Patents Assigned to Osaka Prefectural Hospital Organization
  • Patent number: 11040087
    Abstract: Provided is a therapeutic agent that effectively acts on a disease associated with abnormal glycosylation of dystroglycan. Also provided is a testing method for diseases associated with abnormal glycosylation of dystroglycan. Specifically, provided is a therapeutic agent for diseases associated with abnormal glycosylation of dystroglycan, containing CDP-ribitol as an active ingredient. Ribitol-phosphate is important in the glycan structure of dystroglycan. In order for ribitol-phosphate to be incorporated into a dystroglycan glycan, a material therefor (sugar donor) is required. In the present invention, it has been found for the first time that CDP-ribitol serves as the sugar donor. It has been confirmed that the glycan of ISPD-deficient cells can be restored by administering CDP-ribitol. Thus, the present invention, which allows CDP-ribitol to be utilized for supplementation therapy, has been completed.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: June 22, 2021
    Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, TOKYO METROPOLITAN GERIATRIC HOSPITAL AND INSTITUTE OF GERONTOLOGY, OSAKA PREFECTURAL HOSPITAL ORGANIZATION
    Inventors: Tatsushi Toda, Kazuhiro Kobayashi, Motoi Kanagawa, Tamao Endo, Hiroshi Manya, Yoshinao Wada, Michiko Tajiri
  • Publication number: 20200385708
    Abstract: The object of the invention is to provide a method for counting the number of nucleic acid molecules in a mixture of a plurality of nucleic acid molecules more highly accurately.
    Type: Application
    Filed: January 27, 2020
    Publication date: December 10, 2020
    Applicants: DNA Chip Research Inc., Osaka Prefectural Hospital Organization
    Inventors: Kikuya KATO, Yoji Kukita, Ryo Matoba
  • Patent number: 10702354
    Abstract: An object of the present invention is to provide an emission marker for being indwelled in a lumen, the emission marker having: a base part; a coil wound around the base part; an emission part electrically connected to the coil; and a cover part for covering at least the base part and the coil, wherein the emission part has a light source that emits visible light. Additionally, the present invention relates to a detector for detecting, from outside of a lumen, an emission marker indwelled in the lumen, the detector having a detection unit having an antenna that acts with a coil of the emission marker.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: July 7, 2020
    Assignee: Osaka Prefectural Hospital Organization
    Inventors: Yuma Wada, Norikatsu Miyoshi, Masayuki Ohue, Masayoshi Yasui, Masato Sakon
  • Patent number: 10683485
    Abstract: Method for producing a primary culture of cancer cells, comprising: (a) fragmenting cancer tissues derived from a living body and removing impurities from the fragmented cancer tissues, (b) subjecting the tissue masses obtained in (a) to suspension culture, and (c) subjecting the culture obtained in (b) to adherent culture.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: June 16, 2020
    Assignee: OSAKA PREFECTURAL HOSPITAL ORGANIZATION
    Inventors: Norikatsu Miyoshi, Shiki Fujino, Masayuki Ohue, Masayoshi Yasui
  • Patent number: 10584331
    Abstract: The object of the invention is to provide a method for counting the number of nucleic acid molecules in a mixture of a plurality of nucleic acid molecules more highly accurately.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: March 10, 2020
    Assignees: DNA Chip Research Inc., Osaka Prefectural Hospital Organization
    Inventors: Kikuya Kato, Yoji Kukita, Ryo Matoba
  • Publication number: 20180023055
    Abstract: Method for producing a primary culture of cancer cells, comprising: (a) fragmenting cancer tissues derived from a living body and removing impurities from the fragmented cancer tissues, (b) subjecting the tissue masses obtained in (a) to suspension culture, and (c) subjecting the culture obtained in (b) to adherent culture.
    Type: Application
    Filed: February 28, 2017
    Publication date: January 25, 2018
    Applicant: Osaka Prefectural Hospital Organization
    Inventors: Norikatsu MIYOSHI, Shiki FUJINO, Masayuki OHUE, Masayoshi YASUI
  • Patent number: 9717806
    Abstract: A method of detecting an accessory cancer lesion, comprising an administration step wherein indocyanine green is administered to a living body, an irradiation step wherein a target organ suspected of having cancer is surgically exposed and irradiated with excitation light of indocyanine green, an imaging step wherein a near-infrared fluorescence intensity distribution image from the excited indocyanine green in the target organ is obtained, and an identification step wherein an area having the near-infrared fluorescence in the intensity distribution image, excluding the area detected in preoperative examination or intraoperative macroscopic observation, is identified as an accessory cancer lesion.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: August 1, 2017
    Assignees: OSAKA PREFECTURAL HOSPITAL ORGANIZATION, HAMAMATSU PHOTONICS K.K.
