package adapted for filling the tablet dispenser system, methods of filling the tablet dispenser of the invention and methods of administering a prescribed regimen of medication using the tablet dispenser system of the invention.

Abstract: This invention relates to a substantially circular tablet dispenser component system which may be adapted for a variable day start of a prescribed periodic tablet regimen. Also provided are a tablet dispenser kit, a tablet package adapted for filling the tablet dispenser system, methods of filling the tablet dispenser of the invention and methods of administering a prescribed regimen of medication using the tablet dispenser system of the invention.

Abstract: The 4-arylisoindoles of the following formula are effective analgesics: ##STR1## including the purified stereoisomers and pharmaceutically acceptable salts thereof,wherein ##STR2## R.sup.b is hydroxy or C.sub.1-5 alkylcarbonyloxy.

Abstract: A method for increasing the hematocrit of a normal mammal using erythropoietin (EPO) is provided. The method comprises the steps of administering to the mammal a hematocrit increasing effective amount of EPO, in a pharmaceutically acceptable form. Additionally administered is an effective amount of iron, in a pharmaceutically acceptable form, sufficient to increase the serum iron content of the mammal to an erythropoiesis supportable level. The method is useful for increasing the amount of blood that can be donated for transfusion purposes, in particular autologous transfusion.

Abstract: The 4-arylcyclopenta[c]pyrroles of the following formula are effective analgesics: ##STR1## including stereoisomers and pharmaceutically acceptable salts thereof, wherein ##STR2## with the proviso that the 3a and 6a hydrogens are cis and where there is a 4-position hydroxy then such is trans to the 3a and 6a hydrogens, andwith the proviso that R.sup.b is not hydrogen when the 4-position aryl is cis to the 3a and 6a hydrogens and there is no hydroxy at the 4-position.

Abstract: Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.

Abstract: This invention relates to substituted thiazole derivatives of the following general formula, the substituent groups of which are as defined in the specification herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients. Also included are novel intermediates for preparing the compounds of the invention.

Abstract: The 4-arylcyclopenta[c]pyrroles of the following formula are effective analgesics: ##STR1## including stereoisomers and pharmaceutically acceptable salts thereof, wherein ##STR2## with the proviso that where there is a 4-position hydroxy then such is trans to the 3a and 6a hydrogens.

Abstract: A long-lasting antifungal vaginal cream composition having stable viscosity at human body temperature is disclosed.

Abstract: Compounds represented by the general formula I: ##STR1## are disclosed as useful in treating diseases of the central nervous system.

Abstract: Compounds represented by the formula I: ##STR1## are disclosed as agents for use in treating bone wasting diseases.