    Inventors: Osamu Ishikawa, Terumasa Yamada, Kunihito Gotoh, Mitsuharu Miwa, Takahiro Shikayama
  • Patent number: 8956591
    Abstract: A method of detecting an accessory cancer lesion, comprising an administration step wherein indocyanine green is administered to a living body, an irradiation step wherein a target organ suspected of having cancer is surgically exposed and irradiated with excitation light of indocyanine green, an imaging step wherein a near-infrared fluorescence intensity distribution image from the excited indocyanine green in the target organ is obtained, and an identification step wherein an area having the near-infrared fluorescence in the intensity distribution image, excluding the area detected in preoperative examination or intraoperative macroscopic observation, is identified as an accessory cancer lesion.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: February 17, 2015
    Assignees: Osaka Prefectural Hospital Organization, Hamamatsu Photonics K.K.
    Inventors: Osamu Ishikawa, Terumasa Yamada, Kunihito Gotoh, Mitsuharu Miwa, Takahiro Shikayama
  • Patent number: 8841125
    Abstract: Disclosed is a novel cell mass derived from a cancer tissue, which can reflect the in vivo behavior of a cancer cell correctly. Also disclosed is a process for preparing the cell mass. Specifically disclosed is a cell mass derived from a cancer tissue, which is an separated product that is isolated from a cancer tissue obtained from an individual as a mass containing at least three cancer cells or a cultured product of the separated product and which can retain a proliferation ability in vitro. The cell mass derived from a cancer tissue is produced by, for example, a preparation process comprising the steps of: treating a pulverized product of a cancer tissue removed from a living body with an enzyme; and selecting and collecting a mass containing at least three cancer cells among from an enzymatic treatment product.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: September 23, 2014
    Assignees: Renaissance Energy Investment Co., Ltd., Osaka Prefectural Hospital Organization
    Inventors: Masahiro Inoue, Masayuki Ohue
  • Publication number: 20140227706
    Abstract: The object of the invention is to provide a method for quantitatively assessing the degree of progression of a malignant neoplasm in a patient who has been medicated.
    Type: Application
    Filed: May 16, 2012
    Publication date: August 14, 2014
    Applicants: DNA CHIP RESEARCH INC., Osaka Prefectural Hospital Organization
    Inventors: Kikuya Kato, Fumio Imamura, Kazuya Taniguchi, Toru Kumagai, Junji Uchida, Kazumi Nishino
  • Publication number: 20140227781
    Abstract: Disclosed is a novel cell mass derived from a cancer tissue, which can reflect the in vivo behavior of a cancer cell correctly. Also disclosed is a process for preparing the cell mass. Specifically disclosed is a cell mass derived from a cancer tissue, which is an separated product that is isolated from a cancer tissue obtained from an individual as a mass containing at least three cancer cells or a cultured product of the separated product and which can retain a proliferation ability in vitro. The cell mass derived from a cancer tissue is produced by, for example, a preparation process comprising the steps of: treating a pulverized product of a cancer tissue removed from a living body with an enzyme; and selecting and collecting a mass containing at least three cancer cells among from an enzymatic treatment product.
    Type: Application
    Filed: March 31, 2014
    Publication date: August 14, 2014
    Applicants: Osaka Prefectural Hospital Organization, Renaissance Energy Investment Co., Ltd.
    Inventors: Masahiro Inoue, Masayuki Ohue
  • Patent number: 7729868
    Abstract: The present invention provides a simplified method for analyzing a structure of glycoprotein capable of conducting a peptide sequence analysis, a sugar chain sequence analysis, and an analysis of a sugar chain binding site accurately and rapidly using a mass spectrometer.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: June 1, 2010
    Assignees: Shimadzu Corporation, Osaka Prefectural Hospital Organization
    Inventors: Koichi Tanaka, Yoshinao Wada, Yuzo Yamazaki, Yuko Fukuyama
  • Publication number: 20090285760
    Abstract: A method of detecting an accessory cancer lesion, comprising an administration step wherein indocyanine green is administered to a living body, an irradiation step wherein a target organ suspected of having cancer is surgically exposed and irradiated with excitation light of indocyanine green, an imaging step wherein a near-infrared fluorescence intensity distribution image from the excited indocyanine green in the target organ is obtained, and an identification step wherein an area having the near-infrared fluorescence in the intensity distribution image, excluding the area detected in preoperative examination or intraoperative macroscopic observation, is identified as an accessory cancer lesion.
    Type: Application
    Filed: May 14, 2009
    Publication date: November 19, 2009
    Applicants: OSAKA PREFECTURAL HOSPITAL ORGANIZATION, HAMAMATSU PHOTONICS K.K.
    Inventors: Osamu ISHIKAWA, Terumasa YAMADA, Kunihito GOTOH, Mitsuharu MIWA, Takahiro SHIKAYAMA